JP6286445B2 - がんの治療のためのワクチン及びワクチン有効性を増強するための組成物 - Google Patents

がんの治療のためのワクチン及びワクチン有効性を増強するための組成物 Download PDF

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JP6286445B2
JP6286445B2 JP2015549902A JP2015549902A JP6286445B2 JP 6286445 B2 JP6286445 B2 JP 6286445B2 JP 2015549902 A JP2015549902 A JP 2015549902A JP 2015549902 A JP2015549902 A JP 2015549902A JP 6286445 B2 JP6286445 B2 JP 6286445B2
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cancer
vaccine
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JP2016505003A5 (cg-RX-API-DMAC7.html
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ロス・アーサー・デイヴィ
クリストファー・ジョン・ワイアー
グラハム・ヴィージー
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セル・アイディアズ・ピーティーワイ・リミテッド
ノーザン・シドニー・ローカル・ヘルス・ディストリクト
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/092Streptococcus
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P35/00Antineoplastic agents
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    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • AHUMAN NECESSITIES
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015549902A 2012-12-24 2013-12-24 がんの治療のためのワクチン及びワクチン有効性を増強するための組成物 Expired - Fee Related JP6286445B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
AU2012905667 2012-12-24
AU2012905669 2012-12-24
AU2012905667A AU2012905667A0 (en) 2012-12-24 Vaccines for treatment of cancer
AU2012905669A AU2012905669A0 (en) 2012-12-24 Vaccine booster
AU2013203806 2013-04-11
AU2013203806A AU2013203806B2 (en) 2012-12-24 2013-04-11 Vaccines for the treatment or prevention of cancer
AU2013903592 2013-09-18
AU2013903592A AU2013903592A0 (en) 2013-09-18 Vaccines for the treatment or prevention of cancer
PCT/AU2013/001523 WO2014100857A1 (en) 2012-12-24 2013-12-24 Vaccines for the treatment of cancer and compositions for enhancing vaccine efficacy

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JP2018017162A Division JP2018111695A (ja) 2012-12-24 2018-02-02 がんの治療のためのワクチン及びワクチン有効性を増強するための組成物

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JP2016505003A JP2016505003A (ja) 2016-02-18
JP2016505003A5 JP2016505003A5 (cg-RX-API-DMAC7.html) 2017-02-09
JP6286445B2 true JP6286445B2 (ja) 2018-02-28

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JP2018017162A Pending JP2018111695A (ja) 2012-12-24 2018-02-02 がんの治療のためのワクチン及びワクチン有効性を増強するための組成物

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US (2) US10357538B2 (cg-RX-API-DMAC7.html)
EP (2) EP2934578B1 (cg-RX-API-DMAC7.html)
JP (2) JP6286445B2 (cg-RX-API-DMAC7.html)
AU (1) AU2013370932B2 (cg-RX-API-DMAC7.html)
CA (1) CA2934958A1 (cg-RX-API-DMAC7.html)
NZ (1) NZ629700A (cg-RX-API-DMAC7.html)
WO (1) WO2014100857A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
EP2934578B1 (en) * 2012-12-24 2018-11-21 Northern Sydney Local Health District Vaccines for the treatment of cancer and compositions for enhancing vaccine efficacy
WO2017136539A1 (en) 2016-02-04 2017-08-10 Hare Joshua M Mesenchymal stem cells as vaccine adjuvants and methods for using the same
KR20190003456A (ko) * 2016-04-01 2019-01-09 아프세스 게엠베하 & 씨오. 카게 면역치료의 항-종양 활성을 높이기 위한 중간엽 줄기세포
US12253490B2 (en) 2018-03-19 2025-03-18 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
US12259355B2 (en) 2018-03-19 2025-03-25 Regeneron Pharmaceuticals, Inc. Microchip capillary electrophoresis assays and reagents
CN111868085B (zh) * 2018-03-19 2024-11-05 瑞泽恩制药公司 微芯片毛细管电泳测定法及试剂

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62221636A (ja) * 1986-03-20 1987-09-29 Chemo Sero Therapeut Res Inst B型肝炎ウイルス抗原蛋白の可溶化方法
US5030621A (en) * 1987-04-23 1991-07-09 Bystryn Jean Claude Shed melanoma antigen compositions
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
US6379671B1 (en) * 1996-08-19 2002-04-30 Abbott Laboratories Reagents and methods useful for detecting diseases of the breast
EP1015024A1 (en) * 1997-09-20 2000-07-05 Osiris Therapeutics, Inc. Antigen presenting mesenchymal stem cells
AT408615B (de) 1998-09-15 2002-01-25 Immuno Ag Neue influenzavirus-impfstoffzusammensetzung
GB9923176D0 (en) 1999-09-30 1999-12-01 Smithkline Beecham Biolog Novel composition
AU2002220265A1 (en) * 2000-11-03 2002-05-15 University Of Vermont And State Agricultural College Compositions for inhibiting grb7
CA2477411A1 (en) * 2002-03-02 2003-09-12 Board Of Regents, The University Of Texas Local production and/or delivery of anti-cancer agents by stromal cell precursors
ES2395126T3 (es) 2003-02-28 2013-02-08 Agenus Inc. Uso de lectinas para promover la oligomerización de glicoproteínas y de moléculas antigénicas
AU2003903317A0 (en) 2003-06-27 2003-07-10 Proteome Systems Intellectual Property Pty Ltd Method of isolating a protein
US20050239897A1 (en) 2004-03-22 2005-10-27 Pittenger Mark F Mesenchymal stem cells and uses therefor
US20080095749A1 (en) * 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
AR054822A1 (es) 2005-07-07 2007-07-18 Sanofi Pasteur Emulsion inmuno adyuvante
KR101022401B1 (ko) * 2005-09-29 2011-03-15 아주대학교산학협력단 자살유전자를 발현하는 중간엽 줄기세포를 포함하는 암치료용 조성물
CN1887296B (zh) * 2006-07-31 2011-05-25 南京大学生物制药工程研究中心 一种诱导抗肿瘤免疫的方法及其在制药中的应用
US8685728B2 (en) * 2008-01-31 2014-04-01 Rutgers The State University Of New Jersey Kit containing stem cells and cytokines for use in attenuating immune responses
US8771705B2 (en) * 2009-07-30 2014-07-08 Healthbanks Biotech Co., Ltd. Combination of protein vaccine and mesenchymal stem cells for treating cancer
US20120263685A1 (en) * 2009-10-08 2012-10-18 Rnl Bio Co., Ltd Anti-tumor composition comprising human-derived adult stem cells
WO2011060244A1 (en) * 2009-11-12 2011-05-19 The Texas A & M University System Spheroidal aggregates of mesenchymal stem cells
KR20120132183A (ko) * 2011-05-27 2012-12-05 포항공과대학교 산학협력단 종양 조직에서 유래한 나노소포체 및 이를 이용한 암 백신
WO2013040649A1 (en) 2011-09-23 2013-03-28 Cell Ideas Pty Ltd Therapeutics using adipose cells and cell secretions
EP2934578B1 (en) * 2012-12-24 2018-11-21 Northern Sydney Local Health District Vaccines for the treatment of cancer and compositions for enhancing vaccine efficacy

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Publication number Publication date
NZ629700A (en) 2017-01-27
WO2014100857A1 (en) 2014-07-03
EP3446708A1 (en) 2019-02-27
JP2018111695A (ja) 2018-07-19
EP2934578B1 (en) 2018-11-21
EP2934578A1 (en) 2015-10-28
AU2013370932A1 (en) 2015-07-09
US20190358291A1 (en) 2019-11-28
US20150343040A1 (en) 2015-12-03
CA2934958A1 (en) 2014-07-03
WO2014100857A8 (en) 2014-11-06
WO2014100857A9 (en) 2015-07-09
US10357538B2 (en) 2019-07-23
JP2016505003A (ja) 2016-02-18
EP2934578A4 (en) 2016-07-13
AU2013370932B2 (en) 2019-02-21

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