JP6325453B2 - ヘテロ接合性の消失(lossofheterozygosity)を評価するための方法および材料 - Google Patents
ヘテロ接合性の消失(lossofheterozygosity)を評価するための方法および材料 Download PDFInfo
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- JP6325453B2 JP6325453B2 JP2014548965A JP2014548965A JP6325453B2 JP 6325453 B2 JP6325453 B2 JP 6325453B2 JP 2014548965 A JP2014548965 A JP 2014548965A JP 2014548965 A JP2014548965 A JP 2014548965A JP 6325453 B2 JP6325453 B2 JP 6325453B2
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- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/10—Ploidy or copy number detection
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- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578713P | 2011-12-21 | 2011-12-21 | |
| US61/578,713 | 2011-12-21 | ||
| US201261654402P | 2012-06-01 | 2012-06-01 | |
| US61/654,402 | 2012-06-01 | ||
| PCT/US2012/071380 WO2013096843A1 (en) | 2011-12-21 | 2012-12-21 | Methods and materials for assessing loss of heterozygosity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018076503A Division JP6700333B2 (ja) | 2011-12-21 | 2018-04-12 | ヘテロ接合性の消失(loss of heterozygosity)を評価するための方法および材料 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015506678A JP2015506678A (ja) | 2015-03-05 |
| JP2015506678A5 JP2015506678A5 (https=) | 2016-02-04 |
| JP6325453B2 true JP6325453B2 (ja) | 2018-05-16 |
Family
ID=48669561
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548965A Active JP6325453B2 (ja) | 2011-12-21 | 2012-12-21 | ヘテロ接合性の消失(lossofheterozygosity)を評価するための方法および材料 |
| JP2018076503A Active JP6700333B2 (ja) | 2011-12-21 | 2018-04-12 | ヘテロ接合性の消失(loss of heterozygosity)を評価するための方法および材料 |
| JP2020079997A Active JP7128853B2 (ja) | 2011-12-21 | 2020-04-30 | ヘテロ接合性の消失(loss of heterozygosity)を評価するための方法および材料 |
| JP2022130844A Active JP7595619B2 (ja) | 2011-12-21 | 2022-08-19 | ヘテロ接合性の消失(loss of heterozygosity)を評価するための方法および材料 |
| JP2024205398A Active JP7844597B2 (ja) | 2011-12-21 | 2024-11-26 | ヘテロ接合性の消失(loss of heterozygosity)を評価するための方法および材料 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018076503A Active JP6700333B2 (ja) | 2011-12-21 | 2018-04-12 | ヘテロ接合性の消失(loss of heterozygosity)を評価するための方法および材料 |
| JP2020079997A Active JP7128853B2 (ja) | 2011-12-21 | 2020-04-30 | ヘテロ接合性の消失(loss of heterozygosity)を評価するための方法および材料 |
| JP2022130844A Active JP7595619B2 (ja) | 2011-12-21 | 2022-08-19 | ヘテロ接合性の消失(loss of heterozygosity)を評価するための方法および材料 |
| JP2024205398A Active JP7844597B2 (ja) | 2011-12-21 | 2024-11-26 | ヘテロ接合性の消失(loss of heterozygosity)を評価するための方法および材料 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US9388472B2 (https=) |
| EP (3) | EP2794907B2 (https=) |
| JP (5) | JP6325453B2 (https=) |
| CN (2) | CN107267598B (https=) |
| AU (4) | AU2012358244A1 (https=) |
| BR (1) | BR112014015152A2 (https=) |
| CA (1) | CA2860312C (https=) |
| DK (1) | DK2794907T4 (https=) |
| ES (1) | ES2759533T5 (https=) |
| FI (1) | FI2794907T4 (https=) |
| WO (1) | WO2013096843A1 (https=) |
Families Citing this family (31)
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| EP3012329B1 (en) | 2010-06-18 | 2017-10-25 | Myriad Genetics, Inc. | Methods and materials for assessing loss of heterozygosity |
| WO2012027224A1 (en) | 2010-08-24 | 2012-03-01 | Dana-Farber Cancer Institute, Inc. | Methods for predicting anti-cancer response |
| JP6117194B2 (ja) | 2011-06-17 | 2017-04-19 | ミリアド・ジェネティックス・インコーポレイテッド | アレル不均衡を評価するための方法および材料 |
| BR112014015152A2 (pt) | 2011-12-21 | 2017-07-04 | Myriad Genetics Inc | métodos e materiais para a avaliação da perda de heterozigosidade |
| CA2864481C (en) | 2012-02-23 | 2020-07-14 | Dana-Farber Cancer Institute, Inc. | Methods for predicting anti-cancer response |
| WO2013182645A1 (en) | 2012-06-07 | 2013-12-12 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
| WO2015086473A1 (en) | 2013-12-09 | 2015-06-18 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
| CN105917007A (zh) * | 2014-01-16 | 2016-08-31 | 克洛维斯肿瘤有限公司 | Parp抑制剂用以治疗显示杂合性丧失的乳腺癌或卵巢癌患者的用途 |
| CA2958801A1 (en) | 2014-08-15 | 2016-02-18 | Myriad Genetics, Inc. | Methods and materials for assessing homologous recombination deficiency |
| US20160160294A1 (en) * | 2014-12-08 | 2016-06-09 | Tesaro | Methods and materials for predicting response to niraparib |
| WO2016185406A1 (en) | 2015-05-19 | 2016-11-24 | Nadathur Estates Pvt. Ltd. | Method for identification of a deficient brca1 function |
| GB2555765A (en) | 2016-05-01 | 2018-05-16 | Genome Res Ltd | Method of detecting a mutational signature in a sample |
| EP3452937B1 (en) | 2016-05-01 | 2025-10-22 | Genome Research Limited | Method of characterising a dna sample |
| JP7224185B2 (ja) * | 2016-05-01 | 2023-02-17 | ゲノム・リサーチ・リミテッド | Dnaサンプルを特徴付ける方法 |
| GB201607629D0 (en) * | 2016-05-01 | 2016-06-15 | Genome Res Ltd | Mutational signatures in cancer |
| CN107287285A (zh) * | 2017-03-28 | 2017-10-24 | 上海至本生物科技有限公司 | 一种预测同源重组缺失机制及患者对癌症治疗响应的方法 |
| US11830579B2 (en) | 2017-07-25 | 2023-11-28 | Sophia Genetics Sa | Methods for detecting biallelic loss of function in next-generation sequencing genomic data |
| CN112805563B (zh) * | 2018-05-18 | 2025-06-13 | 约翰·霍普金斯大学 | 用于评估和/或治疗癌症的无细胞dna |
| IT201900013335A1 (it) * | 2019-07-30 | 2021-01-30 | Menarini Silicon Biosystems Spa | Metodo per analizzare la perdita di eterozigosi (loh) a seguito di amplificazione totale del genoma basata su un sito di restrizione deterministico (drs-wga) |
| CN114787374A (zh) * | 2019-10-29 | 2022-07-22 | 斯坦福大学托管董事会 | 基于对治疗的分子反应的治疗方法 |
| EP3945525A1 (en) | 2020-07-27 | 2022-02-02 | Sophia Genetics S.A. | Methods for identifying chromosomal spatial instability such as homologous repair deficiency in low coverage next-generation sequencing data |
| CN112410423B (zh) * | 2020-11-03 | 2021-08-13 | 南京世和基因生物技术股份有限公司 | 同源重组缺失的标志物、检测方法以及检测系统 |
| CN112226495B (zh) * | 2020-12-18 | 2021-03-16 | 北京迈基诺基因科技股份有限公司 | 一种dna同源重组异常的检测方法及其应用 |
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| US20240026462A1 (en) * | 2021-01-10 | 2024-01-25 | Ying Ja CHEN | Homologous recombination deficiency determining method and kit thereof |
| CN113466417B (zh) * | 2021-05-13 | 2023-03-21 | 柳州东风容泰化工股份有限公司 | 一种氟尿嘧啶的制备纯度评估方法及系统 |
| US12188961B2 (en) | 2022-07-29 | 2025-01-07 | International Business Machines Corporation | Method for accurate pad contact testing |
| EP4605937A1 (en) | 2022-10-19 | 2025-08-27 | Vib Vzw | Method of determining loss of heterozygosity status of a tumor |
| WO2025078387A1 (en) | 2023-10-10 | 2025-04-17 | Vib Vzw | Method of detecting loss of heterozygosity status of a tumor |
| WO2025078404A1 (en) | 2023-10-10 | 2025-04-17 | Vib Vzw | Methods of determining response of a tumor to dna-damaging agents or to agents inhibiting or impairing dna repair |
| WO2025173014A1 (en) | 2024-02-16 | 2025-08-21 | Onecell Diagnostics India Private Limited | A method for selecting ovarian cancer patients for parp inhibitor treatment |
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