JP6219271B2 - 治療の方法 - Google Patents
治療の方法 Download PDFInfo
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- JP6219271B2 JP6219271B2 JP2014514631A JP2014514631A JP6219271B2 JP 6219271 B2 JP6219271 B2 JP 6219271B2 JP 2014514631 A JP2014514631 A JP 2014514631A JP 2014514631 A JP2014514631 A JP 2014514631A JP 6219271 B2 JP6219271 B2 JP 6219271B2
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- aerosol
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- chamber
- airway
- entrainment
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Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009049159A1 (en) | 2007-10-10 | 2009-04-16 | Parion Sciences, Inc. | Delivering osmolytes by nasal cannula |
| EP2717855A4 (en) | 2011-06-07 | 2014-11-12 | Parion Sciences Inc | Methods of Treatment |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| EP2806926B2 (en) * | 2012-01-24 | 2019-12-25 | Vapotherm, Inc. | Systems for providing respiratory therapy |
| US9282772B2 (en) | 2012-01-31 | 2016-03-15 | Altria Client Services Llc | Electronic vaping device |
| US9669172B2 (en) * | 2012-07-05 | 2017-06-06 | Resmed Limited | Discreet respiratory therapy system |
| EP2978434A4 (en) * | 2013-03-28 | 2016-08-17 | Pharmacaribe Llc | COMPOSITIONS, FORMULATIONS AND METHODS FOR BIO-ALIGNING THE PH-VALUE OF A STERILE ISOTONIC SALT SOLUTION AND HYPERTONIC SALT SOLUTIONS |
| US12290631B2 (en) | 2013-07-19 | 2025-05-06 | Altria Client Services Llc | Electronic smoking article |
| WO2015013329A1 (en) * | 2013-07-25 | 2015-01-29 | Altria Client Services Inc. | Electronic smoking article |
| AU2013400183B2 (en) * | 2013-09-10 | 2017-04-27 | Kenneth P. Glynn | Carbon dioxide and saline nasal delivery methods and delivery devices |
| EP3151896B1 (en) * | 2014-06-06 | 2018-05-23 | Vapotherm, Inc. | Heated nebulizer adapter for respiratory therapy |
| LT3193835T (lt) * | 2014-09-15 | 2018-06-11 | Verona Pharma Plc | Skysta inhaliuojama vaisto forma, apimanti rpl554 |
| US11291780B2 (en) * | 2014-12-04 | 2022-04-05 | Vyaire Medical Consumables Llc | Breath-actuated nebulizer for medicine inhalation |
| CN107708875A (zh) * | 2015-06-10 | 2018-02-16 | 斯坦福设备有限公司 | 气雾剂产生 |
| US10661283B1 (en) * | 2015-06-18 | 2020-05-26 | Elemental Scientific, Inc. | Treated nebulizer tip and spray chamber |
| US11058842B2 (en) * | 2015-08-23 | 2021-07-13 | Pivotal Biotech LLC | Adapter with moisture trap assembly for respiratory circuit |
| PL3487571T3 (pl) | 2016-07-21 | 2024-07-29 | Fisher & Paykel Healthcare Limited | Rurki medyczne do obwodu oddechowego |
| US9937303B1 (en) | 2016-10-11 | 2018-04-10 | Kaer Biotherapeutics Corporation | Two-stage apparatus and method for generating and concentrating fine particle aerosols |
| US10207064B2 (en) * | 2017-07-11 | 2019-02-19 | Glen McCants | Dual chamber nebulizer apparatus |
| JP7661041B2 (ja) | 2018-01-24 | 2025-04-14 | フィッシャー アンド ペイケル ヘルスケア リミテッド | 呼吸回路のための医療用管 |
| USD855795S1 (en) * | 2018-03-27 | 2019-08-06 | Mercury Enterprises, Inc. | Reusable t-piece resuscitator |
| MX2020012960A (es) | 2018-05-31 | 2021-04-28 | Vapotherm Inc | Nebulizador de malla vibratoria basado en canula. |
| EP4186546A1 (en) | 2018-05-31 | 2023-05-31 | Vapotherm, Inc. | System for providing respiratory therapy to a patient |
| AU2020285714B2 (en) * | 2019-05-24 | 2025-05-22 | Stamford Devices Ltd. | Design of aerosol system and interface to deliver clinically and economically feasible inhaled dose with neonatal CPAP device |
| CN114728147A (zh) | 2019-09-26 | 2022-07-08 | 蒸汽热能公司 | 插管内部安装的雾化器 |
| US20210315849A1 (en) * | 2020-04-10 | 2021-10-14 | Pacific Sinus Solutions LLC | Compositions and methods for treating one or more ailments with a nasal rinse comprising n-acetylcysteine |
| US20210319865A1 (en) * | 2020-04-13 | 2021-10-14 | Cornell University | Computable Phenotypes to Identify Patients with Preventable High Cost |
| EP4461336B1 (en) * | 2020-09-01 | 2026-06-17 | Stamford Devices Limited | High flow therapy apparatus |
| US11253670B1 (en) | 2020-12-09 | 2022-02-22 | Apogee Innovations | Respiratory isolation and/or treatment devices and methods of using the same |
| WO2023164030A1 (en) * | 2022-02-24 | 2023-08-31 | Data Sciences International Inc. | System and method for inhalation exposure |
| US20230321683A1 (en) * | 2022-04-09 | 2023-10-12 | Abdulilah M. Mayet | Method And Apparatus For Atomizing And Vaporizing Liquid |
| WO2025265075A1 (en) * | 2024-06-21 | 2025-12-26 | Parion Sciences, Inc. | Methods of clearing mucus from the lungs |
Family Cites Families (161)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US548953A (en) | 1895-10-29 | Harness-tug | ||
| US2534636A (en) * | 1949-02-12 | 1950-12-19 | American Cyanamid Co | Powder dispenser |
| BE758814A (fr) | 1970-05-11 | 1971-04-16 | Respiratory Care | Atomiseur |
| US4159803A (en) | 1977-03-31 | 1979-07-03 | MistO2 Gen Equipment Company | Chamber for ultrasonic aerosol generation |
| US4268460A (en) * | 1977-12-12 | 1981-05-19 | Warner-Lambert Company | Nebulizer |
| US4312860A (en) | 1980-10-24 | 1982-01-26 | Regents Of The University Of California | Lung surfactant compositions |
| US4479932A (en) | 1982-05-18 | 1984-10-30 | University Of Florida | Brain-specific drug delivery |
| US4540564A (en) | 1982-05-18 | 1985-09-10 | University Of Florida | Brain-specific drug delivery |
| US4501729A (en) | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| GB2152819B (en) * | 1983-12-08 | 1988-05-11 | Anthony John Dyson | Improved nebuliser |
| US4906476A (en) | 1988-12-14 | 1990-03-06 | Liposome Technology, Inc. | Novel liposome composition for sustained release of steroidal drugs in lungs |
| US5100806A (en) | 1989-03-24 | 1992-03-31 | Macri James N | Method for detecting Edwards syndrome |
| CA2063273C (en) | 1989-07-11 | 2002-09-24 | Bradley J. Benson | Surfactant compositions and methods |
| US5007419A (en) | 1989-09-25 | 1991-04-16 | Allan Weinstein | Inhaler device |
| US5002048A (en) | 1989-12-12 | 1991-03-26 | Makiej Jr Walter J | Inhalation device utilizing two or more aerosol containers |
| US5614216A (en) | 1990-10-17 | 1997-03-25 | The Liposome Company, Inc. | Synthetic lung surfactant |
| US5292498A (en) | 1991-06-19 | 1994-03-08 | The University Of North Carolina At Chapel Hill | Method of treating lung disease with uridine triphosphates |
| US5687715A (en) | 1991-10-29 | 1997-11-18 | Airways Ltd Inc | Nasal positive airway pressure apparatus and method |
| US5477852A (en) | 1991-10-29 | 1995-12-26 | Airways Ltd., Inc. | Nasal positive airway pressure apparatus and method |
| US5388574A (en) | 1993-07-29 | 1995-02-14 | Ingebrethsen; Bradley J. | Aerosol delivery article |
| US5437267A (en) | 1993-08-03 | 1995-08-01 | Weinstein; Allan | Device for delivering aerosol to the nasal membranes and method of use |
| AUPM411494A0 (en) * | 1994-02-25 | 1994-03-24 | Central Sydney Area Health Service | Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum |
| US5656256A (en) | 1994-12-14 | 1997-08-12 | The University Of North Carolina At Chapel Hill | Methods of treating lung disease by an aerosol containing benzamil or phenamil |
| US5533506A (en) | 1995-01-13 | 1996-07-09 | Medlife, Inc. | Nasal tube assembly |
| JP3088757B2 (ja) | 1995-03-29 | 2000-09-18 | 大鵬薬品工業株式会社 | ウラシル誘導体並びにそれを含有する抗腫瘍効果増強剤及び抗腫瘍剤 |
| US5483953A (en) * | 1995-04-08 | 1996-01-16 | The United States Of America As Represented By The Secretary Of The Navy | Aerosol dispensing apparatus for dispensing a medicated vapor into the lungs of a patient |
| US5628984A (en) | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
| US5823179A (en) | 1996-02-13 | 1998-10-20 | 1263152 Ontario Inc. | Nebulizer apparatus and method |
| US6015828A (en) | 1996-05-31 | 2000-01-18 | Cuppoletti; John | Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases |
| SE9603804D0 (sv) * | 1996-10-16 | 1996-10-16 | Aga Ab | Sätt och anordning för framställning av en finfördelad aerosol |
| AU5701498A (en) | 1996-12-12 | 1998-07-03 | Johns Hopkins University School Of Medicine, The | Method and apparatus for providing ventilatory support to a patient |
| EP0981534B1 (en) | 1997-02-06 | 2006-05-03 | Inspire Pharmaceuticals, Inc. | Dinucleotides and their uses |
| US7223744B2 (en) | 1997-02-10 | 2007-05-29 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof |
| US6818629B2 (en) | 1997-02-10 | 2004-11-16 | Inspire Pharmaceuticals, Inc. | Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate |
| IL123122A0 (en) | 1998-01-29 | 1998-09-24 | Oridion Medical Ltd | Oral/nasal cannula |
| US6550476B1 (en) | 1998-05-21 | 2003-04-22 | Steven L. Ryder | Heat-moisture exchanger and nebulization device |
| US6264975B1 (en) | 1998-10-20 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Methods of hydrating mucosal surfaces |
| US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| US7074388B2 (en) | 1998-12-10 | 2006-07-11 | Kos Life Science, Inc. | Water stabilized medicinal aerosol formulation |
| CN1348377A (zh) | 1998-12-17 | 2002-05-08 | 希龙公司 | 用气溶胶化的抗生素治疗严重慢性支气管炎(支气管扩张症)的方法 |
| US6926911B1 (en) | 1998-12-22 | 2005-08-09 | The University Of North Carolina At Chapel Hill | Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs |
| US20070137653A1 (en) | 2000-03-13 | 2007-06-21 | Wood Thomas J | Ventilation interface for sleep apnea therapy |
| HK1049621A1 (zh) | 1999-06-09 | 2003-05-23 | 罗伯特‧E‧希弗斯 | 超临界流体辅助的喷雾和鼓泡乾燥 |
| JP2003514660A (ja) * | 1999-09-13 | 2003-04-22 | シェフィールド ファーマスゥーティカルズ インコーポレイテッド | エアロゾル気流制御システムおよび方法 |
| US6530370B1 (en) | 1999-09-16 | 2003-03-11 | Instrumentation Corp. | Nebulizer apparatus |
| DE60025019T2 (de) | 1999-10-29 | 2006-08-24 | Nektar Therapeutics, San Carlos | Trockenpulverzusammensetzungen mit verbesserter dispersivität |
| ES2251416T3 (es) | 1999-12-10 | 2006-05-01 | Vapotherm, Inc. | Aparato para terapia del tracto respiratorio. |
| US7345051B2 (en) | 2000-01-31 | 2008-03-18 | Genaera Corporation | Mucin synthesis inhibitors |
| US8336545B2 (en) | 2000-05-05 | 2012-12-25 | Novartis Pharma Ag | Methods and systems for operating an aerosol generator |
| US6550472B2 (en) | 2001-03-16 | 2003-04-22 | Aerogen, Inc. | Devices and methods for nebulizing fluids using flow directors |
| US20030171332A1 (en) | 2001-05-23 | 2003-09-11 | Abraham William M. | Treatment of respiratory conditions associated with bronchoconstriction with aerosolized hyaluronic acid |
| US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| JP4786866B2 (ja) | 2001-08-31 | 2011-10-05 | スキャンポ・アーゲー | クロライドチャンネルオープナーとしてのプロスタグランジンアナログ |
| CA2370995C (en) | 2001-09-13 | 2010-08-17 | Fisher & Paykel Healthcare Limited | Breathing assistance apparatus |
| US6679265B2 (en) | 2001-10-25 | 2004-01-20 | Worldwide Medical Technologies | Nasal cannula |
| WO2003068301A1 (en) | 2002-02-15 | 2003-08-21 | Oridion Medical 1987 Ltd. | Dual function nasal cannula |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6858614B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
| EP1340492A1 (en) | 2002-03-01 | 2003-09-03 | CHIESI FARMACEUTICI S.p.A. | Aerosol formulations for pulmonary administration of medicaments having systemic effects |
| US7607436B2 (en) | 2002-05-06 | 2009-10-27 | The Research Foundation Of State University Of New York | Methods, devices and formulations for targeted endobronchial therapy |
| US7334580B2 (en) | 2002-05-07 | 2008-02-26 | Smaldone Gerald C | Methods, devices and formulations for targeted endobronchial therapy |
| EP1542667B1 (en) | 2002-07-24 | 2012-03-07 | PTC Therapeutics, Inc. | Ureido substituted benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
| US6903105B2 (en) | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| EP4101846B1 (en) | 2003-04-11 | 2023-08-02 | PTC Therapeutics, Inc. | 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
| AU2004202274B2 (en) | 2003-05-30 | 2006-10-26 | Fisher & Paykel Healthcare Limited | Breathing Assistance Apparatus |
| AU2004266704B2 (en) | 2003-08-18 | 2012-02-23 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| CA2534568A1 (en) | 2003-08-18 | 2005-03-24 | Parion Sciences, Inc. | Aliphatic pyrazinoylguanidine sodium channel blockers |
| US20050090505A1 (en) | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| EP1670474A4 (en) | 2003-08-18 | 2008-08-06 | Parion Sciences Inc | CYCLIC PYRAZINOYLGUANIDINE AS SODIUM CHANNEL BLOCKER |
| US20090253714A1 (en) | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| WO2005023335A2 (en) | 2003-09-05 | 2005-03-17 | Kurve Technology, Inc. | Integrated nebulizer and particle dispersing chamber for delivery of medicament |
| US7499570B2 (en) | 2004-03-02 | 2009-03-03 | Siemens Corporate Research, Inc. | Illumination invariant change detection |
| DE102004012093A1 (de) * | 2004-03-05 | 2005-09-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator mit Merkanaldüse |
| GB0407627D0 (en) | 2004-04-02 | 2004-05-05 | Vectura Ltd | Corkscrew pump |
| US7267121B2 (en) | 2004-04-20 | 2007-09-11 | Aerogen, Inc. | Aerosol delivery apparatus and method for pressure-assisted breathing systems |
| US7290541B2 (en) | 2004-04-20 | 2007-11-06 | Aerogen, Inc. | Aerosol delivery apparatus and method for pressure-assisted breathing systems |
| CA2567334A1 (en) | 2004-05-20 | 2005-12-08 | Discovery Laboratories, Inc. | Methods , systems and devices for noninvasive pulmonary delivery |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| CA2575680A1 (en) | 2004-08-18 | 2006-03-02 | Michael R. Johnson | Cyclic amide & ester pyrazinoylguanidine sodium channel blockers |
| CA2575670A1 (en) | 2004-08-18 | 2006-03-02 | Michael R. Johnson | Aliphatic amide & ester pyrazinoylguanidine sodium channel blockers |
| US7399766B2 (en) | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| US20090324724A1 (en) | 2004-08-18 | 2009-12-31 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| JP2008515992A (ja) | 2004-10-13 | 2008-05-15 | ピーティーシー セラピューティクス，インコーポレーテッド | 体細胞変異に起因する疾患の阻止／治療用医薬を製造するための規定化合物の使用 |
| US8757150B2 (en) | 2004-12-17 | 2014-06-24 | Ric Investments, Llc | Condensation reduction and management systems in a gas flow delivery system |
| JP2009221164A (ja) | 2008-03-17 | 2009-10-01 | Nitto Denko Corp | 肺線維症処置剤 |
| DE102005000922A1 (de) | 2005-01-07 | 2006-07-20 | Seleon Gmbh | Luftbrille, Nasenstück, Y-Stück sowie Verfahren |
| EA017847B1 (ru) | 2005-01-07 | 2013-03-29 | Элнилэм Фармасьютикалз, Инк. | Композиция для лечения респираторных синцитиальных вирусов |
| DE102005016102B3 (de) | 2005-04-08 | 2006-10-26 | Altana Pharma Ag | Vorrichtung zur Dosierung und Trockenvernebelung |
| WO2007008825A2 (en) | 2005-07-11 | 2007-01-18 | Emory University | System and method for optimized delivery of an aerosol to the respiratory tract |
| US7807834B2 (en) | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| WO2008048234A2 (en) | 2005-08-26 | 2008-04-24 | North Carolina State University | Inhaler system for targeted maximum drug-aerosol delivery |
| US8105572B2 (en) | 2007-05-18 | 2012-01-31 | New York University | Method of treating tuberculosis with interferons |
| AU2006297289B2 (en) | 2005-09-29 | 2013-03-21 | Novartis Ag | Antibiotic formulations, unit doses, kits, and methods |
| US8701668B2 (en) | 2005-10-14 | 2014-04-22 | Resmed Limited | Nasal assembly |
| EP2036567A3 (en) | 2005-12-06 | 2009-12-09 | P2-Science APS | Modulation of the P2Y2 receptor pathway |
| AU2006331565A1 (en) | 2005-12-27 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Compounds useful in CFTR assays and methods therewith |
| US20080000473A1 (en) | 2005-12-29 | 2008-01-03 | Hugo Stephenson | pH-Based Methods and Devices for Preventing Hemagglutinin Cell Membrane Fusion |
| JP2007195838A (ja) * | 2006-01-30 | 2007-08-09 | Blue Cross Kk | ネブライザ |
| RU2433841C2 (ru) | 2006-02-09 | 2011-11-20 | Пари Фарма Гмбх | Доставка в легкие альфа-1-ингибитора протеиназ |
| JP2009526063A (ja) | 2006-02-09 | 2009-07-16 | シェーリング コーポレイション | 医薬製剤 |
| US20070202051A1 (en) | 2006-02-10 | 2007-08-30 | Pari Gmbh | Aerosols for sinunasal drug delivery |
| JP2009526003A (ja) | 2006-02-10 | 2009-07-16 | パーリ・ファルマ・ゲーエムベーハー | 吸入療法用噴霧状抗生物質 |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| ATE534383T1 (de) | 2006-05-12 | 2011-12-15 | Vertex Pharma | Zusammensetzungen aus n-ä2,4-bis(1,1- dimethylethyl)-5-hydroxyphenylü-1,4-dihydro-4- oxochinolin-3-carboxamid |
| US7861713B2 (en) | 2006-06-08 | 2011-01-04 | Sunil Kumar Dhuper | Adapter for use in an aerosol delivery system |
| PT2035004E (pt) | 2006-06-09 | 2012-11-21 | Parion Sciences Inc | Bloqueadores dos canais de sódio de pirazinoilguanidona substituída com fenilo que possuem actividade agonista beta |
| US8324218B2 (en) | 2006-06-09 | 2012-12-04 | Parion Sciences, Inc. | Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity |
| US20110195973A1 (en) | 2006-06-09 | 2011-08-11 | Parion Sciences, Inc. | Cyclic substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity |
| US20080035141A1 (en) | 2006-06-16 | 2008-02-14 | Warner W R | Aerosolized therapy kit |
| US8161971B2 (en) | 2006-08-04 | 2012-04-24 | Ric Investments, Llc | Nasal and oral patient interface |
| PT2068889T (pt) | 2006-08-10 | 2020-01-30 | Roy C Levitt | Anakinra para uso no tratamento da síndrome da bronquiolite obliterante |
| CA2698137A1 (en) | 2006-08-30 | 2008-03-06 | Kurve Technology, Inc. | Aerosol generating and delivery device |
| AU2007294547A1 (en) | 2006-09-07 | 2008-03-13 | Parion Sciences, Inc. | Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
| WO2008031048A2 (en) | 2006-09-07 | 2008-03-13 | Parion Sciences, Inc. | Enhanced mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
| WO2008030592A2 (en) | 2006-09-08 | 2008-03-13 | Vapotherm, Inc. | System and method for delivering medications |
| KR20090060348A (ko) * | 2006-09-19 | 2009-06-11 | 디스커버리 래보래토리스, 인크. | 폐 계면활성제 제제 및 점액 클리어런스 촉진 방법 |
| US20080066739A1 (en) | 2006-09-20 | 2008-03-20 | Lemahieu Edward | Methods and systems of delivering medication via inhalation |
| US20080078382A1 (en) | 2006-09-20 | 2008-04-03 | Lemahieu Edward | Methods and Systems of Delivering Medication Via Inhalation |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US7754739B2 (en) | 2007-05-09 | 2010-07-13 | Vertex Pharmaceuticals Incorporated | Modulators of CFTR |
| WO2008060523A2 (en) | 2006-11-15 | 2008-05-22 | Vapotherm, Inc. | Single nasal prong nasal cannula |
| WO2008117265A1 (en) | 2007-03-28 | 2008-10-02 | Stamford Devices Limited | Humidification in breathing circuits |
| WO2008124496A1 (en) | 2007-04-03 | 2008-10-16 | Parion Sciences, Inc. | Method of treating acid-sensing ion channel mediated pain, cough, and central nervous system disorders |
| US8288391B2 (en) | 2007-04-03 | 2012-10-16 | Parion Sciences, Inc. | Pyrazinoylguanidine compounds for use as taste modulators |
| JP2010527914A (ja) | 2007-04-26 | 2010-08-19 | クォーク ファーマシューティカルズ インコーポレーティッド | 呼吸器系への抑制性核酸分子の治療的送達 |
| JP4963084B2 (ja) * | 2007-05-31 | 2012-06-27 | 株式会社吉野工業所 | 吸引式投薬器 |
| EP1997502A1 (en) | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
| WO2008154700A1 (en) | 2007-06-20 | 2008-12-24 | Phylogica Limited | Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ards) and clinical disorders associated with therewith |
| WO2009049159A1 (en) | 2007-10-10 | 2009-04-16 | Parion Sciences, Inc. | Delivering osmolytes by nasal cannula |
| US20090263495A1 (en) | 2007-10-25 | 2009-10-22 | Revalesio Corporation | Bacteriostatic or bacteriocidal compositions and methods |
| US20090227018A1 (en) | 2007-10-25 | 2009-09-10 | Revalesio Corporation | Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction |
| EP2217249A4 (en) | 2007-11-06 | 2011-10-12 | Benaroya Res Inst | INHIBITION OF VERSICAN WITH SIRNA AND OTHER MOLECULES |
| US8479728B2 (en) | 2008-02-18 | 2013-07-09 | Virginia Commonwealth University | Effective delivery of nanoparticles and micrometer-sized pharmaceutical aerosols to the lung through enhanced condensational growth |
| WO2009139948A1 (en) | 2008-02-26 | 2009-11-19 | Johnson Michael R | Poly aromatic sodium channel blockers |
| US20090215734A1 (en) | 2008-02-26 | 2009-08-27 | Elevation Pharmaceuticals, Inc. | Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations |
| CA2716109C (en) | 2008-02-28 | 2016-07-19 | Vertex Pharmaceuticals Incorporated | Heteroaryl derivatives as cftr modulators |
| NZ605600A (en) | 2008-03-04 | 2014-11-28 | Resmed Ltd | Unobtrusive interface systems |
| NZ616097A (en) | 2008-03-31 | 2015-04-24 | Vertex Pharma | Pyridyl derivatives as cftr modulators |
| CA2723832A1 (en) | 2008-05-08 | 2009-11-12 | Edward Masionis | Portable life support apparatus ventilator |
| US20100074881A1 (en) | 2008-07-11 | 2010-03-25 | Parion Sciences, Inc. | Multiple nebulizer systems |
| WO2010035251A2 (en) | 2008-09-26 | 2010-04-01 | Stamford Devices Limited | A supplemental oxygen delivery system |
| US8911711B2 (en) | 2008-09-30 | 2014-12-16 | The Invention Science Fund I, Llc | Method, device, and system to control pH in pulmonary tissue of a subject |
| NZ592504A (en) | 2008-10-23 | 2013-04-26 | Vertex Pharma | Solid forms of n-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide |
| WO2010054083A2 (en) | 2008-11-05 | 2010-05-14 | Pharmacaribe | Inhalation formulation for treating and prophylatic use in bacteria, mycobacterial and fungal respiratory infections |
| DE102009047246A1 (de) | 2008-12-01 | 2010-06-10 | Fisher & Paykel Healthcare Ltd., East Tamaki | Nasenkanüle |
| US20100316628A1 (en) | 2008-12-09 | 2010-12-16 | The General Hospital Corporation | Agents and methods for treating respiratory disorders |
| EP2382197B1 (en) | 2008-12-30 | 2016-10-05 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| WO2010088191A1 (en) | 2009-01-27 | 2010-08-05 | Teleflex Medical Incorporated | Sputum dissolving suctioning solution for endotracheal and tracheostomy tubes |
| US8561607B2 (en) * | 2009-02-06 | 2013-10-22 | Vapotherm, Inc. | Heated nebulizer devices, nebulizer systems, and methods for inhalation therapy |
| PT2315580E (pt) * | 2009-03-26 | 2012-03-28 | Pulmatrix Inc | Formulações farmacêuticas e métodos para o tratamento de infeções do trato respiratório |
| US20110171141A1 (en) | 2009-06-26 | 2011-07-14 | Kellerman Donald J | Administration of dihydroergotamine mesylate particles using a metered dose inhaler |
| US9433588B2 (en) * | 2009-11-09 | 2016-09-06 | Virginia Commonwealth Univeristy | Delivery of submicrometer and nanometer aerosols to the lungs using hygroscopic excipients or dual stream nasal delivery |
| EP4389182A3 (en) | 2009-11-18 | 2024-07-31 | Fisher & Paykel Healthcare Limited | Nasal interface |
| CN105343971B (zh) | 2009-12-22 | 2018-03-30 | 费雪派克医疗保健有限公司 | 用于医疗回路的组件 |
| US20120125332A1 (en) | 2010-11-19 | 2012-05-24 | Vapotherm, Inc. | Apparatus, systems, and methods for respiratory therapy |
| US8893720B2 (en) | 2011-02-15 | 2014-11-25 | Binyomin A. Cohen | Inhalation apparatus |
| US20120304992A1 (en) | 2011-06-06 | 2012-12-06 | Ratto David R | Breathing treatment system and method |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| EP2717855A4 (en) | 2011-06-07 | 2014-11-12 | Parion Sciences Inc | Methods of Treatment |
| CA2894279A1 (en) | 2012-12-07 | 2014-06-12 | Paul Boucher | Nasal cannula for delivery of aerosolized medicaments |
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- 2012-06-07 AU AU2012267938A patent/AU2012267938B2/en not_active Ceased
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| US20130074842A1 (en) | 2013-03-28 |
| AU2017210594A1 (en) | 2017-08-24 |
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| CA2838529A1 (en) | 2012-12-13 |
| CA2838529C (en) | 2020-03-24 |
| JP2017222717A (ja) | 2017-12-21 |
| EP2717855A4 (en) | 2014-11-12 |
| AU2012267938A1 (en) | 2014-01-23 |
| EP2717855A1 (en) | 2014-04-16 |
| US20150101597A1 (en) | 2015-04-16 |
| JP2014516081A (ja) | 2014-07-07 |
| WO2012170677A1 (en) | 2012-12-13 |
| CN103732213A (zh) | 2014-04-16 |
| US10335558B2 (en) | 2019-07-02 |
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