JP6199880B2 - 脳卒中の診断を補助するためのバイオマーカーに基づく方法およびバイオチップ - Google Patents

脳卒中の診断を補助するためのバイオマーカーに基づく方法およびバイオチップ Download PDF

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JP6199880B2
JP6199880B2 JP2014543985A JP2014543985A JP6199880B2 JP 6199880 B2 JP6199880 B2 JP 6199880B2 JP 2014543985 A JP2014543985 A JP 2014543985A JP 2014543985 A JP2014543985 A JP 2014543985A JP 6199880 B2 JP6199880 B2 JP 6199880B2
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stroke
biomarker
biomarkers
concentration
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JP2015500464A (ja
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ラモント，ジョン
マコネル，アイヴァン
フィッツジェラルド，ピーター
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ランドックス ラボラトリーズ リミテッド
ランドックス ラボラトリーズ リミテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/7056—Selectin superfamily, e.g. LAM-1, GlyCAM, ELAM-1, PADGEM
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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JP2014543985A 2011-12-02 2012-12-03 脳卒中の診断を補助するためのバイオマーカーに基づく方法およびバイオチップ Active JP6199880B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1120781.8A GB2497138A (en) 2011-12-02 2011-12-02 Biomarkers for stroke and stroke subtype diagnosis.
GB1120781.8 2011-12-02
PCT/GB2012/052993 WO2013079981A2 (en) 2011-12-02 2012-12-03 Biomarker-based methods and biochips for aiding the diagnosis of stroke

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JP2015500464A JP2015500464A (ja) 2015-01-05
JP2015500464A5 JP2015500464A5 (enExample) 2016-01-28
JP6199880B2 true JP6199880B2 (ja) 2017-09-20

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US (2) US20150126385A1 (enExample)
EP (1) EP2786155B1 (enExample)
JP (1) JP6199880B2 (enExample)
CN (1) CN104272112B (enExample)
AU (2) AU2012343537B2 (enExample)
CA (1) CA2857589C (enExample)
GB (1) GB2497138A (enExample)
WO (1) WO2013079981A2 (enExample)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
GB201309928D0 (en) 2013-06-04 2013-07-17 Randox Lab Ltd Method
JP6312302B2 (ja) * 2014-01-06 2018-04-18 公益財団法人ヒューマンサイエンス振興財団 脳梗塞の診断マーカー
BR112019026389A2 (pt) 2017-06-13 2020-07-21 F. Hoffmann-La Roche Ag método para diagnosticar a fibrilação atrial paroxística, método para auxiliar no diagnóstico de fibrilação atrial paroxística e seus usos
GB2563415A (en) * 2017-06-14 2018-12-19 Randox Laboratories Ltd Combinations for use in stroke diagnosis
GB2563414A (en) * 2017-06-14 2018-12-19 Randox Laboratories Ltd Improvements in stroke diagnostics
JP6499342B2 (ja) * 2018-03-19 2019-04-10 隆樹 日和佐 脳梗塞の診断マーカー
KR102299968B1 (ko) * 2019-11-19 2021-09-09 경북대학교 산학협력단 혈액성분 분리용 다중필터 및 그를 이용한 질병 진단키트
CA3214911A1 (en) * 2021-04-15 2022-10-20 Joan Montaner Villalonga Markers for the diagnosis of large vessel occlusion

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5879010A (en) 1997-07-22 1999-03-09 Green Tweed Of Delaware, Inc. Seal assembly with mechanically joined anti-extrusion rings
GB9929140D0 (en) 1999-12-10 2000-02-02 Univ Geneve Diagnostic assay for stroke
WO2002012892A2 (en) 2000-08-04 2002-02-14 Cis Biotech, Inc. Rapid multiple panel of biomarkers in laboratory blood tests for tia/stroke
AUPR005600A0 (en) * 2000-09-12 2000-10-05 University Of Sydney, The Diagnostic assay
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US20030199000A1 (en) * 2001-08-20 2003-10-23 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
DE60233949D1 (de) * 2001-08-20 2009-11-19 Biosite Inc Diagnostische marker für schlaganfall und hirntrauma sowie verfahren zur verwendung davon
CA2358007C (en) * 2001-10-02 2008-02-19 Royce Technologies Llc, A Nevada Corporation Ceramic biomolecule imaging chip
DK2357477T3 (en) * 2003-09-20 2018-02-05 Electrophoretics Ltd Diagnostic approach for brain injury-related disorders based on detection of NDKA
US20050181386A1 (en) * 2003-09-23 2005-08-18 Cornelius Diamond Diagnostic markers of cardiovascular illness and methods of use thereof
US7634360B2 (en) * 2003-09-23 2009-12-15 Prediction Sciences, LL Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof
US7392140B2 (en) * 2003-09-23 2008-06-24 Prediction Sciences, Llc Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof
US20060099608A1 (en) * 2004-03-29 2006-05-11 Medstar Research Institute Methods of diagnosing cardiovascular disease
WO2007124439A2 (en) * 2006-04-21 2007-11-01 Rules-Based Medicine, Inc. Diagnosis of stroke using metalloproteinase or transaminase
CA2688434A1 (en) * 2007-06-06 2008-12-11 Domantis Limited Polypeptides, antibody variable domains and antagonists
WO2010012834A1 (en) 2008-08-01 2010-02-04 Bio-Rad Pasteur Method for the in vitro diagnosis of stroke
WO2010046136A1 (en) * 2008-10-24 2010-04-29 B.R.A.H.M.S. Ag Prognosis and risk assessment in stroke patients by determining the level of marker peptides
EP2206726A1 (en) * 2009-01-08 2010-07-14 Universite Joseph Fourier Non-invasive tools for detecting vulnerable atherosclerotic plaques
CA2751090A1 (en) 2009-01-30 2010-08-05 Electrophoretics Limited Method for the in vitro diagnosis of stroke

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AU2012343537A1 (en) 2014-06-19
CA2857589C (en) 2020-01-14
US20150126385A1 (en) 2015-05-07
AU2018247291A1 (en) 2018-11-01
GB2497138A (en) 2013-06-05
WO2013079981A2 (en) 2013-06-06
EP2786155A2 (en) 2014-10-08
CN104272112B (zh) 2019-02-19
AU2012343537B2 (en) 2018-11-08
CN104272112A (zh) 2015-01-07
EP2786155B1 (en) 2020-03-11
US20170184611A1 (en) 2017-06-29
JP2015500464A (ja) 2015-01-05
US10914745B2 (en) 2021-02-09
WO2013079981A3 (en) 2013-11-07
CA2857589A1 (en) 2013-06-06
GB201120781D0 (en) 2012-01-11

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