JP6096219B2 - キナーゼ阻害剤として有用なトリアゾリルまたはトリアジアゾリル置換されたピリジル化合物 - Google Patents
キナーゼ阻害剤として有用なトリアゾリルまたはトリアジアゾリル置換されたピリジル化合物 Download PDFInfo
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- JP6096219B2 JP6096219B2 JP2014552318A JP2014552318A JP6096219B2 JP 6096219 B2 JP6096219 B2 JP 6096219B2 JP 2014552318 A JP2014552318 A JP 2014552318A JP 2014552318 A JP2014552318 A JP 2014552318A JP 6096219 B2 JP6096219 B2 JP 6096219B2
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- Prior art keywords
- substituted
- solvent
- alkyl
- acn
- isopropylamino
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- 0 CC(C)N(C)c1cc(Cl)ncc1-c1nnc(C(C*)NC(OC(C)(C)C)=O)[o]1 Chemical compound CC(C)N(C)c1cc(Cl)ncc1-c1nnc(C(C*)NC(OC(C)(C)C)=O)[o]1 0.000 description 3
- ADCPKYQVHGUMLV-UHFFFAOYSA-N CC(C)Nc(cc(Nc(cc1)ccc1C#N)nc1)c1-c1nnc(CN2CCOCC2)[o]1 Chemical compound CC(C)Nc(cc(Nc(cc1)ccc1C#N)nc1)c1-c1nnc(CN2CCOCC2)[o]1 ADCPKYQVHGUMLV-UHFFFAOYSA-N 0.000 description 1
- LLCWQJAAMHGDOS-UHFFFAOYSA-N CC(C)Nc(cc(Nc1cc2n[s]nc2cc1)nc1)c1-c1nc(C(NCCCO)=O)c(C)[o]1 Chemical compound CC(C)Nc(cc(Nc1cc2n[s]nc2cc1)nc1)c1-c1nc(C(NCCCO)=O)c(C)[o]1 LLCWQJAAMHGDOS-UHFFFAOYSA-N 0.000 description 1
- JSADXPHJQCCHLN-CYBMUJFWSA-N CC(C)Nc(cc(Nc1cc2n[s]nc2cc1)nc1)c1-c1nnc(C(N(CC2)C[C@@H]2O)=O)[s]1 Chemical compound CC(C)Nc(cc(Nc1cc2n[s]nc2cc1)nc1)c1-c1nnc(C(N(CC2)C[C@@H]2O)=O)[s]1 JSADXPHJQCCHLN-CYBMUJFWSA-N 0.000 description 1
- CKIAHGRDNIJUIU-UHFFFAOYSA-N CC(C)Nc(cc(Nc1ccc2nc[s]c2c1)nc1)c1-c1nc(C(N)=O)c[s]1 Chemical compound CC(C)Nc(cc(Nc1ccc2nc[s]c2c1)nc1)c1-c1nc(C(N)=O)c[s]1 CKIAHGRDNIJUIU-UHFFFAOYSA-N 0.000 description 1
- VMBPOOVXJLCULF-UHFFFAOYSA-N CC(C)Nc(cc(Nc1ccc2nc[s]c2c1)nc1)c1-c1nnc(NCCCO)[o]1 Chemical compound CC(C)Nc(cc(Nc1ccc2nc[s]c2c1)nc1)c1-c1nnc(NCCCO)[o]1 VMBPOOVXJLCULF-UHFFFAOYSA-N 0.000 description 1
- LXPRJDMMMSEHQG-UHFFFAOYSA-N CC(C)Nc1cc(Cl)ncc1-c1nc(C(O)=O)c(C)[s]1 Chemical compound CC(C)Nc1cc(Cl)ncc1-c1nc(C(O)=O)c(C)[s]1 LXPRJDMMMSEHQG-UHFFFAOYSA-N 0.000 description 1
- VXEZWQCQPCZXSG-UHFFFAOYSA-N CC(C)Nc1cc(Cl)ncc1-c1nnc(C(OC)=O)[o]1 Chemical compound CC(C)Nc1cc(Cl)ncc1-c1nnc(C(OC)=O)[o]1 VXEZWQCQPCZXSG-UHFFFAOYSA-N 0.000 description 1
- KXVDSEWWEHKHAD-UHFFFAOYSA-N CC(C)Nc1cc(Cl)ncc1C(NN)=O Chemical compound CC(C)Nc1cc(Cl)ncc1C(NN)=O KXVDSEWWEHKHAD-UHFFFAOYSA-N 0.000 description 1
- OYYXHUJLHDYELY-UHFFFAOYSA-N CC(C)Nc1cc(Nc2ccc3nc[s]c3c2)ncc1-c1nnc(C(N(CC2)CC2NC(C)=O)=O)[s]1 Chemical compound CC(C)Nc1cc(Nc2ccc3nc[s]c3c2)ncc1-c1nnc(C(N(CC2)CC2NC(C)=O)=O)[s]1 OYYXHUJLHDYELY-UHFFFAOYSA-N 0.000 description 1
- LJTFJXSYAAEBPV-UHFFFAOYSA-N CC(C)Nc1cc(Nc2ccc3nc[s]c3c2)ncc1-c1nnc(C(N)=O)[s]1 Chemical compound CC(C)Nc1cc(Nc2ccc3nc[s]c3c2)ncc1-c1nnc(C(N)=O)[s]1 LJTFJXSYAAEBPV-UHFFFAOYSA-N 0.000 description 1
- OUCNMRXAXYCFGZ-UHFFFAOYSA-N CCOC(c(cnc(Nc1ccc2nc[s]c2c1)c1)c1NC(C)C)=O Chemical compound CCOC(c(cnc(Nc1ccc2nc[s]c2c1)c1)c1NC(C)C)=O OUCNMRXAXYCFGZ-UHFFFAOYSA-N 0.000 description 1
- HVSPPCUUPKDYML-UHFFFAOYSA-N CCOC(c1c[s]c(-c(c(NC(C)C)c2)cnc2Cl)n1)=O Chemical compound CCOC(c1c[s]c(-c(c(NC(C)C)c2)cnc2Cl)n1)=O HVSPPCUUPKDYML-UHFFFAOYSA-N 0.000 description 1
- QCXDJIMFUUFHMN-UHFFFAOYSA-N CCOC(c1c[s]c(-c(c(NC(C)C)c2)cnc2Nc2ccc3nc[s]c3c2)n1)=O Chemical compound CCOC(c1c[s]c(-c(c(NC(C)C)c2)cnc2Nc2ccc3nc[s]c3c2)n1)=O QCXDJIMFUUFHMN-UHFFFAOYSA-N 0.000 description 1
- CQGBKJUMTILWPU-UHFFFAOYSA-N CCc1ccc2nc[s]c2c1 Chemical compound CCc1ccc2nc[s]c2c1 CQGBKJUMTILWPU-UHFFFAOYSA-N 0.000 description 1
- DMUYVIYISCGQSV-GOSISDBHSA-N CNC(c(cc1)ccc1Nc1cc(Nc(cc2)cc3c2nc[s]3)ncc1-c1nnc(C(N(CC2)C[C@@H]2O)=O)[s]1)=O Chemical compound CNC(c(cc1)ccc1Nc1cc(Nc(cc2)cc3c2nc[s]3)ncc1-c1nnc(C(N(CC2)C[C@@H]2O)=O)[s]1)=O DMUYVIYISCGQSV-GOSISDBHSA-N 0.000 description 1
- OZUKRPVWULHWIH-KNQAVFIVSA-N N#Cc(c(N[C@H]([C@@H](CO)O)c1ccccc1)c1)cnc1Nc(cc1)cc2c1nc[s]2 Chemical compound N#Cc(c(N[C@H]([C@@H](CO)O)c1ccccc1)c1)cnc1Nc(cc1)cc2c1nc[s]2 OZUKRPVWULHWIH-KNQAVFIVSA-N 0.000 description 1
- XHDVIHUULTYPEJ-UHFFFAOYSA-N OCC(CNC(c1c[s]c(-c(cnc(Nc2ccc3nc[s]c3c2)c2)c2NCC(CO)O)n1)=O)O Chemical compound OCC(CNC(c1c[s]c(-c(cnc(Nc2ccc3nc[s]c3c2)c2)c2NCC(CO)O)n1)=O)O XHDVIHUULTYPEJ-UHFFFAOYSA-N 0.000 description 1
- VQIWYSRHBWOODL-UHFFFAOYSA-N OCCCNc1nnc(-c(cnc(Nc2cc3n[o]nc3cc2)c2)c2NC(CCC2)C2F)[o]1 Chemical compound OCCCNc1nnc(-c(cnc(Nc2cc3n[o]nc3cc2)c2)c2NC(CCC2)C2F)[o]1 VQIWYSRHBWOODL-UHFFFAOYSA-N 0.000 description 1
- HFKDGJQLQUDCHV-KNQAVFIVSA-N OC[C@H]([C@H](c1ccccc1)Nc(cc(Nc(cc1)cc2c1nc[s]2)nc1)c1-c1ncn[nH]1)O Chemical compound OC[C@H]([C@H](c1ccccc1)Nc(cc(Nc(cc1)cc2c1nc[s]2)nc1)c1-c1ncn[nH]1)O HFKDGJQLQUDCHV-KNQAVFIVSA-N 0.000 description 1
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
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- Neurology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261586148P | 2012-01-13 | 2012-01-13 | |
| US61/586,148 | 2012-01-13 | ||
| PCT/US2013/021134 WO2013106641A1 (en) | 2012-01-13 | 2013-01-11 | Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015503622A JP2015503622A (ja) | 2015-02-02 |
| JP2015503622A5 JP2015503622A5 (https=) | 2016-02-12 |
| JP6096219B2 true JP6096219B2 (ja) | 2017-03-15 |
Family
ID=47595102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014552318A Expired - Fee Related JP6096219B2 (ja) | 2012-01-13 | 2013-01-11 | キナーゼ阻害剤として有用なトリアゾリルまたはトリアジアゾリル置換されたピリジル化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9242976B2 (https=) |
| EP (1) | EP2802579B1 (https=) |
| JP (1) | JP6096219B2 (https=) |
| CN (1) | CN104254533B (https=) |
| ES (1) | ES2575604T3 (https=) |
| WO (1) | WO2013106641A1 (https=) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2802576B1 (en) | 2012-01-13 | 2018-06-27 | Bristol-Myers Squibb Company | Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors |
| WO2014058685A1 (en) | 2012-10-08 | 2014-04-17 | Merck Sharp & Dohme Corp. | Inhibitors of irak4 activity |
| JP6215338B2 (ja) | 2012-11-08 | 2017-10-18 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | キナーゼモジュレーターとして有用な二環式ヘテロ環置換ピリジル化合物 |
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