JP6087264B2 - 成分分析装置、薬効分析装置、及び分析方法 - Google Patents

成分分析装置、薬効分析装置、及び分析方法 Download PDF

Info

Publication number
JP6087264B2
JP6087264B2 JP2013246906A JP2013246906A JP6087264B2 JP 6087264 B2 JP6087264 B2 JP 6087264B2 JP 2013246906 A JP2013246906 A JP 2013246906A JP 2013246906 A JP2013246906 A JP 2013246906A JP 6087264 B2 JP6087264 B2 JP 6087264B2
Authority
JP
Japan
Prior art keywords
container
drug
amount
buffer solution
hepatocytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013246906A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015105842A (ja
JP2015105842A5 (enExample
Inventor
亮介 高橋
亮介 高橋
勝弘 神田
勝弘 神田
祐輔 清水
祐輔 清水
久詞 市川
久詞 市川
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi High Tech Corp
Original Assignee
Hitachi High Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2013246906A priority Critical patent/JP6087264B2/ja
Application filed by Hitachi High Technologies Corp filed Critical Hitachi High Technologies Corp
Priority to CN201710862144.1A priority patent/CN107677779B/zh
Priority to EP20154632.2A priority patent/EP3712245B1/en
Priority to CN201710860736.XA priority patent/CN107513550B/zh
Priority to US14/914,278 priority patent/US9880153B2/en
Priority to EP17186423.4A priority patent/EP3272852B1/en
Priority to PCT/JP2014/081135 priority patent/WO2015080106A1/ja
Priority to EP14866627.4A priority patent/EP3023489B1/en
Priority to CN201480040060.4A priority patent/CN105378053B/zh
Publication of JP2015105842A publication Critical patent/JP2015105842A/ja
Publication of JP2015105842A5 publication Critical patent/JP2015105842A5/ja
Application granted granted Critical
Publication of JP6087264B2 publication Critical patent/JP6087264B2/ja
Priority to US15/847,092 priority patent/US10684276B2/en
Priority to US16/856,459 priority patent/US11789013B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/20—Heating or cooling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067—Liver cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/54—Supports specially adapted for pipettes and burettes
    • B01L9/543—Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00425—Heating or cooling means associated with pipettes or the like, e.g. for supplying sample/reagent at given temperature
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0418—Plate elements with several rows of samples

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Sustainable Development (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2013246906A 2013-11-29 2013-11-29 成分分析装置、薬効分析装置、及び分析方法 Active JP6087264B2 (ja)

Priority Applications (11)

Application Number Priority Date Filing Date Title
JP2013246906A JP6087264B2 (ja) 2013-11-29 2013-11-29 成分分析装置、薬効分析装置、及び分析方法
CN201480040060.4A CN105378053B (zh) 2013-11-29 2014-11-26 成分分析装置、药效分析装置和分析方法
CN201710860736.XA CN107513550B (zh) 2013-11-29 2014-11-26 成分分析方法
US14/914,278 US9880153B2 (en) 2013-11-29 2014-11-26 Componential analyzer, drug efficacy analyzer, and analysis method
EP17186423.4A EP3272852B1 (en) 2013-11-29 2014-11-26 Componential analyzer, drug efficacy analyzer, and analysis method
PCT/JP2014/081135 WO2015080106A1 (ja) 2013-11-29 2014-11-26 成分分析装置、薬効分析装置、及び分析方法
CN201710862144.1A CN107677779B (zh) 2013-11-29 2014-11-26 成分分析装置、药效分析装置和分析方法
EP20154632.2A EP3712245B1 (en) 2013-11-29 2014-11-26 Componential and drug efficacy analysis method
EP14866627.4A EP3023489B1 (en) 2013-11-29 2014-11-26 Componential analyzer, drug efficacy analyzer, and analysis method
US15/847,092 US10684276B2 (en) 2013-11-29 2017-12-19 Componential analyzer, drug efficacy analyzer, and analysis method
US16/856,459 US11789013B2 (en) 2013-11-29 2020-04-23 Componential analyzer, drug efficacy analyzer, and analysis method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2013246906A JP6087264B2 (ja) 2013-11-29 2013-11-29 成分分析装置、薬効分析装置、及び分析方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017014985A Division JP6282362B2 (ja) 2017-01-31 2017-01-31 成分分析装置、薬効分析装置、及び分析方法

Publications (3)

Publication Number Publication Date
JP2015105842A JP2015105842A (ja) 2015-06-08
JP2015105842A5 JP2015105842A5 (enExample) 2016-10-06
JP6087264B2 true JP6087264B2 (ja) 2017-03-01

Family

ID=53199046

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013246906A Active JP6087264B2 (ja) 2013-11-29 2013-11-29 成分分析装置、薬効分析装置、及び分析方法

Country Status (5)

Country Link
US (3) US9880153B2 (enExample)
EP (3) EP3272852B1 (enExample)
JP (1) JP6087264B2 (enExample)
CN (3) CN105378053B (enExample)
WO (1) WO2015080106A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023084648A1 (ja) * 2021-11-10 2023-05-19 株式会社日立ハイテク 薬剤相互作用解析方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6087264B2 (ja) 2013-11-29 2017-03-01 株式会社日立ハイテクノロジーズ 成分分析装置、薬効分析装置、及び分析方法
JP6758026B2 (ja) 2015-04-17 2020-09-23 株式会社日立ハイテク 成分分析装置、薬剤成分分析装置、成分分析方法及び薬剤成分分析方法
JP6582070B2 (ja) * 2018-01-22 2019-09-25 株式会社日立ハイテクノロジーズ 分析方法
US20220113299A1 (en) * 2019-02-26 2022-04-14 Hitachi High-Tech Corporation Method of dynamics analysis for compound in cell
WO2021014519A1 (ja) * 2019-07-22 2021-01-28 株式会社日立ハイテク 試薬キット

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5255976A (en) * 1992-07-10 1993-10-26 Vertex Pharmaceuticals Incorporated Temperature gradient calorimeter
JPH08503610A (ja) 1992-11-25 1996-04-23 メルク エンド カンパニー インコーポレーテッド 肝モデル
CA2130013C (en) * 1993-09-10 1999-03-30 Rolf Moser Apparatus for automatic performance of temperature cycles
US6277655B1 (en) * 1994-10-13 2001-08-21 Solvo Biotechnology Assay and reagent kit for evaluation of multi-drug resistance in cells
US6022733A (en) 1997-12-02 2000-02-08 Tam; Yun K. Simulated biological dissolution and absorption system
US7498164B2 (en) * 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
EP2293063A1 (en) * 1999-03-17 2011-03-09 University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
US7601494B2 (en) 1999-03-17 2009-10-13 The University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
AR035231A1 (es) * 2002-03-11 2004-05-05 Ypf S A Un equipo para analizar el crecimiento de microorganismos y procedimiento para cuantificar la concentracion de microorganismos
US20070184548A1 (en) * 2002-12-23 2007-08-09 Lim Hi Tan Device for carrying out chemical or biological reactions
EP2255841A1 (en) 2008-03-24 2010-12-01 Olympus Corporation Medicine administration device
JP5337169B2 (ja) 2009-01-08 2013-11-06 株式会社日立製作所 動物肝細胞の培養方法
US8906644B2 (en) 2009-08-26 2014-12-09 The University Of Tokyo Method for culture of hepatocytes
EP2684963B1 (en) * 2011-03-10 2016-02-03 Eisai R&D Management Co., Ltd. Method for screening for compound capable of enhancing or inhibiting oatp1b1 transport activity, and method for determining expression level of oatp1b1
US20130164335A1 (en) 2011-12-27 2013-06-27 National Health Research Institutes Methods and compositions for cellular drug release
JP6087264B2 (ja) 2013-11-29 2017-03-01 株式会社日立ハイテクノロジーズ 成分分析装置、薬効分析装置、及び分析方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023084648A1 (ja) * 2021-11-10 2023-05-19 株式会社日立ハイテク 薬剤相互作用解析方法

Also Published As

Publication number Publication date
EP3712245A1 (en) 2020-09-23
EP3712245B1 (en) 2022-05-11
CN107513550A (zh) 2017-12-26
WO2015080106A1 (ja) 2015-06-04
CN105378053A (zh) 2016-03-02
US9880153B2 (en) 2018-01-30
US10684276B2 (en) 2020-06-16
EP3272852A1 (en) 2018-01-24
JP2015105842A (ja) 2015-06-08
US20180106783A1 (en) 2018-04-19
CN107677779B (zh) 2020-06-12
US20160209403A1 (en) 2016-07-21
EP3023489A1 (en) 2016-05-25
EP3023489B1 (en) 2017-11-01
EP3023489A4 (en) 2016-09-21
CN107677779A (zh) 2018-02-09
US11789013B2 (en) 2023-10-17
US20200249223A1 (en) 2020-08-06
CN107513550B (zh) 2022-06-21
CN105378053B (zh) 2017-10-20
EP3272852B1 (en) 2020-03-18

Similar Documents

Publication Publication Date Title
US11789013B2 (en) Componential analyzer, drug efficacy analyzer, and analysis method
Peel et al. Introducing an automated high content confocal imaging approach for Organs-on-Chips
EP2210080A2 (en) Improved methods and devices for cellular analysis
JP5337169B2 (ja) 動物肝細胞の培養方法
JP6582070B2 (ja) 分析方法
JP6282362B2 (ja) 成分分析装置、薬効分析装置、及び分析方法
JP6758026B2 (ja) 成分分析装置、薬剤成分分析装置、成分分析方法及び薬剤成分分析方法
Larsen et al. Protocol for drug screening of patient-derived tumor organoids using high-content fluorescent imaging
JP7113132B2 (ja) 細胞内における化合物の動態解析法
Xu et al. Assessment of hepatotoxicity potential of drug candidate molecules including kinase inhibitors by hepatocyte imaging assay technology and bile flux imaging assay technology
Gillette et al. Wide-field optical redox imaging with leading-edge detection for assessment of patient-derived cancer organoids
AU2014277688A1 (en) Improved methods and devices for cellular analysis

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160725

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160725

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20160725

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160725

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20160901

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160920

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161109

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170104

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170201

R150 Certificate of patent or registration of utility model

Ref document number: 6087264

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350