CN107427429A - Emulsified cosmetic preparation composition with pH buffer systems - Google Patents
Emulsified cosmetic preparation composition with pH buffer systems Download PDFInfo
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- CN107427429A CN107427429A CN201680015173.8A CN201680015173A CN107427429A CN 107427429 A CN107427429 A CN 107427429A CN 201680015173 A CN201680015173 A CN 201680015173A CN 107427429 A CN107427429 A CN 107427429A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The present invention relates to the emulsified cosmetic preparation composition with pH buffer systems.The cosmetic composition with pH buffer systems of the present invention, stimulated caused by its organic acid small, skin pH caused by inside/outside reason can constantly being alleviated changes, additionally it is possible to peels off the allergic state significantly improved with skin barrier including aging, acne and atopy by improving cutin.
Description
Technical field
The present invention relates to the emulsified cosmetic preparation composition with pH buffer systems.
Background technology
Generally, the pH (acidity) of skin is in faintly acid, weakly acidic skin pH and skin serine protease (Serine
Protease), β-glucocerebrosidase (beta-glucocerebrosidase) etc. keeps the activity of the enzyme of normal skin function
It is relevant.Be able to confirm that, not only aging skin and also produce acne, the most skin of the allergy such as atopy is shown
Go out to be higher than normal skin pH.If in addition, handled with the low materials of pH atopy skin and the skin of aging,
Skin barrier is restored, and skin can become normalization (dermatological studies magazine, 2847-2856,127,2007,
Dermatological studies magazine, 1824-1835,129,2009).
But for conventional acid pH system, it is damaged or becomes quick because of atopy or allergy if being applied to
When on the skin of sense, the problem of causing skin irritatin be present, and its effect is temporary transient.Accordingly, there exist change with being difficult to essence
The problem of being apt to skin condition and being difficult to provide effect needed for consumer.
Generally, keratoderma plays the function of the factor protection skin from physics, chemistry.Skin passes through Skin Cell
The turnover (Turn over) for being continuously generated and being carried out in a manner of being peeled off from cuticula, can totally and refreshingly be protected
Hold.But if the environmental factor caused by aging, ultraviolet or pressure, natural cutin, which comes off, to be delayed by so as to which cutin is accumulated
When, skin gloss is reduced, and acne etc. can be accelerated allergic.
Organic acid makes the connecting portion of cuticula relax, and plays a part of contributing to the stripping of interference cutin.As promotion
The organic acid that cutin is peeled off, there is 'alpha '-hydroxy acids, beta-hydroxy acid, polyhydroxy-acid etc..
But in the case where organic acid is directly applied into skin, skin irritatin can be caused, therefore exist and be difficult to quick
The problem of effect needed for skin and allergic skin offer consumer is provided.
Therefore, it is necessary to which one kind can solve the problem that above mentioned problem, so as to which stimulation is small caused by organic acid, can constantly alleviate
The cosmetics for the novel form that skin pH caused by inside/outside reason changes.
The content of the invention
Invent problem to be solved
It is an object of the present invention to provide a kind of emulsified cosmetic preparation composition with pH buffer systems, according to the group
Compound, stimulates caused by organic acid small, and skin pH caused by can constantly alleviating inside/outside reason changes.
The technical scheme solved the problems, such as
As for solving the scheme of above-mentioned problem, the present invention provides the emulsified cosmetic preparation with pH buffer systems and combined
Thing.
It is a feature of the present invention that pH buffer systems include the cushioning liquid containing sour (acid).
Therefore, the cosmetic composition that it is 3~5 comprising the cushioning liquid containing acid and pH that the present invention, which provides,.
As the another program for solving above-mentioned problem, it is 3~5 that the present invention, which is provided comprising the cushioning liquid containing acid and pH,
Skin moisture-keeping and skin pH change alleviation cosmetic compositions.
Invention effect
According to the cosmetic composition with pH buffer systems of the present invention, small, Neng Gouchi is stimulated caused by organic acid
Skin pH caused by alleviating inside/outside reason continuously changes, and also by improving cutin stripping and skin barrier, can significantly improve
The state such as allergic including aging, acne and atopy.
Embodiment
Below, the composition of the present invention is illustrated.
The present invention provides the emulsified cosmetic preparation composition with pH buffer systems.
It is a feature of the present invention that pH buffer systems include the cushioning liquid containing sour (acid).
Therefore, the present invention provides combines comprising the cushioning liquid containing sour (acid) and the pH emulsified cosmetic preparation for being 3~5
Thing.
As long as mixture (the breast of the two or more liquid of the insufficient fusion of emulsified cosmetic preparation composition of the present invention
Liquid), then its type is not particularly limited.For example, the emulsified cosmetic preparation composition of the present invention can be oil-in-water type (oil
inWater；) or water-in-oil type (water in oil O/W；W/O).Alternatively, it is also possible to being water-in-oil-in water (Water in
oil inWater；) or Water-In-Oil oil-in (Oil inWater in oil W/O/W；A variety of emulsion types such as O/W/O).
In a concrete example, emulsified cosmetic preparation composition of the invention can be oil-in-water type.Oil-in-water type emulsion
Cosmetic composition is that by intramolecular while there is hydrophily and oil loving surface to live by the oil phase that oil and wax etc. are formed
Property agent molecule form emulsion structure and the form that is dispersed in the aqueous phase formed by purified water, polyalcohol, thickener etc., with solubilising
Formulation is compared, and moisturizing continuation and skin softness etc. are excellent, so as to be advantageous to constantly improve to generate idiosyncrasy
The advantages of skins of allergy such as property.
Cushioning liquid refers to following solution：Even if from the outside acid or alkali added to a certain degree, also not therefore by big
Influence, consistently keep hydrogen ion concentration, so as to consistently keep solution pH.The present invention cushioning liquid by containing
Acid, the pH that cosmetic composition can be made overall remain 3~5.
In the present invention, pH Range Representation apply some make up the pH test method determinations in test method when pH, the present invention
Cosmetic composition be characterised by, pH be 3~5.When the pH of above-mentioned cosmetic composition is less than 3, skin can be caused
Skin stimulates, and when pH is more than 5, alleviates the low effort of skin pH changes.
In the example of the present invention, 0.1~3.0 parts by weight can be included relative to the parts by weight of total composition 100
Acid.When the content of acid meets above range, not only skin is not stimulated, but also pH constantly can be remained into pH3
~5.
In a concrete example, cushioning liquid includes organic acid and its conjugate base, but can also include organic acid and pH tune
Save agent.By comprising organic acid and its conjugate base or comprising organic acid and pH adjusting agent, can consistently keep pH.
In a concrete example, organic acid can be selected from by citric acid, lactic acid, malic acid, glycolic, tartaric acid, water
One kind in the group that poplar acid, acetic acid, propionic acid, gluconolactone, lactobionic acid, their mixture and their derivative form
More than, but not limited to this.
In a concrete example, as long as pH adjusting agent can make the pH of composition remain the material of pH3~5, so that it may
To use without restriction.PH adjusting agent can use known buffer, such as can be selected from by tromethamine, HEPES
(4- (2- ethoxys) -1- piperazine ethanesulfonic acids (4- (2-hydroxy ethyl) -1-piperazineethanesulfonic
Acid)), HEPPS (3- [4- (ethoxy) -1- piperazinyls] propane sulfonic acid (3- [4- (2-hydroxyethyl) piperazin-1-
Yl] propane-1-sulfonic acid)), TAPS (Pehanorm base propane sulfonic acid (3- [[1,3-dihydroxy-2-
(hydroxymethyl) propan-2-yl] amino] propane-1-sulfonic acid)), MES (2- (N- morpholinyls) second
Sulfonic acid (2- (N-morpholino) ethanesulfonicacid)), TES (2- [[three (methylol) methyl] amino] ethyl sulfonic acids
(2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]ethanesulfonic acid))、
BES (double (2- ethoxys)-Tau (N, N-bis (2-hydroxyethyl) -2- of N, N-
Aminoethanesulfonic acid)), TAPSO (3- Pehanorm -2- hydroxy-propanesulfonic acids (3- [[1,3-
dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]-2-hydroxypropane-1-sulfonic
Acid)), POPSO (piperazine-N, N '-bis- (2- hydroxypropanesulfonic acids) (and Piperazine-N, N '-bis (2-
Hydroxypropanesulfonic acid))), HEPPSO (3- (hydroxyethyl piperazine) -2- hydroxy-propanesulfonic acids (N-
(Hydroxyethyl) piperazine-N ' -2-hydroxypropanesulfonic acid)), DIPSO (3- [N, N- bis-
(ethoxy) amino] -2- hydroxy-propanesulfonic acids (3- (N, N-Bis [2-hydroxyethyl] amino) -2-
Hydroxypropanesulfonic acid)), glycine amide (glycinamide), N- bis- (ethoxy) glycine
(Bicine), N- tri- (methylol) methylglycine (Tricine), glycine amide (Acetamidoglycine), MOPS (3-
Quinoline propane sulfonic acid (3-morpholinopropane-1-sulfonic acid)), their mixture and their derivative institute group
Into one or more of group, but be not limited to this.
, can be with 1 in a concrete example:0.2~1:1 weight ratio includes organic acid and its conjugate base.In organic acid
And its content of conjugate base is not stimulated skin not only when meeting above range, and can be by the pH of composition constantly
It is maintained at pH3~5.
, can be with 1 in a concrete example:0.2~1:1 weight ratio includes organic acid and pH adjusting agent.In organic acid
When meeting above range with the content of pH adjusting agent, not only skin is not stimulated, and can be by the pH of composition constantly
It is maintained at pH3~5.
As being able to confirm that in the following embodiments, the skin moisturization of emulsified cosmetic preparation composition of the invention is excellent
It is different, and can constantly alleviate skin pH changes.With the water holding capacity of raising skin, and alleviate inside/outside portion original
The pH effect of increasing of skin because caused by, so as to which skin to be remained to the normal range (NR) of pH3~5, it can alleviate and improve pH changes
A variety of skin symptoms caused by change.For example, dermatoglyph can be made to become smooth, and skin aging, acne, spy can be alleviated
Different reactive symptom etc..Moreover, with significantly decreasing skin irritatin sense, it is possible to increase the user satisfaction of user.Therefore,
The cosmetic composition of the present invention can be used with skin moisture-keeping, the formulation of pH change alleviation cosmetics provides.
The cosmetics that the emulsified cosmetic preparation composition for containing the present invention is prepared as active ingredient, can be prepared into general
Logical emulsification formulation or the form of solubilized formulation.For example, there can be following formulation：Soft toner or nutrition toner etc. are changed
Adornment water (surfactant)；The emulsion such as facial emulsion or body shower cream；The cremes such as nourishing cream, moisturiser or eye cream；Essence；Make up
Ointment；Spray；Gel；Facial mask；Suncream；Bottom breast before adornment；The vanishing cream such as kind of liquid, solids versions or nozzle types；Powder
Agent；The cosmetic remover such as cleansing cream, cleanser, cleansing oil；Cleaning agents such as cleaning foam, soap, shower lotion etc..
In addition, above-mentioned cosmetics can contain fatty material, organic solvent, lytic agent, concentrating agents, gelling agent, softening agent,
Antioxidant, suspending agent, stabilizer, foaming agent (foaming agent), aromatic, surfactant, water, ionic emulsifying agent,
Nonionic emulsifier, filler, metal ion block agent, chelating agent, preservative, vitamin, retarding agent, wetting agent, essential oil
(Essential Oil), dyestuff, pigment, hydrophilic active agent, lipophile activating agent or lipid folliculus etc. are in cosmetic field
Usually used adjuvant.
Below, by embodiment to the detailed description of the invention.But following embodiments are only used for illustrating the present invention, this hair
Bright content is not limited to following embodiments.
[embodiment]
Embodiment 1~3
According to the composition of table 1 below, oil, wax and surfactant are added, and is heated to 70 DEG C~75 DEG C and is allowed to dissolve,
So as to be prepared for oil phase.As pH cushioning liquid, using organic acid and its conjugate base, or organic acid and organic buffer are used
Compound.PH cushioning liquid, polyalcohol and thickener etc. are being distributed to purified water and are being heated in 70 DEG C~75 DEG C of aqueous phase,
It with the addition of above-mentioned oil phase.Thereafter, under conditions of 1500~3500rpm of homogeneous mixer, stir 10 minutes, and at 50 DEG C
Add additive.Then, stir 5 minutes, 30 DEG C are cooled to, so as to be prepared for that there is the oil-in-water type emulsion of pH buffer systems
Cosmetic composition.
Table 1
Comparative example 1~6
According to the composition of table 2 below, the oil-in-water of no pH buffer systems is prepared with the method same with embodiment 1~6
Type cosmetic composition.
Table 2
[experimental example]
Experimental example 1：PH and hardness confirm
The pH and hardness of above-described embodiment and comparative example are confirmed.PH is the pH examinations in cosmetics test method
Test method measure.Generally, the composition 2g of each embodiment and comparative example is diluted with purified water 30ml, and according to
Functional cosmetics test method, (HORIBA companies) is counted using F-52pH to determine pH.
, will with the speed of 2cm/ minutes to analyzing rod using RTC-3005D hardometers (RHEOTECH companies) for hardness
Resistance when sample is pressed into 25mm depth is measured.It the results are shown in table 3.
Table 3
Experimental example 2：Compared based on pH buffer systems species and the skin pH whetheing there is changes and continuation
For the species according to pH buffer systems and whether there is and remission effect and continuation are changed to skin pH are compared, make
With embodiment 1~3 and the composition of comparative example 1~2.In the thermostatic constant wet chamber for remaining 25 DEG C of temperature, relative humidity 70%,
With the 20 entitled object of men and women with slight atopy, the pH of the pars affecta skin before will testing is determined, also, in order to
Skin pH is artificially improved, after pH10 foam mildy wash cleaning affected part, determines skin pH immediately.Smearing various formulations
Afterwards, in units of 30 minutes, the measure skin pH of 240 minutes, and be compared with average value.Skin pH is to use skin
PH measure devices (Skin-pH-MeterpH905, Courage+Khazaka electronic GmbH companies) measure, by it
As a result it is shown in table 4.
Table 4
From the result of above-mentioned table 4, in the case of embodiment 1~2, being able to confirm that makes skin pH quickly become normal
Change, and be able to confirm that during minute and be continuously kept.In the case of example 3, due to buffer capacity (Buffer
Capacity difference), skin pH normalization are maintained only until smearing untill 180 minutes.But in the case of comparative example 1, energy
Enough confirm to pass through 120 minutes after formulation is smeared, the pH also not returned to before experiment, can be true in the case of comparative example 2
Recognize the fast quick-recoveries of pH after formulation is smeared, but after 90 minutes, the pH returned to before experiment.
This represents the cosmetic composition of the present invention by with pH buffer systems, can constantly alleviate the pH of skin
Change.
Experimental example 3：Improvement that the dermatoglyph that is whether there is based on pH buffer systems, cutin are peeled off, moisture of skin holding capacity
And skin irritatin is compared
In order to be whether there is according to pH buffer systems to dermatoglyph, the improvement of cutin stripping and skin moisture-keeping improvement work(
Effect is compared, and uses the embodiment 1 and comparative example 1~6 for employing different buffer systems.With adult men and women 20 over fifty years old
For object, the dermatoglyph before will testing and skin pH are measured, and according to application method usually, face is made
With the creme of 4 weeks, it was measured every two weeks with being contrasted before experiment, is converted into improvement rate and is compared.
After 4 weeks, with 5 points of indexs for full marks, user satisfaction is confirmed by questionnaire.Use PRIMOS height
Image in different resolution analyzer, in the thermostatic constant wet chamber for remaining 25 DEG C of temperature, relative humidity 70%, dermatoglyph is changed into
Row measure.
The improvement peeled off for cutin, after being coloured with DHA to experiment position, utilize illumination colorimetric device
(Chromameter CR300, German CK Electronic) be not to using the experiment position of sample and the position using sample
It is compared to evaluate the change of brightness value.
Skin is determined using skin moisture content measure device (Corneometer CM825, German CK Electronic)
Skin moisture.End value is converted into improvement rate to be compared with being contrasted before experiment.
For skin irritatin degree, -29 are commented according to cosmetic evaluation/analytic approach, implements the experiment of patch in 24 hours, stimulus index
(PII) it is as follows.
The results are shown in table 5 below.
Table 5
It is able to confirm that there is the embodiment 1 of pH buffer systems compared with comparative example 1~6, display by the result of above-mentioned table 5
Go out the improvement that the improvement of significant dermatoglyph, the improvement of skin moisture content and cutin are peeled off, and contribute to aging skin
The improvement of skin.
In the case of comparative example 2~5, although dermatoglyph, skin moisture content and cutin are peeled off a part and changed
It is kind, but its degree is very low, in the case of comparative example 4 and comparative example 6, is able to confirm that skin irritatin height, therefore be not suitable for sensitivity
The user of skin, user satisfaction are also low.
This represents that pH buffer systems of the invention contribute to the improvement of dermatoglyph, the improvement of skin moisture content, cutin
The improvement of stripping.In addition, the concentration of the organic acid contained in pH buffer systems, organic acid and its conjugate base or organic buffer liquid
The content of compound is than being important for being continuously kept the effect above.
Experimental example 4：The percutaneous moisture loss amount (TEWL) that is whether there is based on pH buffer systems, atopy are improved and made
Compared with satisfaction
In order to improve effect to the skin barrier reparation of atopy affected part and symptom according to pH buffer systems whether there is
It is compared, has used embodiment 1 and comparative example 1~4 using different buffer systems.
With the 20 entitled object of men and women with slight atopy, the percutaneous moisture loss amount before will testing is determined,
And according to application method usually, 4 weeks cremes are used to affected part.Remaining the constant temperature of 25 DEG C of temperature, relative humidity 70%
, will using Tewameter (TM300, German CK Electronic) every two weeks percutaneous moisture loss amounts of measure in humidity room
End value is converted into improvement rate to be compared with being contrasted before experiment.
Improvement for atopy symptom, confirm that being converted into symptom improves personnel's ratio, is using 4 weeks by naked eyes
Afterwards, confirmed with 5 points of indexs for full marks by questionnaire.
For user satisfaction, after using 4 weeks, confirmed with 5 points of indexs for full marks by questionnaire.
The results are shown in table 6.
Table 6
From the result of above-mentioned table 6, there is the embodiment 1 of pH buffer systems compared with comparative example 1~4, show aobvious
The skin barrier improvement of percutaneous moisture loss amount (TEWL) measure of use and the improvement of atopy symptom of work.
Be able to confirm that embodiment 1 atopy improve personnel's ratio it is very high, and atopy improve satisfaction and
User satisfaction is also high.In the case of comparative example 2~4, although being able to confirm that part is present by percutaneous moisture loss amount and meat
The improvement for the symptom that eye confirms, but its degree is very low.
This expression, the skin barrier improvement of pH buffer systems of the invention and the improvement of atopy symptom
It is excellent, so as to the improvement for skin barrier and the alleviation of atopy symptom.In addition, contain in pH buffer systems
Concentration, organic acid and its conjugate base of organic acid or the content ratio of organic buffer compound are for being continuously kept above-mentioned effect
It is important for fruit.
Claims (9)
1. a kind of emulsified cosmetic preparation composition, it is 3~5 that it, which includes the cushioning liquid containing acid and pH,.
2. emulsified cosmetic preparation composition according to claim 1, wherein, relative to the parts by weight of total composition 100, bag
Acid containing 0.1~3.0 parts by weight.
3. emulsified cosmetic preparation composition according to claim 1, wherein, cushioning liquid includes organic acid and its conjugation
Alkali.
4. emulsified cosmetic preparation composition according to claim 1, wherein, cushioning liquid includes organic acid and pH is adjusted
Agent.
5. the emulsified cosmetic preparation composition according to any one of claim 3 to 4, wherein, organic acid is selected from by lemon
Acid, lactic acid, malic acid, glycolic, tartaric acid, salicylic acid, acetic acid, propionic acid, gluconolactone, lactobionic acid, their mixing
One or more of thing and their group of derivative composition.
6. emulsified cosmetic preparation composition according to claim 4, wherein, pH adjusting agent is selected from by tromethamine, HEPES
(4- (2- ethoxys) -1- piperazine ethanesulfonic acids), HEPPS (3- [4- (ethoxy) -1- piperazinyls] propane sulfonic acid), TAPS (three hydroxyl first
Base methylamino propane sulfonic acid), MES (2- (N- morpholinyls) ethyl sulfonic acid), TES (2- [[three (methylol) methyl] amino] ethyl sulfonic acid),
BES (double (2- the ethoxys)-Taus of N, N-), TAPSO (3- Pehanorm -2- hydroxy-propanesulfonic acids), POPSO
(piperazine-N, N '-bis- (2- hydroxypropanesulfonic acids)), HEPPSO (3- (hydroxyethyl piperazine) -2- hydroxy-propanesulfonic acids), DIPSO (3-
[N, N- bis- (ethoxy) amino] -2- hydroxy-propanesulfonic acids), glycine amide, N- bis- (ethoxy) glycine, N- tri- (methylol) first
One in the group that base glycine, glycine amide, MOPS (3- N-morpholinyls), their mixture and their derivative form
More than kind.
7. emulsified cosmetic preparation composition according to claim 3, wherein, with 1:02~1:1 weight ratio includes organic
Acid and its conjugate base.
8. emulsified cosmetic preparation composition according to claim 4, wherein, with 1:02~1:1 weight ratio includes organic
Acid and pH adjusting agent.
9. emulsified cosmetic preparation composition according to claim 1, wherein, the composition is oil-in-water type.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150035050A KR102078140B1 (en) | 2015-03-13 | 2015-03-13 | Emulsified cosmetic composition having a pH buffer system |
| KR10-2015-0035050 | 2015-03-13 | ||
| PCT/KR2016/002341 WO2016148434A1 (en) | 2015-03-13 | 2016-03-09 | Emulsion cosmetic composition having ph buffer system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107427429A true CN107427429A (en) | 2017-12-01 |
| CN107427429B CN107427429B (en) | 2021-09-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201680015173.8A Active CN107427429B (en) | 2015-03-13 | 2016-03-09 | Emulsified cosmetic composition with pH buffer system |
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| Country | Link |
|---|---|
| KR (1) | KR102078140B1 (en) |
| CN (1) | CN107427429B (en) |
| HK (1) | HK1244226A1 (en) |
| WO (1) | WO2016148434A1 (en) |
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| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| US11110049B2 (en) | 2017-06-23 | 2021-09-07 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
| CN114557915A (en) * | 2022-03-23 | 2022-05-31 | 伊美莱(广州)医疗技术有限公司 | Toning lotion and preparation method thereof |
| US11583488B2 (en) | 2020-06-01 | 2023-02-21 | The Procter & Gamble Company | Method of improving penetration of a vitamin B3 compound into skin |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
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| US11110049B2 (en) | 2017-06-23 | 2021-09-07 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| US11583488B2 (en) | 2020-06-01 | 2023-02-21 | The Procter & Gamble Company | Method of improving penetration of a vitamin B3 compound into skin |
| US11911498B2 (en) | 2020-06-01 | 2024-02-27 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| CN114557915A (en) * | 2022-03-23 | 2022-05-31 | 伊美莱(广州)医疗技术有限公司 | Toning lotion and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1244226A1 (en) | 2018-08-03 |
| KR20160109868A (en) | 2016-09-21 |
| CN107427429B (en) | 2021-09-07 |
| WO2016148434A1 (en) | 2016-09-22 |
| KR102078140B1 (en) | 2020-02-17 |
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