JP6147670B2 - 改善された半減期を有する修飾された抗体 - Google Patents

改善された半減期を有する修飾された抗体 Download PDF

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JP6147670B2
JP6147670B2 JP2013544971A JP2013544971A JP6147670B2 JP 6147670 B2 JP6147670 B2 JP 6147670B2 JP 2013544971 A JP2013544971 A JP 2013544971A JP 2013544971 A JP2013544971 A JP 2013544971A JP 6147670 B2 JP6147670 B2 JP 6147670B2
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antibody
immunoglobulin
igg4
human
antibodies
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JP2014503209A5 (https=
JP2014503209A (ja
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ウィルソン デイビッド
ウィルソン デイビッド
徹也 田浦
徹也 田浦
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テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61P33/00—Antiparasitic agents
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    • A61P33/10—Anthelmintics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

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JP2013544971A 2010-12-22 2011-12-22 改善された半減期を有する修飾された抗体 Active JP6147670B2 (ja)

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Application Number Priority Date Filing Date Title
US201061425858P 2010-12-22 2010-12-22
US61/425,858 2010-12-22
PCT/AU2011/001662 WO2012083370A1 (en) 2010-12-22 2011-12-22 Modified antibody with improved half-life

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JP2014503209A JP2014503209A (ja) 2014-02-13
JP2014503209A5 JP2014503209A5 (https=) 2015-02-19
JP6147670B2 true JP6147670B2 (ja) 2017-06-14

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JP2016255652A Active JP6334669B2 (ja) 2010-12-22 2016-12-28 改善された半減期を有する修飾された抗体

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US (1) US9505826B2 (https=)
EP (1) EP2654790B1 (https=)
JP (2) JP6147670B2 (https=)
KR (1) KR101941514B1 (https=)
CN (1) CN103429261A (https=)
AU (1) AU2011349049B2 (https=)
BR (1) BR112013016235B1 (https=)
CA (1) CA2824279A1 (https=)
EA (1) EA201390923A1 (https=)
ES (1) ES2720136T3 (https=)
IL (1) IL227081B (https=)
MX (1) MX2013007392A (https=)
PT (1) PT2654790T (https=)
WO (1) WO2012083370A1 (https=)
ZA (1) ZA201305123B (https=)

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