JP6313203B2 - Ａｌｕ−ｒｎａ誘導変性からの細胞の保護及び細胞保護用阻害剤 - Google Patents

Ａｌｕ−ｒｎａ誘導変性からの細胞の保護及び細胞保護用阻害剤 Download PDF

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JP6313203B2
JP6313203B2 JP2014521695A JP2014521695A JP6313203B2 JP 6313203 B2 JP6313203 B2 JP 6313203B2 JP 2014521695 A JP2014521695 A JP 2014521695A JP 2014521695 A JP2014521695 A JP 2014521695A JP 6313203 B2 JP6313203 B2 JP 6313203B2
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myd88
rpe
caspase
cell
inhibitor
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JP2014528700A5 (https=
JP2014528700A (ja
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アンバティ，ジャヤクリシュナ
タラッロ，ヴァレリア
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University of Kentucky Research Foundation
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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JP2014521695A 2011-07-18 2012-07-16 Ａｌｕ−ｒｎａ誘導変性からの細胞の保護及び細胞保護用阻害剤 Active JP6313203B2 (ja)

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Application Number Priority Date Filing Date Title
US201161508867P 2011-07-18 2011-07-18
US61/508,867 2011-07-18
US201161543038P 2011-10-04 2011-10-04
US61/543,038 2011-10-04
PCT/US2012/046928 WO2013012806A2 (en) 2011-07-18 2012-07-16 Protection of cells from alu-rna-induced degenereation and inhibitors for protecting cells

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JP2014528700A JP2014528700A (ja) 2014-10-30
JP2014528700A5 JP2014528700A5 (https=) 2015-08-20
JP6313203B2 true JP6313203B2 (ja) 2018-04-18

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US (1) US9453226B2 (https=)
EP (2) EP2734240B1 (https=)
JP (1) JP6313203B2 (https=)
CN (1) CN103889461B (https=)
AU (1) AU2012284223B2 (https=)
CA (2) CA2842034C (https=)
ES (1) ES2907620T3 (https=)
PT (1) PT3366302T (https=)
WO (1) WO2013012806A2 (https=)

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EP2734240B1 (en) 2018-03-21
EP3366302B1 (en) 2021-12-08
EP2734240A4 (en) 2015-06-10
CN103889461B (zh) 2016-11-09
EP2734240A2 (en) 2014-05-28
CA3205596A1 (en) 2013-01-24
US9453226B2 (en) 2016-09-27
CN103889461A (zh) 2014-06-25
AU2012284223A1 (en) 2014-02-06
WO2013012806A3 (en) 2013-05-30
CA2842034C (en) 2023-09-05
ES2907620T3 (es) 2022-04-25
US20140178309A1 (en) 2014-06-26
PT3366302T (pt) 2022-03-07
AU2012284223B2 (en) 2017-06-22
CA2842034A1 (en) 2013-01-24
JP2014528700A (ja) 2014-10-30
EP3366302A1 (en) 2018-08-29
WO2013012806A2 (en) 2013-01-24

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