JP6195906B2 - フッ素化2−アミノ−4−(ベンジルアミノ)フェニルカルバメート誘導体 - Google Patents

フッ素化2−アミノ−4−(ベンジルアミノ)フェニルカルバメート誘導体 Download PDF

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JP6195906B2
JP6195906B2 JP2015510264A JP2015510264A JP6195906B2 JP 6195906 B2 JP6195906 B2 JP 6195906B2 JP 2015510264 A JP2015510264 A JP 2015510264A JP 2015510264 A JP2015510264 A JP 2015510264A JP 6195906 B2 JP6195906 B2 JP 6195906B2
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compound
pharmaceutically acceptable
acceptable salt
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hydrogen
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JP2015516988A (ja
JP2015516988A5 (enExample
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マーク イー. ダガン
マーク イー. ダガン
建 古谷
建 古谷
ディー. スコット エドワーズ
ディー. スコット エドワーズ
アジャイ プーロヒット
アジャイ プーロヒット
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サイフルーア ライフ サイエンシズ インコーポレイテッド
サイフルーア ライフ サイエンシズ インコーポレイテッド
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    • C07—ORGANIC CHEMISTRY
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    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
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    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
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  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2015510264A 2012-04-30 2013-03-13 フッ素化2−アミノ−4−(ベンジルアミノ)フェニルカルバメート誘導体 Expired - Fee Related JP6195906B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261640157P 2012-04-30 2012-04-30
US61/640,157 2012-04-30
US201261697690P 2012-09-06 2012-09-06
US61/697,690 2012-09-06
PCT/US2013/030984 WO2013165575A1 (en) 2012-04-30 2013-03-13 Fluorinated 2-amino-4-(benzylamino)phenylcarbamate derivatives

Publications (3)

Publication Number Publication Date
JP2015516988A JP2015516988A (ja) 2015-06-18
JP2015516988A5 JP2015516988A5 (enExample) 2016-03-31
JP6195906B2 true JP6195906B2 (ja) 2017-09-13

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JP2015510264A Expired - Fee Related JP6195906B2 (ja) 2012-04-30 2013-03-13 フッ素化2−アミノ−4−(ベンジルアミノ)フェニルカルバメート誘導体

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US (3) US8916133B2 (enExample)
EP (1) EP2844639A4 (enExample)
JP (1) JP6195906B2 (enExample)
KR (1) KR20150053257A (enExample)
CN (1) CN104470893A (enExample)
AU (2) AU2013257209B2 (enExample)
CA (1) CA2870095A1 (enExample)
HK (1) HK1205735A1 (enExample)
IL (1) IL235012A (enExample)
MX (1) MX2014013166A (enExample)
WO (1) WO2013165575A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150053257A (ko) * 2012-04-30 2015-05-15 사이플루어 라이프 사이언시즈, 엘엘씨 플루오르화 2-아미노-4-(벤질아미노)페닐카르바메이트 유도체
JP2015178576A (ja) * 2014-03-19 2015-10-08 富士フイルム株式会社 化合物、着色組成物、インクジェット記録用インク、インクジェット記録方法、インクジェットプリンタカートリッジ、及びインクジェット記録物
WO2016077724A1 (en) * 2014-11-13 2016-05-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education (2-amino-4(arylamino)phenyl) carbamates
MX2018015251A (es) * 2016-06-10 2019-04-25 Scifluor Life Sciences Inc Derivados de 2-amino-4-(amino sustituido)fenil carbamato fluorinado.
US11857352B2 (en) 2016-09-06 2024-01-02 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
CN107935858B (zh) * 2016-10-12 2020-09-08 利尔化学股份有限公司 5-氟-2-硝基苯酚的制备方法
US11197709B2 (en) 2017-03-13 2021-12-14 Medtronic Advanced Energy Llc Electrosurgical system
CA3085450A1 (en) * 2017-12-13 2019-06-20 Scifluor Life Sciences, Inc. Fluorinated 4-(substituted amino)phenyl carbamate derivatives
WO2019203951A1 (en) 2018-04-20 2019-10-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Selective potassium channel agonists
DE102018212006B3 (de) * 2018-07-18 2019-10-31 Universität Greifswald Thioether als Modulatoren von Kv7.2/Kv7.3-Kanälen
WO2022046605A1 (en) * 2020-08-25 2022-03-03 City Of Hope Compositions and methods for g-protein-coupled receptor 44 detection
CN118530144A (zh) * 2023-02-21 2024-08-23 中国医学科学院药物研究所 一种派恩加滨的制备方法

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
DE4200259A1 (de) * 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung
GB9915414D0 (en) 1999-07-01 1999-09-01 Glaxo Group Ltd Medical use
US6348486B1 (en) * 2000-10-17 2002-02-19 American Home Products Corporation Methods for modulating bladder function
US6589986B2 (en) * 2000-12-20 2003-07-08 Wyeth Methods of treating anxiety disorders
US20020183395A1 (en) 2001-04-04 2002-12-05 Wyeth Methods for treating hyperactive gastric motility
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
MX2010014461A (es) * 2008-06-24 2011-04-28 Valeant Pharmaceuticals Int Derivados de benciloxi anilida utiles como moduladores de canales de potasio.
KR20150053257A (ko) * 2012-04-30 2015-05-15 사이플루어 라이프 사이언시즈, 엘엘씨 플루오르화 2-아미노-4-(벤질아미노)페닐카르바메이트 유도체

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AU2016206246A1 (en) 2016-08-04
AU2013257209B2 (en) 2016-05-19
IL235012A (en) 2017-09-28
WO2013165575A1 (en) 2013-11-07
EP2844639A1 (en) 2015-03-11
HK1205735A1 (en) 2015-12-24
AU2016206246B2 (en) 2017-06-15
CA2870095A1 (en) 2013-11-07
AU2013257209A1 (en) 2014-10-23
MX2014013166A (es) 2015-05-11
JP2015516988A (ja) 2015-06-18
US8916133B2 (en) 2014-12-23
US20130287686A1 (en) 2013-10-31
US20150098902A1 (en) 2015-04-09
US9556114B2 (en) 2017-01-31
CN104470893A (zh) 2015-03-25
EP2844639A4 (en) 2015-12-23
KR20150053257A (ko) 2015-05-15
US20170096390A1 (en) 2017-04-06

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