JP6100704B2 - 治療用抗体についてのインビボ試験の手段および方法 - Google Patents
治療用抗体についてのインビボ試験の手段および方法 Download PDFInfo
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
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- A61K49/0045—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
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- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
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- A—HUMAN NECESSITIES
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- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
- A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
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- Life Sciences & Earth Sciences (AREA)
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- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11001857.9 | 2011-03-07 | ||
| EP11001857 | 2011-03-07 | ||
| PCT/EP2012/053786 WO2012119999A1 (en) | 2011-03-07 | 2012-03-06 | Means and methods for in vivo testing of therapeutic antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014510075A JP2014510075A (ja) | 2014-04-24 |
| JP2014510075A5 JP2014510075A5 (OSRAM) | 2015-04-23 |
| JP6100704B2 true JP6100704B2 (ja) | 2017-03-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2013557068A Expired - Fee Related JP6100704B2 (ja) | 2011-03-07 | 2012-03-06 | 治療用抗体についてのインビボ試験の手段および方法 |
Country Status (4)
| Country | Link |
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| US (1) | US20140099264A1 (OSRAM) |
| EP (1) | EP2683290B1 (OSRAM) |
| JP (1) | JP6100704B2 (OSRAM) |
| WO (1) | WO2012119999A1 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6404687B2 (ja) * | 2014-11-21 | 2018-10-10 | 倉敷紡績株式会社 | 蛍光イメージング装置及び蛍光イメージング方法 |
| CA2992370A1 (en) * | 2015-04-06 | 2016-10-13 | University Of Miami | Imaging device and method for detection of disease |
| WO2017141987A1 (ja) * | 2016-02-19 | 2017-08-24 | コニカミノルタ株式会社 | 実験動物検体を定量評価することを特徴とする、非臨床試験方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| DE69233528T2 (de) | 1991-11-25 | 2006-03-16 | Enzon, Inc. | Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen |
| PT1621554E (pt) | 1992-08-21 | 2009-07-13 | Univ Bruxelles | Imunoglobtainas desprovidas de cadeias leves |
| KR100397020B1 (ko) | 1995-01-30 | 2004-04-29 | 다이이치 가가쿠 야쿠힝 가부시키가이샤 | 진단용마커 |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| JP2000515002A (ja) | 1996-06-27 | 2000-11-14 | フラームス・インテルウニフェルジテール・インスティテュート・フォール・ビオテヒノロジー・ヴェーゼットウェー | 標的分子の活性部位またはクレフトと特異的に相互作用する認識分子 |
| DE19717904A1 (de) | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| US6592847B1 (en) | 1998-05-14 | 2003-07-15 | The General Hospital Corporation | Intramolecularly-quenched near infrared flourescent probes |
| US6083486A (en) | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
| US6615063B1 (en) | 2000-11-27 | 2003-09-02 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
| EP1379284A4 (en) | 2001-01-05 | 2007-07-25 | Gen Hospital | ACTIVE IMAGING PROBES |
| US20030044353A1 (en) | 2001-01-05 | 2003-03-06 | Ralph Weissleder | Activatable imaging probes |
| US20060147378A1 (en) | 2002-09-24 | 2006-07-06 | Ching-Hsuan Tung | Azulene dimer-quenched, near-infrared fluorescent probes |
| EP2284192A3 (en) | 2002-11-08 | 2011-07-20 | Ablynx N.V. | Camelidae antibodies for sublingual administration |
| EP1558647B1 (en) | 2002-11-08 | 2015-06-10 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| EP1679082A1 (en) | 2005-01-07 | 2006-07-12 | Schering AG | Use of cyanine dyes for the diagnosis of proliferative diseases |
| WO2006107864A1 (en) | 2005-04-04 | 2006-10-12 | Blueshift Biotechnologies, Inc. | Screening using polarization anisotropy in fret emissions |
| WO2007067978A1 (en) | 2005-12-09 | 2007-06-14 | Invitrogen Corporation | Optical in vivo imaging contrast agents and methods of use |
| SG178789A1 (en) | 2007-02-16 | 2012-03-29 | Merrimack Pharmaceuticals Inc | Antibodies against erbb3 and uses thereof |
| JP5426026B2 (ja) | 2009-07-28 | 2014-02-26 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 非侵襲性インビボ光学イメージング方法 |
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2012
- 2012-03-06 US US13/261,731 patent/US20140099264A1/en not_active Abandoned
- 2012-03-06 WO PCT/EP2012/053786 patent/WO2012119999A1/en not_active Ceased
- 2012-03-06 JP JP2013557068A patent/JP6100704B2/ja not_active Expired - Fee Related
- 2012-03-06 EP EP12711586.3A patent/EP2683290B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| EP2683290B1 (en) | 2018-11-07 |
| JP2014510075A (ja) | 2014-04-24 |
| EP2683290A1 (en) | 2014-01-15 |
| WO2012119999A1 (en) | 2012-09-13 |
| US20140099264A1 (en) | 2014-04-10 |
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