JP6089106B2 - 核酸を用いた情報記憶方法 - Google Patents

核酸を用いた情報記憶方法 Download PDF

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JP6089106B2
JP6089106B2 JP2015523204A JP2015523204A JP6089106B2 JP 6089106 B2 JP6089106 B2 JP 6089106B2 JP 2015523204 A JP2015523204 A JP 2015523204A JP 2015523204 A JP2015523204 A JP 2015523204A JP 6089106 B2 JP6089106 B2 JP 6089106B2
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oligonucleotide
information
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JP2015533077A (ja
JP2015533077A5 (https=
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ジョージ エム． チャーチ、
ジョージ エム． チャーチ、
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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K19/00—Record carriers for use with machines and with at least a part designed to carry digital markings
    • G06K19/02—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the selection of materials, e.g. to avoid wear during transport through the machine
    • G06K19/022—Processes or apparatus therefor
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K19/00—Record carriers for use with machines and with at least a part designed to carry digital markings
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/12—Computing arrangements based on biological models using genetic models
    • G06N3/123—DNA computing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/20—Sequence assembly

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  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Artificial Intelligence (AREA)
  • Biomedical Technology (AREA)
  • Data Mining & Analysis (AREA)
  • Computing Systems (AREA)
  • Computational Linguistics (AREA)
  • Mathematical Physics (AREA)
  • Software Systems (AREA)
  • Evolutionary Computation (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2015523204A 2012-07-19 2013-07-17 核酸を用いた情報記憶方法 Active JP6089106B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261673690P 2012-07-19 2012-07-19
US61/673,690 2012-07-19
US201261676081P 2012-07-26 2012-07-26
US61/676,081 2012-07-26
PCT/US2013/050815 WO2014014991A2 (en) 2012-07-19 2013-07-17 Methods of storing information using nucleic acids

Publications (3)

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JP2015533077A JP2015533077A (ja) 2015-11-19
JP2015533077A5 JP2015533077A5 (https=) 2016-06-30
JP6089106B2 true JP6089106B2 (ja) 2017-03-01

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US (6) US9384320B2 (https=)
EP (1) EP2875458A2 (https=)
JP (1) JP6089106B2 (https=)
KR (1) KR101743846B1 (https=)
CN (2) CN108875312A (https=)
AU (1) AU2013292709B2 (https=)
CA (1) CA2878042C (https=)
IN (1) IN2015DN01001A (https=)
WO (1) WO2014014991A2 (https=)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES3028417T3 (en) 2012-06-01 2025-06-19 European Molecular Biology Laboratory High-capacity storage of digital information in dna
EP2875458A2 (en) 2012-07-19 2015-05-27 President and Fellows of Harvard College Methods of storing information using nucleic acids
SG11201600853UA (en) 2013-08-05 2016-03-30 Twist Bioscience Corp De novo synthesized gene libraries
WO2015089238A1 (en) 2013-12-11 2015-06-18 Genapsys, Inc. Systems and methods for biological analysis and computation
US10669304B2 (en) 2015-02-04 2020-06-02 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
US11164661B2 (en) 2015-04-10 2021-11-02 University Of Washington Integrated system for nucleic acid-based storage and retrieval of digital data using keys
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
EP3098742A1 (en) * 2015-05-26 2016-11-30 Thomson Licensing Method and apparatus for creating a plurality of oligos with a targeted distribution of nucleotide types
US10423341B1 (en) * 2015-06-12 2019-09-24 Bahram Ghaffarzadeh Kermani Accurate and efficient DNA-based storage of electronic data
JP6920275B2 (ja) * 2015-07-13 2021-08-18 プレジデント アンド フェローズ オブ ハーバード カレッジ 核酸を用いた回収可能な情報記憶のための方法
CA3176469A1 (en) * 2015-07-27 2017-02-02 Illumina, Inc. Spatial mapping of nucleic acid sequence information
EP3350314A4 (en) 2015-09-18 2019-02-06 Twist Bioscience Corporation OLIGONUCLEIC ACID VARIANT LIBRARIES VARIANT AND SYNTHESIS THEREOF
KR102794025B1 (ko) 2015-09-22 2025-04-09 트위스트 바이오사이언스 코포레이션 핵산 합성을 위한 가요성 기판
EP3163512A1 (en) * 2015-10-30 2017-05-03 Thomson Licensing Data processing apparatus and method for recovering a correct code symbol sequence from multiple incorrect copies
US10566077B1 (en) 2015-11-19 2020-02-18 The Board Of Trustees Of The University Of Illinois Re-writable DNA-based digital storage with random access
EP3173961A1 (en) * 2015-11-27 2017-05-31 Thomson Licensing Method for storing user data and decoding information in synthesized oligos, apparatus and substance
CN115920796A (zh) 2015-12-01 2023-04-07 特韦斯特生物科学公司 功能化表面及其制备
US10640822B2 (en) 2016-02-29 2020-05-05 Iridia, Inc. Systems and methods for writing, reading, and controlling data stored in a polymer
US10859562B2 (en) 2016-02-29 2020-12-08 Iridia, Inc. Methods, compositions, and devices for information storage
US10438662B2 (en) 2016-02-29 2019-10-08 Iridia, Inc. Methods, compositions, and devices for information storage
US20170253871A1 (en) * 2016-03-04 2017-09-07 University-Industry Foundation, Yonsei University Method of preparing oligonucleotide pool using one oligonucleotide
US20190102515A1 (en) * 2016-03-08 2019-04-04 Thomson Licensing Method and device for decoding data segments derived from oligonucleotides and related sequencer
US10883140B2 (en) 2016-04-21 2021-01-05 President And Fellows Of Harvard College Method and system of nanopore-based information encoding
WO2017189794A1 (en) * 2016-04-27 2017-11-02 President And Fellows Of Harvard College Method of secure communication via nucleotide polymers
US10892034B2 (en) 2016-07-01 2021-01-12 Microsoft Technology Licensing, Llc Use of homology direct repair to record timing of a molecular event
US11359234B2 (en) 2016-07-01 2022-06-14 Microsoft Technology Licensing, Llc Barcoding sequences for identification of gene expression
ES2817973T3 (es) 2016-07-01 2021-04-08 Microsoft Technology Licensing Llc Almacenamiento a través de la edición iterativa del ADN
EP3500672A4 (en) 2016-08-22 2020-05-20 Twist Bioscience Corporation DE NOVO SYNTHETIZED NUCLEIC ACID LIBRARIES
CN107798219B (zh) * 2016-08-30 2021-07-13 清华大学 将数据进行生物存储并还原的方法
US20180068059A1 (en) * 2016-09-08 2018-03-08 Sap Se Malicious sequence detection for gene synthesizers
US10417457B2 (en) * 2016-09-21 2019-09-17 Twist Bioscience Corporation Nucleic acid based data storage
US10370246B1 (en) * 2016-10-20 2019-08-06 The Board Of Trustees Of The University Of Illinois Portable and low-error DNA-based data storage
IL266197B2 (en) 2016-10-24 2024-03-01 Geneinfosec Inc Hiding information contained within nucleic acids
GB2563105B (en) * 2016-11-16 2022-10-19 Catalog Tech Inc Nucleic acid-based data storage
US10650312B2 (en) 2016-11-16 2020-05-12 Catalog Technologies, Inc. Nucleic acid-based data storage
US11783918B2 (en) 2016-11-30 2023-10-10 Microsoft Technology Licensing, Llc DNA random access storage system via ligation
GB2573069A (en) 2016-12-16 2019-10-23 Twist Bioscience Corp Variant libraries of the immunological synapse and synthesis thereof
US10839948B2 (en) 2016-12-29 2020-11-17 Intel Corporation Microfluidic information-encoding polymer data storage
US10793897B2 (en) 2017-02-08 2020-10-06 Microsoft Technology Licensing, Llc Primer and payload design for retrieval of stored polynucleotides
CN106845158A (zh) * 2017-02-17 2017-06-13 苏州泓迅生物科技股份有限公司 一种利用dna进行信息存储的方法
EP4556433A3 (en) * 2017-02-22 2025-08-06 Twist Bioscience Corporation Nucleic acid based data storage
US10774379B2 (en) 2017-03-15 2020-09-15 Microsoft Technology Licensing, Llc Random access of data encoded by polynucleotides
WO2018170169A1 (en) 2017-03-15 2018-09-20 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
US12227775B2 (en) 2017-05-22 2025-02-18 The Charles Stark Draper Laboratory, Inc. Modified template-independent DNA polymerase
US11612873B2 (en) * 2017-05-31 2023-03-28 Molecular Assemblies, Inc. Homopolymer encoded nucleic acid memory
WO2018222853A1 (en) * 2017-05-31 2018-12-06 Molecular Assemblies, Inc. Homopolymer encoded nucleic acid memory
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
WO2018231872A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
CN109300508B (zh) * 2017-07-25 2020-08-11 南京金斯瑞生物科技有限公司 一种dna数据存储编码解码方法
US11407837B2 (en) 2017-09-11 2022-08-09 Twist Bioscience Corporation GPCR binding proteins and synthesis thereof
US11538554B1 (en) 2017-09-19 2022-12-27 The Board Of Trustees Of The Univ Of Illinois Nick-based data storage in native nucleic acids
EP3694990A4 (en) * 2017-10-10 2022-06-15 Roswell Biotechnologies, Inc. METHODS, DEVICE AND SYSTEMS FOR AMPLIFICATION-FREE DNA DATA STORAGE
CN111565834B (zh) 2017-10-20 2022-08-26 特韦斯特生物科学公司 用于多核苷酸合成的加热的纳米孔
CN111279422B (zh) * 2017-10-25 2023-12-22 深圳华大生命科学研究院 编码/解码方法、编码/解码器和存储方法、装置
WO2019081145A1 (en) 2017-10-27 2019-05-02 Eth Zurich ENCODING AND DECODING INFORMATION IN SYNTHETIC DNA WITH CRYPTOGRAPHIC KEYS GENERATED BASED ON POLYMORPHIC CHARACTERISTICS OF NUCLEIC ACIDS
EP3506135A1 (en) 2017-12-29 2019-07-03 IMEC vzw Method for writing data
KR102804057B1 (ko) 2018-01-04 2025-05-07 트위스트 바이오사이언스 코포레이션 Dna 기반 디지털 정보 저장
AU2019236289B2 (en) 2018-03-16 2024-12-05 Catalog Technologies, Inc. Chemical methods for nucleic acid-based data storage
EP3542903A1 (en) * 2018-03-22 2019-09-25 IMEC vzw Memory writing
KR102138864B1 (ko) 2018-04-11 2020-07-28 경희대학교 산학협력단 Dna 디지털 데이터 저장 장치 및 저장 방법, 그리고 디코딩 방법
WO2019196439A1 (en) * 2018-04-13 2019-10-17 The Hong Kong Polytechnic University Data storage using peptides
JP7585046B2 (ja) 2018-05-16 2024-11-18 カタログ テクノロジーズ， インコーポレイテッド 核酸ベースのデータ記憶のための組成物および方法
WO2019222650A1 (en) * 2018-05-17 2019-11-21 The Charles Stark Draper Laboratory, Inc. Apparatus for high density information storage in molecular chains
CA3100739A1 (en) 2018-05-18 2019-11-21 Twist Bioscience Corporation Polynucleotides, reagents, and methods for nucleic acid hybridization
US11531934B2 (en) * 2018-05-31 2022-12-20 Kyndryl, Inc. Machine learning (ML) modeling by DNA computing
CA3102468A1 (en) 2018-06-07 2019-12-12 Vib Vzw A method of storing information using dna molecules
US11093547B2 (en) * 2018-06-19 2021-08-17 Intel Corporation Data storage based on encoded DNA sequences
EP3826762A1 (en) * 2018-07-23 2021-06-02 DNA Script Massively parallel enzymatic synthesis of nucleic acid strands
US11854669B1 (en) 2018-07-30 2023-12-26 National Technology & Engineering Solutions Of Sandia, Llc Synthetic nucleic acids for information storage and transmission
AU2019315604B2 (en) 2018-08-03 2025-04-17 Catolog Technologies, Inc Systems and methods for storing and reading nucleic acid-based data with error protection
WO2020041570A1 (en) * 2018-08-22 2020-02-27 Massachusetts Institute Of Technology In vitro dna writing for information storage
US11017170B2 (en) * 2018-09-27 2021-05-25 At&T Intellectual Property I, L.P. Encoding and storing text using DNA sequences
EP3856958A2 (en) 2018-09-28 2021-08-04 President and Fellows of Harvard College Storage of information using mixtures of molecules
CN109460822B (zh) * 2018-11-19 2021-11-12 天津大学 基于dna的信息存储方法
EP3904527A4 (en) * 2018-12-26 2022-08-10 BGI Shenzhen METHOD AND DEVICE FOR FIXED POINT EDITING OF A NUCLEO TIDE SEQUENCE STORED WITH DATA
WO2020139871A1 (en) 2018-12-26 2020-07-02 Twist Bioscience Corporation Highly accurate de novo polynucleotide synthesis
CN113766930B (zh) 2019-02-26 2025-07-22 特韦斯特生物科学公司 Glp1受体的变异核酸文库
JP2022522668A (ja) 2019-02-26 2022-04-20 ツイスト バイオサイエンス コーポレーション 抗体を最適化するための変異体核酸ライブラリ
WO2020219853A1 (en) * 2019-04-24 2020-10-29 Molecular Assemblies, Inc. Homopolymer encoded nucleic acid memory
CA3139819A1 (en) 2019-05-09 2020-11-12 Catalog Technologies, Inc. Data structures and operations for searching, computing, and indexing in dna-based data storage
GB201907460D0 (en) 2019-05-27 2019-07-10 Vib Vzw A method of storing information in pools of nucleic acid molecules
US11332738B2 (en) 2019-06-21 2022-05-17 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
US11066661B2 (en) 2019-08-20 2021-07-20 Seagate Technology Llc Methods of gene assembly and their use in DNA data storage
WO2021041667A1 (en) 2019-08-27 2021-03-04 President And Fellows Of Harvard College Modifying messages stored in mixtures of molecules using thin-layer chromatography
US12260937B2 (en) * 2019-09-05 2025-03-25 Microsoft Technology Licensing, Llc Reverse concatenation of error-correcting codes in DNA data storage
EP4034566A4 (en) 2019-09-23 2024-01-24 Twist Bioscience Corporation VARIANT NUCLEIC ACID BANKS FOR CRTH2
JP2022548783A (ja) 2019-09-23 2022-11-21 ツイスト バイオサイエンス コーポレーション 単一ドメイン抗体のバリアント核酸ライブラリー
WO2021062220A1 (en) * 2019-09-27 2021-04-01 President And Fellows Of Harvard College Storage of information using mixtures of molecules
JP7726874B2 (ja) 2019-10-11 2025-08-20 カタログ テクノロジーズ， インコーポレイテッド 核酸セキュリティーおよび認証
US12380337B2 (en) 2019-10-24 2025-08-05 The Board Of Trustees Of The University Of Illinois Coded trace reconstruction
BR112022011235A2 (pt) 2019-12-09 2022-12-13 Twist Bioscience Corp Bibliotecas de variantes de ácido nucleico para receptores de adenosina
US11755640B2 (en) * 2019-12-20 2023-09-12 The Board Of Trustees Of The University Of Illinois DNA-based image storage and retrieval
CN111489791B (zh) * 2020-04-07 2023-05-26 中国科学院重庆绿色智能技术研究院 固态纳米孔高密度编码dna数字存储读取方法
WO2021231493A1 (en) 2020-05-11 2021-11-18 Catalog Technologies, Inc. Programs and functions in dna-based data storage
EP4179112A4 (en) * 2020-07-13 2024-11-20 The Board of Trustees of the Leland Stanford Junior University Systems and methods to assess rna stability
US11837302B1 (en) 2020-08-07 2023-12-05 Iridia, Inc. Systems and methods for writing and reading data stored in a polymer using nano-channels
EP4204015A4 (en) 2020-08-31 2025-01-01 The Board of Trustees of the Leland Stanford Junior University Systems and methods for producing rna constructs with increased translation and stability
CN112079893B (zh) * 2020-09-23 2022-05-03 南京原码科技合伙企业(有限合伙) 一种基于固相化学合成法合成dna存储所需文本的方法
US11990184B2 (en) 2020-09-24 2024-05-21 Seagate Technology Llc DNA backbone editing for DNA data storage
CN112288089B (zh) * 2020-09-28 2022-12-20 清华大学 阵列式核酸信息存储方法及装置
US11823066B2 (en) 2021-05-28 2023-11-21 Bank Of America Corporation Enterprise market volatility predictions through synthetic DNA and mutant nucleotides
US11823065B2 (en) 2021-05-28 2023-11-21 Bank Of America Corporation Enterprise market volatility predictions through synthetic DNA and mutant nucleotides
US11823064B2 (en) 2021-05-28 2023-11-21 Bank Of America Corporation Enterprise market volatility prediction through synthetic DNA and mutant nucleotides
WO2024076044A1 (ko) * 2022-10-06 2024-04-11 이근우 Dna 인코딩 및 디코딩 방법 및 장치
US12587274B2 (en) 2023-03-28 2026-03-24 Quantum Generative Materials Llc Satellite optimization management system based on natural language input and artificial intelligence
CN116597901A (zh) * 2023-05-22 2023-08-15 清华大学深圳国际研究生院 一种基于调制作用的dna信息编解码方法
US12406750B2 (en) * 2023-08-31 2025-09-02 Lenovo (Singapore) Pte. Ltd. Encoding digital data using oligonucleotides
US12368503B2 (en) 2023-12-27 2025-07-22 Quantum Generative Materials Llc Intent-based satellite transmit management based on preexisting historical location and machine learning
US12603701B2 (en) 2023-12-27 2026-04-14 Quantum Generative Materials Llc Distributed satellite constellation management and control system

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US575034A (en) 1897-01-12 Charles nicolas leroy
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
JPH0672011B2 (ja) 1985-09-20 1994-09-14 東ソー株式会社 合成モルデナイト成形体の製造方法
US4959463A (en) 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
US4659774A (en) 1985-11-01 1987-04-21 American Hoechst Corporation Support for solid-phase oligonucleotide synthesis
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5602244A (en) 1988-05-26 1997-02-11 Competitive Technologies, Inc. Polynucleotide phosphorodithioate compounds
US5168038A (en) 1988-06-17 1992-12-01 The Board Of Trustees Of The Leland Stanford Junior University In situ transcription in cells and tissues
ATE142272T1 (de) 1989-01-19 1996-09-15 Behringwerke Ag Nukleinsäure-amplifikation unter verwendung eines einzelprimers
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5141813A (en) 1989-08-28 1992-08-25 Clontech Laboratories, Inc. Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5612199A (en) 1991-10-11 1997-03-18 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
US5428148A (en) 1992-04-24 1995-06-27 Beckman Instruments, Inc. N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
US6294323B1 (en) 1993-04-14 2001-09-25 Behringwerke Ag Self initiating single primer amplification of nucleic acids
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5574146A (en) 1994-08-30 1996-11-12 Beckman Instruments, Inc. Oligonucleotide synthesis with substituted aryl carboxylic acids as activators
US5554744A (en) 1994-09-23 1996-09-10 Hybridon, Inc. Method for loading solid supports for nucleic acid synthesis
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US6261797B1 (en) 1996-01-29 2001-07-17 Stratagene Primer-mediated polynucleotide synthesis and manipulation techniques
US5917031A (en) * 1996-04-19 1999-06-29 Taiko Pharmaceutical Co., Ltd. Method of synthesizing polydeoxyribonucleotides
JP4540754B2 (ja) 1996-06-04 2010-09-08 ユニバーシティ オブ ユタ リサーチ ファウンデーション Ｐｃｒ中のハイブリダイゼーションのモニタリング
JPH10253701A (ja) 1997-03-10 1998-09-25 Mitsubishi Electric Corp 半導体試験装置
JP2001519538A (ja) 1997-10-10 2001-10-23 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ 核酸アレイのレプリカ増幅
WO1999041007A2 (en) 1998-02-11 1999-08-19 University Of Houston Method and apparatus for chemical and biochemical reactions using photo-generated reagents
US6375903B1 (en) 1998-02-23 2002-04-23 Wisconsin Alumni Research Foundation Method and apparatus for synthesis of arrays of DNA probes
DE19813317A1 (de) 1998-03-26 1999-09-30 Roche Diagnostics Gmbh Verbessertes Verfahren zur Primer Extension Präamplifikations-PCR
US6391544B1 (en) 1998-05-15 2002-05-21 Abbott Laboratories Method for using unequal primer concentrations for generating nucleic acid amplification products
US6824866B1 (en) 1999-04-08 2004-11-30 Affymetrix, Inc. Porous silica substrates for polymer synthesis and assays
WO2000068431A2 (en) * 1999-05-06 2000-11-16 Mount Sinai School Of Medicine Of New York University Dna-based steganography
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6800439B1 (en) 2000-01-06 2004-10-05 Affymetrix, Inc. Methods for improved array preparation
US6833450B1 (en) 2000-03-17 2004-12-21 Affymetrix, Inc. Phosphite ester oxidation in nucleic acid array preparation
US6966945B1 (en) 2000-09-20 2005-11-22 Goodrich Corporation Inorganic matrix compositions, composites and process of making the same
CN100404692C (zh) * 2001-05-11 2008-07-23 松下电器产业株式会社 生物分子基底,使用它的检验和诊断方法及装置
CA2447240C (en) 2001-05-18 2013-02-19 Wisconsin Alumni Research Foundation Method for the synthesis of dna sequences
WO2003025123A2 (en) * 2001-08-28 2003-03-27 Mount Sinai School Of Medecine Dna: a medium for long-term information storage specification
US20030087298A1 (en) 2001-11-02 2003-05-08 Roland Green Detection of hybridization on oligonucleotide microarray through covalently labeling microarray probe
US20030099952A1 (en) 2001-11-26 2003-05-29 Roland Green Microarrays with visible pattern detection
GB0201966D0 (en) 2002-01-29 2002-03-13 Smartwater Ltd Improvements in or relating to security products
US7157229B2 (en) 2002-01-31 2007-01-02 Nimblegen Systems, Inc. Prepatterned substrate for optical synthesis of DNA probes
US20040126757A1 (en) 2002-01-31 2004-07-01 Francesco Cerrina Method and apparatus for synthesis of arrays of DNA probes
US7037659B2 (en) 2002-01-31 2006-05-02 Nimblegen Systems Inc. Apparatus for constructing DNA probes having a prismatic and kaleidoscopic light homogenizer
US7422851B2 (en) 2002-01-31 2008-09-09 Nimblegen Systems, Inc. Correction for illumination non-uniformity during the synthesis of arrays of oligomers
US7083975B2 (en) 2002-02-01 2006-08-01 Roland Green Microarray synthesis instrument and method
US20030228611A1 (en) 2002-05-01 2003-12-11 President And Fellows Of Harvard College Nucleic acid memory device
US20040060987A1 (en) * 2002-05-07 2004-04-01 Green Larry R. Digital image analysis method for enhanced and optimized signals in fluorophore detection
EP1546378B1 (en) 2002-05-24 2011-06-22 Roche NimbleGen, Inc. Microarrays and method for running hybridization reaction for multiple samples on a single microarray
US20040001371A1 (en) 2002-06-26 2004-01-01 The Arizona Board Of Regents On Behalf Of The University Of Arizona Information storage and retrieval device using macromolecules as storage media
US7158892B2 (en) 2002-06-28 2007-01-02 International Business Machines Corporation Genomic messaging system
US7498176B2 (en) 2002-09-27 2009-03-03 Roche Nimblegen, Inc. Microarray with hydrophobic barriers
US7482170B2 (en) 2002-09-30 2009-01-27 Roche Nimblegen, Inc. Parallel loading of arrays
WO2004031351A2 (en) 2002-10-01 2004-04-15 Nimblegen Systems, Inc. Microarrays having multiple oligonucleotides in single array features
JP4102157B2 (ja) 2002-10-17 2008-06-18 正幸 園部 生体高分子を通信媒体もしくは記録媒体とした、情報通信方法、情報記録方法、エンコーダおよびデコーダ
US20050053968A1 (en) * 2003-03-31 2005-03-10 Council Of Scientific And Industrial Research Method for storing information in DNA
US7628096B2 (en) 2004-03-25 2009-12-08 Teleflex Corporated Pedal mount assembly
CA2570171A1 (en) 2004-06-09 2005-12-29 Alexander Sunguroff Methods of making nanotechnological and macromolecular biomimetic structures
US8458475B2 (en) * 2005-06-20 2013-06-04 Authentiform Technologies, L.L.C. Systems and methods for product authentication
US7874489B2 (en) * 2005-06-20 2011-01-25 Authentiform Technologies, Llc Product authentication
US20070113137A1 (en) 2005-10-22 2007-05-17 Ho Seung Ryu Error Correction in Binary-encoded DNA Using Linear Feedback Shift Registers
CN101495654A (zh) 2006-04-19 2009-07-29 阿普里拉股份有限公司 无凝胶珠基测序的试剂、方法和文库
DK2171088T3 (en) 2007-06-19 2016-01-25 Stratos Genomics Inc Nucleic acid sequencing in a high yield by expansion
JP2010539982A (ja) 2007-10-01 2010-12-24 アプライド バイオシステムズ， エルエルシー チェイスライゲーション配列決定法
DE102007057802B3 (de) * 2007-11-30 2009-06-10 Geneart Ag Steganographische Einbettung von Informationen in kodierenden Genen
US20110003701A1 (en) * 2008-02-27 2011-01-06 454 Life Sciences Corporation System and method for improved processing of nucleic acids for production of sequencable libraries
ES3028417T3 (en) 2012-06-01 2025-06-19 European Molecular Biology Laboratory High-capacity storage of digital information in dna
EP2875458A2 (en) 2012-07-19 2015-05-27 President and Fellows of Harvard College Methods of storing information using nucleic acids

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