JP6089106B2 - 核酸を用いた情報記憶方法 - Google Patents

核酸を用いた情報記憶方法 Download PDF

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JP6089106B2
JP6089106B2 JP2015523204A JP2015523204A JP6089106B2 JP 6089106 B2 JP6089106 B2 JP 6089106B2 JP 2015523204 A JP2015523204 A JP 2015523204A JP 2015523204 A JP2015523204 A JP 2015523204A JP 6089106 B2 JP6089106 B2 JP 6089106B2
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information
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JP2015533077A (ja
JP2015533077A5 (enExample
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ジョージ エム． チャーチ、
ジョージ エム． チャーチ、
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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K19/00—Record carriers for use with machines and with at least a part designed to carry digital markings
    • G06K19/02—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the selection of materials, e.g. to avoid wear during transport through the machine
    • G06K19/022—Processes or apparatus therefor
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K19/00—Record carriers for use with machines and with at least a part designed to carry digital markings
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/12—Computing arrangements based on biological models using genetic models
    • G06N3/123—DNA computing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/20—Sequence assembly

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  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Theoretical Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Artificial Intelligence (AREA)
  • Computing Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Computational Linguistics (AREA)
  • Mathematical Physics (AREA)
  • Software Systems (AREA)
  • Evolutionary Computation (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2015523204A 2012-07-19 2013-07-17 核酸を用いた情報記憶方法 Active JP6089106B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261673690P 2012-07-19 2012-07-19
US61/673,690 2012-07-19
US201261676081P 2012-07-26 2012-07-26
US61/676,081 2012-07-26
PCT/US2013/050815 WO2014014991A2 (en) 2012-07-19 2013-07-17 Methods of storing information using nucleic acids

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JP2015533077A JP2015533077A (ja) 2015-11-19
JP2015533077A5 JP2015533077A5 (enExample) 2016-06-30
JP6089106B2 true JP6089106B2 (ja) 2017-03-01

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US (6) US9384320B2 (enExample)
EP (1) EP2875458A2 (enExample)
JP (1) JP6089106B2 (enExample)
KR (1) KR101743846B1 (enExample)
CN (2) CN108875312A (enExample)
AU (1) AU2013292709B2 (enExample)
CA (1) CA2878042C (enExample)
IN (1) IN2015DN01001A (enExample)
WO (1) WO2014014991A2 (enExample)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107055468A (zh) 2012-06-01 2017-08-18 欧洲分子生物学实验室 Dna中数字信息的高容量存储
AU2013292709B2 (en) 2012-07-19 2017-04-13 President And Fellows Of Harvard College Methods of storing information using nucleic acids
KR102122632B1 (ko) 2013-08-05 2020-06-16 트위스트 바이오사이언스 코포레이션 드 노보 합성된 유전자 라이브러리
EP3792921A1 (en) 2013-12-11 2021-03-17 Genapsys, Inc. Systems and methods for biological analysis and computation
WO2016126882A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
US11164661B2 (en) 2015-04-10 2021-11-02 University Of Washington Integrated system for nucleic acid-based storage and retrieval of digital data using keys
WO2016172377A1 (en) 2015-04-21 2016-10-27 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
EP3098742A1 (en) * 2015-05-26 2016-11-30 Thomson Licensing Method and apparatus for creating a plurality of oligos with a targeted distribution of nucleotide types
US10423341B1 (en) * 2015-06-12 2019-09-24 Bahram Ghaffarzadeh Kermani Accurate and efficient DNA-based storage of electronic data
KR20180030092A (ko) * 2015-07-13 2018-03-21 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵산을 사용하여 검색 가능한 정보를 저장하는 방법
ES2888626T3 (es) * 2015-07-27 2022-01-05 Illumina Inc Cartografiado espacial de información de secuencia de ácidos nucleicos
EP3350314A4 (en) 2015-09-18 2019-02-06 Twist Bioscience Corporation OLIGONUCLEIC ACID VARIANT LIBRARIES VARIANT AND SYNTHESIS THEREOF
CN108698012A (zh) 2015-09-22 2018-10-23 特韦斯特生物科学公司 用于核酸合成的柔性基底
EP3163512A1 (en) * 2015-10-30 2017-05-03 Thomson Licensing Data processing apparatus and method for recovering a correct code symbol sequence from multiple incorrect copies
US10566077B1 (en) 2015-11-19 2020-02-18 The Board Of Trustees Of The University Of Illinois Re-writable DNA-based digital storage with random access
EP3173961A1 (en) * 2015-11-27 2017-05-31 Thomson Licensing Method for storing user data and decoding information in synthesized oligos, apparatus and substance
CN108603307A (zh) 2015-12-01 2018-09-28 特韦斯特生物科学公司 功能化表面及其制备
US10640822B2 (en) 2016-02-29 2020-05-05 Iridia, Inc. Systems and methods for writing, reading, and controlling data stored in a polymer
US10438662B2 (en) 2016-02-29 2019-10-08 Iridia, Inc. Methods, compositions, and devices for information storage
US10859562B2 (en) 2016-02-29 2020-12-08 Iridia, Inc. Methods, compositions, and devices for information storage
US20170253871A1 (en) * 2016-03-04 2017-09-07 University-Industry Foundation, Yonsei University Method of preparing oligonucleotide pool using one oligonucleotide
US20190102515A1 (en) * 2016-03-08 2019-04-04 Thomson Licensing Method and device for decoding data segments derived from oligonucleotides and related sequencer
WO2017184677A1 (en) * 2016-04-21 2017-10-26 President And Fellows Of Harvard College Method and system of nanopore-based information encoding
WO2017189794A1 (en) * 2016-04-27 2017-11-02 President And Fellows Of Harvard College Method of secure communication via nucleotide polymers
US10892034B2 (en) 2016-07-01 2021-01-12 Microsoft Technology Licensing, Llc Use of homology direct repair to record timing of a molecular event
US10669558B2 (en) 2016-07-01 2020-06-02 Microsoft Technology Licensing, Llc Storage through iterative DNA editing
US11359234B2 (en) 2016-07-01 2022-06-14 Microsoft Technology Licensing, Llc Barcoding sequences for identification of gene expression
GB2568444A (en) 2016-08-22 2019-05-15 Twist Bioscience Corp De novo synthesized nucleic acid libraries
CN107798219B (zh) * 2016-08-30 2021-07-13 清华大学 将数据进行生物存储并还原的方法
US20180068059A1 (en) * 2016-09-08 2018-03-08 Sap Se Malicious sequence detection for gene synthesizers
US10417457B2 (en) * 2016-09-21 2019-09-17 Twist Bioscience Corporation Nucleic acid based data storage
US10370246B1 (en) * 2016-10-20 2019-08-06 The Board Of Trustees Of The University Of Illinois Portable and low-error DNA-based data storage
CN110312825A (zh) 2016-10-24 2019-10-08 吉内恩福赛克公司 隐藏核酸内存在的信息
AU2017363146B2 (en) * 2016-11-16 2023-11-02 Catalog Technologies, Inc. Systems for nucleic acid-based data storage
US10650312B2 (en) 2016-11-16 2020-05-12 Catalog Technologies, Inc. Nucleic acid-based data storage
EP3513346B1 (en) 2016-11-30 2020-04-15 Microsoft Technology Licensing, LLC Dna random access storage system via ligation
CN110366613A (zh) 2016-12-16 2019-10-22 特韦斯特生物科学公司 免疫突触的变体文库及其合成
US10839948B2 (en) 2016-12-29 2020-11-17 Intel Corporation Microfluidic information-encoding polymer data storage
US10793897B2 (en) 2017-02-08 2020-10-06 Microsoft Technology Licensing, Llc Primer and payload design for retrieval of stored polynucleotides
CN106845158A (zh) * 2017-02-17 2017-06-13 苏州泓迅生物科技股份有限公司 一种利用dna进行信息存储的方法
SG11201907713WA (en) * 2017-02-22 2019-09-27 Twist Bioscience Corp Nucleic acid based data storage
CN110913865A (zh) 2017-03-15 2020-03-24 特韦斯特生物科学公司 免疫突触的变体文库及其合成
US10774379B2 (en) 2017-03-15 2020-09-15 Microsoft Technology Licensing, Llc Random access of data encoded by polynucleotides
US12227775B2 (en) 2017-05-22 2025-02-18 The Charles Stark Draper Laboratory, Inc. Modified template-independent DNA polymerase
WO2018222853A1 (en) * 2017-05-31 2018-12-06 Molecular Assemblies, Inc. Homopolymer encoded nucleic acid memory
KR102784398B1 (ko) 2017-06-12 2025-03-19 트위스트 바이오사이언스 코포레이션 심리스 핵산 어셈블리를 위한 방법
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
CN109300508B (zh) * 2017-07-25 2020-08-11 南京金斯瑞生物科技有限公司 一种dna数据存储编码解码方法
JP2020536504A (ja) 2017-09-11 2020-12-17 ツイスト バイオサイエンス コーポレーション Ｇｐｃｒ結合タンパク質およびその合成
US11538554B1 (en) 2017-09-19 2022-12-27 The Board Of Trustees Of The Univ Of Illinois Nick-based data storage in native nucleic acids
CN111373051A (zh) * 2017-10-10 2020-07-03 罗斯威尔生命技术公司 用于无扩增dna数据存储的方法、装置和系统
KR102889470B1 (ko) 2017-10-20 2025-11-21 트위스트 바이오사이언스 코포레이션 폴리뉴클레오타이드 합성을 위한 가열된 나노웰
WO2019080653A1 (zh) 2017-10-25 2019-05-02 深圳华大生命科学研究院 编码/解码方法、编码/解码器和存储方法、装置
WO2019081145A1 (en) 2017-10-27 2019-05-02 Eth Zurich ENCODING AND DECODING INFORMATION IN SYNTHETIC DNA WITH CRYPTOGRAPHIC KEYS GENERATED BASED ON POLYMORPHIC CHARACTERISTICS OF NUCLEIC ACIDS
EP3506135A1 (en) 2017-12-29 2019-07-03 IMEC vzw Method for writing data
WO2019136175A1 (en) 2018-01-04 2019-07-11 Twist Bioscience Corporation Dna-based digital information storage
AU2019236289B2 (en) 2018-03-16 2024-12-05 Catalog Technologies, Inc. Chemical methods for nucleic acid-based data storage
EP3542903A1 (en) 2018-03-22 2019-09-25 IMEC vzw Memory writing
KR102138864B1 (ko) * 2018-04-11 2020-07-28 경희대학교 산학협력단 Dna 디지털 데이터 저장 장치 및 저장 방법, 그리고 디코딩 방법
CN112313749B (zh) * 2018-04-13 2025-02-07 香港理工大学 使用肽的数据存储
WO2019222561A1 (en) 2018-05-16 2019-11-21 Catalog Technologies, Inc. Compositions and methods for nucleic acid-based data storage
US11995558B2 (en) 2018-05-17 2024-05-28 The Charles Stark Draper Laboratory, Inc. Apparatus for high density information storage in molecular chains
CA3100739A1 (en) 2018-05-18 2019-11-21 Twist Bioscience Corporation Polynucleotides, reagents, and methods for nucleic acid hybridization
US11531934B2 (en) * 2018-05-31 2022-12-20 Kyndryl, Inc. Machine learning (ML) modeling by DNA computing
EP3803882A1 (en) 2018-06-07 2021-04-14 Vib Vzw A method of storing information using dna molecules
US11093547B2 (en) * 2018-06-19 2021-08-17 Intel Corporation Data storage based on encoded DNA sequences
CN113056327A (zh) 2018-07-23 2021-06-29 Dna斯克瑞普特公司 核酸链的大规模平行酶促合成
US11854669B1 (en) 2018-07-30 2023-12-26 National Technology & Engineering Solutions Of Sandia, Llc Synthetic nucleic acids for information storage and transmission
WO2020028912A2 (en) 2018-08-03 2020-02-06 Catolog Technologies, Inc Systems and methods for storing and reading nucleic acid-based data with error protection
WO2020041570A1 (en) * 2018-08-22 2020-02-27 Massachusetts Institute Of Technology In vitro dna writing for information storage
US11017170B2 (en) * 2018-09-27 2021-05-25 At&T Intellectual Property I, L.P. Encoding and storing text using DNA sequences
CN112771215A (zh) 2018-09-28 2021-05-07 哈佛学院院长等 使用分子混合物存储信息
CN109460822B (zh) * 2018-11-19 2021-11-12 天津大学 基于dna的信息存储方法
CN119708086A (zh) 2018-12-26 2025-03-28 特韦斯特生物科学公司 高度准确的从头多核苷酸合成
CN113228193B (zh) * 2018-12-26 2023-06-09 深圳华大生命科学研究院 一种定点编辑存储有数据的核酸序列的方法及装置
AU2020227802A1 (en) 2019-02-26 2021-10-14 Twist Bioscience Corporation Variant nucleic acid libraries for antibody optimization
EP3930753A4 (en) 2019-02-26 2023-03-29 Twist Bioscience Corporation VARIANT NUCLEIC ACID LIBRARIES FOR GLP1 RECEPTOR
EP3959330A4 (en) * 2019-04-24 2023-07-05 Molecular Assemblies, Inc. HOMOPOLYMER ENCODED NUCLEIC ACID MEMORY
AU2020268440A1 (en) 2019-05-09 2021-12-02 Catalog Technologies, Inc. Data structures and operations for searching, computing, and indexing in DNA-based data storage
GB201907460D0 (en) 2019-05-27 2019-07-10 Vib Vzw A method of storing information in pools of nucleic acid molecules
CN114729342A (zh) 2019-06-21 2022-07-08 特韦斯特生物科学公司 基于条形码的核酸序列装配
US11939570B2 (en) 2019-08-20 2024-03-26 Seagate Technology Llc Microfluidic lab-on-a-chip for gene synthesis
WO2021041667A1 (en) 2019-08-27 2021-03-04 President And Fellows Of Harvard College Modifying messages stored in mixtures of molecules using thin-layer chromatography
US12260937B2 (en) 2019-09-05 2025-03-25 Microsoft Technology Licensing, Llc Reverse concatenation of error-correcting codes in DNA data storage
WO2021061829A1 (en) 2019-09-23 2021-04-01 Twist Bioscience Corporation Variant nucleic acid libraries for crth2
AU2020355027A1 (en) 2019-09-23 2022-04-21 Twist Bioscience Corporation Antibodies that bind CD3 Epsilon
CN114787929A (zh) * 2019-09-27 2022-07-22 哈佛学院院长等 使用分子混合物的信息存储
CA3157804A1 (en) 2019-10-11 2021-04-15 Catalog Technologies, Inc. Nucleic acid security and authentication
US12380337B2 (en) 2019-10-24 2025-08-05 The Board Of Trustees Of The University Of Illinois Coded trace reconstruction
US11755640B2 (en) * 2019-12-20 2023-09-12 The Board Of Trustees Of The University Of Illinois DNA-based image storage and retrieval
CN111489791B (zh) * 2020-04-07 2023-05-26 中国科学院重庆绿色智能技术研究院 固态纳米孔高密度编码dna数字存储读取方法
EP4538386A3 (en) 2020-05-11 2025-08-13 Catalog Technologies, Inc. Programs and functions in dna-based data storage
WO2022015513A2 (en) * 2020-07-13 2022-01-20 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods to assess rna stability
US11837302B1 (en) 2020-08-07 2023-12-05 Iridia, Inc. Systems and methods for writing and reading data stored in a polymer using nano-channels
US11492611B2 (en) 2020-08-31 2022-11-08 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for producing RNA constructs with increased translation and stability
CN112079893B (zh) * 2020-09-23 2022-05-03 南京原码科技合伙企业(有限合伙) 一种基于固相化学合成法合成dna存储所需文本的方法
US11990184B2 (en) 2020-09-24 2024-05-21 Seagate Technology Llc DNA backbone editing for DNA data storage
CN112288089B (zh) * 2020-09-28 2022-12-20 清华大学 阵列式核酸信息存储方法及装置
US11823066B2 (en) 2021-05-28 2023-11-21 Bank Of America Corporation Enterprise market volatility predictions through synthetic DNA and mutant nucleotides
US11823065B2 (en) 2021-05-28 2023-11-21 Bank Of America Corporation Enterprise market volatility predictions through synthetic DNA and mutant nucleotides
US11823064B2 (en) 2021-05-28 2023-11-21 Bank Of America Corporation Enterprise market volatility prediction through synthetic DNA and mutant nucleotides
WO2024076044A1 (ko) * 2022-10-06 2024-04-11 이근우 Dna 인코딩 및 디코딩 방법 및 장치
CN116597901A (zh) * 2023-05-22 2023-08-15 清华大学深圳国际研究生院 一种基于调制作用的dna信息编解码方法
US12406750B2 (en) * 2023-08-31 2025-09-02 Lenovo (Singapore) Pte. Ltd. Encoding digital data using oligonucleotides
US12368503B2 (en) 2023-12-27 2025-07-22 Quantum Generative Materials Llc Intent-based satellite transmit management based on preexisting historical location and machine learning

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US575034A (en) 1897-01-12 Charles nicolas leroy
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
JPH0672011B2 (ja) 1985-09-20 1994-09-14 東ソー株式会社 合成モルデナイト成形体の製造方法
US4959463A (en) 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
US4659774A (en) 1985-11-01 1987-04-21 American Hoechst Corporation Support for solid-phase oligonucleotide synthesis
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5602244A (en) 1988-05-26 1997-02-11 Competitive Technologies, Inc. Polynucleotide phosphorodithioate compounds
US5168038A (en) 1988-06-17 1992-12-01 The Board Of Trustees Of The Leland Stanford Junior University In situ transcription in cells and tissues
CA2008096A1 (en) 1989-01-19 1990-07-19 Samuel Rose Nucleic acid amplification using single primer
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5141813A (en) 1989-08-28 1992-08-25 Clontech Laboratories, Inc. Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5612199A (en) 1991-10-11 1997-03-18 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
US5428148A (en) 1992-04-24 1995-06-27 Beckman Instruments, Inc. N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
US6294323B1 (en) 1993-04-14 2001-09-25 Behringwerke Ag Self initiating single primer amplification of nucleic acids
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5574146A (en) 1994-08-30 1996-11-12 Beckman Instruments, Inc. Oligonucleotide synthesis with substituted aryl carboxylic acids as activators
US5554744A (en) 1994-09-23 1996-09-10 Hybridon, Inc. Method for loading solid supports for nucleic acid synthesis
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US6261797B1 (en) 1996-01-29 2001-07-17 Stratagene Primer-mediated polynucleotide synthesis and manipulation techniques
US5917031A (en) * 1996-04-19 1999-06-29 Taiko Pharmaceutical Co., Ltd. Method of synthesizing polydeoxyribonucleotides
DK1179600T3 (da) 1996-06-04 2005-09-05 Univ Utah Res Found Overvågning af hybridisering under PCR
JPH10253701A (ja) 1997-03-10 1998-09-25 Mitsubishi Electric Corp 半導体試験装置
AU737174B2 (en) 1997-10-10 2001-08-09 President & Fellows Of Harvard College Replica amplification of nucleic acid arrays
EP1054726B1 (en) 1998-02-11 2003-07-30 University of Houston, Office of Technology Transfer Apparatus for chemical and biochemical reactions using photo-generated reagents
WO1999042813A1 (en) 1998-02-23 1999-08-26 Wisconsin Alumni Research Foundation Method and apparatus for synthesis of arrays of dna probes
DE19813317A1 (de) 1998-03-26 1999-09-30 Roche Diagnostics Gmbh Verbessertes Verfahren zur Primer Extension Präamplifikations-PCR
US6391544B1 (en) 1998-05-15 2002-05-21 Abbott Laboratories Method for using unequal primer concentrations for generating nucleic acid amplification products
US6824866B1 (en) 1999-04-08 2004-11-30 Affymetrix, Inc. Porous silica substrates for polymer synthesis and assays
EP1242618B1 (en) * 1999-05-06 2006-12-06 Mount Sinai School of Medicine of New York University DNA-based steganography
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6800439B1 (en) 2000-01-06 2004-10-05 Affymetrix, Inc. Methods for improved array preparation
US6833450B1 (en) 2000-03-17 2004-12-21 Affymetrix, Inc. Phosphite ester oxidation in nucleic acid array preparation
US6966945B1 (en) 2000-09-20 2005-11-22 Goodrich Corporation Inorganic matrix compositions, composites and process of making the same
CN100485032C (zh) * 2001-05-11 2009-05-06 松下电器产业株式会社 生物分子基底,使用它的检验和诊断方法及装置
WO2002095073A1 (en) 2001-05-18 2002-11-28 Wisconsin Alumni Research Foundation Method for the synthesis of dna sequences
WO2003025123A2 (en) * 2001-08-28 2003-03-27 Mount Sinai School Of Medecine Dna: a medium for long-term information storage specification
US20030087298A1 (en) 2001-11-02 2003-05-08 Roland Green Detection of hybridization on oligonucleotide microarray through covalently labeling microarray probe
US20030099952A1 (en) 2001-11-26 2003-05-29 Roland Green Microarrays with visible pattern detection
GB0201966D0 (en) 2002-01-29 2002-03-13 Smartwater Ltd Improvements in or relating to security products
US7157229B2 (en) 2002-01-31 2007-01-02 Nimblegen Systems, Inc. Prepatterned substrate for optical synthesis of DNA probes
US7037659B2 (en) 2002-01-31 2006-05-02 Nimblegen Systems Inc. Apparatus for constructing DNA probes having a prismatic and kaleidoscopic light homogenizer
US7422851B2 (en) 2002-01-31 2008-09-09 Nimblegen Systems, Inc. Correction for illumination non-uniformity during the synthesis of arrays of oligomers
US20040126757A1 (en) 2002-01-31 2004-07-01 Francesco Cerrina Method and apparatus for synthesis of arrays of DNA probes
US7083975B2 (en) 2002-02-01 2006-08-01 Roland Green Microarray synthesis instrument and method
US20030228611A1 (en) 2002-05-01 2003-12-11 President And Fellows Of Harvard College Nucleic acid memory device
US20040060987A1 (en) * 2002-05-07 2004-04-01 Green Larry R. Digital image analysis method for enhanced and optimized signals in fluorophore detection
CA2487093A1 (en) 2002-05-24 2003-12-04 Nimblegen Systems, Inc. Microarrays and method for running hybridization reaction for multiple samples on a single microarray
US20040001371A1 (en) 2002-06-26 2004-01-01 The Arizona Board Of Regents On Behalf Of The University Of Arizona Information storage and retrieval device using macromolecules as storage media
US7158892B2 (en) 2002-06-28 2007-01-02 International Business Machines Corporation Genomic messaging system
US7498176B2 (en) 2002-09-27 2009-03-03 Roche Nimblegen, Inc. Microarray with hydrophobic barriers
US7482170B2 (en) 2002-09-30 2009-01-27 Roche Nimblegen, Inc. Parallel loading of arrays
DE10393431T5 (de) 2002-10-01 2005-11-17 Nimblegen Systems, Inc., Madison Mikroarrays mit mehreren Oligonukleotiden in einzelnen Array Features
JP4102157B2 (ja) 2002-10-17 2008-06-18 正幸 園部 生体高分子を通信媒体もしくは記録媒体とした、情報通信方法、情報記録方法、エンコーダおよびデコーダ
US20050053968A1 (en) * 2003-03-31 2005-03-10 Council Of Scientific And Industrial Research Method for storing information in DNA
US7628096B2 (en) 2004-03-25 2009-12-08 Teleflex Corporated Pedal mount assembly
CA2570171A1 (en) 2004-06-09 2005-12-29 Alexander Sunguroff Methods of making nanotechnological and macromolecular biomimetic structures
US8458475B2 (en) * 2005-06-20 2013-06-04 Authentiform Technologies, L.L.C. Systems and methods for product authentication
US7874489B2 (en) * 2005-06-20 2011-01-25 Authentiform Technologies, Llc Product authentication
US20070113137A1 (en) 2005-10-22 2007-05-17 Ho Seung Ryu Error Correction in Binary-encoded DNA Using Linear Feedback Shift Registers
CN101495654A (zh) 2006-04-19 2009-07-29 阿普里拉股份有限公司 无凝胶珠基测序的试剂、方法和文库
JP5745842B2 (ja) 2007-06-19 2015-07-08 ストラトス ゲノミクス インコーポレイテッド 拡張によるハイスループット核酸配列決定
WO2009046149A1 (en) 2007-10-01 2009-04-09 Applied Biosystems Inc. Chase ligation sequencing
DE102007057802B3 (de) * 2007-11-30 2009-06-10 Geneart Ag Steganographische Einbettung von Informationen in kodierenden Genen
US20110003701A1 (en) * 2008-02-27 2011-01-06 454 Life Sciences Corporation System and method for improved processing of nucleic acids for production of sequencable libraries
CN107055468A (zh) 2012-06-01 2017-08-18 欧洲分子生物学实验室 Dna中数字信息的高容量存储
AU2013292709B2 (en) 2012-07-19 2017-04-13 President And Fellows Of Harvard College Methods of storing information using nucleic acids

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