JP2014528700A5 - - Google Patents
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- JP2014528700A5 JP2014528700A5 JP2014521695A JP2014521695A JP2014528700A5 JP 2014528700 A5 JP2014528700 A5 JP 2014528700A5 JP 2014521695 A JP2014521695 A JP 2014521695A JP 2014521695 A JP2014521695 A JP 2014521695A JP 2014528700 A5 JP2014528700 A5 JP 2014528700A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- composition
- composition according
- seq
- stranded rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161508867P | 2011-07-18 | 2011-07-18 | |
| US61/508,867 | 2011-07-18 | ||
| US201161543038P | 2011-10-04 | 2011-10-04 | |
| US61/543,038 | 2011-10-04 | ||
| PCT/US2012/046928 WO2013012806A2 (en) | 2011-07-18 | 2012-07-16 | Protection of cells from alu-rna-induced degenereation and inhibitors for protecting cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014528700A JP2014528700A (ja) | 2014-10-30 |
| JP2014528700A5 true JP2014528700A5 (https=) | 2015-08-20 |
| JP6313203B2 JP6313203B2 (ja) | 2018-04-18 |
Family
ID=47558691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014521695A Active JP6313203B2 (ja) | 2011-07-18 | 2012-07-16 | Ａｌｕ−ｒｎａ誘導変性からの細胞の保護及び細胞保護用阻害剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9453226B2 (https=) |
| EP (2) | EP2734240B1 (https=) |
| JP (1) | JP6313203B2 (https=) |
| CN (1) | CN103889461B (https=) |
| AU (1) | AU2012284223B2 (https=) |
| CA (2) | CA2842034C (https=) |
| ES (1) | ES2907620T3 (https=) |
| PT (1) | PT3366302T (https=) |
| WO (1) | WO2013012806A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010138555A2 (en) | 2009-05-26 | 2010-12-02 | University Of Florida Research Foundation, Inc. | Small peptide expression system in mammalian cells |
| DK2631291T3 (da) | 2010-10-22 | 2019-06-11 | Olix Pharmaceuticals Inc | Nukleinsyremolekyler, der inducerer rna-interferens, og anvendelser deraf |
| US9707235B1 (en) | 2012-01-13 | 2017-07-18 | University Of Kentucky Research Foundation | Protection of cells from degeneration and treatment of geographic atrophy |
| WO2013169382A1 (en) * | 2012-05-07 | 2013-11-14 | DePuy Synthes Products, LLC | Methods and devices for treating intervertebral disc disease |
| CN108148838A (zh) | 2012-05-22 | 2018-06-12 | 奥利克斯医药有限公司 | 具有细胞内穿透能力的诱导rna干扰的核酸分子及用途 |
| EP2893014A4 (en) | 2012-09-05 | 2016-06-08 | Cold Spring Harbor Lab | TRANSPORTABLE ELEMENTS, TDP-43 AND NEURODEGENERATIVE DISEASES |
| US10981961B2 (en) | 2013-03-11 | 2021-04-20 | University Of Florida Research Foundation, Incorporated | Delivery of card protein as therapy for occular inflammation |
| US9326983B2 (en) | 2013-08-01 | 2016-05-03 | University Of Kentucky Research Foundation | Compositions and methods for treating retinal degradation |
| WO2015095609A1 (en) * | 2013-12-19 | 2015-06-25 | The J. David Gladstone Institute | Inhibition of interferon-gamma-inducible protein 16 (ifi16) |
| WO2015127094A1 (en) | 2014-02-19 | 2015-08-27 | University Of Florida Research Foundation, Inc. | Delivery of nrf2 as therapy for protection against reactive oxygen species |
| WO2015138628A1 (en) * | 2014-03-11 | 2015-09-17 | University Of Florida Research Foundation, Inc. | Use of aav-expressed m013 protein as an anti-inflammatory therapeutic |
| WO2016022914A1 (en) * | 2014-08-08 | 2016-02-11 | Moderna Therapeutics, Inc. | Compositions and methods for the treatment of ophthalmic diseases and conditions |
| US11219623B2 (en) | 2015-02-26 | 2022-01-11 | University Of Kentucky Research Foundation | Inflammasome inhibition for the treatment of Parkinson's disease, Alzheimer's disease and multiple sclerosis |
| CA2976537C (en) | 2015-02-26 | 2024-05-28 | University Of Kentucky Research Foundation | Compositions and methods for treating retinal degradation |
| CA2997516C (en) | 2015-09-03 | 2024-02-06 | B.G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Analogues of vdac1-derived peptides |
| IL289849B2 (en) * | 2015-11-10 | 2024-01-01 | Nat Inst Biotechnology Negev Ltd | Means and methods for reducing tumorigenicity of cancer stem cells |
| EP4454637A3 (en) | 2015-11-16 | 2025-01-08 | Olix Pharmaceuticals, Inc. | Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3 |
| KR102825946B1 (ko) | 2016-02-02 | 2025-06-27 | 올릭스 주식회사 | IL4Rα, TRPA1, 또는 F2RL1을 표적화하는 RNA 복합체를 사용한 아토피 피부염 및 천식의 치료 |
| CN109415413A (zh) * | 2016-06-07 | 2019-03-01 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 髓样分化因子88(myd88)的主链环化抑制肽 |
| WO2017214553A1 (en) * | 2016-06-09 | 2017-12-14 | The General Hospital Corporation | Modulating the cellular stress response |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| US20190185820A1 (en) * | 2016-08-26 | 2019-06-20 | The Regents Of The University Of California | Compositions and Methods for Inhibiting Stem Cell Aging |
| ES2950100T3 (es) | 2016-12-23 | 2023-10-05 | Casp Aid Inc | Inhibición de la caspasa-1 y usos de esta para la prevención y el tratamiento de afecciones neurológicas |
| US11591600B2 (en) | 2017-02-10 | 2023-02-28 | OliX Pharmaceuticals. Inc. | Long double-stranded RNA for RNA interference |
| GB2561540A (en) | 2017-03-13 | 2018-10-24 | Nodthera Ltd | Chemical compounds |
| CN110709515A (zh) * | 2017-04-03 | 2020-01-17 | 杜克大学 | 用于差异性诱导细胞死亡和干扰素表达的组合物和方法 |
| US20200345756A1 (en) * | 2017-10-10 | 2020-11-05 | University Of Virginia Patent Foundation | Compositions and methods for treating age-related macular degeneration and geographic atrophy |
| CA3103432A1 (en) * | 2018-06-27 | 2020-01-02 | Children's Medical Center Corporation | Compounds for inhibition of inflammation |
| KR102138256B1 (ko) * | 2018-09-13 | 2020-08-13 | 한국과학기술연구원 | 케스페이즈-1 활성 측정용 프로브, 이를 포함하는 염증성 질환 진단용 조성물 |
| EP3863714A4 (en) * | 2018-10-09 | 2022-07-20 | University of Virginia Patent Foundation | ENDOGENOUS CYTOPLASMATIC ALU-COMPLEMENTARY DNA IN AGE-RELATED MACULAR DEGENERATION |
| CN110305957B (zh) * | 2019-08-22 | 2022-07-29 | 中国水产科学研究院淡水渔业研究中心 | 一种鉴定黄颡鱼脂肪肝程度的试剂盒及其鉴定方法 |
| AU2020340298A1 (en) * | 2019-08-23 | 2022-03-24 | University Of Virginia Patent Foundation | DDX17 and NLRC4 targeting for inflammatory diseases |
| JP7459298B2 (ja) * | 2020-01-06 | 2024-04-01 | シーサン・セラピューティクス | 細胞透過性核酸複合体を有効成分として含有する黄斑変性の予防又は治療用組成物 |
| WO2021163327A1 (en) * | 2020-02-11 | 2021-08-19 | University Of Virginia Patent Foundation | Compositions and methods for treating and/or preventing ocular disorders |
| CN111358950A (zh) * | 2020-03-20 | 2020-07-03 | 厦门大学 | Caspase-1及ASC/Caspase-8作为靶点的应用 |
| WO2022034474A1 (en) * | 2020-08-10 | 2022-02-17 | Novartis Ag | Treatments for retinal degenerative diseases |
| JP2023549257A (ja) | 2020-11-18 | 2023-11-22 | ノバルティス アーゲー | Ｎｌｒｃ４－ｇｏｆインフラマソーム病の処置における使用のための二特異性抗体 |
| CN115969844B (zh) * | 2021-12-28 | 2024-04-02 | 首都医科大学附属北京同仁医院 | Nox2特异性抑制剂在制备视网膜变性药物中的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| AU2988200A (en) * | 1999-02-11 | 2000-08-29 | Trustees Of The University Of Pennsylvania, The | Regulation of photoreceptor degeneration |
| GB9930616D0 (en) * | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| US20030186903A1 (en) * | 2001-11-23 | 2003-10-02 | Isis Pharmaceuticals Inc. | Antisense modulation of MyD88 expression |
| CA2472927A1 (en) * | 2002-01-10 | 2003-07-17 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | A novel splice variant of myd88 and uses thereof |
| EP2305812A3 (en) * | 2002-11-14 | 2012-06-06 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
| WO2006006948A2 (en) * | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| WO2005105133A2 (en) * | 2004-04-23 | 2005-11-10 | Massachusetts Eye And Ear Infirmary | Methods and compositions for preserving the viability of photoreceptor cells |
| KR20070094802A (ko) * | 2004-12-20 | 2007-09-21 | 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. | ＭｙＤ８８ 동종이량체화 억제제 |
| US7879992B2 (en) * | 2005-01-31 | 2011-02-01 | Isis Pharmaceuticals, Inc. | Modification of MyD88 splicing using modified oligonucleotides |
| EP1746167A1 (en) * | 2005-07-20 | 2007-01-24 | Apoxis SA | Method for the identification of compounds susceptible to inhibit inflammation |
| WO2007077042A1 (en) * | 2006-01-06 | 2007-07-12 | Topotarget Switzerland Sa | New method for the treatment of gout or pseudogout |
| EP2106445A2 (en) | 2006-12-01 | 2009-10-07 | Loma Linda University Medical Center | Inhibition of brain enzymes involved in cerebral amyloid angiopathy and macular degeneration |
| CA2691039A1 (en) * | 2007-05-29 | 2008-12-11 | Yale University | Il-18 and protein kinase r inhibition for the treatment of copd |
| US20090227487A1 (en) * | 2008-03-05 | 2009-09-10 | Jeremy Pearl | Methods for the control of macrophage-associated inflammation |
| CN102171235A (zh) * | 2008-08-08 | 2011-08-31 | 艾德拉药物股份有限公司 | 通过反义寡核苷酸来调制髓样分化初级应答基因88(MyD88)表达 |
| US20130137642A1 (en) * | 2010-04-23 | 2013-05-30 | Demetrios Vavvas | Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells |
| WO2011153234A2 (en) | 2010-06-01 | 2011-12-08 | University Of Kentucky Research Foundation | Methods of inhibiting alu rna and therapeutic uses thereof |
| US20120177632A1 (en) * | 2011-01-10 | 2012-07-12 | Shinohara Mari L | Methods of optimizing disease treatment |
-
2012
- 2012-07-16 EP EP12814249.4A patent/EP2734240B1/en active Active
- 2012-07-16 EP EP18156266.1A patent/EP3366302B1/en active Active
- 2012-07-16 AU AU2012284223A patent/AU2012284223B2/en active Active
- 2012-07-16 CN CN201280045438.0A patent/CN103889461B/zh active Active
- 2012-07-16 ES ES18156266T patent/ES2907620T3/es active Active
- 2012-07-16 JP JP2014521695A patent/JP6313203B2/ja active Active
- 2012-07-16 CA CA2842034A patent/CA2842034C/en active Active
- 2012-07-16 WO PCT/US2012/046928 patent/WO2013012806A2/en not_active Ceased
- 2012-07-16 CA CA3205596A patent/CA3205596A1/en active Pending
- 2012-07-16 PT PT181562661T patent/PT3366302T/pt unknown
-
2014
- 2014-01-17 US US14/158,357 patent/US9453226B2/en active Active
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