JP6125034B2 - トリアジンを用いた新規処置 - Google Patents
トリアジンを用いた新規処置 Download PDFInfo
- Publication number
- JP6125034B2 JP6125034B2 JP2015546022A JP2015546022A JP6125034B2 JP 6125034 B2 JP6125034 B2 JP 6125034B2 JP 2015546022 A JP2015546022 A JP 2015546022A JP 2015546022 A JP2015546022 A JP 2015546022A JP 6125034 B2 JP6125034 B2 JP 6125034B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- human animal
- triazine
- composition according
- intramuscular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
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Description
‐例えばクラズリル、ジクラズリル、レトラズリル及びスラズリル等の1,2,4‐トリアジンジオンの誘導体;又は
‐例えばトルトラズリル、トルラズリルスルホキシド、トルトラズリルスルホン(例えばポナズリル)等の1,3,5‐トリアジントリオンの誘導体。
「トリアジン」の用語は、特にコクシジウムの感染に対する活性物質の周知の分類を意味する。本発明の方法又は組成物に用いるための典型的なトリアジンは、所定の純度を有する以下の化学式A又はBの化合物であり、好ましくは少なくとも90%の純度を有する、また、その塩、エステル、ラセミ体、異性体、プロドラッグである。
R2はアルキル、アルコキシ、ハロゲン又はSO2N(CH3)2
R3はハロアルキルであり、
R4及びR5は互いに独立して水素又はCl原子であり、
R6はフッ素又は塩素である。
本発明において、処置の用語は、特に、病気に対する非ヒト動物の予防的処置を含む。病気に対する非ヒト動物の予防的処置は、非ヒト動物が病気の病原体(例えば病原菌、ウィルス、原虫、細胞等)に曝露される又は接触される前に、又はその曝露/接触の後で症状の発生の前に、又は病気の発生の早期段階において行われる処置を意味する。また、非ヒト動物の個体群に関して予防的処置の用語は、病気が特定のメンバーで検出された後に、他に広がる及び他を汚染することを制限する又は避けるために、その個体群の全てのメンバーを処置することを意味する。
本発明の重要な一態様は、筋肉内投与経路である。実施例の項で示すように、本発明は、反復注射の必要なく又は長期放出性又は徐放性剤形の必要なく、単回投与であっても、その後、処置された非ヒト動物に有効な予防効果を与える筋肉内投与トリアジンを示す。さらに、本発明は、非ヒト動物への更なる操作を課することなく、有効な処置が得られるように、筋肉内投与トリアジンが更なる筋肉内投与活性剤と組み合わせられ得ることを示す。
トリアジンの用量は、非ヒト動物の種及びトリアジンの性質に依存する。非ヒト動物の体重1kg当たり1〜60mg(mg/kg)のトリアジンといった従来の投与率が用いられ、好ましくは5〜50mg/kgであり、より好ましくは10〜30mg/kgである。
ブタ:20mg/kg(体重)/処置(好ましくは単回投与);
ウシ:15mg/kg(体重)/処置(好ましくは単回投与);
ヒツジ:20mg/kg(体重)/処置(好ましくは単回投与);
家禽:25mg/kg(体重)/処置(好ましくは単回投与)。
本発明は、非ヒト動物における感染症、好ましくは原虫病又は微生物病の処置(例えば保護、予防、遅延、緩和又は治療)に用いられ得る。本発明は、血液及び組織の原虫病(バベシア症、肉胞子虫症又はトキソプラズマ病等)、又は消化管の原虫病(コクシジウム病等)の処置に特に適する。
(プロトコール)
この標的動物の安全性及び有効性研究を、コクシジウム病の周知の歴史を有する農場で行った。その主な目的は、トルトラズリルの筋肉内注射の安全性及び有効性を標準的な経口投与と比較して試験することである。
グループ1:3日齢の8匹の子ブタにSD0において、トルトラズリルの単回筋肉内注射を行った(用量=20mg/kg(体重)で0.4mL/kg(体重))。
グループ2:3日齢の8匹の子ブタにSD0において、トルトラズリルの単回筋肉内注射を行った(用量=60mg/kg(体重)で1.2mL/kg(体重))。
グループ3:3日齢の8匹の子ブタにSD0において、トルトラズリルとしてのCevazurilの標準的な販売剤形を経口投与した(用量=トルトラズリルが20mg/kg(体重)で0.4mL/kg(体重))。
グループ4:3日齢の12匹の子ブタに対して処置をしなかった。
局所的及び全体的耐性、並びに体重増加について評価した。その結果は図1及び図2に示され、以下のように要約される。
‐60mg/kgまでの筋肉内注射の用量では良好な耐性が認められる。
‐痛みは無く、1.2mL/kg(体重)で注射された数匹の子ブタにおいて限定的な局所反応(浮腫)が見られたが、注射後1週間以内で消失した。
‐処置された子ブタにおいて、体重増加は正常であった。
‐筋肉内注射された子ブタは、処置されていないコントロールの子ブタよりも重くなった(SD0+29日で+2kg)。
(プロトコール)
グループ1:2日齢の10匹の子ブタにSD0において、トルトラズリルC629の単回筋肉内注射を行った(用量=トルトラズリルが20mg/kg(体重)で0.4mL/kg(体重))。
グループ2:2日齢の11匹の子ブタにSD0において、トルトラズリルC629の単回筋肉内注射を行った(用量=トルトラズリルが40mg/kg(体重)で0.8mL/kg(体重))。
グループ3:2日齢の9匹の子ブタにSD0において、トルトラズリルとしてCevazurilの標準的な販売剤形を経口投与した(用量=トルトラズリルが20mg/kg(体重)で0.4mL/kg(体重))。
グループ4:8匹の子ブタに対して処置をしなかった。
・局所的及び全体的耐性(グループ1及び2)
・下痢の発生及び糞便の硬さ
・体重増加
・グループ1、2及び3におけるトルトラズリル及びその代謝物のトルトラズリルスルホンの血清濃度。
結果を図3〜5、及び以下の表1に示す。それらは以下の通り要約できる。
・全ての試験された用量において良好な耐性があった。
・処置された動物においてオーシストの排泄は見られず、糞便の硬さは処置された子ブタ(G1、G2及びG3)において変わらなかった。
・感染され、経口又は筋肉内で処置された動物(G1、G2及びG3)は、コントロールの動物(G4)よりも体重がより大きく増加した。
・トルトラズリルは、筋肉内投与の後に良好に吸収される。
・トルトラズリルスルホン(例えばポナズリル)の動態は、経口的に処置された動物(G3)又は筋肉内に処置された動物(G1及びG2)で統計的な差が無かった。
Claims (15)
- 非ヒト動物の感染症の予防的処置に用いられるためのトルトラズリル及び鉄剤を含む組成物であって、
筋肉内又は皮下注射により投与されるための組成物。 - 単回注射により前記非ヒト動物に投与されるための請求項1に記載の組成物。
- 非ヒト哺乳動物の首若しくは耳の後ろ、又はトリの胸骨に隣接する筋肉に筋肉内注射することにより投与されるための請求項1又は2に記載の組成物。
- 前記非ヒト動物の体重1kg当たり1mg〜60mgで投与されるためのトルトラズリルを含む請求項3に記載の組成物。
- 前記非ヒト動物の体重1kg当たり10mg〜30mgで投与されるためのトルトラズリルを含む請求項4に記載の組成物。
- 抗生物質、駆虫剤、エンデクトサイド、抗炎症剤、ビタミン、及び/又はミネラルから選択される1つ又はそれ以上の追加的活性剤を含む請求項1〜5のいずれか1項に記載の組成物。
- 前記鉄剤は、鉄複合体である請求項1〜6のいずれか1項に記載の組成物。
- 前記トルトラズリル及び鉄剤は、共に筋肉内又は皮下注射されるために同一の剤形で組み合わせられている請求項1〜7のいずれか1項に記載の組成物。
- 前記剤形は懸濁液である請求項1〜8のいずれか1項に記載の組成物。
- 前記非ヒト動物は、ブタ、ヒツジ、ウシ、イヌ、ネコ又はトリから選択される請求項1〜9のいずれか1項に記載の組成物。
- 前記非ヒト動物における原虫感染症の予防的処置に用いられるための請求項1〜10のいずれか1項に記載の組成物。
- ブタのコクシジウム病の予防的処置に用いられるための請求項1〜11のいずれか1項に記載の組成物。
- 非ヒト動物の感染症の予防的処置に用いられるための組成物であって、
1mg〜60mgのトルトラズリルと、鉄複合体とを含み懸濁液であり、前記非ヒト動物に筋肉内注射で投与されるための組成物。 - 前記鉄複合体は、β‐オキシ水酸化鉄及びデキストラングルコヘプトン酸の水性コロイド溶液である請求項7又は13に記載の組成物。
- 前記非ヒト動物は、子ブタ又は子ウシである請求項13に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12306546.8A EP2740469A1 (en) | 2012-12-07 | 2012-12-07 | New treatments with triazines |
EP12306546.8 | 2012-12-07 | ||
PCT/EP2013/075755 WO2014086958A1 (en) | 2012-12-07 | 2013-12-06 | New treatments with triazines |
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JP2016501252A JP2016501252A (ja) | 2016-01-18 |
JP6125034B2 true JP6125034B2 (ja) | 2017-05-10 |
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JP2015546022A Active JP6125034B2 (ja) | 2012-12-07 | 2013-12-06 | トリアジンを用いた新規処置 |
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US (1) | US9877969B2 (ja) |
EP (3) | EP2740469A1 (ja) |
JP (1) | JP6125034B2 (ja) |
KR (1) | KR102253497B1 (ja) |
CN (3) | CN113144202A (ja) |
AU (1) | AU2013353982B2 (ja) |
BR (3) | BR112015013182A2 (ja) |
CA (1) | CA2892886C (ja) |
CL (1) | CL2015001563A1 (ja) |
CY (1) | CY1123190T1 (ja) |
DK (1) | DK2928454T3 (ja) |
ES (1) | ES2778950T3 (ja) |
FR (1) | FR20C1044I2 (ja) |
HR (1) | HRP20200630T1 (ja) |
HU (2) | HUE049950T2 (ja) |
MX (1) | MX2015007128A (ja) |
NL (1) | NL301064I2 (ja) |
PH (1) | PH12015501220A1 (ja) |
PL (1) | PL2928454T3 (ja) |
PT (1) | PT2928454T (ja) |
RU (1) | RU2696265C2 (ja) |
SI (1) | SI2928454T1 (ja) |
WO (1) | WO2014086958A1 (ja) |
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DE102007025908A1 (de) | 2007-06-01 | 2008-12-04 | Bayer Healthcare Ag | Formulierungen enthaltend Triazinone und Eisen |
EP2740469A1 (en) | 2012-12-07 | 2014-06-11 | Ceva Sante Animale | New treatments with triazines |
EP2740470A1 (en) * | 2012-12-07 | 2014-06-11 | Ceva Sante Animale | Treatment of Coccidiosis with intramuscular triazine composition |
EP2740492A1 (en) | 2012-12-07 | 2014-06-11 | Ceva Sante Animale | Triazine formulations with a second active ingredient and surfactant(s) |
EP3578182A1 (en) | 2018-06-05 | 2019-12-11 | Bayer Animal Health GmbH | Formulations containing triazinones and iron with a low amount of free iron ions |
EP3578181A1 (en) | 2018-06-05 | 2019-12-11 | Bayer Animal Health GmbH | Formulation for use in the simultaneous treatment of coccidial infections and iron deficiencies |
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GB1183940A (en) | 1966-10-22 | 1970-03-11 | Fisons Pharmaceuticals Ltd | Ferric Hydroxide Complexes |
DE2718799A1 (de) | 1977-04-27 | 1978-11-09 | Bayer Ag | 1-(4-phenoxy-phenyl)-1,3,5-triazin- derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel und wachstumsfoerderer |
US4493826A (en) * | 1982-01-25 | 1985-01-15 | Schering Corporation | Gentamicin-gleptoferron compositions |
US5219853A (en) | 1983-01-12 | 1993-06-15 | Bayer Aktiengesellschaft | Agent for coccidiosis |
DE3300793A1 (de) | 1983-01-12 | 1984-07-12 | Bayer Ag, 5090 Leverkusen | Coccidiosemittel |
DE3516632A1 (de) | 1985-05-09 | 1986-11-13 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 1,3,5-triazintrionen |
JPH0776524A (ja) * | 1993-07-13 | 1995-03-20 | Takeda Chem Ind Ltd | 動物用抗貧血剤 |
DE19603984A1 (de) | 1996-02-05 | 1997-08-07 | Bayer Ag | Granulate von Triazinen |
DE19603954C2 (de) | 1996-02-05 | 2003-04-17 | Wagon Automotive Gmbh | Prallträger für ein Kraftfahrzeug |
DE19824483A1 (de) | 1998-06-02 | 1999-12-09 | Bayer Ag | Halbfeste wäßrige Zubereitungen für orale Applikation von Toltrazuril-Sulfon |
WO2000019964A2 (en) | 1998-10-08 | 2000-04-13 | New Ace Research Company | Novel compositions and methods for prevention and treatment of protozoal disease |
AU4034800A (en) | 1999-10-08 | 2001-04-23 | New Ace Research Company | Novel compositions and methods for prevention and treatment of protozoal disease |
DE10040174A1 (de) * | 2000-08-17 | 2002-02-28 | Bayer Ag | Verwendung von Triazintrion-Sulfonen zur Bekämpfung von Coccidiosen |
AU2005312301B2 (en) | 2004-12-01 | 2012-02-09 | Acushot Inc. | Needle-free injector |
JP5180195B2 (ja) | 2006-06-07 | 2013-04-10 | アキュショット インク | 無針注射器用の充薬機構 |
DE102006038292A1 (de) | 2006-08-16 | 2008-02-21 | Bayer Healthcare Ag | Transdermale Anwendung von Triazinen zur Bekämpfung von Coccidien-Infektionen |
DE102007025908A1 (de) | 2007-06-01 | 2008-12-04 | Bayer Healthcare Ag | Formulierungen enthaltend Triazinone und Eisen |
WO2009111794A1 (en) | 2008-03-07 | 2009-09-11 | Pharmajet, Inc. | Intradermal injector and uses thereof |
SI22751A (sl) | 2008-04-03 | 2009-10-31 | Krka, D.D., Novo Mesto | Toltrazuril z izboljĺ animi lastnostmi za raztapljanje |
FR2946882B1 (fr) * | 2009-06-18 | 2011-08-26 | Ceva Sante Animale | Suspension veterinaire gelifiee de fer |
CN101947201B (zh) | 2010-09-08 | 2011-12-28 | 洛阳惠中兽药有限公司 | 兽药纳米混悬剂及其制备方法与应用 |
CN102512366A (zh) | 2011-12-28 | 2012-06-27 | 广州市和生堂动物药业有限公司 | 妥曲珠利悬浮乳剂及其制备方法 |
CN102743334A (zh) * | 2012-07-30 | 2012-10-24 | 郑州后羿制药有限公司 | 一种妥曲珠利注射剂及其制备方法 |
EP2740470A1 (en) | 2012-12-07 | 2014-06-11 | Ceva Sante Animale | Treatment of Coccidiosis with intramuscular triazine composition |
EP2740492A1 (en) | 2012-12-07 | 2014-06-11 | Ceva Sante Animale | Triazine formulations with a second active ingredient and surfactant(s) |
EP2740469A1 (en) | 2012-12-07 | 2014-06-11 | Ceva Sante Animale | New treatments with triazines |
EP3578181A1 (en) | 2018-06-05 | 2019-12-11 | Bayer Animal Health GmbH | Formulation for use in the simultaneous treatment of coccidial infections and iron deficiencies |
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2012
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2015
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