JP6205175B2 - 精神・神経疾患バイオマーカー - Google Patents

精神・神経疾患バイオマーカー Download PDF

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Publication number
JP6205175B2
JP6205175B2 JP2013104124A JP2013104124A JP6205175B2 JP 6205175 B2 JP6205175 B2 JP 6205175B2 JP 2013104124 A JP2013104124 A JP 2013104124A JP 2013104124 A JP2013104124 A JP 2013104124A JP 6205175 B2 JP6205175 B2 JP 6205175B2
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psychiatric
chain
immunoglobulin
neurological disorder
free
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JP2013104124A
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Japanese (ja)
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JP2014224759A (ja
JP2014224759A5 (cg-RX-API-DMAC10.html
Inventor
新 大西
新 大西
敬史 南本
敬史 南本
哲也 須原
哲也 須原
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RESVO INC.
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RESVO INC.
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Priority to JP2013104124A priority Critical patent/JP6205175B2/ja
Priority to US14/891,301 priority patent/US10041954B2/en
Priority to EP14797879.5A priority patent/EP3002588B1/en
Priority to PCT/JP2014/057227 priority patent/WO2014185145A1/ja
Publication of JP2014224759A publication Critical patent/JP2014224759A/ja
Publication of JP2014224759A5 publication Critical patent/JP2014224759A5/ja
Priority to US15/645,907 priority patent/US20180120328A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/525—Tumor necrosis factor [TNF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5412—IL-6
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/545—IL-1
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/301—Anxiety or phobic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/302—Schizophrenia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/304—Mood disorders, e.g. bipolar, depression

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2013104124A 2013-05-16 2013-05-16 精神・神経疾患バイオマーカー Expired - Fee Related JP6205175B2 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2013104124A JP6205175B2 (ja) 2013-05-16 2013-05-16 精神・神経疾患バイオマーカー
US14/891,301 US10041954B2 (en) 2013-05-16 2014-03-18 Biomarker for psychiatric and neurological disorders
EP14797879.5A EP3002588B1 (en) 2013-05-16 2014-03-18 Use of a biomarker for diagnosing schizophrenia
PCT/JP2014/057227 WO2014185145A1 (ja) 2013-05-16 2014-03-18 精神・神経疾患バイオマーカー
US15/645,907 US20180120328A1 (en) 2013-05-16 2017-07-10 Biomarker for psychiatric and neurological disorders

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2013104124A JP6205175B2 (ja) 2013-05-16 2013-05-16 精神・神経疾患バイオマーカー

Publications (3)

Publication Number Publication Date
JP2014224759A JP2014224759A (ja) 2014-12-04
JP2014224759A5 JP2014224759A5 (cg-RX-API-DMAC10.html) 2016-07-28
JP6205175B2 true JP6205175B2 (ja) 2017-10-04

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JP2013104124A Expired - Fee Related JP6205175B2 (ja) 2013-05-16 2013-05-16 精神・神経疾患バイオマーカー

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US (2) US10041954B2 (cg-RX-API-DMAC10.html)
EP (1) EP3002588B1 (cg-RX-API-DMAC10.html)
JP (1) JP6205175B2 (cg-RX-API-DMAC10.html)
WO (1) WO2014185145A1 (cg-RX-API-DMAC10.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6205175B2 (ja) 2013-05-16 2017-10-04 株式会社Ｒｅｓｖｏ 精神・神経疾患バイオマーカー
JP7301327B2 (ja) * 2017-11-24 2023-07-03 学校法人 京都産業大学 マウスのうつ及び／又は不安症バイオマーカー
JP6737995B2 (ja) * 2018-11-29 2020-08-12 株式会社Ｒｅｓｖｏ 精神疾患発症危険状態の診断用バイオマーカー
GB202000634D0 (en) * 2020-01-15 2020-02-26 Nat Institute Of Mental Health Diagnostic method
JP6817666B2 (ja) * 2020-06-24 2021-01-20 株式会社Ｒｅｓｖｏ 精神疾患発症危険状態の診断用バイオマーカー

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243558A (en) * 1991-07-15 1994-06-27 Wellcome Found Recombinant primate antibodies and their production
US20060191026A1 (en) * 2005-02-18 2006-08-24 Origen Therapeutics, Inc. Tissue specific expression of antibodies in chickens
AU2003298607B9 (en) * 2002-10-29 2011-08-04 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
HRP20140673T1 (hr) * 2006-02-17 2014-10-10 Atsuo Sekiyama Indikator biološkog materijala i postupak mjerenja biološkog materijala
GB0724735D0 (en) 2007-12-19 2008-01-30 Psynova Neurotech Ltd Methods and biomarkers for diagnosing and monitoring psychotic disorders
US20120178118A1 (en) * 2010-12-06 2012-07-12 Bo Pi Biomarkers for monitoring treatment of neuropsychiatric diseases
WO2010141716A2 (en) * 2009-06-05 2010-12-09 Mayo Foundation For Medical Education And Research Methods and materials for diagnosing light chain amyloidosis
GB0915736D0 (en) * 2009-09-09 2009-10-07 Cambridge Entpr Ltd Biomarkers
GB201008340D0 (en) * 2010-05-19 2010-07-07 Cambridge Entpr Ltd Biomarkers
JP5641471B2 (ja) 2010-06-29 2014-12-17 国立大学法人名古屋大学 統合失調症マーカー及びその利用
US20120238837A1 (en) * 2011-03-16 2012-09-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System, devices, and methods for real-time monitoring of cerebrospinal fluid for markers of progressive conditions
JP6205175B2 (ja) 2013-05-16 2017-10-04 株式会社Ｒｅｓｖｏ 精神・神経疾患バイオマーカー

Also Published As

Publication number Publication date
US20160131663A1 (en) 2016-05-12
JP2014224759A (ja) 2014-12-04
EP3002588A4 (en) 2017-08-23
WO2014185145A1 (ja) 2014-11-20
US10041954B2 (en) 2018-08-07
US20180120328A1 (en) 2018-05-03
EP3002588A1 (en) 2016-04-06
EP3002588B1 (en) 2022-01-12

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