JP6324381B2 - 抗ｅｇｆｒ薬物による処置のための非小細胞肺癌患者を同定するための組織学的マーカー - Google Patents

抗ｅｇｆｒ薬物による処置のための非小細胞肺癌患者を同定するための組織学的マーカー Download PDF

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JP6324381B2
JP6324381B2 JP2015525570A JP2015525570A JP6324381B2 JP 6324381 B2 JP6324381 B2 JP 6324381B2 JP 2015525570 A JP2015525570 A JP 2015525570A JP 2015525570 A JP2015525570 A JP 2015525570A JP 6324381 B2 JP6324381 B2 JP 6324381B2
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treatment
egfr
nsclc
lung cancer
cetuximab
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JP2015527341A5 (enExample
JP2015527341A (ja
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ヘンリー チシャン リ
ヘンリー チシャン リ
メンメン ヤン
メンメン ヤン
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クラウン バイオサイエンス インコーポレイテッド（タイカン）
クラウン バイオサイエンス インコーポレイテッド（タイカン）
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    • G01N33/57423—Specifically defined cancers of lung
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2015525570A 2012-07-31 2013-07-31 抗ｅｇｆｒ薬物による処置のための非小細胞肺癌患者を同定するための組織学的マーカー Expired - Fee Related JP6324381B2 (ja)

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Application Number Priority Date Filing Date Title
CNPCT/CN2012/079399 2012-07-31
CN2012079399 2012-07-31
PCT/US2013/053091 WO2014028221A1 (en) 2012-07-31 2013-07-31 Histological markers for identifying non-small cell lung carcinoma patients for treatment with an anti-egfr drug

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JP2015527341A JP2015527341A (ja) 2015-09-17
JP2015527341A5 JP2015527341A5 (enExample) 2016-07-07
JP6324381B2 true JP6324381B2 (ja) 2018-05-16

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US (1) US9921222B2 (enExample)
EP (1) EP2879712B1 (enExample)
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RU2017112960A (ru) * 2014-09-16 2018-10-17 Эббви Инк. Велипариб в комбинации с карбоплатином и паклитакселом для лечения немелкоклеточного рака легких у курильщиков
TWI859118B (zh) * 2017-03-29 2024-10-21 大陸商中美冠科生物技術（太倉）有限公司 測定對胃癌之西妥昔單抗（ｃｅｔｕｘｉｍａｂ）敏感性的系統及方法
CN112813164A (zh) * 2021-01-18 2021-05-18 四川省肿瘤医院 Ereg促进nsclc细胞对egfr-tki产生耐药性原因的验证方法

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AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
US5942602A (en) 1997-02-13 1999-08-24 Schering Aktiengessellschaft Growth factor receptor antibodies
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
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EP1622941A2 (en) 2003-03-20 2006-02-08 ImClone Systems Incorporated Method of producing an antibody to epidermal growth factor receptor
WO2005090407A1 (en) 2004-03-19 2005-09-29 Imclone Systems Incorporated Human anti-epidermal growth factor receptor antibody
WO2007001868A1 (en) 2005-06-28 2007-01-04 Genentech, Inc. Egfr and kras mutations
WO2007058823A2 (en) 2005-11-12 2007-05-24 Eli Lilly And Company Anti-egfr antibodies
WO2008140493A2 (en) 2006-11-21 2008-11-20 The Regents Of The University Of Californina Anti-egfr family antibodies, bispecific anti-egfr family antibodies and methods of use thereof
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
KR100968591B1 (ko) 2007-06-14 2010-07-08 한국과학기술연구원 약물전달용 폴리포스파젠계 하이드로젤, 그의 제조방법 및그의 용도
US20100009390A1 (en) 2008-05-09 2010-01-14 The Regents Of The University Of California Mutant antibodies with high affinity for egfr
CN102164960A (zh) 2008-09-26 2011-08-24 罗氏格黎卡特股份公司 双特异性抗-egfr/抗-igf-1r抗体
WO2010080463A1 (en) 2008-12-18 2010-07-15 Imclone Llc Antibody humanization
KR101108642B1 (ko) 2009-09-29 2012-02-09 주식회사 녹십자 표피 성장 인자 수용체에 특이적으로 결합하는 항체
ES2639056T3 (es) 2009-10-28 2017-10-25 Abbvie Biotherapeutics Inc. Anticuerpos anti-EGFR y sus usos
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US20150168411A1 (en) 2015-06-18
EP2879712A1 (en) 2015-06-10
WO2014028221A1 (en) 2014-02-20
JP2015527341A (ja) 2015-09-17
EP2879712B1 (en) 2018-04-25
ES2668861T3 (es) 2018-05-22
US9921222B2 (en) 2018-03-20
EP2879712A4 (en) 2016-03-16

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