JP6324381B2 - 抗ｅｇｆｒ薬物による処置のための非小細胞肺癌患者を同定するための組織学的マーカー - Google Patents

抗ｅｇｆｒ薬物による処置のための非小細胞肺癌患者を同定するための組織学的マーカー Download PDF

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JP6324381B2
JP6324381B2 JP2015525570A JP2015525570A JP6324381B2 JP 6324381 B2 JP6324381 B2 JP 6324381B2 JP 2015525570 A JP2015525570 A JP 2015525570A JP 2015525570 A JP2015525570 A JP 2015525570A JP 6324381 B2 JP6324381 B2 JP 6324381B2
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treatment
egfr
nsclc
lung cancer
cetuximab
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JP2015527341A (ja
JP2015527341A5 (enExample
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ヘンリー チシャン リ
ヘンリー チシャン リ
メンメン ヤン
メンメン ヤン
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クラウン バイオサイエンス インコーポレイテッド（タイカン）
クラウン バイオサイエンス インコーポレイテッド（タイカン）
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    • G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015525570A 2012-07-31 2013-07-31 抗ｅｇｆｒ薬物による処置のための非小細胞肺癌患者を同定するための組織学的マーカー Expired - Fee Related JP6324381B2 (ja)

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CNPCT/CN2012/079399 2012-07-31
CN2012079399 2012-07-31
PCT/US2013/053091 WO2014028221A1 (en) 2012-07-31 2013-07-31 Histological markers for identifying non-small cell lung carcinoma patients for treatment with an anti-egfr drug

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JP2015527341A JP2015527341A (ja) 2015-09-17
JP2015527341A5 JP2015527341A5 (enExample) 2016-07-07
JP6324381B2 true JP6324381B2 (ja) 2018-05-16

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US (1) US9921222B2 (enExample)
EP (1) EP2879712B1 (enExample)
JP (1) JP6324381B2 (enExample)
CN (1) CN104168921B (enExample)
ES (1) ES2668861T3 (enExample)
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JP2017527627A (ja) * 2014-09-16 2017-09-21 アッヴィ・インコーポレイテッド 喫煙者における非小細胞肺癌の治療のための、カルボプラチンおよびパクリタキセルと併用したベリパリブ
CN110520543A (zh) 2017-03-29 2019-11-29 中美冠科生物技术（太仓）有限公司 确定胃癌对西妥昔单抗敏感性的系统和方法
CN112813164A (zh) * 2021-01-18 2021-05-18 四川省肿瘤医院 Ereg促进nsclc细胞对egfr-tki产生耐药性原因的验证方法
CN115810399A (zh) * 2022-11-14 2023-03-17 南京工业大学 一种基于转录模式的肺腺癌组织学亚型分类方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
US5942602A (en) 1997-02-13 1999-08-24 Schering Aktiengessellschaft Growth factor receptor antibodies
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
EP2110138A1 (en) 1999-08-27 2009-10-21 Genentech, Inc. Dosages for treatment of anti-erbB2 antibodies
EP1622941A2 (en) 2003-03-20 2006-02-08 ImClone Systems Incorporated Method of producing an antibody to epidermal growth factor receptor
ES2387809T3 (es) 2004-03-19 2012-10-02 Imclone Llc Anticuerpo frente al receptor del factor de crecimiento epidérmico humano
SI1913157T2 (sl) 2005-06-28 2017-02-28 Genentech, Inc. EGFR in KRAS mutacije za napoved bolnikovega odziva na zdravljenje z EGFR inhibitorjem
JP2009515878A (ja) 2005-11-12 2009-04-16 イーライ リリー アンド カンパニー 抗ｅｇｆｒ抗体
AU2007353412A1 (en) 2006-11-21 2008-11-20 Fox Chase Cancer Center Anti-EGFR family antibodies, bispecific anti-EGFR family antibodies and methods of use thereof
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
KR100968591B1 (ko) 2007-06-14 2010-07-08 한국과학기술연구원 약물전달용 폴리포스파젠계 하이드로젤, 그의 제조방법 및그의 용도
US20100009390A1 (en) 2008-05-09 2010-01-14 The Regents Of The University Of California Mutant antibodies with high affinity for egfr
KR20110047255A (ko) 2008-09-26 2011-05-06 로슈 글리카트 아게 이중특이적 항-ｅｇｆｒ／항-ｉｇｆ-１ｒ 항체
WO2010080463A1 (en) 2008-12-18 2010-07-15 Imclone Llc Antibody humanization
KR101108642B1 (ko) 2009-09-29 2012-02-09 주식회사 녹십자 표피 성장 인자 수용체에 특이적으로 결합하는 항체
US8658175B2 (en) 2009-10-28 2014-02-25 Abbvie Biotherapeutics Inc. Anti-EGFR antibodies and their uses
US20110118298A1 (en) * 2009-11-13 2011-05-19 Infinity Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer
US20110158987A1 (en) 2009-12-29 2011-06-30 F. Hoffmann-Laroche Ag Novel antibody formulation
JP2011144124A (ja) 2010-01-13 2011-07-28 Fujirebio Inc 活性型ｅｇｆｒ特異抗体
WO2011140151A1 (en) 2010-05-04 2011-11-10 Dyax Corp. Antibodies against epidermal growth factor receptor (egfr)
WO2011140254A1 (en) 2010-05-04 2011-11-10 Adimab, Llc Antibodies against epidermal growth factor receptor (egfr) and uses thereof
US9029513B2 (en) 2010-06-04 2015-05-12 Toagosei Co. Ltd. Anti-EGFR antibody and use thereof
WO2011156617A2 (en) 2010-06-09 2011-12-15 Aveo Pharmaceuticals, Inc. Anti-egfr antibodies
BR112013003257A2 (pt) 2010-08-10 2016-06-14 Glycotope Gmbh anticorpos egfr humanizados.
US9155802B2 (en) 2010-11-01 2015-10-13 Symphogen A/S Pan-HER antibody composition
US8691231B2 (en) 2011-06-03 2014-04-08 Merrimack Pharmaceuticals, Inc. Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies

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WO2014028221A1 (en) 2014-02-20
ES2668861T3 (es) 2018-05-22
EP2879712B1 (en) 2018-04-25
EP2879712A1 (en) 2015-06-10
CN104168921B (zh) 2018-06-08
CN104168921A (zh) 2014-11-26
US9921222B2 (en) 2018-03-20
JP2015527341A (ja) 2015-09-17
US20150168411A1 (en) 2015-06-18
EP2879712A4 (en) 2016-03-16

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