JP6302929B2 - ヒドロキシ脂肪族置換フェニルアミノアルキルエーテル誘導体 - Google Patents
ヒドロキシ脂肪族置換フェニルアミノアルキルエーテル誘導体 Download PDFInfo
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- JP6302929B2 JP6302929B2 JP2015548639A JP2015548639A JP6302929B2 JP 6302929 B2 JP6302929 B2 JP 6302929B2 JP 2015548639 A JP2015548639 A JP 2015548639A JP 2015548639 A JP2015548639 A JP 2015548639A JP 6302929 B2 JP6302929 B2 JP 6302929B2
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- phenylpropoxy
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- ethanol
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- 0 C*CCC(C1C=C1)Oc1cc(O)cc(N)c1 Chemical compound C*CCC(C1C=C1)Oc1cc(O)cc(N)c1 0.000 description 1
- PWIYUWBWFFSLNR-UHFFFAOYSA-N CC(OCCc(cc1)ccc1OC(CCNC)c1ccccc1)=O Chemical compound CC(OCCc(cc1)ccc1OC(CCNC)c1ccccc1)=O PWIYUWBWFFSLNR-UHFFFAOYSA-N 0.000 description 1
- OSMZFAGUHXSZPW-UHFFFAOYSA-N CNCCC(c1ccccc1)Oc1cc(CO)cc(CO)c1 Chemical compound CNCCC(c1ccccc1)Oc1cc(CO)cc(CO)c1 OSMZFAGUHXSZPW-UHFFFAOYSA-N 0.000 description 1
- GIGVAWWBRRBBAJ-SFHVURJKSA-N CNCC[C@@H](c1ccccc1)Oc1ccc(CCO)cc1 Chemical compound CNCC[C@@H](c1ccccc1)Oc1ccc(CCO)cc1 GIGVAWWBRRBBAJ-SFHVURJKSA-N 0.000 description 1
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- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Orthopedic Medicine & Surgery (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12382527.5 | 2012-12-21 | ||
| EP12382527.5A EP2745876A1 (en) | 2012-12-21 | 2012-12-21 | Hydroxy aliphatic substituted phenyl aminoalkyl ether derivatives |
| PCT/EP2013/077731 WO2014096377A1 (en) | 2012-12-21 | 2013-12-20 | Hydroxy aliphatic substituted phenyl aminoalkyl ether derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016504992A JP2016504992A (ja) | 2016-02-18 |
| JP2016504992A5 JP2016504992A5 (enExample) | 2017-01-05 |
| JP6302929B2 true JP6302929B2 (ja) | 2018-03-28 |
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| JP2015548639A Active JP6302929B2 (ja) | 2012-12-21 | 2013-12-20 | ヒドロキシ脂肪族置換フェニルアミノアルキルエーテル誘導体 |
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| EP (2) | EP2745876A1 (enExample) |
| JP (1) | JP6302929B2 (enExample) |
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| HU (1) | HUE032461T2 (enExample) |
| PT (1) | PT2945702T (enExample) |
| WO (1) | WO2014096377A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2647377A1 (en) | 2012-04-06 | 2013-10-09 | Sanofi | Use of an h3 receptor antagonist for the treatment of alzheimer's disease |
| CN105764510A (zh) * | 2013-09-09 | 2016-07-13 | 赛诺菲 | H3受体拮抗剂与胆碱酶抑制剂组合用于阿尔茨海默氏病治疗中的用途 |
| CN106349211B (zh) * | 2016-08-26 | 2020-10-16 | 江苏恩华药业股份有限公司 | 2-甲基-3-芳氧基-3-杂芳基丙胺类化合物及应用 |
| KR101864085B1 (ko) * | 2017-09-22 | 2018-06-01 | 동아대학교 산학협력단 | 발프로산 유도체, 이의 제조방법 및 이를 포함하는 항경련제 |
| JP2020536941A (ja) * | 2017-10-16 | 2020-12-17 | エステベ ファーマシューティカルズ, ソシエダッド アノニマEsteve Pharmaceuticals, S.A. | 疼痛及び疼痛に関連する状態を治療するためのプロパンアミン誘導体 |
| CN112313238B (zh) | 2018-04-27 | 2025-01-17 | 盐野义制药株式会社 | 具有选择性bace1抑制活性的四氢吡喃并噁嗪衍生物 |
| US12139476B2 (en) | 2018-08-17 | 2024-11-12 | Shanghai Leado Pharmatech Co. Ltd. | 3-aryloxyl-3-five-membered heteroaryl propylamine compound and use thereof |
| AU2020306249B2 (en) * | 2019-06-28 | 2025-06-26 | University Of Copenhagen | Treatment of CNS disorders with sleep disturbances |
| KR20250030127A (ko) * | 2023-08-24 | 2025-03-05 | 경희대학교 산학협력단 | 피니톨을 함유한 감각 운동 관문 장애 예방 또는 치료용 조성물 |
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| CA2441080A1 (en) * | 2001-03-23 | 2002-10-03 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
| ES2256472T3 (es) * | 2002-04-03 | 2006-07-16 | Puleva Biotech, S.A. | Productos fenolicos naturales y derivados de los mismos para la proteccion frente a enfermedades neurodegenerativas. |
| EA200601798A1 (ru) | 2004-04-30 | 2007-04-27 | Уорнер-Ламберт Компани Ллс | Замещенные соединения морфолина для лечения расстройств центральной нервной системы |
| GB0409744D0 (en) | 2004-04-30 | 2004-06-09 | Pfizer Ltd | Novel compounds |
| SE526297C2 (sv) | 2004-07-27 | 2005-08-16 | Jan Norrman | Kopplingsstycke innefattande en ledare med flertal trådar vilka är fördelade kring en deformerbar kropps ytteromkrets |
| GB0505509D0 (en) * | 2005-03-17 | 2005-04-27 | Ic Innovations Ltd | Compounds |
| PL1813614T3 (pl) | 2006-01-25 | 2012-03-30 | Sanofi Sa | Środki cytotoksyczne zawierające nowe pochodne tomaymycyny |
| CN100528832C (zh) * | 2007-02-08 | 2009-08-19 | 刘宏民 | 左旋盐酸倍他洛尔合成工艺 |
| WO2011150347A2 (en) * | 2010-05-28 | 2011-12-01 | Pharmatrophix | Non-peptide bdnf neurotrophin mimetics |
| EP2664616A1 (en) * | 2012-05-15 | 2013-11-20 | Vivalis | Hydantoin and thiohydantoin derivatives as antiviral drugs |
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| Publication number | Publication date |
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| US20150344408A1 (en) | 2015-12-03 |
| CA2895592C (en) | 2019-10-29 |
| HRP20170539T1 (hr) | 2017-06-16 |
| US9624158B2 (en) | 2017-04-18 |
| PT2945702T (pt) | 2017-04-20 |
| CA2895592A1 (en) | 2014-06-26 |
| EP2745876A1 (en) | 2014-06-25 |
| WO2014096377A1 (en) | 2014-06-26 |
| AU2013366502B2 (en) | 2017-12-14 |
| ES2621960T3 (es) | 2017-07-05 |
| EP2945702A1 (en) | 2015-11-25 |
| US20170239197A1 (en) | 2017-08-24 |
| HUE032461T2 (en) | 2017-09-28 |
| EP2945702B1 (en) | 2017-01-11 |
| US9980928B2 (en) | 2018-05-29 |
| JP2016504992A (ja) | 2016-02-18 |
| AU2013366502A1 (en) | 2015-07-09 |
| DK2945702T3 (en) | 2017-04-18 |
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