JP6132853B2 - 全身性抗炎症反応を提供する、複数のプロスタグランジン受容体で作用する化合物 - Google Patents

全身性抗炎症反応を提供する、複数のプロスタグランジン受容体で作用する化合物 Download PDF

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JP6132853B2
JP6132853B2 JP2014550353A JP2014550353A JP6132853B2 JP 6132853 B2 JP6132853 B2 JP 6132853B2 JP 2014550353 A JP2014550353 A JP 2014550353A JP 2014550353 A JP2014550353 A JP 2014550353A JP 6132853 B2 JP6132853 B2 JP 6132853B2
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alkyl
methyl
carboxylic acid
disease
pyrazole
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JP2015503562A5 (OSRAM
JP2015503562A (ja
Inventor
ユッシ ジェイ カンガスメトサ
ユッシ ジェイ カンガスメトサ
ウィリアム アール カーリング
ウィリアム アール カーリング
ホセ エル マルトス
ホセ エル マルトス
デイヴィッド エフ ウッドワード
デイヴィッド エフ ウッドワード
ジェニー ダブリュ ワン
ジェニー ダブリュ ワン
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Allergan Inc
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Allergan Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Surgery (AREA)
  • Emergency Medicine (AREA)
JP2014550353A 2011-12-27 2012-12-19 全身性抗炎症反応を提供する、複数のプロスタグランジン受容体で作用する化合物 Expired - Fee Related JP6132853B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161580474P 2011-12-27 2011-12-27
US61/580,474 2011-12-27
PCT/US2012/070664 WO2013101598A1 (en) 2011-12-27 2012-12-19 Compounds acting at multiple prostaglandin receptors giving a general anti-inflammatory response

Publications (3)

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JP2015503562A JP2015503562A (ja) 2015-02-02
JP2015503562A5 JP2015503562A5 (OSRAM) 2016-02-18
JP6132853B2 true JP6132853B2 (ja) 2017-05-24

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JP2014550353A Expired - Fee Related JP6132853B2 (ja) 2011-12-27 2012-12-19 全身性抗炎症反応を提供する、複数のプロスタグランジン受容体で作用する化合物

Country Status (6)

Country Link
US (1) US9035071B2 (OSRAM)
EP (1) EP2797893B1 (OSRAM)
JP (1) JP6132853B2 (OSRAM)
AU (1) AU2012362724C1 (OSRAM)
CA (1) CA2862263C (OSRAM)
WO (1) WO2013101598A1 (OSRAM)

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US8859606B2 (en) 2010-07-01 2014-10-14 Allergan, Inc. Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response
EP2945932B1 (en) * 2013-01-21 2018-11-21 Allergan, Inc. Compounds act at multiple prostaglandin receptors giving a general anti-inflammatory response
ITMI20132201A1 (it) * 2013-12-23 2015-06-24 Isagro Spa Processo per la sintesi regioselettiva di pirazoli
EP3886854A4 (en) 2018-11-30 2022-07-06 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
KR20230107228A (ko) 2020-11-13 2023-07-14 오노 야꾸힝 고교 가부시키가이샤 Ep4 길항약과 면역 체크포인트 저해 물질의 병용에 의한 암 치료

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DE19924872A1 (de) 1999-05-29 2000-11-30 Dresden Arzneimittel Antikonvulsiv wirkende Pyrazolo[3,4-d][1,2,3]triazine und Verfahren zu ihrer Herstellung
US7273883B2 (en) 2000-09-14 2007-09-25 Allergan, Inc. Prostaglandin EP4 antagonist
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US7217725B2 (en) 2000-09-14 2007-05-15 Allergan, Inc. Prostaglandin D2 antagonist
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WO2003042183A1 (en) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Process for production of pyrazole compounds
ATE386725T1 (de) * 2003-10-24 2008-03-15 Glaxo Group Ltd Heterocyclylverbindungen
CN1890241A (zh) * 2003-10-31 2007-01-03 Cv医药有限公司 A2b腺苷受体拮抗剂
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AU2012362724A1 (en) 2014-07-24
AU2012362724B2 (en) 2017-09-14
US20130165666A1 (en) 2013-06-27
EP2797893A1 (en) 2014-11-05
CA2862263A1 (en) 2013-07-04
CA2862263C (en) 2016-09-06
WO2013101598A1 (en) 2013-07-04
EP2797893B1 (en) 2017-11-22
AU2012362724C1 (en) 2018-01-18
US9035071B2 (en) 2015-05-19
JP2015503562A (ja) 2015-02-02

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