JP6193230B2 - 統合失調症の処置方法 - Google Patents
統合失調症の処置方法 Download PDFInfo
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- JP6193230B2 JP6193230B2 JP2014523545A JP2014523545A JP6193230B2 JP 6193230 B2 JP6193230 B2 JP 6193230B2 JP 2014523545 A JP2014523545 A JP 2014523545A JP 2014523545 A JP2014523545 A JP 2014523545A JP 6193230 B2 JP6193230 B2 JP 6193230B2
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- JP
- Japan
- Prior art keywords
- compound
- alkyl
- hydroxy
- difluoro
- oxooctyl
- Prior art date
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| PCT/JP2012/070411 WO2013022079A1 (en) | 2011-08-05 | 2012-08-03 | Method for treating schizophrenia |
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| CN103450128B (zh) * | 2013-08-15 | 2015-04-08 | 河南中帅医药科技股份有限公司 | 用于治疗青光眼的前列腺素类似物中间体Corey醛的制备方法 |
| US20150057351A1 (en) * | 2013-08-22 | 2015-02-26 | Sucampo Ag | Method for treating neuropathic pain |
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| US5166174A (en) | 1987-01-28 | 1992-11-24 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti-ulcers containing same |
| CA1322749C (en) | 1987-01-28 | 1993-10-05 | Ryuzo Ueno | Prostaglandins of the d series, and tranquilizers and soporifics containing the same |
| US5380709A (en) | 1987-01-28 | 1995-01-10 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti ulcers containing same |
| US5225439A (en) | 1987-01-28 | 1993-07-06 | K.K. Ueno Seiyaku Oyo Kenkyujo | Prostaglandins E and anti ulcers containing same |
| CA1324129C (en) | 1987-04-30 | 1993-11-09 | Ryuzo Ueno | Prostaglandins of the f series |
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| GB2209939B (en) * | 1987-09-18 | 1992-01-02 | R Tech Ueno Ltd | The use of 13,14-dihydro-15-keto-prostaglandins as ocular hypotensive agents |
| CA2030345C (en) | 1989-11-22 | 1998-12-08 | Ryuji Ueno | Use of 15-keto-prostaglandin compound for improvement of encephalic function |
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| CA2150287C (en) | 1994-06-03 | 2004-08-10 | Ryuji Ueno | Agent for treating hepato-biliary diseases |
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| ITRM20010356A1 (it) * | 2001-06-21 | 2002-12-23 | Sigma Tau Ind Farmaceuti | "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina. |
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| JP5147404B2 (ja) * | 2005-01-27 | 2013-02-20 | スキャンポ・アーゲー | 中枢神経系障害の処置のための方法および組成物 |
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| US7211703B2 (en) * | 2005-04-27 | 2007-05-01 | Calgon Carbon Corporation | Method of separating E and Z isomers of an alkene alcohol and derivatives thereof |
| US20080255203A1 (en) * | 2007-04-12 | 2008-10-16 | Abbott Laboratories | Heterocyclic compounds and their methods of use |
| CN101808623B (zh) * | 2007-07-19 | 2013-08-14 | 株式会社·R-技术上野 | 包含11-脱氧-前列腺素化合物的药物组合物和使该化合物稳定化的方法 |
| JP6023082B2 (ja) * | 2011-01-24 | 2016-11-09 | インセプタム リサーチ アンド セラピューティクス，インク． | 精神神経性の疾病を処置するためのプロスタグランジンを含む組成物 |
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| EP2739278A4 (en) | 2015-03-18 |
| WO2013022079A1 (en) | 2013-02-14 |
| US20140031428A1 (en) | 2014-01-30 |
| RU2014108423A (ru) | 2015-09-10 |
| JP2014527048A (ja) | 2014-10-09 |
| ZA201400707B (en) | 2014-11-26 |
| NZ620300A (en) | 2015-09-25 |
| CN103841966A (zh) | 2014-06-04 |
| JP2017222708A (ja) | 2017-12-21 |
| BR112014002712A2 (pt) | 2017-06-13 |
| KR20140076551A (ko) | 2014-06-20 |
| AR087468A1 (es) | 2014-03-26 |
| TW201316992A (zh) | 2013-05-01 |
| IL230552A (en) | 2017-09-28 |
| MX359697B (es) | 2018-10-08 |
| CN107903173A (zh) | 2018-04-13 |
| CA2842455A1 (en) | 2013-02-14 |
| AU2017203092A1 (en) | 2017-06-01 |
| EP2739278A1 (en) | 2014-06-11 |
| IL254289A0 (en) | 2017-10-31 |
| RU2648474C2 (ru) | 2018-03-26 |
| BR112014002712A8 (pt) | 2017-06-20 |
| HK1252353A1 (zh) | 2019-05-24 |
| US8592483B2 (en) | 2013-11-26 |
| TWI619498B (zh) | 2018-04-01 |
| AU2012293157A1 (en) | 2014-03-13 |
| MX2014001409A (es) | 2014-05-28 |
| IL230552A0 (en) | 2014-03-31 |
| TWI619497B (zh) | 2018-04-01 |
| TW201808302A (zh) | 2018-03-16 |
| AU2017203092B2 (en) | 2018-11-08 |
| US20130035393A1 (en) | 2013-02-07 |
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