JP6326086B2 - トランス−2−ノナデシル−4−ヒドロキシメチル−1、3−ジオキソラン化合物とその調製方法 - Google Patents
トランス−2−ノナデシル−4−ヒドロキシメチル−1、3−ジオキソラン化合物とその調製方法 Download PDFInfo
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- JP6326086B2 JP6326086B2 JP2016095437A JP2016095437A JP6326086B2 JP 6326086 B2 JP6326086 B2 JP 6326086B2 JP 2016095437 A JP2016095437 A JP 2016095437A JP 2016095437 A JP2016095437 A JP 2016095437A JP 6326086 B2 JP6326086 B2 JP 6326086B2
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- 238000002360 preparation method Methods 0.000 title claims description 5
- -1 Trans-2-nonadecyl-4-hydroxymethyl-1,3-dioxolane compound Chemical class 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 16
- LEHBURLTIWGHEM-UHFFFAOYSA-N pyridinium chlorochromate Chemical compound [O-][Cr](Cl)(=O)=O.C1=CC=[NH+]C=C1 LEHBURLTIWGHEM-UHFFFAOYSA-N 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 5
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims description 3
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- BUIQRTDBPCHRIR-UHFFFAOYSA-L O[Cr](Cl)(=O)=O Chemical compound O[Cr](Cl)(=O)=O BUIQRTDBPCHRIR-UHFFFAOYSA-L 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 30
- 239000004480 active ingredient Substances 0.000 description 14
- 208000019425 cirrhosis of liver Diseases 0.000 description 10
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- 241000269959 Xiphias gladius Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 235000021335 sword fish Nutrition 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 208000019423 liver disease Diseases 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 235000013372 meat Nutrition 0.000 description 5
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 4
- 206010016654 Fibrosis Diseases 0.000 description 3
- 238000005481 NMR spectroscopy Methods 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
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- 238000004809 thin layer chromatography Methods 0.000 description 3
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 2
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010019668 Hepatic fibrosis Diseases 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- HPXRASQACBNMFL-DHIUTWEWSA-N [(2R,4R)-2-nonadecyl-1,3-dioxolan-4-yl]methanol Chemical compound C(CCCCCCCCCCCCCCCCCC)[C@@H]1OC[C@H](O1)CO HPXRASQACBNMFL-DHIUTWEWSA-N 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
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- 239000000706 filtrate Substances 0.000 description 2
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- 201000007270 liver cancer Diseases 0.000 description 2
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- 238000010898 silica gel chromatography Methods 0.000 description 2
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- 230000001225 therapeutic effect Effects 0.000 description 2
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- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 description 1
- 241000251730 Chondrichthyes Species 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
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- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical class [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000003377 acid catalyst Substances 0.000 description 1
- 210000004404 adrenal cortex Anatomy 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001793 charged compounds Chemical class 0.000 description 1
- 229960001338 colchicine Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
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- 238000007796 conventional method Methods 0.000 description 1
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- 235000015872 dietary supplement Nutrition 0.000 description 1
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- 238000010828 elution Methods 0.000 description 1
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- 208000010706 fatty liver disease Diseases 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
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- 230000006870 function Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
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- 239000004615 ingredient Substances 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 238000005184 irreversible process Methods 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000009993 protective function Effects 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
化学式(II)の化合物と化学式(III)の化合物をアセタール反応させて、化学式(I)の化合物を含む混合物を得ることができる。
本発明の実施例において、該化学式(I)の化合物を含む混合物は分離方法によって精製され、該分離方法はカラムクロマトグラフィ、溶離または当業者が熟知する方法を含んでいるが、これに限定されない。
化学式(I)の化合物の調製
先ず、等量の化学式(IV)の化合物とクロロクロム酸ピリジニウム(pyridinium chlorochromate、PCC)を共にジクロロメタン(CH2Cl2)内に溶解して、30℃で撹拌混合する。本実施例の中で、化学式(IV)の化合物とクロロクロム酸ピリジニウムはそれぞれ1グラムで、ジクロロメタンは20ミリリットルである。化学式(IV)の化合物とクロロクロム酸ピリジニウムを有するジクロロメタンをセライト(celite)により空気抽出・ろ過を行うことでろ過液が得られ、その後、該ろ過液を減圧濃縮して化学式(II)の化合物が得られることができる。化学式(II)は白色固体である。
シジミを精製することによって肝臓保護機能を有する活性成分
従来技術において、65キログラムのシジミを取って、殻を剥くことで約27.7キログラムのシジミ肉を得る。シジミ肉を熱風で乾燥し、乾燥後のシジミ肉の重量が約2.5キログラムで、更に乾燥されたシジミ肉量の3倍のアルコール内に浸漬し、抽出を行って、約1キログラムのシジミ酒抽出物を得る。
Claims (3)
-
-
nium chlorochromate)が有機溶媒内で酸化反応を行って得られていることを特徴とする
請求項1に記載の調製方法。 - 前記化学式(I)の化合物を含む混合物は、分離方法によって精製されていることを特徴
とする請求項1に記載の化学式(I)の化合物またはそれの医薬上で受けられる塩の調製
方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW103102539 | 2014-01-23 | ||
TW103102539A TWI553000B (zh) | 2014-01-23 | 2014-01-23 | 反式-2-19烷基-4-羥甲基-1,3-二氧戊環化合物及其製備方法 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014085186A Division JP2015137277A (ja) | 2014-01-23 | 2014-04-17 | トランス−2−ノナデシル−4−ヒドロキシメチル−1、3−ジオキソラン化合物とその調製方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2016138150A JP2016138150A (ja) | 2016-08-04 |
JP2016138150A5 JP2016138150A5 (ja) | 2017-06-15 |
JP6326086B2 true JP6326086B2 (ja) | 2018-05-16 |
Family
ID=53544198
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014085186A Pending JP2015137277A (ja) | 2014-01-23 | 2014-04-17 | トランス−2−ノナデシル−4−ヒドロキシメチル−1、3−ジオキソラン化合物とその調製方法 |
JP2016095437A Active JP6326086B2 (ja) | 2014-01-23 | 2016-05-11 | トランス−2−ノナデシル−4−ヒドロキシメチル−1、3−ジオキソラン化合物とその調製方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014085186A Pending JP2015137277A (ja) | 2014-01-23 | 2014-04-17 | トランス−2−ノナデシル−4−ヒドロキシメチル−1、3−ジオキソラン化合物とその調製方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20150203466A1 (ja) |
JP (2) | JP2015137277A (ja) |
KR (1) | KR101644450B1 (ja) |
CN (1) | CN104803966A (ja) |
MY (1) | MY182857A (ja) |
TW (1) | TWI553000B (ja) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2906807A1 (fr) * | 2006-10-09 | 2008-04-11 | Arkema France | Procede de synthese d'acetals cycliques par extraction reactive d'un polyol en solution concentree |
FR2950894B1 (fr) * | 2009-10-06 | 2011-12-23 | Arkema France | Utilisation d'acetals de glycerol comme agents de coalescence pour laques, peintures ou vernis et compositions les comprenant |
TW201114465A (en) * | 2009-10-19 | 2011-05-01 | Univ Nat Kaohsiung Marine | Purification process and substance for clam |
-
2014
- 2014-01-23 TW TW103102539A patent/TWI553000B/zh active
- 2014-03-17 CN CN201410099171.4A patent/CN104803966A/zh active Pending
- 2014-03-28 KR KR1020140036865A patent/KR101644450B1/ko active IP Right Grant
- 2014-04-17 JP JP2014085186A patent/JP2015137277A/ja active Pending
- 2014-08-11 US US14/456,066 patent/US20150203466A1/en not_active Abandoned
- 2014-08-12 MY MYPI2014702242A patent/MY182857A/en unknown
-
2016
- 2016-05-11 JP JP2016095437A patent/JP6326086B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
JP2016138150A (ja) | 2016-08-04 |
TW201529564A (zh) | 2015-08-01 |
JP2015137277A (ja) | 2015-07-30 |
KR20150088162A (ko) | 2015-07-31 |
KR101644450B1 (ko) | 2016-08-10 |
TWI553000B (zh) | 2016-10-11 |
CN104803966A (zh) | 2015-07-29 |
MY182857A (en) | 2021-02-05 |
US20150203466A1 (en) | 2015-07-23 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
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R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |