JP6110037B2 - コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤 - Google Patents

コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤 Download PDF

Info

Publication number
JP6110037B2
JP6110037B2 JP2016533212A JP2016533212A JP6110037B2 JP 6110037 B2 JP6110037 B2 JP 6110037B2 JP 2016533212 A JP2016533212 A JP 2016533212A JP 2016533212 A JP2016533212 A JP 2016533212A JP 6110037 B2 JP6110037 B2 JP 6110037B2
Authority
JP
Japan
Prior art keywords
group
polyvalent amine
crosslinked
chondroitin sulfate
cross
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016533212A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2016114397A1 (ja
Inventor
奨 舩山
奨 舩山
梨紗 野寺
梨紗 野寺
貴弘 畠中
貴弘 畠中
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seikagaku Corp
Original Assignee
Seikagaku Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seikagaku Corp filed Critical Seikagaku Corp
Application granted granted Critical
Publication of JP6110037B2 publication Critical patent/JP6110037B2/ja
Publication of JPWO2016114397A1 publication Critical patent/JPWO2016114397A1/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/738—Cross-linked polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2016533212A 2015-01-16 2016-01-15 コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤 Active JP6110037B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2015007072 2015-01-16
JP2015007072 2015-01-16
JP2015150976 2015-07-30
JP2015150976 2015-07-30
PCT/JP2016/051176 WO2016114397A1 (ja) 2015-01-16 2016-01-15 コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017043621A Division JP6715201B2 (ja) 2015-01-16 2017-03-08 コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤

Publications (2)

Publication Number Publication Date
JP6110037B2 true JP6110037B2 (ja) 2017-04-05
JPWO2016114397A1 JPWO2016114397A1 (ja) 2017-04-27

Family

ID=56405937

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016533212A Active JP6110037B2 (ja) 2015-01-16 2016-01-15 コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤
JP2017043621A Active JP6715201B2 (ja) 2015-01-16 2017-03-08 コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017043621A Active JP6715201B2 (ja) 2015-01-16 2017-03-08 コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤

Country Status (5)

Country Link
US (3) US10420796B2 (https=)
EP (2) EP3831394B1 (https=)
JP (2) JP6110037B2 (https=)
ES (1) ES2938482T3 (https=)
WO (1) WO2016114397A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019060696A1 (en) 2017-09-25 2019-03-28 Surface Pharmaceuticals, Inc. OPTHALMIC PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR SURFACE DISEASE
CA3124945A1 (en) 2018-12-27 2020-07-02 Surface Ophthalmics, Inc. Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease
BR112022018535A2 (pt) * 2020-03-19 2022-11-29 Glycologix Inc Biomateriais de glicosaminoglicano sulfatado como miméticos de proteoglicanos
US12440510B2 (en) 2021-05-10 2025-10-14 Surface Ophthalmics, Inc. Use of chondroitin sulfate for relieving ocular pain
US12310981B2 (en) 2021-05-10 2025-05-27 Surface Ophthalmics, Inc. Use of chondroitin sulfate for relieving ocular pain
CN116687959B (zh) * 2022-05-18 2024-10-22 朱小丰 一种硫酸软骨素生物多胺复合物、其制备方法及用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863907A (en) * 1984-06-29 1989-09-05 Seikagaku Kogyo Co., Ltd. Crosslinked glycosaminoglycans and their use
US5527893A (en) 1987-09-18 1996-06-18 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
RU2113221C1 (ru) 1990-05-04 1998-06-20 Ииссум Рисерч Дивелопмент Компани оф дзе Хебрю Юниверсити оф Иеруcалим Фармацевтическая форма для введения лекарственного средства в ободочную кишку, способ введения лекарственного препарата и способ получения матриц для такой формы
IL98087A (en) 1990-05-04 1996-11-14 Perio Prod Ltd Preparation for dispensing drugs in the colon
JP2855307B2 (ja) 1992-02-05 1999-02-10 生化学工業株式会社 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法
JPH07223966A (ja) 1994-02-08 1995-08-22 Seiko Epson Corp 眼科用人工涙液
JP3059092B2 (ja) 1995-11-15 2000-07-04 田辺製薬株式会社 ドライアイおよびドライアイを原因とする疾患の予防・治療剤
IT1303738B1 (it) * 1998-11-11 2001-02-23 Aquisitio S P A Processo di reticolazione di polisaccaridi carbossilati.
JP3903475B2 (ja) * 1999-04-30 2007-04-11 ニプロ株式会社 乾性角膜症治療剤
CA2671572C (en) 2006-12-04 2015-05-26 Johns Hopkins University Imidated biopolymer adhesive and hydrogel
EP3040117A1 (en) * 2014-12-29 2016-07-06 Galderma S.A. Ether cross-linked chondroitin sulfate hydrogels and their use for soft tissue applications
WO2016107834A1 (en) * 2014-12-29 2016-07-07 Galderma S.A. Carboxyl cross-linked chondroitin hydrogels and their use for soft tissue applications

Also Published As

Publication number Publication date
ES2938482T3 (es) 2023-04-11
JPWO2016114397A1 (ja) 2017-04-27
WO2016114397A1 (ja) 2016-07-21
EP3831394B1 (en) 2022-12-21
US10420796B2 (en) 2019-09-24
EP3831394A1 (en) 2021-06-09
US20210052634A1 (en) 2021-02-25
JP6715201B2 (ja) 2020-07-01
US20190365796A1 (en) 2019-12-05
US20170368093A1 (en) 2017-12-28
EP3246037A4 (en) 2018-07-11
US11207345B2 (en) 2021-12-28
US10716804B2 (en) 2020-07-21
EP3246037A1 (en) 2017-11-22
JP2017125203A (ja) 2017-07-20

Similar Documents

Publication Publication Date Title
JP6110037B2 (ja) コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤
AU2023285850B2 (en) PTH prodrugs
Agibayeva et al. Gellan gum and its methacrylated derivatives as in situ gelling mucoadhesive formulations of pilocarpine: In vitro and in vivo studies
US8969319B2 (en) Agent for applying to mucosa and method for the production thereof
CN101631804B (zh) 由疏水性氨基酸官能化的葡聚糖
CN106456536A (zh) 水性眼用溶液和治疗干眼综合征的方法
CN1946743B (zh) 透明质酸/甲氨蝶呤化合物
JP5001645B2 (ja) ヒアルロン酸−メトトレキサート結合体
US20240390411A1 (en) Composition comprising glycosaminoglycan derivative and chemokine receptor activity regulator
JP2022044579A (ja) 点眼剤
US11376274B2 (en) Joint cavity injection preparation and use thereof
US20230018472A1 (en) Rhinenchysis composition containing olopatadine
JP6757731B2 (ja) 眼用デバイス適用剤
JP2017025016A (ja) 粘膜適用組成物
BR112017008353B1 (pt) Formulação termoesterilizada compreendendo quitosana e processo de preparação da mesma
HK1102481B (en) Hyaluronic acid/methotrexate compound

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160520

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160520

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20160520

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20160706

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160712

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160906

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161115

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170207

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170308

R150 Certificate of patent or registration of utility model

Ref document number: 6110037

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250