JP6324381B2 - 抗egfr薬物による処置のための非小細胞肺癌患者を同定するための組織学的マーカー - Google Patents
抗egfr薬物による処置のための非小細胞肺癌患者を同定するための組織学的マーカー Download PDFInfo
- Publication number
- JP6324381B2 JP6324381B2 JP2015525570A JP2015525570A JP6324381B2 JP 6324381 B2 JP6324381 B2 JP 6324381B2 JP 2015525570 A JP2015525570 A JP 2015525570A JP 2015525570 A JP2015525570 A JP 2015525570A JP 6324381 B2 JP6324381 B2 JP 6324381B2
- Authority
- JP
- Japan
- Prior art keywords
- treatment
- egfr
- nsclc
- lung cancer
- cetuximab
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2012/079399 | 2012-07-31 | ||
| CN2012079399 | 2012-07-31 | ||
| PCT/US2013/053091 WO2014028221A1 (en) | 2012-07-31 | 2013-07-31 | Histological markers for identifying non-small cell lung carcinoma patients for treatment with an anti-egfr drug |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015527341A JP2015527341A (ja) | 2015-09-17 |
| JP2015527341A5 JP2015527341A5 (cg-RX-API-DMAC7.html) | 2016-07-07 |
| JP6324381B2 true JP6324381B2 (ja) | 2018-05-16 |
Family
ID=50101405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015525570A Expired - Fee Related JP6324381B2 (ja) | 2012-07-31 | 2013-07-31 | 抗egfr薬物による処置のための非小細胞肺癌患者を同定するための組織学的マーカー |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9921222B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2879712B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6324381B2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2668861T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014028221A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017527627A (ja) * | 2014-09-16 | 2017-09-21 | アッヴィ・インコーポレイテッド | 喫煙者における非小細胞肺癌の治療のための、カルボプラチンおよびパクリタキセルと併用したベリパリブ |
| CN110520543A (zh) | 2017-03-29 | 2019-11-29 | 中美冠科生物技术(太仓)有限公司 | 确定胃癌对西妥昔单抗敏感性的系统和方法 |
| CN112813164A (zh) * | 2021-01-18 | 2021-05-18 | 四川省肿瘤医院 | Ereg促进nsclc细胞对egfr-tki产生耐药性原因的验证方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
| US5942602A (en) | 1997-02-13 | 1999-08-24 | Schering Aktiengessellschaft | Growth factor receptor antibodies |
| US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| BR0013814A (pt) | 1999-08-27 | 2002-04-23 | Genentech Inc | Métodos de tratamentos de um paciente humano suscetìvel a ou diagnosticado com uma doença com anticorpos anti-erbb2, artigos industrializados, métodos de tratamentos de câncer em pacientes humanos e usos do anticorpo anti-erbb2 |
| EP1622941A2 (en) | 2003-03-20 | 2006-02-08 | ImClone Systems Incorporated | Method of producing an antibody to epidermal growth factor receptor |
| ES2387809T3 (es) | 2004-03-19 | 2012-10-02 | Imclone Llc | Anticuerpo frente al receptor del factor de crecimiento epidérmico humano |
| JP2008546421A (ja) | 2005-06-28 | 2008-12-25 | ジェネンテック・インコーポレーテッド | Egfrおよびkras変異 |
| ATE461220T1 (de) | 2005-11-12 | 2010-04-15 | Lilly Co Eli | Anti-egfr-antikörper |
| AU2007353412A1 (en) | 2006-11-21 | 2008-11-20 | Fox Chase Cancer Center | Anti-EGFR family antibodies, bispecific anti-EGFR family antibodies and methods of use thereof |
| US7977336B2 (en) | 2006-12-28 | 2011-07-12 | Banyu Pharmaceutical Co. Ltd | Aminopyrimidine derivatives as PLK1 inhibitors |
| KR100968591B1 (ko) | 2007-06-14 | 2010-07-08 | 한국과학기술연구원 | 약물전달용 폴리포스파젠계 하이드로젤, 그의 제조방법 및그의 용도 |
| US20100009390A1 (en) | 2008-05-09 | 2010-01-14 | The Regents Of The University Of California | Mutant antibodies with high affinity for egfr |
| KR20110047255A (ko) | 2008-09-26 | 2011-05-06 | 로슈 글리카트 아게 | 이중특이적 항-egfr/항-igf-1r 항체 |
| WO2010080463A1 (en) | 2008-12-18 | 2010-07-15 | Imclone Llc | Antibody humanization |
| KR101108642B1 (ko) | 2009-09-29 | 2012-02-09 | 주식회사 녹십자 | 표피 성장 인자 수용체에 특이적으로 결합하는 항체 |
| EP2493929B1 (en) | 2009-10-28 | 2017-08-16 | AbbVie Biotherapeutics Inc. | Anti-egfr antibodies and their uses |
| JP2013510585A (ja) | 2009-11-13 | 2013-03-28 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 癌の同定、評価、予防および治療のための組成物、キットおよび方法 |
| BR112012013148A2 (pt) | 2009-12-29 | 2017-03-21 | F Hoffmann - La Roche Ag | formulação farmacêutica e uso |
| JP2011144124A (ja) | 2010-01-13 | 2011-07-28 | Fujirebio Inc | 活性型egfr特異抗体 |
| WO2011140151A1 (en) | 2010-05-04 | 2011-11-10 | Dyax Corp. | Antibodies against epidermal growth factor receptor (egfr) |
| JP2013533211A (ja) | 2010-05-04 | 2013-08-22 | メリマック ファーマシューティカルズ インコーポレーティッド | 上皮成長因子受容体(egfr)に対する抗体およびその使用 |
| JP5965838B2 (ja) | 2010-06-04 | 2016-08-10 | 東亞合成株式会社 | 抗体およびその利用 |
| WO2011156617A2 (en) | 2010-06-09 | 2011-12-15 | Aveo Pharmaceuticals, Inc. | Anti-egfr antibodies |
| EP2603527A1 (en) | 2010-08-10 | 2013-06-19 | Glycotope GmbH | Humanized egfr antibodies |
| US9155802B2 (en) | 2010-11-01 | 2015-10-13 | Symphogen A/S | Pan-HER antibody composition |
| US8691231B2 (en) | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
-
2013
- 2013-07-31 WO PCT/US2013/053091 patent/WO2014028221A1/en not_active Ceased
- 2013-07-31 ES ES13829184.4T patent/ES2668861T3/es active Active
- 2013-07-31 EP EP13829184.4A patent/EP2879712B1/en active Active
- 2013-07-31 US US14/418,684 patent/US9921222B2/en not_active Expired - Fee Related
- 2013-07-31 JP JP2015525570A patent/JP6324381B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2879712B1 (en) | 2018-04-25 |
| JP2015527341A (ja) | 2015-09-17 |
| US9921222B2 (en) | 2018-03-20 |
| ES2668861T3 (es) | 2018-05-22 |
| WO2014028221A1 (en) | 2014-02-20 |
| EP2879712A1 (en) | 2015-06-10 |
| US20150168411A1 (en) | 2015-06-18 |
| EP2879712A4 (en) | 2016-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Li et al. | Adenosquamous carcinoma of the lung | |
| Yoon et al. | Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas | |
| Viola et al. | A validation study for the use of ROS1 immunohistochemical staining in screening for ROS1 translocations in lung cancer | |
| Okines et al. | Biomarker analysis in oesophagogastric cancer: Results from the REAL3 and TransMAGIC trials | |
| US20140109245A1 (en) | Prostate cancer cell lines, gene signatures and uses thereof | |
| EP1861715A2 (en) | Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors | |
| WO2014028222A1 (en) | Biomarkers for identifying esophageal cancer patients for treatment with an anti-egfr drug | |
| Kogo et al. | Transformation to large cell neuroendocrine carcinoma as acquired resistance mechanism of EGFR tyrosine kinase inhibitor | |
| US10442862B2 (en) | Use of EGFR biomarkers for the treatment of gastric cancer with anti-EGFR agents | |
| Garg et al. | Establishment and characterization of novel human primary and metastatic anaplastic thyroid cancer cell lines and their genomic evolution over a year as a primagraft | |
| Jung et al. | Update on C-cell neuroendocrine neoplasm: prognostic and predictive histopathologic and molecular features of medullary thyroid carcinoma | |
| Nakata et al. | EGFR gene copy number alteration is a better prognostic indicator than protein overexpression in oral tongue squamous cell carcinomas | |
| JP6324381B2 (ja) | 抗egfr薬物による処置のための非小細胞肺癌患者を同定するための組織学的マーカー | |
| JP2016540993A (ja) | タンパク質生体マーカー及びその使用 | |
| Mimae et al. | Protein expression and gene copy number changes of receptor tyrosine kinase in thymomas and thymic carcinomas | |
| Zhu et al. | Primary NTRK-rearranged spindle cell neoplasm of the lung: a clinicopathologic and molecular analysis of 3 cases | |
| CN104168921B (zh) | 用于为抗egfr药物治疗鉴定非小细胞肺癌患者的组织学标志物 | |
| Wang et al. | Immunohistochemical screening and fluorescence in situ hybridization confirmation of ALK translocation in lung adenocarcinoma and its clinicopathological significance: a single-center large-scale investigation of Chinese patients | |
| Chen et al. | Combined analysis of EGFR and PTEN status in patients with KRAS wild-type metastatic colorectal cancer | |
| JP6576249B2 (ja) | 癌におけるクロマチン転写促進因子(fact)の使用 | |
| CN105188742A (zh) | Egfr生物标志物用于利用抗egfr试剂治疗胃癌的用途 | |
| JP2013521487A (ja) | Egfr阻害剤を用いる処置のための患者を選択する方法 | |
| US20150218647A1 (en) | Biomarkers for identifying esophageal cancer patients for treatment with an anti-egfr drug | |
| Haapala | Rapid Identification of Brain Tumours with Differential Mobility Spectrometry | |
| CN105407913A (zh) | 用于鉴定可用抗egfr药物治疗的食管癌患者的生物标志物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20150610 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20150729 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20150729 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160516 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160516 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170209 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20170508 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170531 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20171101 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20180129 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180205 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20180314 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180410 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6324381 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |