JP6224597B2 - グリオーマを処置するための組成物及び方法 - Google Patents

グリオーマを処置するための組成物及び方法 Download PDF

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JP6224597B2
JP6224597B2 JP2014533645A JP2014533645A JP6224597B2 JP 6224597 B2 JP6224597 B2 JP 6224597B2 JP 2014533645 A JP2014533645 A JP 2014533645A JP 2014533645 A JP2014533645 A JP 2014533645A JP 6224597 B2 JP6224597 B2 JP 6224597B2
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temozolomide
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JP2014531461A5 (cg-RX-API-DMAC7.html
JP2014531461A (ja
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ハルス レザ
ハルス レザ
サハ サウラブ
サハ サウラブ
ジェイムズ ロイックス ジェフリー
ジェイムズ ロイックス ジェフリー
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バイオメッド バレー ディスカバリーズ，インコーポレイティド
バイオメッド バレー ディスカバリーズ，インコーポレイティド
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US201161539779P 2011-09-27 2011-09-27
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PCT/US2012/057085 WO2013049045A1 (en) 2011-09-27 2012-09-25 Compositions and methods of treating gliomas

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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0314738D0 (en) 2003-06-24 2003-07-30 Glaxo Group Ltd Novel compounds
WO2014023329A1 (en) * 2012-08-06 2014-02-13 Life And Brain Gmbh Niclosamide and its derivatives for use in the treatment of solid tumors
WO2016062279A1 (zh) * 2014-10-24 2016-04-28 朗齐生物医学股份有限公司 苹果酸丙氯陪拉辛锭用于制备治疗癌症药物的用途
KR101773244B1 (ko) * 2015-02-27 2017-09-01 이화여자대학교 산학협력단 암로디핀을 포함하는 뇌종양 예방 또는 치료용 약학적 조성물
CA2992674A1 (en) * 2015-07-31 2017-02-09 Inflectis Bioscience Method of treating cancer with a combination of benzylideneguanidine derivatives and chemotherapeutic agent
CN107088194A (zh) * 2016-02-17 2017-08-25 深圳市坤健创新药物研究院 药物氨氯地平的新用途
TW201739453A (zh) * 2016-04-29 2017-11-16 奧托德里克有限公司 使用ace抑制劑、arb或西里柯斯比(celecoxib)及奧美沙坦(olmesartan)之用於治療癌症的方法
EP3970719A1 (en) 2016-09-12 2022-03-23 Intra-Cellular Therapies, Inc. Pde1 inhibitor for use in a method of treatment or prophylaxis of inflammation and/or an inflammatory disease or disorder
KR102005887B1 (ko) * 2016-12-09 2019-07-31 서울대학교산학협력단 뇌종양의 예방 또는 치료용 약학 조성물
EP3773579A4 (en) 2018-03-26 2022-03-09 Clear Creek Bio, Inc. COMPOSITIONS AND METHODS FOR INHIBITING DIHYDROOROTATE DEHYDROGENASE
AU2019275453B2 (en) * 2018-05-25 2023-12-21 Intra-Cellular Therapies, Inc. Organic compounds
EP3908285A4 (en) 2019-01-07 2022-10-19 Intra-Cellular Therapies, Inc. ORGANIC COMPOUNDS
CN111773377B (zh) * 2019-04-04 2023-03-14 中南大学 阿尼芬净在制备抗肿瘤药物中的应用及抗肿瘤药物
CN110876800B (zh) * 2019-11-18 2023-06-27 中南大学 米卡芬净在制备抗肿瘤药物中的应用及抗肿瘤药物
CN110960533A (zh) * 2019-12-31 2020-04-07 苏州青雅启瑞生物科技有限公司 马尼地平联用替莫唑胺及其药物组合在制备用于治疗脑胶质瘤的药物中的应用
WO2021189018A1 (en) 2020-03-20 2021-09-23 Clear Creek Bio, Inc. Methods of treating viral infections using inhibitors of nucleotide synthesis pathways
US12364695B2 (en) 2020-06-02 2025-07-22 Intra-Cellular Therapies, Inc. Methods of treating inflammatory disease
CN111803497A (zh) * 2020-09-02 2020-10-23 中国科学院昆明动物研究所 乐卡地平类药物在制备治疗人神经胶质瘤药物中的用途
WO2022091809A1 (ja) * 2020-10-28 2022-05-05 国立大学法人東海国立大学機構 悪性中皮腫の治療剤および悪性中皮腫患者の選択方法
EP4333815A1 (en) * 2021-05-07 2024-03-13 Eli Lilly And Company Taste masked compostions of 2,4,6-trifluoro- n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2- ylj-benzamide hemisuccinate, and orally disentegrating tablet comprising the same
WO2023113538A1 (ko) * 2021-12-17 2023-06-22 숙명여자대학교산학협력단 뇌종양 치료를 위한 글리세오플빈 병용요법
KR102893290B1 (ko) * 2021-12-17 2025-12-01 숙명여자대학교산학협력단 뇌종양 치료를 위한 글리세오플빈 병용요법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007525442A (ja) 2003-03-05 2007-09-06 ピーアール ファーマシューティカルズ，インコーポレイテッド オキシトシン制御放出処方物およびオキシトシン制御放出処方物を使用する方法
US20060009506A1 (en) 2004-07-09 2006-01-12 Odyssey Thera, Inc. Drugs for the treatment of neoplastic disorders
WO2006086562A2 (en) * 2005-02-09 2006-08-17 Microbia, Inc. Phenylazetidinone derivatives
TW200716141A (en) * 2005-05-05 2007-05-01 Combinatorx Inc Compositions and methods for treatment for neoplasms
RU2473560C2 (ru) 2005-11-02 2013-01-27 Дьюк Юниверсити Совместная химиотерапия и иммунотерапия
CN101336300A (zh) * 2005-12-16 2008-12-31 健泰科生物技术公司 神经胶质瘤的诊断、预后和治疗方法
TWI494134B (zh) * 2006-06-20 2015-08-01 Siegfried Generics Int Ag 含有坎地沙坦酯的組成物、錠劑和顆粒及該錠劑的製造方法
DK2038252T3 (en) 2006-07-12 2016-12-19 Univ Tennessee Res Found SUBSTITUTED AND ACYLANILIDER methods of use thereof
EP1958637A1 (en) 2007-02-14 2008-08-20 Revotar Biopharmaceuticals AG Pharmaceutical composition for the treatment of IL-8 mediated diseases
JP2010518147A (ja) 2007-02-16 2010-05-27 ノバルティス アーゲー 有機化合物の使用
TWI473610B (zh) * 2008-10-28 2015-02-21 Twi Biotechnology Inc 包含雙醋瑞因（ｄｉａｃｅｒｅｉｎ）之醫藥組合物

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