JP6315848B2 - Ｍｅｋ／ｐｉ３ｋ二重阻害剤および該阻害剤を使用する治療方法 - Google Patents

Ｍｅｋ／ｐｉ３ｋ二重阻害剤および該阻害剤を使用する治療方法 Download PDF

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JP6315848B2
JP6315848B2 JP2016501365A JP2016501365A JP6315848B2 JP 6315848 B2 JP6315848 B2 JP 6315848B2 JP 2016501365 A JP2016501365 A JP 2016501365A JP 2016501365 A JP2016501365 A JP 2016501365A JP 6315848 B2 JP6315848 B2 JP 6315848B2
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JP2016516702A (ja
JP2016516702A5 (cg-RX-API-DMAC7.html
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ロス，ブライアン，ディー．
ドルト，マルシャン ヴァン
ドルト，マルシャン ヴァン
ホワイトヘッド，クリストファー
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ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン
ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016501365A 2013-03-13 2014-03-12 Ｍｅｋ／ｐｉ３ｋ二重阻害剤および該阻害剤を使用する治療方法 Active JP6315848B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361779462P 2013-03-13 2013-03-13
US61/779,462 2013-03-13
PCT/US2014/023860 WO2014164942A1 (en) 2013-03-13 2014-03-12 Dual mek/pi3k inhibitors and therapeutic methods using the same

Publications (3)

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JP2016516702A JP2016516702A (ja) 2016-06-09
JP2016516702A5 JP2016516702A5 (cg-RX-API-DMAC7.html) 2018-04-12
JP6315848B2 true JP6315848B2 (ja) 2018-04-25

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JP2016501365A Active JP6315848B2 (ja) 2013-03-13 2014-03-12 Ｍｅｋ／ｐｉ３ｋ二重阻害剤および該阻害剤を使用する治療方法

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US (1) US9611258B2 (cg-RX-API-DMAC7.html)
EP (1) EP2968345B1 (cg-RX-API-DMAC7.html)
JP (1) JP6315848B2 (cg-RX-API-DMAC7.html)
CN (1) CN105358156A (cg-RX-API-DMAC7.html)
CA (1) CA2901613C (cg-RX-API-DMAC7.html)
WO (1) WO2014164942A1 (cg-RX-API-DMAC7.html)

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CA2954934C (en) 2014-06-30 2023-09-26 Glykos Finland Oy Drug derivative and conjugates
US9968604B2 (en) 2015-04-16 2018-05-15 Chiesi Farmaceutici S.P.A. Chromene derivatives as phoshoinositide 3-kinases inhibitors
US20190038713A1 (en) 2015-11-07 2019-02-07 Multivir Inc. Compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
EP4086250B1 (en) * 2016-07-06 2024-12-11 The Regents Of The University Of Michigan Multifunctional inhibitors of mek/pi3k and mtor/mek/pi3k biological pathways and therapeutic methods using the same
WO2018111902A1 (en) 2016-12-12 2018-06-21 Multivir Inc. Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases
JP7350336B2 (ja) * 2017-08-11 2023-09-26 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン ＭＥＫ／ＰＩ３Ｋ、ＪＡＫ／ＭＥＫ、ＪＡＫ／ＰＩ３Ｋ／ｍＴＯＲおよびＭＥＫ／ＰＩ３Ｋ／ｍＴＯＲの生物学的経路の阻害剤、および治療化合物のリンパ取り込み、生物学的利用能、および溶解性を改善する方法
CN112020510B (zh) 2018-03-19 2024-10-11 茂体外尔公司 包含用于治疗癌症的肿瘤抑制基因疗法和cd122/cd132激动剂的方法及组合物
WO2021113644A1 (en) 2019-12-05 2021-06-10 Multivir Inc. Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
WO2021142144A1 (en) * 2020-01-10 2021-07-15 Immuneering Corporation Mek inhibitors and therapeutic uses thereof
CN111135309B (zh) * 2020-01-15 2023-04-28 重庆大学 一种核壳结构的替拉扎明药物载体及其制备方法和应用
AR121078A1 (es) 2020-01-22 2022-04-13 Chugai Pharmaceutical Co Ltd Derivados de arilamida con actividad antitumoral
CN118922183A (zh) * 2022-01-06 2024-11-08 医疗免疫工程公司 Mek免疫肿瘤学抑制剂及其治疗用途
WO2024102859A1 (en) * 2022-11-09 2024-05-16 Immuneering Corporation Mek immune oncology inhibitors and therapeutic uses thereof
WO2025010287A2 (en) * 2023-07-03 2025-01-09 Immuneering Corporation Mek immune oncology inhibitors and therapeutic uses thereof
WO2025114495A1 (en) * 2023-11-28 2025-06-05 Universität Basel Pi3k inhibitors and use thereof

Family Cites Families (12)

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YU2503A (sh) * 2000-07-19 2006-05-25 Warner-Lambert Company Oksigenovani estri 4-jodo fenilamino benzhidroksamskih kiselina
AR059339A1 (es) * 2006-02-09 2008-03-26 Chugai Pharmaceutical Co Ltd Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
WO2008032060A1 (en) * 2006-09-14 2008-03-20 Astrazeneca Ab 4-benzimidaz0lyl-6-m0rph0lin0-2-piperazinylpyrimidine derivatives as p13k and mtor inhibitors for the treatment of proliferative disorders
WO2008032033A1 (en) * 2006-09-14 2008-03-20 Astrazeneca Ab 4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
WO2009014100A1 (ja) * 2007-07-20 2009-01-29 Chugai Seiyaku Kabushiki Kaisha ｐ２７蛋白質誘導剤
JP2011515462A (ja) * 2008-03-27 2011-05-19 アウククランド ウニセルビセス リミテッド 置換されたピリミジン、及びトリアジン、並びに癌療法におけるこれらの使用
CA2729914A1 (en) * 2008-07-11 2010-01-14 Novartis Ag Combination of (a) a phosphoinositide 3-kinase inhibitor and (b) a modulator of ras/raf/mek pathway
MX2011010105A (es) 2009-03-27 2012-01-12 Pathway Therapeutics Inc Sulfonamidas de pirimidinilo y 1,3,5-triazinilo benzimidazol y su uso en terapia de cancer.
AR080945A1 (es) 2009-07-07 2012-05-23 Pathway Therapeutics Inc Pirimidinil y 1,3,5-triazinil benzimidazoles y su uso en la terapia contra el cancer
US20110166191A1 (en) * 2010-01-07 2011-07-07 Shijun Zhang 3-(2-amino-ethyl)-5-(3-cyclohexyl-propylidene)-thiazolidine-2,4-dione and its derivatives as multiple signaling pathway inhibitors and for the treatment of cancer
GB201007227D0 (en) * 2010-04-30 2010-06-16 Univ Basel Piperazinotriazines
EP2651442B1 (en) * 2010-12-14 2020-04-22 University of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer

Also Published As

Publication number Publication date
CN105358156A (zh) 2016-02-24
EP2968345A4 (en) 2016-08-17
CA2901613C (en) 2020-10-20
JP2016516702A (ja) 2016-06-09
WO2014164942A1 (en) 2014-10-09
EP2968345A1 (en) 2016-01-20
US9611258B2 (en) 2017-04-04
CA2901613A1 (en) 2014-10-09
US20160002212A1 (en) 2016-01-07
EP2968345B1 (en) 2017-12-13

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