JP6225030B2 - 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物 - Google Patents

酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物 Download PDF

Info

Publication number
JP6225030B2
JP6225030B2 JP2013554551A JP2013554551A JP6225030B2 JP 6225030 B2 JP6225030 B2 JP 6225030B2 JP 2013554551 A JP2013554551 A JP 2013554551A JP 2013554551 A JP2013554551 A JP 2013554551A JP 6225030 B2 JP6225030 B2 JP 6225030B2
Authority
JP
Japan
Prior art keywords
cream
oxymetazoline
skin
acid
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013554551A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014505733A5 (OSRAM
JP2014505733A (ja
Inventor
スチュアート ディー シャンラー
スチュアート ディー シャンラー
クリストファー ポワラ
クリストファー ポワラ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of JP2014505733A publication Critical patent/JP2014505733A/ja
Publication of JP2014505733A5 publication Critical patent/JP2014505733A5/ja
Application granted granted Critical
Publication of JP6225030B2 publication Critical patent/JP6225030B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
JP2013554551A 2011-02-15 2012-02-14 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物 Active JP6225030B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161443210P 2011-02-15 2011-02-15
US61/443,210 2011-02-15
PCT/US2012/025068 WO2012112566A1 (en) 2011-02-15 2012-02-14 Pharmaceutical cream compositions of oxymetazoline for treating symptoms of rosacea

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017002106A Division JP6389534B2 (ja) 2011-02-15 2017-01-10 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物

Publications (3)

Publication Number Publication Date
JP2014505733A JP2014505733A (ja) 2014-03-06
JP2014505733A5 JP2014505733A5 (OSRAM) 2015-04-09
JP6225030B2 true JP6225030B2 (ja) 2017-11-01

Family

ID=45757218

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2013554551A Active JP6225030B2 (ja) 2011-02-15 2012-02-14 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物
JP2017002106A Active JP6389534B2 (ja) 2011-02-15 2017-01-10 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物
JP2018153450A Abandoned JP2018193399A (ja) 2011-02-15 2018-08-17 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2017002106A Active JP6389534B2 (ja) 2011-02-15 2017-01-10 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物
JP2018153450A Abandoned JP2018193399A (ja) 2011-02-15 2018-08-17 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物

Country Status (11)

Country Link
US (4) US20120208858A1 (OSRAM)
EP (2) EP3578178A1 (OSRAM)
JP (3) JP6225030B2 (OSRAM)
KR (2) KR20190114010A (OSRAM)
CN (2) CN103458897A (OSRAM)
AU (3) AU2012217858A1 (OSRAM)
BR (1) BR112013020770A2 (OSRAM)
CA (1) CA2827373C (OSRAM)
ES (1) ES2742273T3 (OSRAM)
RU (1) RU2648439C2 (OSRAM)
WO (1) WO2012112566A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017066162A (ja) * 2011-02-15 2017-04-06 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
MX2007009796A (es) 2007-08-14 2009-02-25 Cell Therapy And Technology S Gel conteniendo pirfenidona.
US20120225918A1 (en) * 2011-03-03 2012-09-06 Voom, Llc Compositions and Methods for Non-Surgical Treatment of Ptosis
MX2011007675A (es) 2011-07-19 2012-07-11 Cell Therapy And Technology S A De C V Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.
ES2600153T3 (es) * 2011-08-04 2017-02-07 Omeros Corporation Soluciones antiinflamatorias estables para inyección
AU2012311239B2 (en) 2011-09-20 2017-10-19 Allergan, Inc. Compositions and methods for treating presbyopia, mild hyperopia, and irregular astigmatism
MX346763B (es) 2012-03-28 2017-03-31 Cell Therapy And Tech S A De C V Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné.
MX356551B (es) 2012-08-23 2018-06-04 Grupo Medifarma S A De C V Star Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné.
FR3000395A1 (fr) * 2012-12-31 2014-07-04 Galderma Res & Dev Combinaison de laropiprant et d'oxymetazoline pour le traitement de la rosacee
CA2899339C (en) 2013-02-01 2021-07-06 Ocularis Pharma, Llc Aqueous ophthalmic solutions of phentolamine and medical uses thereof
ES2835398T3 (es) 2013-02-01 2021-06-22 Ocuphire Pharma Inc Métodos y composiciones para la administración oftálmica diaria de fentolamina para mejorar el rendimiento visual
WO2015062611A1 (en) * 2013-10-28 2015-05-07 Astion Pharma A/S Compositions for dermatological use
EP3137055A4 (en) * 2014-05-01 2017-12-06 Anterios, Inc. Demonstrable efficacy across or within patient populations
ES2796871T3 (es) 2014-06-11 2020-11-30 Epi Health Llc Formulaciones de oximetazolina estabilizadas y sus usos
WO2017049148A1 (en) * 2015-09-17 2017-03-23 June Jacobs Laboratiories, Llc Compositions and methods for the treatment and prevention of radiation dermatitis
EP3476393A4 (en) * 2016-06-28 2019-07-17 Doris Maria Hexsel USE OF AN ACTIVE AGENT FOR THE TREATMENT OF TELANGIEKTATISCHEM MELASMA
KR102487144B1 (ko) 2016-11-21 2023-01-12 에이리온 테라퓨틱스, 인코포레이티드 큰 물질의 경피 전달
EA202090763A1 (ru) 2017-11-15 2020-08-03 Борис Славинович ФАРБЕР Фармацевтическая композиция для стимуляции деления стволовых клеток и подавления вирулентности бактерий
MX368750B (es) * 2018-08-31 2019-10-15 Cell Therapy And Tech S A De C V Composiciones farmaceuticas semisolidas de base oleosa conteniendo pirfenidona para su aplicacion en la reparacion tisular.
AU2019360953A1 (en) 2018-10-15 2021-05-13 Ocuphire Pharma, Inc. Methods and compositions for treatment of glaucoma and related conditions
EP3870170A4 (en) 2018-10-26 2022-07-20 Ocuphire Pharma, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF PRESBYOPIA, MYDRIASIS AND OTHER EYE DISEASES
BR112021009700A2 (pt) * 2018-11-26 2021-08-17 Cellix Bio Private Limited composto de fórmula i, ii e iii e hidratos, solvatos, pró-fármacos, enantiômeros e estereoisômeros farmaceuticamente aceitáveis destes, composição farmacêutica e composto da estrutura
CA3133733A1 (en) * 2019-04-30 2020-11-05 Xin-Yuan Fu Compounds for treating inflammation induced autoimmune skin diseases and uses thereof
CN115368310B (zh) 2021-05-18 2025-06-27 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法
KR102633256B1 (ko) * 2021-10-08 2024-02-05 (주)우리스마트바이오 참당귀 추출물을 이용한 피부개선용 화장품 조성물, 이를 포함한 피부개선용 화장품 및 피부개선용 화장품 제조방법
EP4460310A4 (en) * 2022-01-05 2025-11-12 Asymmetric Therapeutics Llc METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROLIFERATIVE SKIN DISORDERS AND OTHER SKIN CONDITIONS
US20240423959A1 (en) * 2022-06-21 2024-12-26 Jjr&D, Llc Topical benzimidazole formulations and methods for use in treating inflammatory dermatoses

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3147275A (en) 1964-09-01 Nh-cha
US8093293B2 (en) * 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
US6433024B1 (en) 2000-05-08 2002-08-13 Karl F. Popp Topical anti-acne composition
EP1310099B1 (en) 2000-08-16 2005-11-02 Dolby Laboratories Licensing Corporation Modulating one or more parameters of an audio or video perceptual coding system in response to supplemental information
US6479060B1 (en) * 2001-09-04 2002-11-12 Healthpoint, Ltd. Elegant hydrogenated castor oil ointments
US6824786B2 (en) 2001-11-27 2004-11-30 Ruey J. Yu Compositions comprising phenyl-glycine derivatives
US6573301B1 (en) 2002-04-23 2003-06-03 Bradley Pharmaceuticals, Inc. Carbamide peroxide compositions for the treatment of dermatological disorders and methods for their use
US7439241B2 (en) 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
US7812049B2 (en) * 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
PL1761266T3 (pl) * 2004-05-25 2013-09-30 Galderma Pharma Sa Związki, preparaty i sposoby leczenia lub zapobiegania procesom zapalnym skóry
WO2006098625A1 (en) 2005-03-15 2006-09-21 Campina Nederland Holding B.V. Dermatologic use of milk proteins
KR20080006568A (ko) * 2005-03-30 2008-01-16 레반스 테라퓨틱스, 아이엔씨. 여드름 치료용 조성물 및 방법
CN101212965A (zh) 2005-06-29 2008-07-02 帝斯曼知识产权资产管理有限公司 包括异黄酮纳米颗粒的局部用组合物
CA2644311C (en) * 2006-03-01 2012-07-10 Tristrata, Inc. Composition and method for topical treatment of tar-responsive dermatological disorders
US20080031979A1 (en) * 2006-08-04 2008-02-07 Claude Saliou Use of extracts for the treatment of viral disorders
RU2310439C1 (ru) * 2006-10-05 2007-11-20 Закрытое акционерное общество Фармацевтическое научно-производственное предприятие "Ретиноиды" (ЗАО "Ретиноиды") Мазевая акарицидная композиция и способ лечения демодекоза и сопутствующих ему заболеваний
US9511016B2 (en) * 2007-06-12 2016-12-06 Epicentrx, Inc. Topical composition for treating pain
US20090061020A1 (en) 2007-08-31 2009-03-05 Theobald Klaus P Brimonidine Compositions for Treating Erythema
BRPI0819075A2 (pt) 2007-11-16 2014-10-07 Vicept Therapeutics Inc Método para tratar púrpura em um indivíduo e método para diminuir a púrpura em um indivíduo antes de um procedimento cirúrgico
US20090130029A1 (en) * 2007-11-21 2009-05-21 Foamix Ltd. Glycerol ethers vehicle and pharmaceutical compositions thereof
US20110224216A1 (en) 2009-10-26 2011-09-15 Galderma Laboratories Inc. Methods of Treating or Preventing Acute Erythema
US20120082625A1 (en) 2010-09-28 2012-04-05 Michael Graeber Combination treatment for rosacea
AU2011336449B2 (en) 2010-12-03 2016-07-07 Epi Health, Llc Pharmaceutical cream compositions comprising oxymetazoline
RU2648439C2 (ru) 2011-02-15 2018-03-26 Аллерган, Инк. Фармацевтическая композиция в виде крема, содержащая оксиметазолин, для лечения симптомов розацеа
KR20140074883A (ko) 2011-07-14 2014-06-18 알러간, 인코포레이티드 옥시메타졸린의 겔 조성물들 및 사용 방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017066162A (ja) * 2011-02-15 2017-04-06 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物

Also Published As

Publication number Publication date
KR20190114010A (ko) 2019-10-08
EP3578178A1 (en) 2019-12-11
AU2019203993B2 (en) 2020-05-28
RU2648439C2 (ru) 2018-03-26
AU2017202726B2 (en) 2019-03-07
ES2742273T3 (es) 2020-02-13
JP2018193399A (ja) 2018-12-06
JP2017066162A (ja) 2017-04-06
US20140113947A1 (en) 2014-04-24
US20200276108A1 (en) 2020-09-03
CA2827373C (en) 2019-05-14
CN107007546A (zh) 2017-08-04
JP6389534B2 (ja) 2018-09-12
CA2827373A1 (en) 2012-08-23
AU2019203993A1 (en) 2019-06-27
US11541000B2 (en) 2023-01-03
EP2675449B1 (en) 2019-04-24
AU2017202726A1 (en) 2017-05-18
RU2013141845A (ru) 2015-03-27
AU2012217858A1 (en) 2013-09-05
KR102058756B1 (ko) 2020-01-22
JP2014505733A (ja) 2014-03-06
KR20140020912A (ko) 2014-02-19
US20190167566A1 (en) 2019-06-06
EP2675449A1 (en) 2013-12-25
US20120208858A1 (en) 2012-08-16
CN103458897A (zh) 2013-12-18
BR112013020770A2 (pt) 2019-08-27
WO2012112566A1 (en) 2012-08-23

Similar Documents

Publication Publication Date Title
JP6389534B2 (ja) 酒さの症状を治療するためのオキシメタゾリンの薬学的クリーム組成物
JP6030067B2 (ja) 薬学的クリーム組成物および使用法
HK1192724A (en) Pharmaceutical cream compositions of oxymetazoline for treating symptoms of rosacea
HK1192724B (en) Pharmaceutical cream compositions of oxymetazoline for treating symptoms of rosacea
HK1190307B (en) Pharmaceutical cream compositions comprising oxymetazoline

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150216

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150216

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160115

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160118

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160418

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160620

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160719

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20160907

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170110

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20170221

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20170324

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20171006

R150 Certificate of patent or registration of utility model

Ref document number: 6225030

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250