JP6219272B2 - ベンゾジアゼピン組成物の投与 - Google Patents

ベンゾジアゼピン組成物の投与 Download PDF

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Publication number
JP6219272B2
JP6219272B2 JP2014515967A JP2014515967A JP6219272B2 JP 6219272 B2 JP6219272 B2 JP 6219272B2 JP 2014515967 A JP2014515967 A JP 2014515967A JP 2014515967 A JP2014515967 A JP 2014515967A JP 6219272 B2 JP6219272 B2 JP 6219272B2
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Japan
Prior art keywords
benzodiazepine
diazepam
drug
drug solution
administration
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JP2014515967A
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English (en)
Japanese (ja)
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JP2014519525A (ja
JP2014519525A5 (cg-RX-API-DMAC7.html
Inventor
カート，スティーブ
メデイロス，デイビッド
グヴォーズ，ギャリー，トーマス
ロクスレー，アンドリュー
ミッチニック，マーク
ヘイル，デイビッド
マッジオ，エドワード，ティー．
Original Assignee
ヘイル バイオファーマ ベンチャーズ，エルエルシー
ヘイル バイオファーマ ベンチャーズ，エルエルシー
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Application filed by ヘイル バイオファーマ ベンチャーズ，エルエルシー, ヘイル バイオファーマ ベンチャーズ，エルエルシー filed Critical ヘイル バイオファーマ ベンチャーズ，エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2014515967A 2011-06-14 2012-06-13 ベンゾジアゼピン組成物の投与 Active JP6219272B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161497017P 2011-06-14 2011-06-14
US61/497,017 2011-06-14
US201161570110P 2011-12-13 2011-12-13
US61/570,110 2011-12-13
PCT/US2012/042311 WO2012174158A2 (en) 2011-06-14 2012-06-13 Administration of benzodiazepine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017185485A Division JP6523397B2 (ja) 2011-06-14 2017-09-26 ベンゾジアゼピン組成物の投与

Publications (3)

Publication Number Publication Date
JP2014519525A JP2014519525A (ja) 2014-08-14
JP2014519525A5 JP2014519525A5 (cg-RX-API-DMAC7.html) 2015-07-30
JP6219272B2 true JP6219272B2 (ja) 2017-10-25

Family

ID=47357711

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2014515967A Active JP6219272B2 (ja) 2011-06-14 2012-06-13 ベンゾジアゼピン組成物の投与
JP2017185485A Active JP6523397B2 (ja) 2011-06-14 2017-09-26 ベンゾジアゼピン組成物の投与
JP2019083274A Active JP6883918B2 (ja) 2011-06-14 2019-04-24 ベンゾジアゼピン組成物の投与
JP2021078241A Pending JP2021130663A (ja) 2011-06-14 2021-05-05 ベンゾジアゼピン組成物の投与

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2017185485A Active JP6523397B2 (ja) 2011-06-14 2017-09-26 ベンゾジアゼピン組成物の投与
JP2019083274A Active JP6883918B2 (ja) 2011-06-14 2019-04-24 ベンゾジアゼピン組成物の投与
JP2021078241A Pending JP2021130663A (ja) 2011-06-14 2021-05-05 ベンゾジアゼピン組成物の投与

Country Status (10)

Country Link
US (6) US8895546B2 (cg-RX-API-DMAC7.html)
EP (3) EP2720699B1 (cg-RX-API-DMAC7.html)
JP (4) JP6219272B2 (cg-RX-API-DMAC7.html)
CN (2) CN107737100A (cg-RX-API-DMAC7.html)
DK (2) DK2720699T3 (cg-RX-API-DMAC7.html)
ES (2) ES2683902T3 (cg-RX-API-DMAC7.html)
HK (1) HK1250647A1 (cg-RX-API-DMAC7.html)
PL (1) PL3415139T3 (cg-RX-API-DMAC7.html)
PT (1) PT3415139T (cg-RX-API-DMAC7.html)
WO (1) WO2012174158A2 (cg-RX-API-DMAC7.html)

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CA2723470C (en) * 2007-05-07 2013-12-03 Hale Biopharma Ventures, Llc Nasal administration of benzodiazepines
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EP2720699B1 (en) 2011-06-14 2018-05-16 Hale Biopharma Ventures, Llc Administration of benzodiazepine
US20130224300A1 (en) * 2011-08-26 2013-08-29 Edward T. Maggio Compositions and methods thereof for oral administration of drugs
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US11458091B2 (en) * 2016-11-18 2022-10-04 Opiant Pharmaceuticals, Inc. Compositions and methods for the treatment of opioid overdose
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