JP6089106B2 - 核酸を用いた情報記憶方法 - Google Patents

核酸を用いた情報記憶方法 Download PDF

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JP6089106B2
JP6089106B2 JP2015523204A JP2015523204A JP6089106B2 JP 6089106 B2 JP6089106 B2 JP 6089106B2 JP 2015523204 A JP2015523204 A JP 2015523204A JP 2015523204 A JP2015523204 A JP 2015523204A JP 6089106 B2 JP6089106 B2 JP 6089106B2
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information
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ジョージ エム. チャーチ、
ジョージ エム. チャーチ、
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    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06KGRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K19/00Record carriers for use with machines and with at least a part designed to carry digital markings
    • G06K19/02Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the selection of materials, e.g. to avoid wear during transport through the machine
    • G06K19/022Processes or apparatus therefor
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06KGRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K19/00Record carriers for use with machines and with at least a part designed to carry digital markings
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/12Computing arrangements based on biological models using genetic models
    • G06N3/123DNA computing
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/20Sequence assembly

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  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Artificial Intelligence (AREA)
  • Biomedical Technology (AREA)
  • Data Mining & Analysis (AREA)
  • Computing Systems (AREA)
  • Computational Linguistics (AREA)
  • Mathematical Physics (AREA)
  • Software Systems (AREA)
  • Evolutionary Computation (AREA)
  • Wood Science & Technology (AREA)
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  • Immunology (AREA)
  • Biochemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2015523204A 2012-07-19 2013-07-17 核酸を用いた情報記憶方法 Active JP6089106B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261673690P 2012-07-19 2012-07-19
US61/673,690 2012-07-19
US201261676081P 2012-07-26 2012-07-26
US61/676,081 2012-07-26
PCT/US2013/050815 WO2014014991A2 (en) 2012-07-19 2013-07-17 Methods of storing information using nucleic acids

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JP2015533077A JP2015533077A (ja) 2015-11-19
JP2015533077A5 JP2015533077A5 (https=) 2016-06-30
JP6089106B2 true JP6089106B2 (ja) 2017-03-01

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US (6) US9384320B2 (https=)
EP (1) EP2875458A2 (https=)
JP (1) JP6089106B2 (https=)
KR (1) KR101743846B1 (https=)
CN (2) CN108875312A (https=)
AU (1) AU2013292709B2 (https=)
CA (1) CA2878042C (https=)
IN (1) IN2015DN01001A (https=)
WO (1) WO2014014991A2 (https=)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3346404B1 (en) 2012-06-01 2025-04-02 European Molecular Biology Laboratory High-capacity storage of digital information in dna
CN108875312A (zh) 2012-07-19 2018-11-23 哈佛大学校长及研究员协会 利用核酸存储信息的方法
TWI707038B (zh) 2013-08-05 2020-10-11 美商扭轉生物科技有限公司 重新合成之基因庫
WO2015089238A1 (en) 2013-12-11 2015-06-18 Genapsys, Inc. Systems and methods for biological analysis and computation
WO2016126882A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
WO2016164779A1 (en) * 2015-04-10 2016-10-13 University Of Washington Integrated system for nucleic acid-based storage of digital data
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
EP3098742A1 (en) * 2015-05-26 2016-11-30 Thomson Licensing Method and apparatus for creating a plurality of oligos with a targeted distribution of nucleotide types
US10423341B1 (en) * 2015-06-12 2019-09-24 Bahram Ghaffarzadeh Kermani Accurate and efficient DNA-based storage of electronic data
EP3322812B1 (en) 2015-07-13 2022-05-18 President and Fellows of Harvard College Methods for retrievable information storage using nucleic acids
ES2888626T3 (es) * 2015-07-27 2022-01-05 Illumina Inc Cartografiado espacial de información de secuencia de ácidos nucleicos
KR20180050411A (ko) 2015-09-18 2018-05-14 트위스트 바이오사이언스 코포레이션 올리고핵산 변이체 라이브러리 및 그의 합성
KR102794025B1 (ko) 2015-09-22 2025-04-09 트위스트 바이오사이언스 코포레이션 핵산 합성을 위한 가요성 기판
EP3163512A1 (en) * 2015-10-30 2017-05-03 Thomson Licensing Data processing apparatus and method for recovering a correct code symbol sequence from multiple incorrect copies
US10566077B1 (en) 2015-11-19 2020-02-18 The Board Of Trustees Of The University Of Illinois Re-writable DNA-based digital storage with random access
EP3173961A1 (en) * 2015-11-27 2017-05-31 Thomson Licensing Method for storing user data and decoding information in synthesized oligos, apparatus and substance
CN115920796A (zh) 2015-12-01 2023-04-07 特韦斯特生物科学公司 功能化表面及其制备
US10859562B2 (en) 2016-02-29 2020-12-08 Iridia, Inc. Methods, compositions, and devices for information storage
US10438662B2 (en) 2016-02-29 2019-10-08 Iridia, Inc. Methods, compositions, and devices for information storage
US10640822B2 (en) 2016-02-29 2020-05-05 Iridia, Inc. Systems and methods for writing, reading, and controlling data stored in a polymer
KR101953663B1 (ko) * 2016-03-04 2019-03-04 연세대학교 산학협력단 하나의 올리고뉴클레오티드를 이용해서 올리고뉴클레오티드 풀을 생산하는 방법
WO2017153351A1 (en) * 2016-03-08 2017-09-14 Thomson Licensing Method and device for decoding data segments derived from oligonucleotides and related sequencer
US10883140B2 (en) 2016-04-21 2021-01-05 President And Fellows Of Harvard College Method and system of nanopore-based information encoding
WO2017189794A1 (en) * 2016-04-27 2017-11-02 President And Fellows Of Harvard College Method of secure communication via nucleotide polymers
US10892034B2 (en) 2016-07-01 2021-01-12 Microsoft Technology Licensing, Llc Use of homology direct repair to record timing of a molecular event
CN109477130B (zh) 2016-07-01 2022-08-30 微软技术许可有限责任公司 通过迭代dna编辑的存储
US11359234B2 (en) 2016-07-01 2022-06-14 Microsoft Technology Licensing, Llc Barcoding sequences for identification of gene expression
JP6854340B2 (ja) 2016-08-22 2021-04-07 ツイスト バイオサイエンス コーポレーション デノボ合成された核酸ライブラリ
CN107798219B (zh) * 2016-08-30 2021-07-13 清华大学 将数据进行生物存储并还原的方法
US20180068059A1 (en) * 2016-09-08 2018-03-08 Sap Se Malicious sequence detection for gene synthesizers
US10417457B2 (en) * 2016-09-21 2019-09-17 Twist Bioscience Corporation Nucleic acid based data storage
US10370246B1 (en) * 2016-10-20 2019-08-06 The Board Of Trustees Of The University Of Illinois Portable and low-error DNA-based data storage
IL266197B2 (en) 2016-10-24 2024-03-01 Geneinfosec Inc Hiding information contained within nucleic acids
US10650312B2 (en) 2016-11-16 2020-05-12 Catalog Technologies, Inc. Nucleic acid-based data storage
AU2017363139B2 (en) * 2016-11-16 2023-09-21 Catalog Technologies, Inc. Nucleic acid-based data storage
WO2018102064A1 (en) 2016-11-30 2018-06-07 Microsoft Technology Licensing, Llc. Dna random access storage system via ligation
KR102514213B1 (ko) 2016-12-16 2023-03-27 트위스트 바이오사이언스 코포레이션 면역 시냅스의 변이체 라이브러리 및 그의 합성
US10839948B2 (en) 2016-12-29 2020-11-17 Intel Corporation Microfluidic information-encoding polymer data storage
US10793897B2 (en) 2017-02-08 2020-10-06 Microsoft Technology Licensing, Llc Primer and payload design for retrieval of stored polynucleotides
CN106845158A (zh) * 2017-02-17 2017-06-13 苏州泓迅生物科技股份有限公司 一种利用dna进行信息存储的方法
CN110892485B (zh) * 2017-02-22 2024-03-22 特韦斯特生物科学公司 基于核酸的数据存储
WO2018170169A1 (en) 2017-03-15 2018-09-20 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
US10774379B2 (en) 2017-03-15 2020-09-15 Microsoft Technology Licensing, Llc Random access of data encoded by polynucleotides
US12227775B2 (en) 2017-05-22 2025-02-18 The Charles Stark Draper Laboratory, Inc. Modified template-independent DNA polymerase
US10982276B2 (en) * 2017-05-31 2021-04-20 Molecular Assemblies, Inc. Homopolymer encoded nucleic acid memory
US11612873B2 (en) * 2017-05-31 2023-03-28 Molecular Assemblies, Inc. Homopolymer encoded nucleic acid memory
US10696965B2 (en) 2017-06-12 2020-06-30 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
CN109300508B (zh) 2017-07-25 2020-08-11 南京金斯瑞生物科技有限公司 一种dna数据存储编码解码方法
CN111566125A (zh) 2017-09-11 2020-08-21 特韦斯特生物科学公司 Gpcr结合蛋白及其合成
US11538554B1 (en) 2017-09-19 2022-12-27 The Board Of Trustees Of The Univ Of Illinois Nick-based data storage in native nucleic acids
EP3694990A4 (en) * 2017-10-10 2022-06-15 Roswell Biotechnologies, Inc. METHODS, DEVICE AND SYSTEMS FOR AMPLIFICATION-FREE DNA DATA STORAGE
CN111565834B (zh) 2017-10-20 2022-08-26 特韦斯特生物科学公司 用于多核苷酸合成的加热的纳米孔
WO2019080653A1 (zh) 2017-10-25 2019-05-02 深圳华大生命科学研究院 编码/解码方法、编码/解码器和存储方法、装置
EP3682449A1 (en) * 2017-10-27 2020-07-22 ETH Zurich Encoding and decoding information in synthetic dna with cryptographic keys generated based on polymorphic features of nucleic acids
EP3506135A1 (en) * 2017-12-29 2019-07-03 IMEC vzw Method for writing data
KR102804057B1 (ko) 2018-01-04 2025-05-07 트위스트 바이오사이언스 코포레이션 Dna 기반 디지털 정보 저장
WO2019178551A1 (en) 2018-03-16 2019-09-19 Catalog Technologies, Inc. Chemical methods for nucleic acid-based data storage
EP3542903A1 (en) * 2018-03-22 2019-09-25 IMEC vzw Memory writing
KR102138864B1 (ko) 2018-04-11 2020-07-28 경희대학교 산학협력단 Dna 디지털 데이터 저장 장치 및 저장 방법, 그리고 디코딩 방법
EP3776557B1 (en) 2018-04-13 2025-01-29 The Hong Kong Polytechnic University Data storage using peptides
AU2019270159B2 (en) 2018-05-16 2025-02-13 Catalog Technologies, Inc. Compositions and methods for nucleic acid-based data storage
US11995558B2 (en) 2018-05-17 2024-05-28 The Charles Stark Draper Laboratory, Inc. Apparatus for high density information storage in molecular chains
CA3100739A1 (en) 2018-05-18 2019-11-21 Twist Bioscience Corporation Polynucleotides, reagents, and methods for nucleic acid hybridization
US11531934B2 (en) * 2018-05-31 2022-12-20 Kyndryl, Inc. Machine learning (ML) modeling by DNA computing
CN112449716A (zh) 2018-06-07 2021-03-05 非营利性组织佛兰芒综合大学生物技术研究所 一种使用dna分子存储信息的方法
US11093547B2 (en) * 2018-06-19 2021-08-17 Intel Corporation Data storage based on encoded DNA sequences
AU2019311199B2 (en) * 2018-07-23 2024-12-19 Dna Script Massively parallel enzymatic synthesis of nucleic acid strands
US11854669B1 (en) 2018-07-30 2023-12-26 National Technology & Engineering Solutions Of Sandia, Llc Synthetic nucleic acids for information storage and transmission
US12437841B2 (en) 2018-08-03 2025-10-07 Catalog Technologies, Inc. Systems and methods for storing and reading nucleic acid-based data with error protection
US20200063119A1 (en) * 2018-08-22 2020-02-27 Massachusetts Institute Of Technology In vitro dna writing for information storage
US11017170B2 (en) * 2018-09-27 2021-05-25 At&T Intellectual Property I, L.P. Encoding and storing text using DNA sequences
WO2020112233A2 (en) 2018-09-28 2020-06-04 President And Fellows Of Harvard College Storage of information using mixtures of molecules
CN109460822B (zh) * 2018-11-19 2021-11-12 天津大学 基于dna的信息存储方法
CN113228193B (zh) * 2018-12-26 2023-06-09 深圳华大生命科学研究院 一种定点编辑存储有数据的核酸序列的方法及装置
US12357959B2 (en) 2018-12-26 2025-07-15 Twist Bioscience Corporation Highly accurate de novo polynucleotide synthesis
CN113766930B (zh) 2019-02-26 2025-07-22 特韦斯特生物科学公司 Glp1受体的变异核酸文库
CA3131691A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for antibody optimization
EP3959330A4 (en) * 2019-04-24 2023-07-05 Molecular Assemblies, Inc. HOMOPOLYMER ENCODED NUCLEIC ACID MEMORY
US11610651B2 (en) 2019-05-09 2023-03-21 Catalog Technologies, Inc. Data structures and operations for searching, computing, and indexing in DNA-based data storage
GB201907460D0 (en) 2019-05-27 2019-07-10 Vib Vzw A method of storing information in pools of nucleic acid molecules
AU2020298294A1 (en) 2019-06-21 2022-02-17 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
US11939570B2 (en) 2019-08-20 2024-03-26 Seagate Technology Llc Microfluidic lab-on-a-chip for gene synthesis
WO2021041667A1 (en) 2019-08-27 2021-03-04 President And Fellows Of Harvard College Modifying messages stored in mixtures of molecules using thin-layer chromatography
US12260937B2 (en) * 2019-09-05 2025-03-25 Microsoft Technology Licensing, Llc Reverse concatenation of error-correcting codes in DNA data storage
WO2021061842A1 (en) 2019-09-23 2021-04-01 Twist Bioscience Corporation Variant nucleic acid libraries for single domain antibodies
JP2022548309A (ja) 2019-09-23 2022-11-17 ツイスト バイオサイエンス コーポレーション Crth2のバリアント核酸ライブラリー
CN114787929A (zh) * 2019-09-27 2022-07-22 哈佛学院院长等 使用分子混合物的信息存储
KR20220080172A (ko) 2019-10-11 2022-06-14 카탈로그 테크놀로지스, 인크. 핵산 보안 및 인증
US12380337B2 (en) 2019-10-24 2025-08-05 The Board Of Trustees Of The University Of Illinois Coded trace reconstruction
IL293670A (en) 2019-12-09 2022-08-01 Twist Bioscience Corp Variable nucleic acid libraries for adenosine receptors
US11755640B2 (en) * 2019-12-20 2023-09-12 The Board Of Trustees Of The University Of Illinois DNA-based image storage and retrieval
CN111489791B (zh) * 2020-04-07 2023-05-26 中国科学院重庆绿色智能技术研究院 固态纳米孔高密度编码dna数字存储读取方法
AU2021271639A1 (en) 2020-05-11 2022-12-08 Catalog Technologies, Inc. Programs and functions in DNA-based data storage
WO2022015513A2 (en) * 2020-07-13 2022-01-20 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods to assess rna stability
US11837302B1 (en) 2020-08-07 2023-12-05 Iridia, Inc. Systems and methods for writing and reading data stored in a polymer using nano-channels
US11492611B2 (en) 2020-08-31 2022-11-08 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for producing RNA constructs with increased translation and stability
CN112079893B (zh) * 2020-09-23 2022-05-03 南京原码科技合伙企业(有限合伙) 一种基于固相化学合成法合成dna存储所需文本的方法
US11990184B2 (en) 2020-09-24 2024-05-21 Seagate Technology Llc DNA backbone editing for DNA data storage
CN112288089B (zh) * 2020-09-28 2022-12-20 清华大学 阵列式核酸信息存储方法及装置
US11823066B2 (en) 2021-05-28 2023-11-21 Bank Of America Corporation Enterprise market volatility predictions through synthetic DNA and mutant nucleotides
US11823065B2 (en) 2021-05-28 2023-11-21 Bank Of America Corporation Enterprise market volatility predictions through synthetic DNA and mutant nucleotides
US11823064B2 (en) 2021-05-28 2023-11-21 Bank Of America Corporation Enterprise market volatility prediction through synthetic DNA and mutant nucleotides
WO2024076044A1 (ko) * 2022-10-06 2024-04-11 이근우 Dna 인코딩 및 디코딩 방법 및 장치
US12587274B2 (en) 2023-03-28 2026-03-24 Quantum Generative Materials Llc Satellite optimization management system based on natural language input and artificial intelligence
CN116597901A (zh) * 2023-05-22 2023-08-15 清华大学深圳国际研究生院 一种基于调制作用的dna信息编解码方法
US12406750B2 (en) * 2023-08-31 2025-09-02 Lenovo (Singapore) Pte. Ltd. Encoding digital data using oligonucleotides
US12603701B2 (en) 2023-12-27 2026-04-14 Quantum Generative Materials Llc Distributed satellite constellation management and control system
US12368503B2 (en) 2023-12-27 2025-07-22 Quantum Generative Materials Llc Intent-based satellite transmit management based on preexisting historical location and machine learning

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US575034A (en) 1897-01-12 Charles nicolas leroy
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
JPH0672011B2 (ja) 1985-09-20 1994-09-14 東ソー株式会社 合成モルデナイト成形体の製造方法
US4959463A (en) 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
US4659774A (en) 1985-11-01 1987-04-21 American Hoechst Corporation Support for solid-phase oligonucleotide synthesis
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5602244A (en) 1988-05-26 1997-02-11 Competitive Technologies, Inc. Polynucleotide phosphorodithioate compounds
US5168038A (en) 1988-06-17 1992-12-01 The Board Of Trustees Of The Leland Stanford Junior University In situ transcription in cells and tissues
ATE142272T1 (de) 1989-01-19 1996-09-15 Behringwerke Ag Nukleinsäure-amplifikation unter verwendung eines einzelprimers
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5141813A (en) 1989-08-28 1992-08-25 Clontech Laboratories, Inc. Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5612199A (en) 1991-10-11 1997-03-18 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
US5428148A (en) 1992-04-24 1995-06-27 Beckman Instruments, Inc. N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
US6294323B1 (en) 1993-04-14 2001-09-25 Behringwerke Ag Self initiating single primer amplification of nucleic acids
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5574146A (en) 1994-08-30 1996-11-12 Beckman Instruments, Inc. Oligonucleotide synthesis with substituted aryl carboxylic acids as activators
US5554744A (en) 1994-09-23 1996-09-10 Hybridon, Inc. Method for loading solid supports for nucleic acid synthesis
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US6261797B1 (en) 1996-01-29 2001-07-17 Stratagene Primer-mediated polynucleotide synthesis and manipulation techniques
US5917031A (en) * 1996-04-19 1999-06-29 Taiko Pharmaceutical Co., Ltd. Method of synthesizing polydeoxyribonucleotides
EP1033411B1 (en) 1996-06-04 2006-02-22 University of Utah Research Foundation Fluorescent donor-acceptor pair
JPH10253701A (ja) 1997-03-10 1998-09-25 Mitsubishi Electric Corp 半導体試験装置
US6432360B1 (en) 1997-10-10 2002-08-13 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
JP4503828B2 (ja) 1998-02-11 2010-07-14 ユニバーシティー オブ ヒューストン 光生成試薬を用いる化学反応および生化学反応のための方法および装置
WO1999042813A1 (en) 1998-02-23 1999-08-26 Wisconsin Alumni Research Foundation Method and apparatus for synthesis of arrays of dna probes
DE19813317A1 (de) 1998-03-26 1999-09-30 Roche Diagnostics Gmbh Verbessertes Verfahren zur Primer Extension Präamplifikations-PCR
US6391544B1 (en) 1998-05-15 2002-05-21 Abbott Laboratories Method for using unequal primer concentrations for generating nucleic acid amplification products
US6824866B1 (en) 1999-04-08 2004-11-30 Affymetrix, Inc. Porous silica substrates for polymer synthesis and assays
AU4703300A (en) * 1999-05-06 2000-11-21 Mount Sinai School Of Medicine Of The City University Of New York, The Dna-based steganography
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6800439B1 (en) 2000-01-06 2004-10-05 Affymetrix, Inc. Methods for improved array preparation
US6833450B1 (en) 2000-03-17 2004-12-21 Affymetrix, Inc. Phosphite ester oxidation in nucleic acid array preparation
US6966945B1 (en) 2000-09-20 2005-11-22 Goodrich Corporation Inorganic matrix compositions, composites and process of making the same
CN100485032C (zh) * 2001-05-11 2009-05-06 松下电器产业株式会社 生物分子基底,使用它的检验和诊断方法及装置
ATE403013T1 (de) 2001-05-18 2008-08-15 Wisconsin Alumni Res Found Verfahren zur synthese von dna-sequenzen die photolabile linker verwenden
WO2003025123A2 (en) * 2001-08-28 2003-03-27 Mount Sinai School Of Medecine Dna: a medium for long-term information storage specification
WO2003040410A1 (en) 2001-11-02 2003-05-15 Nimblegen Systems, Inc. Detection of hybridization oligonucleotide microarray through covalently labeling microarray probe
US20030099952A1 (en) 2001-11-26 2003-05-29 Roland Green Microarrays with visible pattern detection
GB0201966D0 (en) 2002-01-29 2002-03-13 Smartwater Ltd Improvements in or relating to security products
US7037659B2 (en) 2002-01-31 2006-05-02 Nimblegen Systems Inc. Apparatus for constructing DNA probes having a prismatic and kaleidoscopic light homogenizer
US7422851B2 (en) 2002-01-31 2008-09-09 Nimblegen Systems, Inc. Correction for illumination non-uniformity during the synthesis of arrays of oligomers
US7157229B2 (en) 2002-01-31 2007-01-02 Nimblegen Systems, Inc. Prepatterned substrate for optical synthesis of DNA probes
US20040126757A1 (en) 2002-01-31 2004-07-01 Francesco Cerrina Method and apparatus for synthesis of arrays of DNA probes
US7083975B2 (en) 2002-02-01 2006-08-01 Roland Green Microarray synthesis instrument and method
US20030228611A1 (en) 2002-05-01 2003-12-11 President And Fellows Of Harvard College Nucleic acid memory device
US20040060987A1 (en) * 2002-05-07 2004-04-01 Green Larry R. Digital image analysis method for enhanced and optimized signals in fluorophore detection
US7888106B2 (en) 2002-05-24 2011-02-15 Roche Nimblegen, Inc. Microarrays and method for running hybridization reaction for multiple samples on a single microarray
US20040001371A1 (en) 2002-06-26 2004-01-01 The Arizona Board Of Regents On Behalf Of The University Of Arizona Information storage and retrieval device using macromolecules as storage media
US7158892B2 (en) 2002-06-28 2007-01-02 International Business Machines Corporation Genomic messaging system
US7498176B2 (en) 2002-09-27 2009-03-03 Roche Nimblegen, Inc. Microarray with hydrophobic barriers
AU2003282885A1 (en) 2002-09-30 2004-04-23 Nimblegen Systems, Inc. Parallel loading of arrays
WO2004031351A2 (en) 2002-10-01 2004-04-15 Nimblegen Systems, Inc. Microarrays having multiple oligonucleotides in single array features
JP4102157B2 (ja) 2002-10-17 2008-06-18 正幸 園部 生体高分子を通信媒体もしくは記録媒体とした、情報通信方法、情報記録方法、エンコーダおよびデコーダ
US20050053968A1 (en) * 2003-03-31 2005-03-10 Council Of Scientific And Industrial Research Method for storing information in DNA
US7628096B2 (en) 2004-03-25 2009-12-08 Teleflex Corporated Pedal mount assembly
WO2005123766A2 (en) 2004-06-09 2005-12-29 Alexander Sunguroff Methods of making nanotechnological and macromolecular biomimetic structures
US8458475B2 (en) * 2005-06-20 2013-06-04 Authentiform Technologies, L.L.C. Systems and methods for product authentication
US7874489B2 (en) * 2005-06-20 2011-01-25 Authentiform Technologies, Llc Product authentication
US20070113137A1 (en) 2005-10-22 2007-05-17 Ho Seung Ryu Error Correction in Binary-encoded DNA Using Linear Feedback Shift Registers
CN101495654A (zh) 2006-04-19 2009-07-29 阿普里拉股份有限公司 无凝胶珠基测序的试剂、方法和文库
ES2959127T3 (es) 2007-06-19 2024-02-20 Hoffmann La Roche Secuenciación de ácidos nucleicos de alto rendimiento por expansión
JP2010539982A (ja) 2007-10-01 2010-12-24 アプライド バイオシステムズ, エルエルシー チェイスライゲーション配列決定法
DE102007057802B3 (de) * 2007-11-30 2009-06-10 Geneart Ag Steganographische Einbettung von Informationen in kodierenden Genen
US20110003701A1 (en) * 2008-02-27 2011-01-06 454 Life Sciences Corporation System and method for improved processing of nucleic acids for production of sequencable libraries
EP3346404B1 (en) 2012-06-01 2025-04-02 European Molecular Biology Laboratory High-capacity storage of digital information in dna
CN108875312A (zh) 2012-07-19 2018-11-23 哈佛大学校长及研究员协会 利用核酸存储信息的方法

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