JP6084319B2 - インスリン分泌促進用食品 - Google Patents
インスリン分泌促進用食品 Download PDFInfo
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- JP6084319B2 JP6084319B2 JP2016049112A JP2016049112A JP6084319B2 JP 6084319 B2 JP6084319 B2 JP 6084319B2 JP 2016049112 A JP2016049112 A JP 2016049112A JP 2016049112 A JP2016049112 A JP 2016049112A JP 6084319 B2 JP6084319 B2 JP 6084319B2
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- Prior art keywords
- fatty acid
- acid ester
- oil
- hlb
- insulin secretion
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Images
Description
ラットに対して、糖負荷と同時に、油脂又は油脂とポリグリセリン脂肪酸エステルであるヘキサステアリン酸ペンタグリセリン(HLB:4)を投与することにより、ポリグリセリン脂肪酸エステルの血漿インスリン分泌に対する効果の検討を行った。
40%グルコース(D(+)−Glucose,和光純薬社製)溶液10mlに、油脂(商品名:日清キャノーラ油,長鎖脂肪酸トリグリセライド(LCT),日清オイリオグループ社製)2gと、牛血清アルブミン(SIGMA社製)200mgとを添加し、得られた溶液を氷上で冷却しながら超音波処理(5分間を2セット、合計10分間)し、試料1を得た。
40%グルコース(D(+)−Glucose,和光純薬社製)溶液10mlに、ポリグリセリン脂肪酸エステルとしてヘキサステアリン酸ペンタグリセリン(商品名:サンソフトA−186E,HLB:4,太陽化学社製)20mgと、油脂(商品名:日清キャノーラ油,長鎖脂肪酸トリグリセライド(LCT),日清オイリオグループ社製)2gと、牛血清アルブミン(SIGMA社製)200mgとを添加し、得られた溶液を氷上で冷却しながら超音波処理(5分間を2セット、合計10分間)し、試料2を得た。
ラットに対して、糖負荷と同時に、油脂又は油脂とポリグリセリン脂肪酸エステルであるトリオレイン酸ペンタグリセリン(HLB:7)を投与することにより、ポリグリセリン脂肪酸エステルの血漿インスリン分泌に対する効果の検討を行った。
40%グルコース(D(+)−Glucose,和光純薬社製)溶液10mlに、ポリグリセリン脂肪酸エステルとしてトリオレイン酸ペンタグリセリン(商品名:サンソフトA−173E,HLB:7,太陽化学社製)20mgと、油脂(商品名:日清キャノーラ油,長鎖脂肪酸トリグリセライド(LCT),日清オイリオグループ社製)2gと、牛血清アルブミン(SIGMA社製)200mgとを添加し、得られた溶液を氷上で冷却しながら超音波処理(5分間を2セット、合計10分間)し、試料3を得た。
ラットに対して、糖負荷と同時に、油脂又は油脂とポリグリセリン脂肪酸エステルであるデカオレイン酸デカグリセリン(HLB:3)とを投与することにより、ポリグリセリン脂肪酸エステルの血漿インスリン分泌に対する効果の検討を行った。
40%グルコース(D(+)−Glucose,和光純薬社製)溶液10mlに、デカオレイン酸デカグリセリン(商品名:サンソフトQ−1710S,HLB:3,太陽化学社製)20mgと、油脂(商品名:日清キャノーラ油,長鎖脂肪酸トリグリセライド(LCT),日清オイリオグループ社製)2gと、牛血清アルブミン(SIGMA社製)200mgとを添加し、得られた溶液を氷上で冷却しながら超音波処理(5分間を2セット、合計10分間)し、試料4を得た。
ラットに対して、糖負荷と同時に、油脂又は油脂とポリグリセリン脂肪酸エステルであるモノオレイン酸テトラグリセリン(HLB:8.8)を投与することにより、ポリグリセリン脂肪酸エステルの血漿インスリン分泌に対する効果の検討を行った。
40%グルコース(D(+)−Glucose,和光純薬社製)溶液10mlに、ポリグリセリン脂肪酸エステルとしてモノオレイン酸テトラグリセリン(商品名:SYグリスターMO−3S,HLB:8.8,阪本薬品工業社製)20mgと、油脂(商品名:日清キャノーラ油,長鎖脂肪酸トリグリセライド(LCT),日清オイリオグループ社製)2gと、牛血清アルブミン(SIGMA社製)200mgとを添加し、得られた溶液を氷上で冷却しながら超音波処理(5分間を2セット、合計10分間)し、試料5を得た。
Claims (4)
- HLB4〜9のポリグリセリン脂肪酸エステルを有効成分として含有することを特徴とするインスリン分泌促進用食品。
- 前記ポリグリセリン脂肪酸エステルを、油脂とともに含有する請求項1に記載のインスリン分泌促進用食品。
- 油脂と併用される請求項1に記載のインスリン分泌促進用食品。
- II型糖尿病の予防又は治療に用いられる請求項1から3のいずれか1項に記載のインスリン分泌促進用食品。
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