JP6328648B2 - 新規薬物−タンパク質コンジュゲート - Google Patents
新規薬物−タンパク質コンジュゲート Download PDFInfo
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- JP6328648B2 JP6328648B2 JP2015538560A JP2015538560A JP6328648B2 JP 6328648 B2 JP6328648 B2 JP 6328648B2 JP 2015538560 A JP2015538560 A JP 2015538560A JP 2015538560 A JP2015538560 A JP 2015538560A JP 6328648 B2 JP6328648 B2 JP 6328648B2
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- auristatin
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Landscapes
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| PCT/GB2013/052661 WO2014064423A1 (en) | 2012-10-24 | 2013-10-11 | Drug-protein conjugates |
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| JP6747971B2 (ja) | 2013-10-15 | 2020-08-26 | シアトル ジェネティックス， インコーポレイテッド | 改善されたリガンド−薬物コンジュゲート薬物動態のためのｐｅｇ化薬物−リンカー |
| EP3145552B1 (en) * | 2014-05-23 | 2020-03-04 | Novartis AG | Methods for making conjugates from disulfide-containing proteins |
| MY177148A (en) * | 2014-06-12 | 2020-09-08 | Cspc Megalith Biopharmaceutical Co Ltd | Homogenous antibody drug conjugates via enzymatic methods |
| ES2885854T3 (es) | 2014-10-14 | 2021-12-15 | Polytherics Ltd | Proceso para la conjugación de un péptido o proteína con un reactivo que comprende un grupo saliente que incluye una porción de PEG |
| US20170290925A1 (en) * | 2014-10-24 | 2017-10-12 | Polytherics Limited | Conjugates And Conjugating Reagents |
| GB201419108D0 (en) | 2014-10-27 | 2014-12-10 | Glythera Ltd | Materials and methods relating to linkers for use in antibody drug conjugates |
| CN107043406B (zh) | 2015-11-03 | 2021-08-17 | 财团法人工业技术研究院 | 化合物、连接子-药物、及配体-药物耦合体 |
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| US11229708B2 (en) | 2015-12-04 | 2022-01-25 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
| EP3433278A4 (en) | 2016-03-25 | 2019-11-06 | Seattle Genetics, Inc. | METHOD FOR THE PRODUCTION OF PEGYLATED ACTIVE LINKERS AND INTERMEDIATE PRODUCTS THEREOF |
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| GB201608936D0 (en) | 2016-05-20 | 2016-07-06 | Polytherics Ltd | Novel conjugates and novel conjugating reagents |
| ES2965349T3 (es) * | 2016-06-06 | 2024-04-12 | Abzena Uk Ltd | Anticuerpos, usos de los mismos y conjugados de los mismos |
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| CN110430901B (zh) | 2017-03-24 | 2024-08-16 | 西雅图基因公司 | 制备葡糖苷酸药物-接头及其中间体的方法 |
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| CN119345387A (zh) * | 2020-04-15 | 2025-01-24 | 深圳康源久远生物技术有限公司 | 抗体药物缀合物 |
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| US20250222124A1 (en) * | 2022-01-27 | 2025-07-10 | Glyco-Therapy Biotechnology Co., Ltd. | Protein conjugates with multiple payloads and methods for making the same |
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| WO2010100430A1 (en) | 2009-03-04 | 2010-09-10 | Polytherics Limited | Conjugated proteins and peptides |
| MX2011010264A (es) * | 2009-04-01 | 2011-10-11 | Genentech Inc | Anticuerpos anti-fcrh5 e inmunoconjugados y metodos de uso. |
| UY32913A (es) * | 2009-10-02 | 2011-04-29 | Sanofi Aventis | Nuevos maitansinoides y el uso de dichos maitansinoides para preparar conjugados con un anticuero |
| JP6384963B2 (ja) * | 2012-04-25 | 2018-09-05 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 勾配コイルを置くためのシステム及び方法 |
| EP2861261A2 (en) * | 2012-06-19 | 2015-04-22 | Polytherics Limited | Process for preparation of antibody conjugates and antibody conjugates |
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2013
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- 2013-10-11 EP EP16203350.0A patent/EP3159013A1/en not_active Withdrawn
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- 2013-10-11 WO PCT/GB2013/052661 patent/WO2014064423A1/en not_active Ceased
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| CA2884299A1 (en) | 2014-05-01 |
| US20220062436A1 (en) | 2022-03-03 |
| CN104870021B (zh) | 2018-03-13 |
| AU2013336409A1 (en) | 2015-04-02 |
| SG11201501618WA (en) | 2015-04-29 |
| DK2911700T3 (en) | 2017-05-15 |
| US20150290342A1 (en) | 2015-10-15 |
| EP2911700B1 (en) | 2017-02-08 |
| CN104870021A (zh) | 2015-08-26 |
| MY169147A (en) | 2019-02-18 |
| KR102209395B1 (ko) | 2021-01-28 |
| KR20150103656A (ko) | 2015-09-11 |
| DK2911700T5 (en) | 2017-05-22 |
| BR112015008376A2 (pt) | 2017-09-26 |
| EP3159013A1 (en) | 2017-04-26 |
| EP2911700A1 (en) | 2015-09-02 |
| JP2015533847A (ja) | 2015-11-26 |
| RU2015119561A (ru) | 2016-12-20 |
| WO2014064423A1 (en) | 2014-05-01 |
| AU2013336409B2 (en) | 2017-08-03 |
| IL237672A0 (en) | 2015-04-30 |
| MX2015005122A (es) | 2015-10-29 |
| IL237672B (en) | 2018-02-28 |
| IN2015DN02349A (enExample) | 2015-08-28 |
| ZA201501642B (en) | 2016-01-27 |
| ES2623209T3 (es) | 2017-07-10 |
| HK1208187A1 (en) | 2016-02-26 |
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