JP6124041B2 - 細胞足場構造体 - Google Patents
細胞足場構造体 Download PDFInfo
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- JP6124041B2 JP6124041B2 JP2011534906A JP2011534906A JP6124041B2 JP 6124041 B2 JP6124041 B2 JP 6124041B2 JP 2011534906 A JP2011534906 A JP 2011534906A JP 2011534906 A JP2011534906 A JP 2011534906A JP 6124041 B2 JP6124041 B2 JP 6124041B2
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| US20130317315A1 (en) * | 2012-05-22 | 2013-11-28 | Tony V. Lu | Method of age management |
| US20130317622A1 (en) * | 2012-05-25 | 2013-11-28 | Antonio Sambusseti | Surgical method for grafting an artificial implant in a bladder and/or in a urethral or ureteral segment |
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| WO2017056866A1 (ja) * | 2015-09-29 | 2017-04-06 | 株式会社カネカ | 生体組織作製情報生成装置、生体組織作製システム、医療費演算システム |
| US20190015190A1 (en) | 2015-12-30 | 2019-01-17 | Wake Forest University Health Sciences | Tissue-engineered gut-sphincter complexes and methods of making the same |
| RU2633309C2 (ru) * | 2016-02-25 | 2017-10-11 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Тверской государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО Тверской ГМУ Минздрава России) | Комбинированный хирургический дренаж |
| USD815285S1 (en) | 2016-05-11 | 2018-04-10 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| USD814638S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| USD814637S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| US10548977B1 (en) | 2016-05-20 | 2020-02-04 | Emery Korpas | Pain relief utilizing a combination of polymer based materials |
| US10702704B2 (en) | 2016-05-20 | 2020-07-07 | E.K. Licensing, Llc | Pain relief utilizing polymer based materials or a combination of LED bulbs, polymer based materials and a near field accelerator |
| USD808529S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
| USD808528S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
| EP3624729A1 (en) * | 2017-05-19 | 2020-03-25 | Mayo Foundation for Medical Education and Research | Methods and materials for treating urinary calculi |
| US11443433B2 (en) * | 2018-02-10 | 2022-09-13 | The Trustees Of The University Of Pennsylvania | Quantification and staging of body-wide tissue composition and of abnormal states on medical images via automatic anatomy recognition |
| CN113038907B (zh) | 2018-07-06 | 2024-09-03 | 库克医学技术有限责任公司 | 储存装置、装载装置、递送系统、套件、以及相关方法 |
| CN110448730A (zh) * | 2019-08-29 | 2019-11-15 | 上海白衣缘生物工程有限公司 | 一种用于鼓膜修复的生物补片及其制备方法 |
| GB2601793B (en) * | 2020-12-10 | 2025-07-23 | The Francis Crick Institute Ltd | Thymic constructs and uses thereof |
| CN113750297B (zh) * | 2021-09-03 | 2022-04-15 | 东华大学 | 一种结构和功能仿生尿道支架及其制备方法 |
| US20230132318A1 (en) * | 2021-10-25 | 2023-04-27 | Satellite Biosciences, Inc. | Methods of implanting engineered tissue constructs |
| CN114848898B (zh) * | 2022-06-23 | 2023-07-21 | 点云生物(杭州)有限公司 | 一种基于3d打印工艺制造的人工骨支架及方法 |
| WO2024044371A2 (en) * | 2022-08-26 | 2024-02-29 | The Texas A&M University System | Tubular structures, methods, and apparatuses for making and using the same |
Family Cites Families (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4182339A (en) | 1978-05-17 | 1980-01-08 | Hardy Thomas G Jr | Anastomotic device and method |
| US4217664A (en) * | 1979-02-02 | 1980-08-19 | Faso Joseph M | Prosthesis and method for creating a stoma |
| US4520821A (en) | 1982-04-30 | 1985-06-04 | The Regents Of The University Of California | Growing of long-term biological tissue correction structures in vivo |
| US5863531A (en) | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| US5804178A (en) | 1986-11-20 | 1998-09-08 | Massachusetts Institute Of Technology | Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue |
| CA1340581C (en) | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
| US5567612A (en) | 1986-11-20 | 1996-10-22 | Massachusetts Institute Of Technology | Genitourinary cell-matrix structure for implantation into a human and a method of making |
| WO1993007913A1 (en) | 1991-10-24 | 1993-04-29 | Children's Medical Center Corporation | Neomorphogenesis of urological structures in vivo from cell culture |
| US6283761B1 (en) | 1992-09-08 | 2001-09-04 | Raymond Anthony Joao | Apparatus and method for processing and/or for providing healthcare information and/or healthcare-related information |
| US5514378A (en) | 1993-02-01 | 1996-05-07 | Massachusetts Institute Of Technology | Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures |
| US5399352A (en) * | 1993-04-14 | 1995-03-21 | Emory University | Device for local drug delivery and methods for using the same |
| US6039749A (en) * | 1994-02-10 | 2000-03-21 | Endovascular Systems, Inc. | Method and apparatus for deploying non-circular stents and graftstent complexes |
| US20020055786A1 (en) * | 1994-08-16 | 2002-05-09 | Anthony Atala | Reconstruction of urological structures with polymeric matrices |
| US5654273A (en) | 1994-09-22 | 1997-08-05 | Children's Medical Center Corporation | Synducin mediated modulation of tissue repair |
| US5618718A (en) | 1994-12-30 | 1997-04-08 | Universite Laval | Production of a contractile smooth muscle |
| US5586438A (en) | 1995-03-27 | 1996-12-24 | Organ, Inc. | Portable device for preserving organs by static storage or perfusion |
| DE69622548T2 (de) | 1995-04-07 | 2003-09-18 | Methodist Health Group, Inc. | Gewebetransplantat zur blasenrekonstruktion |
| US5855610A (en) | 1995-05-19 | 1999-01-05 | Children's Medical Center Corporation | Engineering of strong, pliable tissues |
| US6090618A (en) * | 1996-10-07 | 2000-07-18 | Arch Development Corporation | DNA constructs and viral vectors comprising a smooth muscle promoter |
| US5714359A (en) | 1995-10-12 | 1998-02-03 | The University Of Akron | Apparatus and method for electrostatic endothelial cell seeding in a vascular prosthesis |
| US6171344B1 (en) | 1996-08-16 | 2001-01-09 | Children's Medical Center Corporation | Bladder submucosa seeded with cells for tissue reconstruction |
| US5902336A (en) * | 1996-10-15 | 1999-05-11 | Mirimedical, Inc. | Implantable device and method for removing fluids from the blood of a patient method for implanting such a device and method for treating a patient experiencing renal failure |
| AU743779B2 (en) * | 1996-12-10 | 2002-02-07 | Cook Biotech, Inc. | Tubular grafts from purified submucosa |
| FR2759575B1 (fr) | 1997-02-14 | 1999-04-30 | Assist Publ Hopitaux De Paris | Implant artificiel destine au remplacement de l'appareil excreteur urinaire chez l'etre humain |
| CA2306346C (en) | 1997-07-03 | 2010-09-14 | Massachusetts Institute Of Technology | Tissue-engineered tubular construct having circumferentially oriented smooth muscle cells |
| US6142272A (en) * | 1997-08-26 | 2000-11-07 | Luk Getriebe-Systeme Gmbh | Hydrodynamic torque converter |
| CA2307567C (en) * | 1997-10-31 | 2009-01-20 | Children's Medical Center Corporation | Polymer matrix/cell construct for bladder reconstruction |
| AU1588099A (en) | 1997-11-17 | 1999-06-07 | Beth Israel Deaconess Medical Center | Hybrid tissues for tissue engineering |
| US6371992B1 (en) * | 1997-12-19 | 2002-04-16 | The Regents Of The University Of California | Acellular matrix grafts: preparation and use |
| US20030082152A1 (en) | 1999-03-10 | 2003-05-01 | Hedrick Marc H. | Adipose-derived stem cells and lattices |
| DE19912472B4 (de) | 1999-03-18 | 2011-03-17 | Wassermann, Helmut, Prof. | Künstliches Harnableitungssystem |
| US7131996B2 (en) | 1999-03-18 | 2006-11-07 | Helmut Wasserman | Artificial urinary diversion device |
| US6709465B2 (en) * | 1999-03-18 | 2004-03-23 | Fossa Medical, Inc. | Radially expanding ureteral device |
| US6503273B1 (en) | 1999-11-22 | 2003-01-07 | Cyograft Tissue Engineering, Inc. | Tissue engineered blood vessels and methods and apparatus for their manufacture |
| US6432712B1 (en) | 1999-11-22 | 2002-08-13 | Bioscience Consultants, Llc | Transplantable recellularized and reendothelialized vascular tissue graft |
| US6428802B1 (en) | 1999-12-29 | 2002-08-06 | Children's Medical Center Corp. | Preparing artificial organs by forming polylayers of different cell populations on a substrate |
| US6376244B1 (en) | 1999-12-29 | 2002-04-23 | Children's Medical Center Corporation | Methods and compositions for organ decellularization |
| US6866686B2 (en) * | 2000-01-28 | 2005-03-15 | Cryolife, Inc. | Tissue graft |
| AT411328B (de) * | 2000-07-12 | 2003-12-29 | Universitaetsklinikum Freiburg | Röhrensystem zur rekonstruktion einer harnröhre |
| KR20020094074A (ko) * | 2001-06-07 | 2002-12-18 | (주)에이치비메디컬스 | 체내 이식관 |
| NZ536563A (en) * | 2002-05-02 | 2008-03-28 | Purdue Research Foundation | Vascularization enhanced graft constructs |
| US7299805B2 (en) * | 2002-06-07 | 2007-11-27 | Marctec, Llc | Scaffold and method for implanting cells |
| US20040029266A1 (en) | 2002-08-09 | 2004-02-12 | Emilio Barbera-Guillem | Cell and tissue culture device |
| CN1194653C (zh) * | 2002-12-30 | 2005-03-30 | 中国中医研究院西苑医院 | 具有防治再狭窄药物涂层的体内腔管内支架及其制造方法 |
| US7182745B2 (en) * | 2003-03-25 | 2007-02-27 | Boston Scientific Scimed, Inc. | Retaining stent |
| GB0402103D0 (en) * | 2004-02-02 | 2004-03-03 | Hengelmolen Rudy | Tubular graft |
| AU2005219660B2 (en) * | 2004-03-09 | 2009-07-16 | Absorber Ab | Endothelial progenitor cells and methods of use thereof |
| CN101141933B (zh) * | 2004-03-10 | 2015-07-29 | 祥丰医疗有限公司 | 内皮配体结合涂覆的医疗装置 |
| US8425539B2 (en) * | 2004-04-12 | 2013-04-23 | Xlumena, Inc. | Luminal structure anchoring devices and methods |
| US9801527B2 (en) * | 2004-04-19 | 2017-10-31 | Gearbox, Llc | Lumen-traveling biological interface device |
| US7935096B2 (en) * | 2004-09-06 | 2011-05-03 | Ostomycure As | Percutaneous implant |
| US20060199265A1 (en) * | 2005-03-02 | 2006-09-07 | Wolf Michael F | Seeding implantable medical devices with cells |
| US7531503B2 (en) * | 2005-03-11 | 2009-05-12 | Wake Forest University Health Sciences | Cell scaffold matrices with incorporated therapeutic agents |
| US20080109058A1 (en) * | 2005-06-01 | 2008-05-08 | Cook Incorporated | Intraoperative Anastomosis Method |
| WO2007001992A2 (en) * | 2005-06-21 | 2007-01-04 | Regents Of The University Of Minnesota | Ureteral stent with axial and radial variability |
| US7531355B2 (en) | 2005-07-29 | 2009-05-12 | The Regents Of The University Of California | Methods and compositions for smooth muscle reconstruction |
| FR2890977A1 (fr) * | 2005-09-19 | 2007-03-23 | Assist Publ Hopitaux De Paris | Procede d'obtention de cellules musculaires lisses humaines et leurs applications |
| ITMI20051854A1 (it) * | 2005-10-03 | 2007-04-04 | Sambusseti Antonio | Patch per la sostituzione di una porzione di parete vescicale a seguito di vescitectomia parziale |
| JP4644786B2 (ja) * | 2005-10-18 | 2011-03-02 | 国立大学法人 東京医科歯科大学 | マイクロビーズの製造方法 |
| WO2007095192A2 (en) | 2006-02-10 | 2007-08-23 | Tengion Inc. | Bioreactor for organ reconstruction and augmentation |
| CA2641733C (en) * | 2006-02-10 | 2015-03-31 | Tengion, Inc. | Scaffolds for organ reconstruction and augmentation |
| US20080081323A1 (en) * | 2006-09-29 | 2008-04-03 | Daniel Keeley | Regenerative Medicine Devices and Melt-Blown Methods of Manufacture |
| EP2180906B1 (fr) * | 2007-08-31 | 2014-12-24 | Synolyne Pharma | Prothese destinee a promouvoir la reconstruction in vivo d'un organe creux ou d'une partie d'organe creux |
| US8992409B2 (en) * | 2007-10-11 | 2015-03-31 | Peter Forsell | Method for controlling flow in a bodily organ |
| CN101147810B (zh) * | 2007-11-01 | 2010-05-19 | 南昌大学第一附属医院 | 细胞-生物可降解材料复合物及其制备方法和应用 |
| EP2210248B1 (en) | 2007-11-13 | 2016-04-20 | Cook Medical Technologies LLC | Intraluminal bypass prosthesis |
| US20090254039A1 (en) * | 2007-12-21 | 2009-10-08 | O'brien Nicole Sams | Designer accessory for use with an intracorporeal medical device |
| KR101724639B1 (ko) * | 2008-11-04 | 2017-04-07 | 리젠메드 (케이만) 엘티디. | 세포-지지체 구조물 |
| US8192500B2 (en) * | 2008-12-12 | 2012-06-05 | Boston Scientific Scimed, Inc. | Ureteral stent |
| WO2010087769A1 (en) * | 2009-01-29 | 2010-08-05 | Milux Holding S.A | Implant comprising an expandable section |
| US8900116B2 (en) * | 2009-07-14 | 2014-12-02 | Stimatix Gi Ltd. | Inflatable stomal implant |
| CA3025090A1 (en) * | 2010-05-03 | 2011-11-10 | Inregen | Smooth muscle cell constructs |
| WO2012016575A1 (en) * | 2010-08-03 | 2012-02-09 | King Saud University | Stoma coat |
| US20120095483A1 (en) * | 2010-10-19 | 2012-04-19 | Allergan, Inc. | Anchored non-piercing duodenal sleeve and delivery systems |
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