JP6134148B2 - Transparent lotion - Google Patents

Description

  The present invention relates to a transparent lotion that contains a specific nonionic surfactant and hexanediol or pentanediol and stably solubilizes ceramides.

  Ceramides are abundant in intercellular lipids that form the stratum corneum of the epidermis, and play an important role in maintaining moisture in the skin by preventing the evaporation of moisture by constructing a lipid barrier necessary for moisture retention. For this reason, preparation of a cosmetic preparation of a mixture containing ceramides intended to retain moisture in the skin by applying to the skin has been attempted. However, ceramides are substances with high crystallinity, low solubility, and it has been difficult to ensure stability over time in cosmetics due to reasons such as precipitation of crystals at low temperatures. In particular, in a lotion containing a lot of water among cosmetics, it has been very difficult to obtain a transparent lotion in which ceramides are stably solubilized.

  In addition, there are many types of cosmetics to be applied to the skin, such as lotions, emulsions, creams, etc. However, in the lotions, transparency is important for product selectivity, solubilizing ceramides A transparent lotion with good stability has been desired. However, because of the low solubility of ceramides, a transparent composition that is stably dissolved with water alone cannot be realized, and it is necessary to add some solubilizer such as a surfactant. In the conventional technology, in order to obtain a transparent lotion in which ceramides are solubilized, it is necessary to increase the amount of solubilizer, which may impair safety and usability. On the other hand, if the amount of the surfactant is reduced, white turbidity or translucent emulsion is observed, ceramides cannot be solubilized, precipitation, oil floating, etc. occur and sufficient aging stability cannot be secured. It was.

  As a method for improving the problem that it is difficult to solubilize ceramide, a method of blending a nonionic surfactant of HLB9-20 and a liquid polyhydric alcohol is disclosed (Patent Document 1). In addition, an external preparation for skin (Patent Document 2) containing a specific fatty acid or a specific surfactant in order to stably mix ceramide into a transparent preparation is disclosed. In any case, the amount of nonionic surfactant or polyhydric alcohol should be reduced, or the amount of nonionic surfactant or polyhydric alcohol It does not describe the problem that if it is reduced, it becomes difficult to solubilize ceramides and obtain a transparent composition.

  In addition, although not intended to be transparent, it is not a translucent cosmetic (Patent Document 3) or an aqueous composition containing an oil such as sterols or a nonionic surfactant in order to stably incorporate ceramide. In order to blend ceramide stably over time, an emulsified cosmetic containing 1,2-pentanediol (Patent Document 4) is disclosed.

Japanese Patent Laid-Open No. 2002-338459 JP 2001-316217 A International Publication No. 2004/045566 Pamphlet JP 2003-176210 A

In the above situation, there has been a demand for a transparent lotion that contains ceramides that are free from problems such as skin irritation and that are excellent in feeling of use and in which ceramides are stably solubilized. In particular, there has been a demand for a lotion in which the amount of components necessary for solubilization is as small as possible.

  As a result of intensive studies to solve the above problems, the present inventors have determined that the content of the nonionic surfactant is 1.0% by mass or less by blending hexanediol or pentanediol. It was found that a transparent skin lotion solubilized with water was obtained. Specifically, it contains (a) ceramides, (b) nonionic surfactant 0.1-1.0% by mass, (c) hexanediol or pentanediol 0.1-5.0% by mass, and (d) 50.0% by mass or more of water. As a result, it was found that (a) a transparent lotion with less irritation to the skin in which ceramides were stably solubilized was obtained.

That is, this invention provides the ceramide containing lotion shown below.
(1) (a) Ceramides,
(B) 0.1-1.0% by mass of a nonionic surfactant,
(C) Hexanediol or pentanediol 0.1-5.0% by mass,
(D) A lotion containing 50.0% by mass or more of water.
(2) The skin lotion according to (1), wherein (c) hexanediol or pentanediol is 0.1-2.0% by mass of hexanediol or 0.5-5.0% by mass of pentanediol.
(3) The lotion according to (1) or (2), wherein the (a) ceramide is a natural ceramide or a pseudoceramide.
(4) The lotion according to (3), wherein the natural ceramide is natural ceramide or natural ceramide.
(5) The natural ceramide is selected from the group consisting of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 6II, ceramide 7, ceramide 8, ceramide 9 and ceramide 10 which are human ceramides. The lotion according to the above (4), which is one or more selected.
(6) The lotion according to (5), wherein the human ceramide is ceramide 2.
(7) The nonionic surfactant (b) is polyoxyethylene hydrogenated castor oil, polyoxyethylene sterol / hydrogenated sterol, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, sorbitan fatty acid ester, The lotion according to any one of the above (1) to (6), which is one or more selected from the group consisting of polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester and polyoxyethylene glycerin fatty acid ester.
(8) The lotion according to any one of the above (1) to (7), wherein (a) ceramide is 0.00001-1.0% by mass.
(9) The lotion according to any one of (1) to (8), which does not contain ethanol. (10) The lotion according to any one of (1) to (9), which does not contain a preservative.
(11) The above (1), wherein (a) the ceramide is ceramide 2, (b) the nonionic surfactant is polyoxyethylene hydrogenated castor oil, (c) hexanediol or pentanediol is hexanediol. Or the lotion in any one of (10).

(12) (a) 0.00001-0.15% by mass of natural ceramides as ceramides, (b) polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether as nonionic surfactant Or 0.1 to 1.0% by mass of polyoxyethylene sorbitan fatty acid ester, (c) 0.1 to 2.0% by mass of hexanediol, and (d) 70.0% by mass or more of water. The lotion described.
(13) (a) 0.00001-0.05% by mass of natural ceramide as ceramides, (b) 0.1-1.0% by mass of polyoxyethylene hydrogenated castor oil or polyoxyethylene polyoxypropylene alkyl ether as nonionic surfactant (C) The lotion according to any one of (1) to (12) above, containing hexanediol in an amount of 0.8-1.0% by mass and (d) 70.0% by mass or more of water.
(14) 0.00001-0.15% by mass of ceramide 2 as (a) ceramides, (b) 0.4-1.0% by mass of polyoxyethylene hydrogenated castor oil as nonionic surfactant, and (c) 0.8-hexanediol. The lotion according to any one of the above (1) to (13), containing 1.0% by mass and (d) 70.0% by mass or more of water.
The present invention also provides the following method for solubilizing ceramides to obtain a transparent lotion. (15) (a) Ceramides,
(B) 0.1-1.0% by mass of a nonionic surfactant,
And (c) 0.1-5.0% by weight of hexanediol or pentanediol
A composition that is confused by heating above 80 ° C
(D) heated to 80 ° C. or higher and mixed with 50.0% by mass or more of water,
(A) A method for preparing a transparent skin lotion in which ceramides are solubilized.
(16) (a) Ceramides and (c) Hexanediol or pentanediol 0.1-5.0% by mass
Heated to over 80 ℃ and confused,
(B) A composition to which 0.1-1.0% by mass of a nonionic surfactant is added
Add to (d) 50.0% by mass or more of water at 80 ° C or higher, and mix.
(A) The preparation method according to the above (15), which contains 0.00001-1.0% by mass of ceramides and (a) ceramides are solubilized.
(17) The preparation method according to (15) or (16), wherein the (a) ceramide is a natural ceramide or a pseudoceramide.
(18) The preparation method according to (17), wherein the natural ceramide is natural ceramide or natural ceramide.

(19) The natural ceramide is selected from the group consisting of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 6II, ceramide 7, ceramide 8, ceramide 9 and ceramide 10 which are human ceramides. The preparation method according to the above (18), which is one or more selected.
(20) The preparation method according to the above (19), wherein the human ceramide is ceramide 2.
(21) The nonionic surfactant (b) is polyoxyethylene hydrogenated castor oil, polyoxyethylene sterol / hydrogenated sterol, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, sorbitan fatty acid ester, The preparation method according to any one of (15) to (20) above, which is one or more selected from the group consisting of polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, and polyoxyethylene glycerin fatty acid ester. . (22) The preparation method according to any one of (15) to (21), wherein (c) hexanediol or pentanediol is 0.1-2.0% by mass of hexanediol or 0.5-5.0% by mass of pentanediol.
(23) The preparation method according to any one of (15) to (22), which does not contain ethanol.
(24) The preparation method according to any one of (15) to (23), which does not contain a preservative.
(25) The preparation method according to any one of (15) to (24), wherein (a) ceramides are 0.0001-0.15% by mass.
(26) The above (15), wherein (a) the ceramide is ceramide 2, (b) the nonionic surfactant is polyoxyethylene hydrogenated castor oil, and (c) hexanediol or pentanediol is hexanediol. Thru | or the preparation method in any one of (25).

  According to the present invention, ceramides can be solubilized, stable over time, no precipitation such as precipitation or oil floating occurs, skin irritation due to the surfactant to be blended, etc. is reduced, and the feeling of use is excellent. Provide transparent lotion.

The present invention is described in detail below.
The lotion according to the present invention comprises (a) ceramides, (b) 0.1-1.0% by mass of a nonionic surfactant, (c) hexanediol or pentanediol 0.1-5.0% by mass, and (d) 50.0% by mass of water. The present invention relates to a transparent lotion containing at least% and having ceramides solubilized, stable over time and free from precipitation.
Natural ceramides or pseudo-ceramides can be used as (a) ceramides in the present invention.

  The natural ceramides of the present invention are extracted from naturally occurring animals or plants (in the present invention, they may be referred to as animal-derived or plant-derived. The same shall apply hereinafter). Even natural ceramides have the same structure as natural ceramides. Natural ceramide obtained by synthesis having For example, natural ceramide extracted from rice bran is called rice bran glycosphingolipid or rice pork glycosphingolipid, and natural ceramide obtained by synthesis having the same structure as ceramide present in human horny layer is called human ceramide. . Natural ceramides, both natural ceramides and natural ceramides, may be not only ceramides but also glycosphingolipids in which sugars are bound to ceramides. Glycosphingolipids vary depending on the sugar that binds to ceramide, and include cerebrosides linked to monosaccharides or gangliosides linked to oligosaccharides. Examples of cerebroside include galactosylceramide whose monosaccharide is galactose or glucose glucosylceramide. The pseudo-ceramides of the present invention are compounds obtained by synthesis and having at least one function that the natural ceramide has, although the structure is partially different from that of natural ceramide, and are also called ceramide-like compounds or synthetic pseudo-ceramides. Or any of various substances known as analogs thereof may be used.

  The (a) ceramides in the present invention are preferably natural ceramides or natural ceramides of natural ceramides, more preferably natural ceramides. The natural ceramide is preferably a human ceramide, which is ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 6II, ceramide 7, ceramide 8, ceramide 9 or ceramide 10 which are human ceramides. Among them, ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 6II or ceramide 7 is more preferable, ceramide 2, ceramide 3, ceramide 5, ceramide 6II is more preferable. Is ceramide 2. Ceramide 2 is also referred to as (2S, 3R) -2-octadecanoylaminooctadecane-1,3-diol.

Natural ceramides include natural ceramides extracted from animals or plants, specifically extracted from rice bran, rice, corn, konjac, maitake, tamogitake, soybean, beet, wheat, horse spinal cord or brain, etc. Is more preferable, and more preferably derived from rice bran. As the natural ceramide, ceramide or a glycosphingolipid having a saccharide bonded to ceramide is preferably a glycosphingolipid, and among the glycosphingolipid, cerebroside is preferable, and glucosylceramide is more preferable. Specifically, glycosphingolipid derived from rice bran is preferable, and rice glucosylceramide derived from rice bran is more preferable.
As natural ceramide, there is human ceramide having the same structure as ceramide present in human skin horny layer. As human ceramide, ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5 , Ceramide 6, ceramide 6II, ceramide 7, ceramide 8, ceramide 9 or ceramide 10, preferably ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 6II or ceramide 7. More preferred are ceramide 2, ceramide 3, ceramide 5, and ceramide 6II, and more preferred is ceramide 2.

Pseudoceramides include N-lauroyl-L-glutamate di (phytosteryl, 2-octyldodecyl), (glyceryl amidoethyl methacrylate / stearyl methacrylate) copolymer, polyquaternium 51, N- (tetradecyloxyhydroxypropyl) -N -Hydroxydecanamide and the like, preferably N-lauroyl-L-glutamate di (phytosteryl 2-octyldodecyl).
The ceramides can be used alone or in admixture of two or more.
(A) The blending amount of ceramides is preferably 0.00001% by mass or more, more preferably 0.0001% by mass or more for exhibiting effects such as moisture retention of skin, and preferably for solubilization in skin lotions. Is 1.0 mass% or less, More preferably, it is 0.3 mass% or less, More preferably, it is 0.15 mass% or less. The natural ceramides are preferably 0.15% by mass or less, the natural ceramides are preferably 0.15% by mass or less, and the natural ceramides are preferably 0.05% by mass or less. Further, the pseudo-ceramides are preferably 0.06% by mass or less.

The nonionic surfactant (b) in the present invention includes polyoxyethylene hydrogenated castor oil, polyoxyethylene sterol / hydrogenated sterol, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, sorbitan fatty acid ester, polyoxyethylene sterol Examples thereof include oxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, and polyoxyethylene glycerin fatty acid ester. The nonionic surfactant of the present invention is not limited by the number of added moles, but examples of the polyoxyethylene hydrogenated castor oil include those having an added mole number of 40 mol or more and 80 mol or less, such as 40 mol or 60 mol. Is more preferable, and 60 mol is more preferable. Polyoxyethylene sterols and hydrogenated sterols include polyoxyethylene (5) phytosterol, polyoxyethylene (10) phytosterol, polyoxyethylene (20) phytosterol, polyoxyethylene (30) phytosterol, polyoxyethylene (25) phyto Examples include stanol and polyoxyethylene (30) cholestanol. Examples of the polyoxyethylene alkyl ether include polyoxyethylene behenyl ether and polyoxyethylene oleyl ether, preferably polyoxyethylene oleyl ether. Examples of the polyoxyethylene polyoxypropylene alkyl ether include polyoxyethylene (30) polyoxypropylene (6) decyl tetradecyl ether. Sorbitan fatty acid esters include sorbitan monocaprylate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan monooleate, sorbitan sesquioleate, sorbitan trioleate, sorbitan monoisostearate, sorbitan sesquiisostearate Rate and the like. Examples of the polyoxyethylene sorbitan fatty acid ester include polyoxyethylene sorbitan (20E.O.) isostearate. Polyoxyethylene hydrogenated castor oil, polyoxyethylene sterol / hydrogenated sterol, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester Or, among polyoxyethylene glycerin fatty acid esters, preferably polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether or polyoxyethylene sorbitan fatty acid ester, more preferably polyoxyethylene hardened Castor oil or polyoxyethylene polyoxypropylene alkyl ether, more preferably A polyoxyethylene hardened castor oil, most preferably a polyoxyethylene hydrogenated castor oil addition mol number 60.

The surfactant may be commercially available after being diluted with water or the like. In this specification, (b) the nonionic surfactant is the mass% of the surfactant itself based on the total amount of the lotion unless otherwise specified. As shown.
(B) The compounding quantity of a nonionic surfactant becomes like this. Preferably it is 0.1-1.0 mass%, More preferably, it is 0.4-1.0 mass%. In any case, when the content is more than 1.0% by mass, the skin irritation is exhibited, the feeling of use is deteriorated, and the stability of the preparation is impaired. In addition, when the amount is less than 0.1% by mass, a transparent lotion in which ceramides are solubilized stably over time cannot be obtained.

In the present invention, hexanediol is preferably 1,2-hexanediol, and pentanediol is preferably 1,2-pentanediol. The blending amount of hexanediol or pentanediol is preferably 0.1 to 5.0% by mass, more preferably 0.1 to 2.0% by mass of hexanediol, 0.5 to 5.0% by mass of pentanediol, and further preferably 0.8 to 1.0 of hexanediol. Mass%, pentanediol 0.5-2.0 mass%. In any case, when the content is more than 5.0% by mass, the skin irritation is exhibited and the stability of the preparation is impaired. In addition, if less than 0.1% by mass is added, ceramides cannot be solubilized stably over time.
The water in the present invention comprises 100% by mass of the whole lotion in the present invention, a) ceramides, (b) 0.1-1.0% by mass of a nonionic surfactant and (c) hexanediol or pentanediol 0.1-5.0. The balance is 50% by mass or more, more preferably 70% by mass or more.

  The lotion of this invention can mix | blend the component which can be mix | blended with lotions, such as cosmetics and a quasi-drug, in the range which does not impair the effect of this invention other than the said essential component. Specifically, hardened oils derived from animal and vegetable oils, silicone oil phase components, fluorinated oil phase components, glycerophospholipids such as lecithin and its derivatives, higher alcohols, higher fatty acids, thickeners, wetting agents, UV absorption Agents, powders, pigments, sugars, polymer compounds, anti-skin roughening ingredients, physiologically active ingredients, transdermal absorption promoters, antioxidants, pH adjusters, chelating agents, fragrances and the like can be included.

In terms of solubilization of ceramides, the formulation of anionic surfactants, which have a stronger solubilizing power than nonionic surfactants, may be considered, but anionic surfactants can be applied to cosmetics that do not wash away. Blending is not preferred because of its skin irritation, and the content in the lotion of the present invention is preferably 1.0% by mass or less, more preferably not contained.
In addition, ethanol that helps dissolve ceramides may be added to increase the amount of ceramide, but lotion is often used first after face washing, and may be used frequently among cosmetics. Of particular concern is the potential for skin irritation problems. Therefore, in the lotion of the present invention, the ethanol content is preferably 10.0% by mass or less, more preferably not contained.

Further, antiseptics that are often blended in order to ensure antiseptic properties as a product of skin lotion have a problem of irritation to the skin. Among the preservatives, parabens are particularly difficult to dissolve, and when blended with a nonionic surfactant, parabens are solubilized. There may be a problem that an ionic surfactant needs to be blended. Furthermore, parabens have a problem that if the amount of the surfactant is small, the parabens are precipitated by thawing after freezing. In addition, phenoxyethanol tends to be colored over time or with temperature, and there may be a problem that it is not suitable for a transparent lotion. Therefore, it is preferable that the lotion of the present invention does not contain a preservative. In the present invention, the preservative refers to parabens (paraoxybenzoic acid ester) such as methyl paraben, ethyl paraben, propyl paraben, isopropyl paraben, butyl paraben, isobutyl paraben, benzyl paraben and phenoxyethanol.
Further, the lotion of the present invention preferably contains no other solubilizing components as much as possible, for example, sterols such as cholesterol, campesterol, sitosterol, stigmasterol, isopalmityl alcohol, isostearyl alcohol, oleyl alcohol. Higher alcohols such as jojoba alcohol, stearyl alcohol, cetyl alcohol, and behenyl alcohol, phosphatidylcholines, phosphatidylglycerols, phosphatidylethanolamines, phosphatidylinositol, phosphatidylserine, phosphatidic acid and other phospholipids, decaglycerin monostearate, pentaglycerin monostearate, It is desirable that no polyglycerin fatty acid ester such as decaglycerin isostearate is contained.

The lotion in the present invention may be any one of lotion, lotion, water-based cosmetic, water-based cosmetic composition, water-based cosmetic, water-based cosmetic composition, and application for approval of quasi-drugs. The preparation form classification in the manufacturing method may be a lotion type, and may be cosmetics or quasi-drugs under the Pharmaceutical Affairs Law.
Solubilization in the present invention is different from the state in which ceramides to be solubilized are dispersed in a solution, and are not only transparent immediately after the preparation, but also have stability over time, precipitation of crystals and It refers to not producing turbidity. Therefore, even if it is transparent at the time of preparation, it can be judged that those that can be confirmed to have crystal precipitation, turbidity, oil floating on the liquid surface, etc. are not solubilized over time.

  The term “transparent” in the present invention refers not only to visual observation but also to a state where the brightness (L value in the L * a * b * color system) is 99.0 or more, more preferably 99.4 or more. Lightness is one of the attributes of a color, the degree of lightness and darkness of the color is represented by 0.0 to 100.0, and becomes more transparent as the L value increases. Although it can measure with a spectrocolorimeter, it will not be specifically limited if it is the method of measuring other normal brightness.

  The stability over time in the present invention refers to a state in which neither crystal precipitation nor turbidity occurs even after 1 month at 0 ° C. and 1 month at 40 ° C. from the preparation. In the present invention, 40 ° C for 1 month is more difficult to maintain the stability over time than 0 ° C for 1 month, and the lotion of the present invention having stability over time at 40 ° C for 1 month In addition, it has been confirmed that it has stability over time even at 0 ° C. for one month. Therefore, by confirming the temporal stability at 40 ° C. for one month, it can be determined that the temporal stability has been confirmed at either 0 ° C. for one month or 40 ° C. for one month.

  In the present invention, a stably solubilized transparent skin lotion is transparent immediately after production and is stable without causing crystallization and turbidity in the solution of the solubilized product. It indicates that it has stability over time. Specifically, in the determination of solubilization in the present invention, the solubilization is determined by visual observation, the transparency is determined from the lightness (L value) measured by a colorimeter or the like, and whether or not any of these criteria is satisfied. Can be done with. The determination by visual observation and the determination by lightness can be performed immediately after preparation and after one month at 40 ° C., and it can be determined that solubilization can be realized if both satisfy the criteria.

The feeling of use in the present invention can be determined by a sensory test including irritation to the skin, and there are no uncomfortable points or problems in use such as stickiness, and presence or absence of skin irritation. It is determined that an excellent usability is achieved. The skin irritation in the present invention is a pain or tingling irritation, and the degree is also included in a weak irritation. The feeling of use and skin irritation can be checked by a test by a general panelist or a specialized panelist, and a stinging test or a patch test (patch test) can be performed to judge from the test results. Judgment may be made from test results by panelists. In these tests, it is desirable that the number of subjects is large, and specifically 10 or more. However, it is also possible to determine that a subject having a feeling of use or a strong skin irritation is irritating even in a test by a specialized panelist alone. The pH of the lotion in the present invention is preferably 4.5 to 8.0 in terms of (a) solubilizing ceramides.

  The method for producing the lotion of the present invention is not particularly limited, and can be produced by a known production method. Specifically, (a) ceramides, (b) nonionic surfactant, and (c) hexanediol or pentanediol mixed by heating are mixed with heated (d) water. A method is mentioned. The temperature for heating each component is preferably 80 ° C. or higher, more preferably 85 ° C. or higher. In addition, (c) hexanediol or pentanediol and other components to be mixed are likely to be oxidized or modified, and the composition is rich in water from the viewpoint of economics such as cost and labor required for heating. Since the composition ratio changes as water evaporates, the heating temperature is preferably not too high, specifically 100 ° C or lower, preferably 90 ° C or lower. It is more preferable. The range of the heating temperature is preferably 80 to 100 ° C, more preferably 80 to 90 ° C, and still more preferably 85 to 90 ° C. The mixing order of (a) ceramides, (b) nonionic surfactant, and (c) hexanediol or pentanediol may be simultaneous, but preferably (a) ceramides and (c) hexanediol or In this method, pentanediol is first mixed, and then (b) a nonionic surfactant is added.

Examples of preferred embodiments of the lotion of the present invention include, for example, [1].
(A) 0.00001-0.15% by mass of natural ceramides,
(B) 0.1-1.0% by mass of polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether or polyoxyethylene sorbitan fatty acid ester,
(C) 0.1-2.0% by mass of hexanediol,
(D) Transparent lotion containing 70.0% by mass or more of water, wherein (a) is solubilized,
[2]
(A) 0.00001-0.05% by mass of natural ceramide,
(B) 0.4 to 1.0% by mass of polyoxyethylene hydrogenated castor oil or polyoxyethylene polyoxypropylene alkyl ether as a nonionic surfactant;
(C) 0.8-1.0% by mass of hexanediol,
(D) Transparent lotion containing 70.0% by mass or more of water, wherein (a) is solubilized,
[3]
(A) 0.00001-0.05% by mass of human ceramide,
(B) 0.1-1.0% by mass of polyoxyethylene hydrogenated castor oil or polyoxyethylene polyoxypropylene alkyl ether;
(C) 0.1-1.0% by mass of hexanediol,
(D) Transparent lotion containing 70.0% by mass or more of water, wherein (a) is solubilized,
[4]
(A) 0.00001-0.05 mass% of ceramide 2, ceramide 3, ceramide 5, or ceramide 6II,
(B) 0.4-1.0% by mass of polyoxyethylene hydrogenated castor oil,
(C) 0.8-1.0% by mass of hexanediol,
(D) a transparent lotion containing 70.0% by mass or more of water, wherein (a) is solubilized, and [5]
(A) 0.0001-0.15 mass% of ceramide 2;
(B) 0.4-1.0% by mass of polyoxyethylene hydrogenated castor oil (60E.O),
(C) 0.8-1.0% by mass of hexanediol,
(D) Transparent lotion containing 70.0% by mass or more of water and solubilized (a) can be mentioned.

EXAMPLES Next, the present invention will be specifically described with reference to examples, but the present invention is not limited to these examples.
(Examples 1 , 2, 4 to 12, Reference Example 3, Reference Example 13 , Comparative Examples 1 to 5)
Each component shown in Table 1 which is 100% by mass in total is prepared by the above-described manufacturing method, specifically, (a) ceramides heated to 85-90 ° C., and (c) hexanediol or pentanediol, Next, (b) a nonionic surfactant was added and mixed, and (d) the composition of the skin lotion prepared, and the results of judgment of the feeling of use and the feeling of use in the method of adding to and mixing with water heated to 85-90 ° C. It is shown in 1. (C) A lotion containing 1,3-butylene glycol, dipropylene glycol or propylene glycol as a comparative example instead of hexanediol or pentanediol was also prepared in the same manner.
Judgment of solubilization is made by visual observation and lightness (L value), and “○” indicates that the skin lotion that is “◯” by visual judgment and “○” or “◎” by lightness judgment has achieved solubilization. The skin lotion in which either or both of the visual judgment and the lightness judgment were “x” was judged as “x” as the solubilization was not achieved.
The lightness determination and visual determination used for determination of solubilization are performed according to the following determination criteria, and the lightness (L value) of each lotion is measured using a spectral colorimeter COLOR JP7200F manufactured by Color Techno System Co., Ltd. Performed by visible light.
Lightness criterion: Judged by L value
(◎: 99.4 or more, ○: 99.0 or more, ×: less than 99.0)
Visual criteria: Judgment based on turbidity, precipitation of crystals, and presence of oil floating on the liquid surface
(O: No turbidity, no precipitation of crystals and no oil floating on the liquid surface,
×: There is one or more of turbidity, crystal precipitation, or oil floating on the liquid surface)
The sensory test including skin irritation was judged based on a sensory test that included irritation to the skin. ”Was determined as“ x ”because an excellent feeling of use could not be achieved if any one of uncomfortable points, problems, and skin irritation occurred during use. In addition, the usability | use_condition determination was abbreviate | omitted for what has not achieved solubilization immediately after preparation.

The symbols A1 to A3, B1 to B5, and C1 to C5 in the table mean the following.
A1: Ceramide 2 (human ceramide: (2S, 3R) -2-octadecanoylaminooctadecane-1,3-diol)
A2: N-lauroyl-L-glutamate di (phytosteryl 2-octyldodecyl) (pseudoceramide)
A3: Sphingoglycolipid derived from rice bran (natural ceramide)
B1: Polyoxyethylene hydrogenated castor oil (60E.O.)
B2: Polyoxyethylene hydrogenated castor oil (40E.O.)
B3: Polyoxyethylene oleyl ether B4: Polyoxyethylene (30) Polyoxypropylene (6) Decyl tetradecyl ether B5: Polyoxyethylene sorbitan stearate (20E.O.)
C1: 1,2-hexanediol C2: 1,2-pentanediol C3: dipropylene glycol C4: 1,3-butylene glycol C5: propylene glycol

In Table 1, the same amount of nonionic surfactant (polyoxyethylene hydrogenated castor oil (60E.O)) as in Example 1 or Reference Example 3 was blended, and the same amount was used instead of hexanediol or pentanediol. In the lotion (Comparative Examples 1, 2, and 3) containing dipropylene glycol, 1,3-butylene glycol, and propylene glycol, ceramides were not solubilized at the time of preparation. Specifically, in Comparative Example 2 in which 1,3-butylene glycol was blended, white turbidity was observed, and in Comparative Examples 1 and 3 in which dipropylene glycol or propylene glycol was blended, oil floating on the liquid surface was observed.
Toner lotion (Comparative Example 4, 5: 2.0% by mass, 5.0% by mass) containing more than 1.0% by mass of a nonionic surfactant could be solubilized, but by an expert panelist, skin irritation (pain) It was confirmed that the feeling of use deteriorated because it had a sticky feel. In addition, lotion containing hexanediol or pentanediol in an amount of more than 5.0% by mass has skin irritation and a feeling of use such as stickiness is deteriorated.
It was confirmed that the pH of the lotion prepared in Table 1 was 5.04 in Example 1, 7.93 in Example 6, 6.30 in Example 9, 4.17 in Comparative Example 1, and 4.22 in Comparative Example 3. From this, it is considered that the pH of the skin lotion of the present invention is preferably 4.5-8.0.

表２に示す通り、実施例１、４、６、８、９、１０および１１並びに参考例３における明度判定は「◎」であり、実施例２、５および７における明度判定は「○」である。本発明におけるセラミド類の可溶化において、実施例２の明度判定から、セラミド類としては天然セラミド類が好ましいと考えられ、実施例５および７の明度判定から、非イオン性界面活性剤としてはポリオキシエチレン硬化ヒマシ油（60E.O.)（Ｂ１）、ポリオキシエチレン硬化ヒマシ油（40E.O.)（Ｂ２）またはポリオキシエチレン（30）ポリオキシプロピレン（6）デシルテトラデシルエーテル（Ｂ４）が好ましいと考えられる。
表１で得られた実施例１、２、５、６および１０並びに参考例３の各組成物について、調製直後および40℃１ヶ月保存後における明度（Ｌ値）、明度判定結果、目視判定結果および可溶化判定結果を表３に示す。

表３より、可溶化が達成できていると判定されているものは、調製直後だけでなく、40℃ 1ヶ月保存後においても、目視判定および明度判定が可溶化の判定基準を満たしていることが確認された。 Test example 1
About the composition of Example 1 , 2 , 4-11 obtained in Table 1 , the reference example 3, and the comparative example 1-5, the said test result for performing the lightness determination and visual determination which were used for determination of solubilization Table 2 shows the lightness (L value), lightness determination result, visual determination result, and solubilization determination result performed immediately after the preparation.

As shown in Table 2, the lightness determination in Examples 1, 4, 6, 8, 9, 10, and 11 and Reference Example 3 is “◎”, and the lightness determination in Examples 2, 5, and 7 is “◯”. is there. In the solubilization of ceramides in the present invention, it is considered that natural ceramides are preferable as ceramides from the lightness determination of Example 2, and from the lightness determinations of Examples 5 and 7, polyionics are used as nonionic surfactants. Oxyethylene hydrogenated castor oil (60E.O.) (B1), polyoxyethylene hydrogenated castor oil (40E.O.) (B2) or polyoxyethylene (30) polyoxypropylene (6) decyltetradecyl ether (B4) Is considered preferable.
EXAMPLE obtained in Tables 1, 2, 5, 6 About your and 10 as well as the composition of Reference Example 3, the brightness just after and 40 ° C. 1 month after storage preparation (L value), the brightness determination result, visual determination The results and solubilization determination results are shown in Table 3.

From Table 3, it is determined that solubilization has been achieved not only immediately after preparation but also after storage at 40 ° C for 1 month, the visual judgment and lightness judgment satisfy the criteria for solubilization. Was confirmed.

Claims (9)

(A) Ceramides 0.00001-1.0% by mass, (b) Nonionic surfactant 0.1-1.0% by mass, (c) Hexanediol 0.1-5.0% by mass, and (d) Water 50.0% by mass or more,
(A) A lotion characterized by being stably solubilized and transparent with ceramides ,
There is no visual turbidity, no crystal precipitation and no oil floating on the liquid surface, and
Lightness (L value) measured with a spectrocolorimeter is 99.0% or more,
A lotion that does not cause crystal precipitation or turbidity even after 1 month at 40 ° C. from the preparation .
(C) The lotion of Claim 1 whose hexanediol is 0.1-2.0 mass % . (A) The lotion according to claim 1 or 2, wherein the ceramide is a natural ceramide or a pseudo-ceramide. The lotion according to claim 3, wherein the natural ceramide is natural ceramide or natural ceramide. The natural ceramide is one selected from the group consisting of ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6, ceramide 6II, ceramide 7, ceramide 8, ceramide 9 and ceramide 10 which are human ceramides. The lotion of Claim 4 which is the above. The lotion according to claim 5, wherein the human-type ceramide is ceramide 2. (B) Nonionic surfactant is polyoxyethylene hydrogenated castor oil, polyoxyethylene sterol / hydrogenated sterol, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, sorbitan fatty acid ester, polyoxyethylene sorbitan The lotion of any one of Claims 1-6 which is 1 or more types chosen from the group which consists of fatty acid ester, glycerol fatty acid ester, polyglycerol fatty acid ester, and polyoxyethylene glycerol fatty acid ester. (A) 0.00001-0.15% by mass of natural ceramides as ceramides, (b) polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether or polyoxy as nonionic surfactant 0.1-1.0% by mass of ethylene sorbitan fatty acid ester, 0.1-2.0% by mass of (c) hexanediol,
And (d) the lotion according to any one of claims 1 to 7, comprising 70.0% by mass or more of water. (A) 0.00001-0.15% by mass of ceramide 2 as ceramides, (b) 0.4-1.0% by mass of polyoxyethylene hydrogenated castor oil as nonionic surfactant, (c) 0.8-1.0% by mass of hexanediol, And (d) the lotion according to any one of claims 1 to 8, which contains 70.0% by mass or more of water.