BR112022018535A2 - Biomateriais de glicosaminoglicano sulfatado como miméticos de proteoglicanos - Google Patents
Biomateriais de glicosaminoglicano sulfatado como miméticos de proteoglicanosInfo
- Publication number
- BR112022018535A2 BR112022018535A2 BR112022018535A BR112022018535A BR112022018535A2 BR 112022018535 A2 BR112022018535 A2 BR 112022018535A2 BR 112022018535 A BR112022018535 A BR 112022018535A BR 112022018535 A BR112022018535 A BR 112022018535A BR 112022018535 A2 BR112022018535 A2 BR 112022018535A2
- Authority
- BR
- Brazil
- Prior art keywords
- proteoglycan
- biomaterials
- mimetics
- sulfate glycosaminoglycan
- polymer conjugates
- Prior art date
Links
- 229920002683 Glycosaminoglycan Polymers 0.000 title abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 title abstract 2
- 239000012620 biological material Substances 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 abstract 3
- 102000016611 Proteoglycans Human genes 0.000 abstract 2
- 108010067787 Proteoglycans Proteins 0.000 abstract 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 abstract 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 abstract 1
- 238000001311 chemical methods and process Methods 0.000 abstract 1
- 210000002808 connective tissue Anatomy 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 210000002744 extracellular matrix Anatomy 0.000 abstract 1
- 210000004872 soft tissue Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
Abstract
BIOMATERIAIS DE GLICOSAMINOGLICANO SULFATADO COMO MIMÉTICOS DE PROTEOGLICANOS. São fornecidos conjugados de polímero que são capazes de imitar as funções de proteoglicanos naturais encontrados na matriz extracelular dos tecidos conjuntivos. Os conjugados de polímeros da invenção têm utilidade no tratamento de um indivíduo que sofre de condições degenerativas de tecidos moles. Também são fornecidos processos químicos simples e escaláveis para a preparação dos conjugados de polímeros da invenção.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062991804P | 2020-03-19 | 2020-03-19 | |
PCT/US2021/023133 WO2021188882A1 (en) | 2020-03-19 | 2021-03-19 | Sulfated glycosaminoglycan biomaterials as proteoglycan mimics |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022018535A2 true BR112022018535A2 (pt) | 2022-11-29 |
Family
ID=77747215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022018535A BR112022018535A2 (pt) | 2020-03-19 | 2021-03-19 | Biomateriais de glicosaminoglicano sulfatado como miméticos de proteoglicanos |
Country Status (10)
Country | Link |
---|---|
US (1) | US11911411B2 (pt) |
EP (1) | EP4121064A4 (pt) |
JP (1) | JP2023518382A (pt) |
KR (1) | KR20220156863A (pt) |
CN (1) | CN115697352A (pt) |
AU (1) | AU2021237704A1 (pt) |
BR (1) | BR112022018535A2 (pt) |
CA (1) | CA3171629A1 (pt) |
IL (1) | IL296548A (pt) |
WO (1) | WO2021188882A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117384246B (zh) * | 2023-12-11 | 2024-05-10 | 北京大学第三医院(北京大学第三临床医学院) | 一种多肽及含该多肽的水凝胶、其制备方法与应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7723057B1 (en) * | 1992-09-23 | 2010-05-25 | Proteotech, Inc. | Screening assay for macromolecules that inhibit binding of sulfated glycosaminoglycan to beta amyloid |
HU0700024D0 (en) * | 2007-01-11 | 2007-03-28 | Mta Szegedi Biolog Koezpont | Use of enhancers in biglycan activuty in the preparation of pharmaceutical compositions having utility in cardiac diseases |
US8912149B1 (en) * | 2007-11-28 | 2014-12-16 | California Institute Of Technology | Glycosaminoglycan mimetics |
US20130052155A1 (en) * | 2009-11-09 | 2013-02-28 | Drexel University | Compositions and Methods for Treating a Disorder or Defect in Soft Tissue |
WO2014172526A1 (en) * | 2013-04-18 | 2014-10-23 | Drexel University | Novel methods of use of biomimetic proteoglycans |
WO2015162287A1 (en) * | 2014-04-25 | 2015-10-29 | Phi Pharma Sa | Keratan sulfate specific transporter molecules |
WO2016033095A1 (en) * | 2014-08-26 | 2016-03-03 | Drexel University | Novel methods of preparing biomimetic proteoglycans |
EP3389674A4 (en) * | 2015-12-18 | 2019-09-11 | Tega Therapeutics, Inc. | CELLULAR GLYCOSAMINOGLYCAN COMPOSITIONS AND METHODS OF PREPARATION AND USE |
JP2019529645A (ja) * | 2016-09-16 | 2019-10-17 | グリコロジクス、エルエルシー | プロテオグリカン模倣物としての硫酸化グリコサミノグリカン生体材料 |
CN110845568B (zh) * | 2019-11-21 | 2023-06-09 | 山东大学 | 一种工程化组装蛋白聚糖及其制备方法和应用 |
-
2021
- 2021-03-19 US US17/206,643 patent/US11911411B2/en active Active
- 2021-03-19 CN CN202180034575.3A patent/CN115697352A/zh active Pending
- 2021-03-19 KR KR1020227035687A patent/KR20220156863A/ko unknown
- 2021-03-19 CA CA3171629A patent/CA3171629A1/en active Pending
- 2021-03-19 BR BR112022018535A patent/BR112022018535A2/pt not_active Application Discontinuation
- 2021-03-19 JP JP2022555864A patent/JP2023518382A/ja active Pending
- 2021-03-19 WO PCT/US2021/023133 patent/WO2021188882A1/en unknown
- 2021-03-19 EP EP21770686.0A patent/EP4121064A4/en active Pending
- 2021-03-19 AU AU2021237704A patent/AU2021237704A1/en active Pending
- 2021-03-19 IL IL296548A patent/IL296548A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2021188882A1 (en) | 2021-09-23 |
US20210290657A1 (en) | 2021-09-23 |
EP4121064A1 (en) | 2023-01-25 |
EP4121064A4 (en) | 2024-04-10 |
KR20220156863A (ko) | 2022-11-28 |
IL296548A (en) | 2022-11-01 |
JP2023518382A (ja) | 2023-05-01 |
CA3171629A1 (en) | 2021-09-23 |
AU2021237704A1 (en) | 2022-10-13 |
US11911411B2 (en) | 2024-02-27 |
CN115697352A (zh) | 2023-02-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing |