JP6152269B2 - Skin external preparation for hair - Google Patents

Description

  The present invention relates to a skin external preparation for hair, and more particularly, contains an extract of the convolvulaceae (Evolvulus) plant, and a bark extract of Tabebuia impetiginosa (Tabebuia Impetiginosa) bark extract By doing this, it is related with the skin external preparation for hair excellent in the stability which does not generate | occur | produce the starch derived from the extract of Asagaokakaraksa plant.

As an active ingredient of a hair restorer, not only its effectiveness, but also plant-derived extracts have been often used from the viewpoint of safety. However, plant-derived extracts may generate starch over time depending on the standing conditions, and it has been desired to develop a stable hair restorer that does not generate starch under any standing conditions.

  So far, it has been known that the extract of the genus Asagaoka Rakusa has a hair-growth effect (see, for example, Patent Document 1, Patent Document 2, etc.). Was leaving. On the other hand, by adding it to the skin external preparation for hair together with the bark extract of Tabebuia Impetiginosa, it prevents the occurrence of starch derived from the extract of Asagao-arakusa plants under any standing condition. That was not known at all.

Japanese Patent Laid-Open No. 2003-137741 JP 2003-137742 A

  An object of the present invention is to provide a skin external preparation for hair that does not generate starch under any standing conditions.

In view of such a situation, as a result of intensive studies, the present inventors have found that an extract of the genus Asagaokakaraksa and a bark extract of the genus Tabebia genus Tabebuia Impetiginosa (Tabebuia Impetiginosa), The present invention was completed by finding a skin external preparation for hair that does not generate a starch derived from the extract of the genus Asagaoka, and has excellent stability. That is, the skin external preparation for hair of the present invention is as follows.
(1) A skin external preparation for hair, characterized by containing an extract of a convolvulaceae (Evolvulus) plant and a bark extract of the genus Tabebia Impetiginosa (Tabebuia Impetiginosa).
(2) The morning glory genus plants are morning glory (Evolvulus alsinoides L.), white-faced grasshopper (Evolvulus boninensis), Evolvulus rotundifolia, Evolvulus glomeratus (Evolvulus glomeratus), Evolvulus glomeratus, Evolvulus glomeratus, Evolvulus glomeratus Evolvulus pilosus, Evolvulus arbusculassp. Canus, Evolvulus nummularius, or Evolvulus serisceus var holoserice The skin external preparation for hair as described in (1).
(3) The extract of the morning glory plant belongs to 0.0001% by mass to 1% by mass as a solid content with respect to the total amount of the external preparation for skin, described in (1) or (2) Skin external preparation for hair.
(4) It is characterized by containing 0.00001% by mass to 0.1% by mass as a solid content of the bark extract of the genus Tabebuia Impetiginosa (Tabebuia Impetiginosa) based on the total amount of the external preparation for skin. The skin external preparation for hair according to any one of (1) to (3).
(5) The skin external preparation for hair according to any one of (1) to (4), which is for hair growth.
(6) The skin external preparation for hair according to any one of (1) to (5), which is a hair cosmetic.

  ADVANTAGE OF THE INVENTION According to this invention, the skin external preparation for hair which does not generate | occur | produce a starch by any leaving conditions can be provided.

(1) Extract of Convolvulaceae Aspergillus plant of the present invention The topical skin preparation for hair of the present invention is characterized by containing an extract of Aspergillus plant (Evolvulus) as an essential component. The plant derived from the extract of the genus Evolvulus (Evolvulus), which is an essential component of the skin external preparation for hair of the present invention, includes Evolvulus alsinoides L., Evolvulus boninensis, Evolvulus rotundifolia (Evolvulus rotundifolia). ), Evolvulus glomeratus, Evolvulus arbusculus, Evolvulus pilosus, Evolvulus arbusculus, Evolvulus bulus It is selected from one or more of (Evolvulus serisceus var holosericeus). Any of these plants can be used as the extract of the present invention. Among them, the extract of morning glory (Evolvulus alsinoides L.) is preferable. The plant part to be extracted is preferably whole plant. This is because the whole plant contains many hair growth promoting substances. As the skin external preparation for hair of the present invention, a whole plant solvent extract or a solvent removed product thereof can be preferably exemplified, and a polar solvent can be preferably exemplified as such a solvent. Examples of such polar solvents include alcohols such as water, ethanol, methanol, 1,3-butanediol, and propylene glycol, esters such as ethyl acetate and methyl formate, ketones such as acetone and methyl ethyl ketone, chloroform, and the like. Preferred examples include one or more selected from halogenated hydrocarbons such as methylene chloride, nitriles such as acetonitrile, and ethers such as diethyl ether and tetrahydrofuran. Of these, water and / or alcohols are more preferable. A particularly preferred solvent is 50% ethanol. In order to prepare such an extract, a 1 to 10-fold amount of a solvent is added to a plant body or a processed product, and it is immersed for several days at room temperature or for several hours at a temperature near the boiling point. Thereafter, the insoluble matter is removed by filtration or the like, and the solvent can be removed by vacuum concentration or lyophilization as necessary.

The extract of the Aspergillus genus plant of the present invention exerts its hair-growing effect when it is contained in a skin external preparation for hair, and is excellent in preventing and improving wrinkles, thinning hair, hair loss and the like. In the external skin preparation for hair of the present invention, the preferable content of the extract of the plant of the genus Asagaoka Rakusa is 0.0001% by mass to 1% by mass, more preferably, as a solid content with respect to the total amount of the external preparation for skin. Is 0.001% by mass to 0.5% by mass. This is because if the amount is too small, the hair-restoring effect may not be exhibited, and if the amount is too large, the effect may reach a limit and the degree of freedom of other prescription ingredients may be impaired.

<Production Example 1>
Extract 100 g of dried grass of Eagarukakuara (Evolvulus alsinoides L.) with 1 l of 50% ethanol at room temperature for 7 to 10 days, concentrate under reduced pressure, and freeze-dry to obtain 10.5 g of the dried solid product. It was.

(2) Tabebuia impetiginosa bark extract of the present invention The skin external preparation for hair of the present invention contains a barb extract of the genus Tabebuia Impetiginosa as an essential component. And Tabebuia Impetiginosa is called Paudarco, Ipe, Iperoscio, Rapacho, Tahibo, etc. in Brazil, and synonyms include Tabebuia Avellaneda [T. Avellanedae], Tabebuaipe [T. ipe] and the like.

  Preparation of tabebuia impetigenosa bark extract is carried out by washing the inner bark with water as necessary, drying, preferably further chopping or pulverizing, and then using an appropriate method such as dipping or countercurrent extraction. Done by making contact with.

  Examples of the extraction solvent include water, lower alcohols such as methanol, ethanol, and propanol, higher alcohols such as oleyl alcohol, stearyl alcohol, and octyldodecanol, and many solvents such as ethylene glycol, propylene glycol, 1,3-butylene glycol, and glycerin. Monohydric alcohols, esters such as ethyl acetate, butyl acetate, methyl propionate and glyceryl trioctanoate, ketones such as acetone and methyl ethyl ketone, ethers such as ethyl ether and isopropyl ether, carbonization such as n-hexane, toluene and chloroform Examples thereof include hydrogen solvents, and these are used alone or in combination of two or more. Furthermore, it is preferable to use one kind of single solvent or two or more kinds of mixed solvents selected from water, lower alcohols and polyhydric alcohols from the viewpoint that they can be widely applied to cosmetics. Single use is most preferred.

  The mixing ratio in the case of using a mixed solvent is, for example, 1: 1 to 25: 1 by volume ratio (hereinafter the same) if the mixed solvent is water and ethyl alcohol, and 1: if the mixed solvent is water and glycerin. In the case of a mixed solvent of 1 to 20: 1, or water and 1,3-butylene glycol, it is preferably in the range of 1: 1 to 20: 1.

  In the preparation of the extract of the present invention, the pH of the extract is preferably maintained in the range of 4 to 8. In this sense, if necessary, the extraction solvent may be sodium hydroxide, sodium carbonate, potassium hydroxide. In addition, an alkaline adjusting agent such as arginine, an acidic adjusting agent such as citric acid, hydrochloric acid, phosphoric acid, sulfuric acid, or the like may be blended to adjust to a desired pH.

  In the case of the immersion method, the amount ratio of the extraction solvent to the extract is generally in the range of 1: 1 to 1: 200 (mass ratio), preferably in the range of 1: 5 to 1:20.

  In addition, the extraction conditions such as extraction temperature and time vary depending on the type of solvent used, the extraction site of the plant, the degree of shredding, etc., for example, in the case of the immersion method, the extraction temperature is generally 1 to 80 ° C., The temperature is preferably in the range of 40 ° C. or less, and the extraction time is preferably about 1 hour to 1 week, particularly about 12 to 36 hours.

  The extract solution obtained here may generally be adjusted to a pH of 4 to 8 and adjusted to an appropriate concentration as it is or by dilution or concentration under reduced pressure, etc. Depending on the case, it may be pulverized according to a conventional method such as spray-drying method or freeze-drying method, and blended with the external preparation for skin. The tabebuia impetigenosa bark extract of the present invention can also be prepared and used as described above.

  The tabebuia impetigenosa bark extract of the present invention prepared as described above has an action of preventing the generation of starch derived from the extract of the genus Asagaokakaracusa.

  The tabebuia impetiginosa bark extract in the external preparation for skin of the present invention varies depending on the use, application site, etc. of the external preparation for skin, but is generally in the range of 0.00001% by mass to 0.1% by mass as the solid content. It is good to mix | blend with 0.0001 mass%-0.01 mass% in a more preferable range. When the amount is less than this range, there may be a case where the effect of preventing the occurrence of starch derived from the extract of the genus Asagao genus plant cannot be sufficiently exhibited, and when the amount is too large, the effect may reach its peak. Further, the mass ratio of the extract of the genus Asagaoaracus and the barbecued impetigenous bark extract is preferably 50: 1 to 1:50, more preferably 30: 1 to 1:30. If it is out of this range, the balance between the hair-restoring effect and the starch-preventing effect may be reduced.

<Production Example 2>
Purified water (1000 g) was mixed with 100 g of the internal bark of Tabebuia impetigenosa, and extracted at 4 ° C. for 24 hours, followed by filtration to obtain 655 g of a light brown transparent extract solution. This was concentrated under reduced pressure and freeze-dried to obtain 8.5 g of the dried product.

(3) Skin external preparation for hair according to the present invention The skin external preparation for hair according to the present invention containing the extract of the plant of the genus Asagaokaracus and the extract of barbeuia impetigenosa bark is a cosmetic, pharmaceutical part. It can be used as an external product or a medicine. Examples of the dosage form include hair artic, scalp essence, hair shampoo, hair rinse, hair treatment and the like, but are not limited thereto.

In the external preparation for skin of the present invention, known as hair restorer, minoxidil, phytosterol maltoside, pantothenyl ethyl ether, alloxazine, adenosine 3 ′, 5′-cyclic monophosphate (c-AMP), vitamin E acetate, When combined with carpronium chloride, benzyl nicotinate, nicotinic acid, DL-α-tocopherol, DL-α-tocopherol nicotinate and methyl nicotinate, the hair growth effect is excellent due to a synergistic effect. Furthermore, in addition to the above-mentioned components, it is possible to contain optional components that are usually used in cosmetics and external medicine for skin. Examples of such optional ingredients include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, and hardened coconut oil. Oils such as hardened oil, mole, castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, waxes, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl alcohol, Higher alcohols such as alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol, cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, diacid malate Isostearyl, ethylene glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, glycerin tri-2-ethylhexanoate, tri-2-ethylhexanoate trimethylolpropane, triisostearin Synthetic ester oils such as acid trimethylolpropane, tetra-2-ethylhexanoic acid pentane erythritol, dimethylpolysiloxane, methylphenylpolysiloxane, diphenyl Linear polysiloxanes such as polypolysiloxane, cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified Oil agents such as silicone oils such as modified polysiloxanes such as polysiloxane, fatty acid soap (sodium laurate, sodium palmitate, etc.), anionic surfactants such as potassium lauryl sulfate, alkyl sulfate triethanolamine ether, stearyl trimethyl chloride Cationic surfactants such as ammonium, benzalkonium chloride, laurylamine oxide, imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide) Side-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan monostearate) , Sorbitan sesquioleate, etc.), glycerin fatty acids (such as glyceryl monostearate), propylene glycol fatty acid esters (such as propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan) Monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), POE glycerin fatty acid esters (POE-) Lysine monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl ether, etc.), Pluronic Molds, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), sucrose fatty acid ester, Nonionic surfactants such as alkyl glucoside, polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipro Polyhydric alcohols such as lenglycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol, sodium pyrrolidonecarboxylate, lactic acid, Moisturizing ingredients such as sodium lactate, surface may be treated, powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, barium sulfate, The surface may be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, the surface may be treated, mica titanium, fish phosphorus Foil, pearl agents such as bismuth oxychloride, red 202, red 228, red 22 which may be raked No. 6, Yellow No. 4, Blue No. 404, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201 Organic dyes such as purple 201, red 204, polyethylene powder, polymethyl methacrylate, nylon powder, organic powders such as organopolysiloxane elastomer, paraaminobenzoic acid UV absorber, anthranilic acid UV absorber , Salicylic acid UV absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV absorbers, 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4 UV absorbers such as' -t-butyldibenzoylmethane, lower alcohols such as ethanol and isopropanol, vitamin A or Derivatives thereof, vitamin B ₆ hydrochloride, vitamin B ₆ tripalmitate, vitamin B ₆ dioctanoate, vitamin B ₂ or derivatives thereof, vitamin B ₁₂ such as vitamin B ₁₂ , vitamin B ₁₅ or derivatives thereof, α-tocopherol, β- Preferred examples include vitamin E such as tocopherol, γ-tocopherol and vitamin E acetate, vitamin D, vitamin H, vitamins such as pantothenic acid, panthetin and pyrroloquinoline quinone, and antibacterial agents such as phenoxyethanol.

  Hereinafter, the present invention will be described in more detail with reference to examples. However, it is needless to say that the present invention is not limited to these examples.

<Examples 1-2 > Hair art The skin external preparation for hair of this invention was produced according to prescription of Table 1 shown below. That is, the components shown in Table 1 were combined, dissolved, and cooled to prepare the hair art of the present invention. In the same manner, the extract of Tabebuia impetigenosa bark extract of Example 2 was replaced with water, and the extract of morning glory and Tabebuia impetigenosa bark extract of Example 2 were replaced with water. Control Example 1 was also prepared. Further, Comparative Example 2 was also prepared with the formulation shown in Table 1.

<Test Example> Stability Test Example 2, Comparative Example 1 and Control Example 1 were allowed to stand at each temperature condition (5 ° C., 20 ° C., 40 ° C.), immediately after preparation, after 2 weeks of standing, and after 1 month of standing. The occurrence of starch was observed with the naked eye. Starch was not generated: ◯, starch was generated but was lost when shaken: Δ, starch was generated, and even if shaken, x was evaluated in three stages. The results are shown in Table 2.

  From the results in Table 2, it can be seen that the tabebuia impetigenosa bark extract has an excellent effect of preventing the occurrence of starch derived from the extract of the morning glory extract even under each standing condition.

<Example 3 > Hair shampoo A skin external preparation for hair of the present invention was prepared according to the formulation shown in Table 3 below. That is, (1) to (11) were sequentially added to (12), heated and mixed, and then cooled to prepare the hair shampoo of the present invention.

<Example 4 > Hair rinse A skin external preparation for hair of the present invention was prepared according to the formulation shown in Table 4 below. That is, (1), (2), (7) to (15) are heated and mixed in (16), (3) to (5) are heated and mixed in (6), both are mixed and emulsified, The hair rinse of the present invention was prepared.

<Example 5 > Hair treatment A skin external preparation for hair of the present invention was prepared according to the formulation shown in Table 5 below. That is, (1), (2), (11) to (18) are heated and mixed with (19), and (3) to (5) and (7) to (9) are added to the mixture of (6) and (10). ) Were heated and mixed, and both were mixed and emulsified to produce the hair treatment of the present invention.

Claims (5)

And the extract of the family Convolvulaceae morning glory color grasses plants of the genus (Evolvulus), bignoniaceae Tabebuia genus Tabebuia Inn Petty Guinot Sa (Tabebuia impetiginosa) bark extract and solids
The skin external preparation for hair characterized by containing by mass ratio 50: 1-1:50 of this. Asaga oakweed plants are Evolvulus alsinoides L., Evolvulus boninensis, Evolvulus rotundifolia, Evolvulus glomeratus, Evolvulus glomeratus, Evolvulus glomeratus, Evolvulus glomeratus, Evolvulus glomeratus, Evolvulus glomeratus Evolvulus pilosus), Evolvulus arbusculassp. Canus, Evolvulus nummularius, Evolvulus ceremusus bar, or one or more kinds of Evolvulus serisceus var holosericeus A skin external preparation for hair described in 1.   The skin for hair according to claim 1 or 2, characterized by containing 0.0001% by mass to 1% by mass of the extract of the morning glory plant as a solid content with respect to the total amount of the external preparation for skin. Topical agent. 0.00001 mass% to 0% of the bark extract of the genus Tabebia impetiginosa as a solid content with respect to the total amount of the external preparation for skin.
. The skin external preparation for hair according to any one of claims 1 to 3, which is contained in an amount of 1% by mass. The skin external preparation for hair according to any one of claims 1 to 4 , which is for hair growth.