JP6216954B2 - トロンビン結合性抗体分子及びその使用 - Google Patents

トロンビン結合性抗体分子及びその使用 Download PDF

Info

Publication number
JP6216954B2
JP6216954B2 JP2014546649A JP2014546649A JP6216954B2 JP 6216954 B2 JP6216954 B2 JP 6216954B2 JP 2014546649 A JP2014546649 A JP 2014546649A JP 2014546649 A JP2014546649 A JP 2014546649A JP 6216954 B2 JP6216954 B2 JP 6216954B2
Authority
JP
Japan
Prior art keywords
thrombin
exosite
seq
antibody molecule
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2014546649A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015501830A (ja
JP2015501830A5 (https=
Inventor
アンドリュー ハンティントン ジェイムズ
アンドリュー ハンティントン ジェイムズ
バグリン トレバー
バグリン トレバー
ラングダウン ジョナサン
ラングダウン ジョナサン
Original Assignee
ヤンセン ファーマシューティカルズ インコーポレイテッド
ヤンセン ファーマシューティカルズ インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ヤンセン ファーマシューティカルズ インコーポレイテッド, ヤンセン ファーマシューティカルズ インコーポレイテッド filed Critical ヤンセン ファーマシューティカルズ インコーポレイテッド
Publication of JP2015501830A publication Critical patent/JP2015501830A/ja
Publication of JP2015501830A5 publication Critical patent/JP2015501830A5/ja
Application granted granted Critical
Publication of JP6216954B2 publication Critical patent/JP6216954B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014546649A 2011-12-14 2012-12-14 トロンビン結合性抗体分子及びその使用 Expired - Fee Related JP6216954B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1121513.4A GB201121513D0 (en) 2011-12-14 2011-12-14 Thrombin-binding antibody molecules and uses thereof
GB1121513.4 2011-12-14
PCT/GB2012/053140 WO2013088164A1 (en) 2011-12-14 2012-12-14 Thrombin-binding antibody molecules and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017165700A Division JP6705785B2 (ja) 2011-12-14 2017-08-30 トロンビン結合性抗体分子及びその使用

Publications (3)

Publication Number Publication Date
JP2015501830A JP2015501830A (ja) 2015-01-19
JP2015501830A5 JP2015501830A5 (https=) 2017-02-02
JP6216954B2 true JP6216954B2 (ja) 2017-10-25

Family

ID=45560465

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014546649A Expired - Fee Related JP6216954B2 (ja) 2011-12-14 2012-12-14 トロンビン結合性抗体分子及びその使用
JP2017165700A Expired - Fee Related JP6705785B2 (ja) 2011-12-14 2017-08-30 トロンビン結合性抗体分子及びその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017165700A Expired - Fee Related JP6705785B2 (ja) 2011-12-14 2017-08-30 トロンビン結合性抗体分子及びその使用

Country Status (34)

Country Link
US (5) US9518129B2 (https=)
EP (2) EP2791177B1 (https=)
JP (2) JP6216954B2 (https=)
KR (1) KR102114506B1 (https=)
CN (2) CN107936119B (https=)
AU (2) AU2012351858B2 (https=)
BR (1) BR112014014605A2 (https=)
CA (1) CA2856656C (https=)
CO (1) CO7101192A2 (https=)
CY (1) CY1119599T1 (https=)
DK (1) DK2791177T3 (https=)
ES (1) ES2642718T3 (https=)
GB (1) GB201121513D0 (https=)
HK (1) HK1246326A1 (https=)
HR (1) HRP20171775T1 (https=)
HU (1) HUE034793T2 (https=)
IL (1) IL232797B (https=)
LT (1) LT2791177T (https=)
ME (1) ME02901B (https=)
MX (2) MX376876B (https=)
MY (1) MY170980A (https=)
NO (1) NO2791177T3 (https=)
PE (2) PE20190171A1 (https=)
PH (1) PH12014501169B1 (https=)
PL (1) PL2791177T3 (https=)
PT (1) PT2791177T (https=)
RS (1) RS56510B1 (https=)
RU (2) RU2642276C2 (https=)
SG (1) SG11201402560WA (https=)
SI (1) SI2791177T1 (https=)
SM (1) SMT201700580T1 (https=)
UA (1) UA116531C2 (https=)
WO (1) WO2013088164A1 (https=)
ZA (1) ZA201403836B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201121513D0 (en) 2011-12-14 2012-01-25 Cambridge Entpr Ltd Thrombin-binding antibody molecules and uses thereof
US9518128B2 (en) 2011-12-14 2016-12-13 Janssen Pharmaceuticals, Inc. Thrombin-binding antibody molecules
GB201310949D0 (en) * 2013-06-19 2013-07-31 Cambridge Entpr Ltd Binding Motif
GB201310948D0 (en) * 2013-06-19 2013-07-31 Cambridge Entpr Ltd Screening methods
CN107043423B (zh) * 2016-02-05 2021-02-26 江苏恒瑞医药股份有限公司 凝血酶抗体、其抗原结合片段及医药用途
EP3412688A4 (en) * 2016-02-05 2019-12-04 Jiangsu Hengrui Medicine Co., Ltd. THROMBIN ANTIBODY, ANTIGENBINDING FRAGMENT, AND PHARMACEUTICAL USE THEREOF
WO2018081534A1 (en) * 2016-10-28 2018-05-03 President And Fellows Of Harvard College Assay for exo-site binding molecules
WO2019030706A1 (en) 2017-08-10 2019-02-14 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE IN ORTHOPEDIC SURGERY
WO2019035055A1 (en) 2017-08-16 2019-02-21 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE WITH PLATELET ANTI-AGGREGATE AGENTS
WO2020003077A1 (en) * 2018-06-25 2020-01-02 Janssen Pharmaceutica Nv Anti-thrombin antibody molecules for use in patients at risk for gastrointestinal (gi) bleeding

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989011297A1 (en) * 1988-05-27 1989-11-30 Centocor, Inc. Freeze-dried formulation for antibody products
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5240913A (en) 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5196404B1 (en) 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
CA2082643A1 (en) 1990-05-10 1991-11-11 Jan H. Nuijens Inhibitors of factor xii activation and applications thereof
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5443827A (en) * 1993-05-03 1995-08-22 President And Fellows Of Harvard College Fibrin-targeted inhibitors of thrombin
AU1378495A (en) * 1993-12-27 1995-07-17 Hamilton Civic Hospitals Research Development, Inc. Methods and compositions for inhibiting thrombogenesis
GB9613718D0 (en) 1996-06-29 1996-08-28 Thrombosis Res Inst Thrombin inhibitors
US5985833A (en) 1996-09-17 1999-11-16 Wisconsin Alumni Research Foundation Thrombin inhibitor
WO2001000667A2 (en) 1999-06-29 2001-01-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-thrombin peptide from anopheles albimanus salivary gland
CA2378473A1 (en) * 1999-07-23 2001-02-01 The Regents Of The University Of California Modulation of platelet activation
BR0015872A (pt) * 2000-05-15 2004-08-03 Smithkline Beecham Corp Agentes antitrombóticos
AU2001286900A1 (en) 2000-08-31 2002-03-13 Cor Therapeutics, Inc. Therapeutics and diagnostics based on a novel signal transduction system in platelets
EP1411964A4 (en) * 2001-07-06 2006-06-14 Oregon Health Science Universi PEPTIDES MODULATING BLOOD COAGULATION AND METHODS OF USE
TWI338009B (en) * 2001-10-29 2011-03-01 Genentech Inc Antibodies for inhibiting blood coagulation and methods of use thereof
BRPI0614961A2 (pt) 2005-08-26 2016-09-13 Archemix Corp aptâmero, método, e, composição
EP2001504A2 (en) 2006-03-15 2008-12-17 Emory University Use of thrombin mutants to inhibit the anticoagulation effect of thrombin inhibitors
GB0711779D0 (en) 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor
WO2009154461A1 (en) 2008-06-19 2009-12-23 Prothix Bv Use of anti-factors xi antibodies for prevention of thrombus formation
US20110275701A1 (en) * 2008-09-18 2011-11-10 Archemix Corp. Anti-thrombin aptamer formulations and methods for use
ES3005912T3 (en) 2011-07-22 2025-03-17 Csl Behring Gmbh Inhibitory anti-factor xii/xiia monoclonal antibodies and their uses
US9518128B2 (en) * 2011-12-14 2016-12-13 Janssen Pharmaceuticals, Inc. Thrombin-binding antibody molecules
GB201121513D0 (en) 2011-12-14 2012-01-25 Cambridge Entpr Ltd Thrombin-binding antibody molecules and uses thereof

Also Published As

Publication number Publication date
KR20140105556A (ko) 2014-09-01
RU2017144629A (ru) 2019-02-18
MX2014007170A (es) 2015-04-17
PE20141706A1 (es) 2014-11-13
ZA201403836B (en) 2015-12-23
SMT201700580T1 (it) 2018-01-11
CO7101192A2 (es) 2014-10-31
GB201121513D0 (en) 2012-01-25
UA116531C2 (uk) 2018-04-10
NZ625386A (en) 2017-03-31
JP2015501830A (ja) 2015-01-19
SI2791177T1 (en) 2018-03-30
CN104053673A (zh) 2014-09-17
DK2791177T3 (en) 2017-12-18
HUE034793T2 (en) 2018-02-28
EP2791177A1 (en) 2014-10-22
IL232797A0 (en) 2014-07-31
US20190276558A1 (en) 2019-09-12
CN107936119A (zh) 2018-04-20
CN107936119B (zh) 2021-06-15
EP3275903A1 (en) 2018-01-31
US20180334511A1 (en) 2018-11-22
ES2642718T3 (es) 2017-11-17
HRP20171775T1 (hr) 2017-12-29
CA2856656C (en) 2021-01-19
WO2013088164A1 (en) 2013-06-20
BR112014014605A2 (pt) 2017-06-13
PL2791177T3 (pl) 2018-03-30
SG11201402560WA (en) 2014-06-27
AU2012351858A1 (en) 2014-06-12
KR102114506B1 (ko) 2020-05-22
MX376876B (es) 2025-03-07
HK1246326A1 (en) 2018-09-07
AU2017268655B2 (en) 2019-05-09
RU2017144629A3 (https=) 2021-04-05
HK1202564A1 (en) 2015-10-02
MY170980A (en) 2019-09-23
US20140370008A1 (en) 2014-12-18
PH12014501169A1 (en) 2014-09-08
CA2856656A1 (en) 2013-06-20
US10287363B2 (en) 2019-05-14
LT2791177T (lt) 2017-11-27
US20170066842A1 (en) 2017-03-09
US20210371543A1 (en) 2021-12-02
RU2642276C2 (ru) 2018-01-24
CN104053673B (zh) 2018-01-12
RS56510B1 (sr) 2018-02-28
PH12014501169B1 (en) 2014-09-08
US9988463B2 (en) 2018-06-05
PE20190171A1 (es) 2019-02-01
AU2017268655A1 (en) 2017-12-21
US9518129B2 (en) 2016-12-13
NO2791177T3 (https=) 2018-02-03
CY1119599T1 (el) 2018-04-04
IL232797B (en) 2018-07-31
PT2791177T (pt) 2017-11-29
JP6705785B2 (ja) 2020-06-03
ME02901B (me) 2018-04-20
EP2791177B1 (en) 2017-09-06
AU2012351858B2 (en) 2017-10-05
RU2014124985A (ru) 2016-02-10
JP2018039798A (ja) 2018-03-15
MX353281B (es) 2018-01-08

Similar Documents

Publication Publication Date Title
JP6216954B2 (ja) トロンビン結合性抗体分子及びその使用
US11155637B2 (en) Thrombin-binding antibody molecules and uses thereof
WO2014202992A1 (en) Screening methods for thrombin binding agent and uses of thrombin binding agent for inhibiting or preventing coagulation
WO2014202991A1 (en) Antidote
NZ625386B2 (en) Thrombin-binding antibody molecules and uses thereof
HK1202564B (en) Thrombin-binding antibody molecules and uses thereof
WO2014202993A1 (en) Binding motif for thrombin inhibitors

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140814

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151214

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151214

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160913

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20161213

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170124

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170421

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170801

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20170829

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170831

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20170829

R150 Certificate of patent or registration of utility model

Ref document number: 6216954

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees
S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R360 Written notification for declining of transfer of rights

Free format text: JAPANESE INTERMEDIATE CODE: R360

R360 Written notification for declining of transfer of rights

Free format text: JAPANESE INTERMEDIATE CODE: R360

R371 Transfer withdrawn

Free format text: JAPANESE INTERMEDIATE CODE: R371