JP6078105B2 - 上気道感染症の症状および心理的安寧のβ−グルカン治療 - Google Patents
上気道感染症の症状および心理的安寧のβ−グルカン治療 Download PDFInfo
- Publication number
- JP6078105B2 JP6078105B2 JP2015111978A JP2015111978A JP6078105B2 JP 6078105 B2 JP6078105 B2 JP 6078105B2 JP 2015111978 A JP2015111978 A JP 2015111978A JP 2015111978 A JP2015111978 A JP 2015111978A JP 6078105 B2 JP6078105 B2 JP 6078105B2
- Authority
- JP
- Japan
- Prior art keywords
- glucan
- health
- subjects
- poms
- symptoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229920002498 Beta-glucan Polymers 0.000 title claims description 108
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 title claims description 98
- 208000024891 symptom Diseases 0.000 title claims description 74
- 238000011282 treatment Methods 0.000 title description 35
- 230000010490 psychological well-being Effects 0.000 title description 9
- 210000002345 respiratory system Anatomy 0.000 title 1
- 238000000034 method Methods 0.000 claims description 45
- 239000000203 mixture Substances 0.000 claims description 38
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 31
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims description 29
- 206010016256 fatigue Diseases 0.000 claims description 25
- 230000009467 reduction Effects 0.000 claims description 15
- 206010011224 Cough Diseases 0.000 claims description 13
- 201000007100 Pharyngitis Diseases 0.000 claims description 13
- 206010039101 Rhinorrhoea Diseases 0.000 claims description 13
- 208000010753 nasal discharge Diseases 0.000 claims description 13
- 206010019233 Headaches Diseases 0.000 claims description 11
- 206010028735 Nasal congestion Diseases 0.000 claims description 11
- 208000002193 Pain Diseases 0.000 claims description 11
- 231100000869 headache Toxicity 0.000 claims description 11
- 206010025482 malaise Diseases 0.000 claims description 11
- 206010041232 sneezing Diseases 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 6
- 206010068319 Oropharyngeal pain Diseases 0.000 claims description 4
- 241000235070 Saccharomyces Species 0.000 claims 1
- 230000036541 health Effects 0.000 description 73
- 206010057190 Respiratory tract infections Diseases 0.000 description 68
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 68
- 229920001503 Glucan Polymers 0.000 description 53
- 230000036651 mood Effects 0.000 description 53
- 230000035882 stress Effects 0.000 description 53
- 229940068196 placebo Drugs 0.000 description 49
- 239000000902 placebo Substances 0.000 description 49
- 239000002245 particle Substances 0.000 description 37
- 230000003862 health status Effects 0.000 description 22
- 230000004044 response Effects 0.000 description 22
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 20
- 239000000243 solution Substances 0.000 description 20
- 238000000605 extraction Methods 0.000 description 19
- 239000000047 product Substances 0.000 description 19
- 210000005253 yeast cell Anatomy 0.000 description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 239000002253 acid Substances 0.000 description 14
- 238000012360 testing method Methods 0.000 description 14
- 230000002354 daily effect Effects 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 12
- 210000000987 immune system Anatomy 0.000 description 12
- 230000007423 decrease Effects 0.000 description 11
- 238000009472 formulation Methods 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- -1 polyoxyethylene Polymers 0.000 description 11
- 230000009469 supplementation Effects 0.000 description 11
- 239000000725 suspension Substances 0.000 description 11
- 239000000969 carrier Substances 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- 239000004094 surface-active agent Substances 0.000 description 10
- 230000008569 process Effects 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 230000002829 reductive effect Effects 0.000 description 9
- 230000035807 sensation Effects 0.000 description 9
- 239000003826 tablet Substances 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- 238000005119 centrifugation Methods 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 229960000583 acetic acid Drugs 0.000 description 7
- 239000002775 capsule Substances 0.000 description 7
- 210000002421 cell wall Anatomy 0.000 description 7
- 239000000306 component Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000013589 supplement Substances 0.000 description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000000227 grinding Methods 0.000 description 6
- 206010022000 influenza Diseases 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 238000012216 screening Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 150000007513 acids Chemical class 0.000 description 5
- 239000003513 alkali Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 230000029087 digestion Effects 0.000 description 5
- 230000007717 exclusion Effects 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 5
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 239000013504 Triton X-100 Substances 0.000 description 4
- 229920004890 Triton X-100 Polymers 0.000 description 4
- 238000010306 acid treatment Methods 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 239000012670 alkaline solution Substances 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 238000000855 fermentation Methods 0.000 description 4
- 230000004151 fermentation Effects 0.000 description 4
- 239000001963 growth medium Substances 0.000 description 4
- 230000003308 immunostimulating effect Effects 0.000 description 4
- 239000002198 insoluble material Substances 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 201000009240 nasopharyngitis Diseases 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 229940032147 starch Drugs 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 241000193738 Bacillus anthracis Species 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- 229920002527 Glycogen Polymers 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000000259 anti-tumor effect Effects 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000000356 contaminant Substances 0.000 description 3
- 238000007405 data analysis Methods 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 235000001727 glucose Nutrition 0.000 description 3
- 229940096919 glycogen Drugs 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 239000000314 lubricant Substances 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 230000009323 psychological health Effects 0.000 description 3
- 230000007115 recruitment Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 235000002639 sodium chloride Nutrition 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000012549 training Methods 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 102000005575 Cellulases Human genes 0.000 description 2
- 108010084185 Cellulases Proteins 0.000 description 2
- 229920002101 Chitin Polymers 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 229920000057 Mannan Polymers 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 2
- 208000022338 anthrax infection Diseases 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000002518 antifoaming agent Substances 0.000 description 2
- 239000007900 aqueous suspension Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 235000021152 breakfast Nutrition 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000005802 health problem Effects 0.000 description 2
- 230000008004 immune attack Effects 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 239000002955 immunomodulating agent Substances 0.000 description 2
- 230000002584 immunomodulator Effects 0.000 description 2
- 229940121354 immunomodulator Drugs 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 230000004630 mental health Effects 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 210000000822 natural killer cell Anatomy 0.000 description 2
- 238000007427 paired t-test Methods 0.000 description 2
- 230000008447 perception Effects 0.000 description 2
- 230000037081 physical activity Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000006388 psychological stress response Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000002195 soluble material Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 238000000528 statistical test Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 238000011287 therapeutic dose Methods 0.000 description 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical group FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- GUBGYTABKSRVRQ-DCSYEGIMSA-N Beta-Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-DCSYEGIMSA-N 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 108700011498 Glucocorticoid Receptor Deficiency Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 102100024023 Histone PARylation factor 1 Human genes 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101001047783 Homo sapiens Histone PARylation factor 1 Proteins 0.000 description 1
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 description 1
- 101000935040 Homo sapiens Integrin beta-2 Proteins 0.000 description 1
- 206010020400 Hostility Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102100022338 Integrin alpha-M Human genes 0.000 description 1
- 102100025390 Integrin beta-2 Human genes 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 241001580017 Jana Species 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010037180 Psychiatric symptoms Diseases 0.000 description 1
- 241000220010 Rhode Species 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- NFXPEBHDHBEHQC-YZJMRIMCSA-N [NH4+].[NH4+].[O-]S([O-])(=O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O Chemical compound [NH4+].[NH4+].[O-]S([O-])(=O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NFXPEBHDHBEHQC-YZJMRIMCSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229940023476 agar Drugs 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical group 0.000 description 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- WQZGKKKJIJFFOK-UHFFFAOYSA-N alpha-D-glucopyranose Natural products OCC1OC(O)C(O)C(O)C1O WQZGKKKJIJFFOK-UHFFFAOYSA-N 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000013011 aqueous formulation Substances 0.000 description 1
- 230000000386 athletic effect Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- 229940092782 bentonite Drugs 0.000 description 1
- 235000012216 bentonite Nutrition 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229960005069 calcium Drugs 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- LLSDKQJKOVVTOJ-UHFFFAOYSA-L calcium chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Ca+2] LLSDKQJKOVVTOJ-UHFFFAOYSA-L 0.000 description 1
- 229940052299 calcium chloride dihydrate Drugs 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000000828 canola oil Substances 0.000 description 1
- 235000019519 canola oil Nutrition 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000002962 chemical mutagen Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 108010047295 complement receptors Proteins 0.000 description 1
- 102000006834 complement receptors Human genes 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000021004 dietary regimen Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
- 239000007911 effervescent powder Substances 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229940044631 ferric chloride hexahydrate Drugs 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 208000026352 glucocorticoid resistance Diseases 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 238000011554 guinea pig model Methods 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hcl hcl Chemical compound Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000033444 hydroxylation Effects 0.000 description 1
- 238000005805 hydroxylation reaction Methods 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000000899 immune system response Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229940099472 immunoglobulin a Drugs 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 229960001438 immunostimulant agent Drugs 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 230000000266 injurious effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- NQXWGWZJXJUMQB-UHFFFAOYSA-K iron trichloride hexahydrate Chemical compound O.O.O.O.O.O.[Cl-].Cl[Fe+]Cl NQXWGWZJXJUMQB-UHFFFAOYSA-K 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- LUEWUZLMQUOBSB-GFVSVBBRSA-N mannan Chemical class O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-GFVSVBBRSA-N 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- 231100000707 mutagenic chemical Toxicity 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- CGVLVOOFCGWBCS-RGDJUOJXSA-N n-octyl β-d-thioglucopyranoside Chemical compound CCCCCCCCS[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O CGVLVOOFCGWBCS-RGDJUOJXSA-N 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 239000006179 pH buffering agent Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000008430 psychophysiology Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000012807 shake-flask culturing Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000012496 stress study Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000002476 tumorcidal effect Effects 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Otolaryngology (AREA)
- Physiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Plant Substances (AREA)
Description
1. Nieman, D. C., J. C. Ahle, D. A. Henson, et al. 1995. Indomethacin does not alter the natural killer cell response to 2.5 hours of running. J. Appl. Physiol. 79: 748-755.2. Nieman, D. C. 2003. Current perspectives on exercise immunology. Curr. Sports Med. Rep. 2:239-242.
3. Matthews, C. E., I. S. Ockene, P. S. Freedson, M. C. Rosal, P.A. Merriam and J. R. Hebert. 2002. Moderate to vigorous activity and risk of upper-respiratory tract infection. Med. And Sci. in Sports and Exercise. 34:1242-1248.
4. Strasner, A, C. E. Barlow, J. B. Kampert and A. L. Dunn. 2001. Impact of physical activity on URTI symptoms in Project PRIME participants. Med and Sci. in Sports and Exercise. 31(Suppl.):S304.
5. Nieman, D. C. 1997. Exercise immunology: practical applications. Intl. J. of Sports Med. 18(suppl 1):S91-S100.
6. Shinkai, S. Y. Kurokawa, S. Hino, et al. 1993. Triathalon competition induced a transient immunosuppressive change in the peripheral blood of athletes. J. of Sports Med. And Phys. Fitness. 33:70-78.
7. Mackinnon, L. T. and S. L. Hooper. 1994. Mucosal (secretory) immune system responses to exercise of varying intensity and during overtraining. Intl. J. of Sports Med. 15:S179-S183.
8. Nieman, D. C., S. Simandle, D. A. Henson et al. 1995. Lymphocyte proliferation response to 2.5 hours of running. Intl. J. of Sports Med. 16:406-410.
9. Cohen, S. 195. Psychological stress and susceptibility to the common cold. N. Eng. J. Med. 325:606-612.
10. Cohen, S., W. J. Doyle, D. P. Skoner et al. 1998. Types of stressors that increase susceptibility to the common cold in healthy adults. Health Psychol. 17:214-223.
11. Miller, G. E., S. Cohen, S. Pressman et al. 2004. Psychological stress and antibody response to influenza vaccination: when is the critical period for stress, and how does it get inside the body? Pshchomatic Medicine. 66:215-223.
12. Uchakin, P. N., B. Tobin, M. Cubbage, G. Marshall Jr., and C. Sams. 2001. Immune responsiveness following academic stress in first-year medical students. J. of Interferon and Cytokine Res. 21:687-694.
13. Deinzer, R., C. Kleineidam, R. Stiller-Winkler, H. Idel and D. Bachg. 2000. Prolonged reduction in salivary immunoglobulin A (sIgA) after a major academic exam. Intl. J. of Psychophysiology. 37:219-232.
14. Kang, D. H. and C. Fox. 2001. Th1 and Th2 cytokine responses to academic stress. Res. In Nursing and Health. 24:245-257.
15. Miller, G. E., S. Cohen and A. K. Ritchey. 2002. Chronic psychological stress and the reduction of pro-inflammatory cytokines: A glucocorticoid-resistance model. Health Psychol. 21:531-541.
16. Pressman, S. D., S. Cohen, G. E. Miller, A. Barkin, B. S. Rabin and J. J. Treanor. 2005. Loneliness, social network size, and immune response to influenza vaccination in college freshman. 2005. Health Psychol. 24:297-306.
17. Ader R, D. L. Felton and N. Cohen. 1991. Psycho-neuroimmunology. San Diego, CA: Academic Press.
18. Glaser R. and J. K. Kiecolt-Glaser. 1994. Handbook of human stress and immunity. New York: Academic Press.
19. Nieman, D. C., Bishop, N. C. 2006. Nutritional strategies to counter stress to the immune system in athletes, with speciall reference to football. J. Sports Sci. 24:763-772.
20. Langkamp-Henken, B. et al. 2004. Nutritional formula enhanced immune function and reduced days of symptoms of upper respiratory tract infection. J. Am. Geriatr. Soc. 52:3-12.
21. Hong, F., Yun, J. Baran J.T., Allendorf, D.J., Hansen, R. D. Ostroff, G.R., Xing, P.X., Cheung, N. V. and Ross, G. D. 2004. Mechanism by which orally administered β-1,3 glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. J. Immunol. 173:797-806.
22. McNair, D. M., J. W. P. Heuchert and E. Shilony. 2003. Profile of Mood States: Bibliography 1964-2002. Toronto, Canada: Mulit-Health Systems, Inc.
23. McNair, D. M., Lorr, M., & Droppleman, L. F. (1971). Manual for the Profile of Mood States. San Diego, CA: Educational and Industrial Testing Services.
24. Konig D., D. Grathwohl, C. Weinstock, H. Northoff and A. Berg. 2000. Upper respiratory tract infection in athletes: influence of lifestyle, type of sport, training effort and immunostimulant intake. Exercise Immunology Reviews. 6:102-120.
25. Cohen S., W. J. Doyle and D. P. Skoner. 1999. Psychological Stress, Cytokine Production, and Severity of Upper Respiratory Illness. Psychosomatic Medicine. 61:175-180.
26. Vetvicka, V., Terayma, K., Mandeville, R., Brousseau, P., Kournakakis, B. and Ostroff, G. 2002. Pilot study: Orally-administered yeast beta 1-3-glucan prophylactically protects against anthrax infection and cancer in mice. JANA 5:1-5.27. Kernodle, D. S., H. Gates and A. B. Kaiser. 1998. Prophylactic anti-Infective activity of poly-[1-6]--D-glucopyranosyl-[1-3]D glucopyranose glucan in a guinea pig model of Staphylococcal wound infection. Antimicrobial Agents and Chemotherapy. 42:545549
28. Yan J., Vetvicka, V., Xia, Y., Coxon, A., Carroll, M. C., Mayadas, T. N., and Ross, G. D. 1999.β-glucan, a “specific” biological response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18). J. Immunol. 163:3045-3052.
表1
プラセボ群と比較して2つのWGP治療群においてURTI症状の有意な(p<0.05)減少があった。2週間のインターバルで、プラセボ群における被験者の32%は、URTIに関連した症状を報告したが、2つの1,3/1,6−β−グルカン(250mgおよび500mg)介入群でそれぞれ10%および8%のみが類似したURTI症状を報告した。上気道感染症は、4週間目で、プラセボ被験者の28%に対して、両方の治療群における被験者の8%のみが報告した。
2. McEwans BS. Protective and damaging effects of stress mediators. N Engl J Med 1998;338:171-9
3. Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull 2004;130:601-30
4. Baum A, Cohen L, Hall M. Control and intrusive memories as possible determinants of chronic stress. Psychosom Med 1993;55:274-86
5. Rozanski A, Blumenthal JA, Kaplan J. Impact of psychological factors of cardiovascular disease and implications for therapy. Circulation 1999;99:2192-217
6. Heffner KL, Loving TJ, Robles TF, Kiecolt-Glaser JK. Examining psychosocial factors related to cancer incidence and progression: in search of the silver lining. Brain Behav Immunol 2003;17:S109-11
7. Cohen S. Psychological stress and susceptibility to the common cold. N Engl J Med 1991;325:606-12
8. Cohen S, Frank E, Doyle WJ, Skoner DP, Rabin BS, Gwaltney JM Jr. Types of stressors that increase susceptibility to the common cold in healthy adults. Health Psychol 1998;17:214-23
9. Miller GE, Cohen S, Pressman S, Barkin A, Rabin BS, Treanor JJ. Psychological stress and antibody response to influenza vaccination: when is the critical period for stress, and how does it get inside the body? Psychosom Med 2004;66:215-23.
10. Uchakin PN, Tobin B, Cubbage M, Marshall Jr G, Sams C. Immune responsiveness following academic stress in first-year medical students. J Interferon Cytokine Res 2001;687-94
11. Deinzer R, Kleineidam C, Stiller-Winkler R, Idel H, Bachg D. Prolonged reduction in salivary immunoglobulin A (sIgA) after a major academic exam. Int J Psychophysiol 2000;37:219-32.
12. Kang DH, Fox C. Th1 and Th2 cytokine responses to academic stress. Res Nurs Health 2001;24:245-57
13. Miller GE, Cohen S, Ritchey AK. Chronic psychological stress and the reduction of pro-inflammatory cytokines: a glucocorticoid-resistance model. Health Psychol 2002;21:531-41
14. Pressman SD, Cohen S, Miller GE, Barkin A, Rabin BS, Treanor JJ. Loneliness, social network size, and immune response to influenza vaccination in college freshmen. Health Psychol 2005;24:297-306
15. Ader R, Felton DL, Cohen N. Psycho-neuroimmunology. San Diego, CA: Academic Press; 1991
16. Glaser R, Kiecolt-Glaser JK. Handbook of human stress and immunity. New York. Academic Press; 1994
17. Nieman DC, Bishop NC. Nutritional strategies to counter stress to the immune system in athletes, with special reference to football. J Sports Sci 2006;24:763-72
18. Langkamp-Henken B, Bender BS, Gardner EM, Herrlinger-Garcia KA, Kelley MJ, Murasko DM, Schaller JP, Stechmiller JK, Thomas DJ, Wood SM. Nutritional formula enhanced immune function and reduced days of symptoms of upper respiratory tract infection in seniors. J Am Geriatr Soc 2004;52:3-12
19. Hong F, Yun J, Baran JT, Allendorf DJ, Hansen RD, Ostroff GR, Xing PX, Cheung N-KV, Ross GD. Mechanism by which orally administered β-1,3 glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. J Immunol 2004;173:797-806
20. McNair DM, Lorr M, Droppleman LF. EdITS Manual for the Profile of Mood States. San Diego, CA; Educational and Industrial Testing Services; 1992
21. Strasner A, Barlow CE, Kampert JB, Dunn AL. Impact of physical activity on URTI symptoms in Project PRIME participants. Med Sci Sports Exerc 2001;33(Suppl):S301
22. Konig D, Grathwohl D, Weinstock C, Northoff H, Berg A. Upper respiratory tract infection in athletes: influence of lifestyle, type of sport, training effort, and immunstiumulant intake. Exerc Immunol Rev 2000;6:102-20
23. Matthews CE, Ockene IS, Freedson PS, Rosal MC, Merriam PA, Hebert JR. Moderate to vigorous activity and risk of upper-respiratory tract infection. Med Sci Sports Exerc 2002;34:1242-48
24. Shinkai S, Kurokawa Y, Hino S, Hinrose M, Torii J, Watanabe S, Watanabe S, Shiraishi S, Oka K, Watanabe T. Triathalon competition induced a transient immunosuppressive change in the peripheral blood of athletes. J Sports Med Phys Fitness 1993;33:70-8
25. Vetvicka V, Terayma K, Mandeville R, Brousseau P, Kournaka B, Ostroff G. Pilot study: Orally administered yeast β1,3-glucan prophylactically protects against anthrax infection and cancer in mice. J Am Nutraceut Assoc 2002;5(2):5-9
26. Kernodle DS, Gates H, Kaiser AB. Prophylactic anti-infective activity of poly-[1-6]-D-glucopyranosyl-[1-3]-D-glucopyranose glucans in a guinea pig model of staphylococcal wound infection. Antimicrob Agents Chemother 1998;42:545-9
27. Yan J, Vetvicka V, Xia Y, Coxon A, Carroll MC, Mayadas TN, Ross GD. β-glucan, a “specific” biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18). J Immunol 1999;163:3045-52
改変された結合を有する最終処理製品の流体力学的パラメーター(K)は、最終式に従う処理時間に依存する。
K1=−0.0021(時間)+0.26
式中、時間は分であり、
時間は1時間未満である。
パラメーターKは、相対粘度と直接関連(比例)する。水性懸濁液の事例において、実際の粘度がセンチポアズで測定される場合、相対粘度は実際の粘度に等しい。
1/濃度=K1×(1/log(相対粘度))+K2
式中、
K1=(形状係数)×(流体力学的体積);および
K2(流体力学的体積)/(最大充填率)。
形状係数は、その水性環境におけるグルカンマトリックスの形状について記述する経験的に決定された値である。形状係数は粒子の長さ:幅の比率の関数であり、顕微鏡で決定することができる。流体力学的体積は、懸濁液中にある場合、粒子が占める体積の測定値である。これは、それがグルカンマトリックスの高容水量を示すという点でグルカン懸濁液についての重要なパラメーターである。最大充填率は、懸濁液の単位体積の中へ充填することができるグルカンの最も高い達成可能な体積分率として記載することができる。
錠剤は任意でコートまたは刻み目を付けることができ、活性成分の遅延放出または制御放出性)提供するように製剤化することができる。錠剤を任意で腸溶コーティングして胃ではない腸の一部分における放出を提供することができる。
本発明の態様として、例えば以下のものがある。
1.ストレスを受けた被験者における上気道感染症の症状を低減する方法であって、
前記被験者に効果的な量のβ−グルカンを投与し;
前記被験者が上気道感染症に関連した症状の低減を報告することを含む方法。
2.ストレスを受けた被験者の心理的安寧を増加する方法であって、
前記被験者に効果的な量のβ−グルカンを投与し;
前記被験者が心理的安寧の増加を報告することを含む方法。
〔1〕肉体的又は心理的ストレスを受けた被験者における、鼻づまり、鼻汁、咽頭炎、くしゃみ、咳、疲労、頭痛、全身倦怠および体の痛みからなる群から選択される1種以上の症状を低減するための組成物であって、酵母由来β−グルカンを含む組成物。
〔2〕毎日投与される、前記〔1〕に記載の組成物。
〔3〕前記酵母由来β−グルカンが、粒状β−グルカンである、前記〔1〕に記載の組成物。
〔4〕1日当たり250mg又は1日当たり500mg投与される、前記〔1〕に記載の組成物。
〔5〕肉体的又は心理的ストレスを受けた被験者における、鼻づまり、鼻汁、咽頭炎、くしゃみ、咳、疲労、頭痛、全身倦怠および体の痛みからなる群から選択される1種以上の症状を低減するための薬剤の製造のための、酵母由来β−グルカンの使用。
〔6〕肉体的又は心理的ストレスを受けた非ヒト被験者における、鼻づまり、鼻汁、咽頭炎、くしゃみ、咳、疲労、頭痛、全身倦怠および体の痛みからなる群から選択される1種以上の症状を低減する方法であって、
前記非ヒト被験者に効果的な量の酵母由来β−グルカンを投与することを含む方法。
本発明の更にまた別の態様は、以下のとおりであってもよい。
〔1'〕運動により引き起こされる肉体的ストレスを受けた被験者における、鼻づまり、鼻汁、咽頭炎、くしゃみ、咳、疲労、頭痛、全身倦怠および体の痛みからなる群から選択される1種以上の症状の低減のための組成物であって、酵母由来β−グルカンを含む組成物。
〔2'〕毎日投与される、前記〔1'〕に記載の組成物。
〔3'〕前記酵母由来β−グルカンが、粒状β−グルカンである、前記〔1'〕に記載の組成物。
〔4'〕前記酵母由来β−グルカンが、可溶性β−グルカンである、前記〔1'〕に記載の組成物。
〔5'〕1日当たり250mg又は1日当たり500mg投与される、前記〔1'〕に記載の組成物。
〔6'〕運動により引き起こされる肉体的ストレスを受けた被験者における、鼻づまり、鼻汁、咽頭炎、くしゃみ、咳、疲労、頭痛、全身倦怠および体の痛みからなる群から選択される1種以上の症状の低減のための薬剤の製造のための、酵母由来β−グルカンの使用。
〔7'〕運動により引き起こされる肉体的ストレスを受けた非ヒト被験者における、鼻づまり、鼻汁、咽頭炎、くしゃみ、咳、疲労、頭痛、全身倦怠および体の痛みからなる群から選択される1種以上の症状を低減する方法であって、
前記非ヒト被験者に効果的な量の酵母由来β−グルカンを投与することを含む、前記方法。
Claims (7)
- 運動により引き起こされる肉体的ストレスを受けた被験者における、鼻づまり、鼻汁、咽頭炎、くしゃみ、咳、疲労、頭痛、全身倦怠および体の痛みからなる群から選択される1種以上の症状の低減のための組成物であって、サッカロミセス セレヴィシエ由来β−グルカンを含む組成物。
- 毎日投与される、請求項1に記載の組成物。
- 前記β−グルカンが、粒状β−グルカンである、請求項1に記載の組成物。
- 前記β−グルカンが、可溶性β−グルカンである、請求項1に記載の組成物。
- 1日当たり250mg又は1日当たり500mg投与される、請求項1に記載の組成物。
- 運動により引き起こされる肉体的ストレスを受けた被験者における、鼻づまり、鼻汁、咽頭炎、くしゃみ、咳、疲労、頭痛、全身倦怠および体の痛みからなる群から選択される1種以上の症状の低減のための薬剤の製造のための、サッカロミセス セレヴィシエ由来β−グルカンの使用。
- 運動により引き起こされる肉体的ストレスを受けた非ヒト被験者における、鼻づまり、鼻汁、咽頭炎、くしゃみ、咳、疲労、頭痛、全身倦怠および体の痛みからなる群から選択される1種以上の症状を低減する方法であって、
前記非ヒト被験者に効果的な量のサッカロミセス セレヴィシエ由来β−グルカンを投与することを含む、前記方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97573407P | 2007-09-27 | 2007-09-27 | |
US60/975,734 | 2007-09-27 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010526967A Division JP2010540531A (ja) | 2007-09-27 | 2008-09-29 | 上気道感染症の症状および心理的安寧のβ−グルカン治療 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015155475A JP2015155475A (ja) | 2015-08-27 |
JP6078105B2 true JP6078105B2 (ja) | 2017-02-08 |
Family
ID=40511769
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010526967A Pending JP2010540531A (ja) | 2007-09-27 | 2008-09-29 | 上気道感染症の症状および心理的安寧のβ−グルカン治療 |
JP2015111978A Active JP6078105B2 (ja) | 2007-09-27 | 2015-06-02 | 上気道感染症の症状および心理的安寧のβ−グルカン治療 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010526967A Pending JP2010540531A (ja) | 2007-09-27 | 2008-09-29 | 上気道感染症の症状および心理的安寧のβ−グルカン治療 |
Country Status (15)
Country | Link |
---|---|
US (1) | US20110112048A1 (ja) |
EP (2) | EP2205250B1 (ja) |
JP (2) | JP2010540531A (ja) |
KR (3) | KR20100077175A (ja) |
CN (3) | CN102309503B (ja) |
AU (1) | AU2008305545B2 (ja) |
CA (1) | CA2700922C (ja) |
CO (1) | CO6321155A2 (ja) |
ES (2) | ES2580159T3 (ja) |
HK (1) | HK1166016A1 (ja) |
MX (1) | MX340664B (ja) |
MY (1) | MY156219A (ja) |
PL (1) | PL3072518T3 (ja) |
TR (1) | TR201807223T4 (ja) |
WO (1) | WO2009042230A1 (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK500492010A3 (sk) * | 2010-11-06 | 2012-06-04 | Pleuran, S.R.O. | Use of beta-D-glucane for decreasing undesirable effect of depression of immune response to excessive physical strain |
CN103783370B (zh) * | 2014-02-12 | 2015-05-20 | 北京同仁堂健康药业股份有限公司 | 一种保护呼吸道和肺部的组合物 |
TW201613618A (en) * | 2014-07-02 | 2016-04-16 | Shaklee Corp | Compositions and methods for enhancing immunity |
CN106038582A (zh) * | 2016-05-06 | 2016-10-26 | 云南大学 | 以树突状细胞相关c型植物凝集素‑1为靶点的抗抑郁症药物及其筛选方法 |
US11815435B2 (en) | 2017-02-24 | 2023-11-14 | Hibercell, Inc. | Beta glucan immunopharmacodynamics |
PT3664894T (pt) | 2017-08-11 | 2021-12-17 | Biocodex | Saccharomyces boulardii para o tratamento de perturbações do humor |
PL3700357T3 (pl) | 2017-10-23 | 2024-07-29 | Nutrileads B.V. | Hydrolizowane enzymatycznie polisacharydy pektynowe do leczenia lub zapobiegania zakażeniom |
BR112020011197A2 (pt) | 2017-12-04 | 2020-11-17 | Nutrileads B.V. | composição para uso na prevenção ou tratamento de salmonelose em animais, método para preparar uma composição comestível e composição comestível |
US20220132902A1 (en) * | 2020-08-12 | 2022-05-05 | Pharmavite, Llc | Prebiotic composition of pectin, beta-glucan, xylooligosaccharide and/or ashwagandha and a method of improving mood |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4992540A (en) | 1984-11-28 | 1991-02-12 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
AU650626B2 (en) | 1989-09-08 | 1994-06-30 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
US5811542A (en) | 1989-09-08 | 1998-09-22 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
US5622939A (en) | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
WO1991003248A2 (en) * | 1989-09-08 | 1991-03-21 | Alpha Beta Technology, Inc. | Method for immune system activation |
US5223491A (en) | 1989-11-09 | 1993-06-29 | Donzis Byron A | Method for revitalizing skin by applying topically water insoluble glucan |
US5576015A (en) | 1995-03-02 | 1996-11-19 | Donzis; Byron A. | Substantially purified beta (1,3) finely ground yeast cell wall glucan composition with dermatological and nutritional uses |
US6130244A (en) * | 1998-02-25 | 2000-10-10 | Abbott Laboratories | Product and method to reduce stress induced immune suppression |
JP2002209598A (ja) * | 2001-01-15 | 2002-07-30 | Kirin Brewery Co Ltd | 酵母由来可溶性多糖 |
US6939864B1 (en) * | 2001-07-09 | 2005-09-06 | Purdue Research Foundation | Animal feed compositions and methods of using the same |
US6503506B1 (en) * | 2001-08-10 | 2003-01-07 | Millenium Biotechnologies, Inc. | Nutrient therapy for immuno-compromised patients |
KR20030087383A (ko) * | 2002-05-08 | 2003-11-14 | 강상모 | 효모벽 추출물의 베타-글루칸을 이용한 건강증진 방법 |
DE202004013521U1 (de) * | 2004-08-30 | 2006-01-05 | Almapharm Christian F.A. Botzenhardt Gmbh + Co | Präparat aus beta-Glucan und Nukleotid zur Verabreichung an Tiere |
US20060084629A1 (en) * | 2004-10-15 | 2006-04-20 | Alvin Needleman | Immune system activating formula composed of selected long chain polysaccharides from natural sources |
JP2007190002A (ja) * | 2006-01-16 | 2007-08-02 | Elson Kk | ストレス適応形成を促進させる機能性飲食品 |
-
2008
- 2008-09-29 KR KR1020107009071A patent/KR20100077175A/ko not_active Application Discontinuation
- 2008-09-29 TR TR2018/07223T patent/TR201807223T4/tr unknown
- 2008-09-29 AU AU2008305545A patent/AU2008305545B2/en active Active
- 2008-09-29 CN CN2011102256964A patent/CN102309503B/zh active Active
- 2008-09-29 EP EP08833584.9A patent/EP2205250B1/en active Active
- 2008-09-29 KR KR1020167014275A patent/KR20160067982A/ko active Search and Examination
- 2008-09-29 US US12/286,185 patent/US20110112048A1/en not_active Abandoned
- 2008-09-29 CN CN200880117733A patent/CN101873860A/zh active Pending
- 2008-09-29 PL PL16165948T patent/PL3072518T3/pl unknown
- 2008-09-29 MX MX2010003462A patent/MX340664B/es active IP Right Grant
- 2008-09-29 WO PCT/US2008/011249 patent/WO2009042230A1/en active Application Filing
- 2008-09-29 KR KR1020157013487A patent/KR20150064233A/ko active Search and Examination
- 2008-09-29 MY MYPI2010001341A patent/MY156219A/en unknown
- 2008-09-29 CA CA2700922A patent/CA2700922C/en active Active
- 2008-09-29 ES ES08833584.9T patent/ES2580159T3/es active Active
- 2008-09-29 CN CN201510514507.3A patent/CN105326852B/zh active Active
- 2008-09-29 EP EP16165948.7A patent/EP3072518B1/en active Active
- 2008-09-29 JP JP2010526967A patent/JP2010540531A/ja active Pending
- 2008-09-29 ES ES16165948.7T patent/ES2675942T3/es active Active
-
2010
- 2010-04-27 CO CO10049552A patent/CO6321155A2/es not_active Application Discontinuation
-
2012
- 2012-07-11 HK HK12106829.0A patent/HK1166016A1/xx unknown
-
2015
- 2015-06-02 JP JP2015111978A patent/JP6078105B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
EP3072518A1 (en) | 2016-09-28 |
AU2008305545B2 (en) | 2014-07-17 |
AU2008305545A1 (en) | 2009-04-02 |
CN105326852B (zh) | 2018-11-23 |
JP2015155475A (ja) | 2015-08-27 |
MX340664B (es) | 2016-07-20 |
HK1166016A1 (en) | 2012-10-19 |
TR201807223T4 (tr) | 2018-06-21 |
EP2205250A1 (en) | 2010-07-14 |
MX2010003462A (es) | 2010-08-18 |
CN102309503A (zh) | 2012-01-11 |
CN102309503B (zh) | 2013-11-20 |
WO2009042230A1 (en) | 2009-04-02 |
JP2010540531A (ja) | 2010-12-24 |
KR20150064233A (ko) | 2015-06-10 |
CA2700922C (en) | 2016-07-05 |
CA2700922A1 (en) | 2009-04-02 |
EP2205250B1 (en) | 2016-05-04 |
ES2675942T3 (es) | 2018-07-13 |
CN101873860A (zh) | 2010-10-27 |
CN105326852A (zh) | 2016-02-17 |
KR20100077175A (ko) | 2010-07-07 |
CO6321155A2 (es) | 2011-09-20 |
EP2205250A4 (en) | 2011-04-06 |
MY156219A (en) | 2016-01-29 |
PL3072518T3 (pl) | 2018-10-31 |
US20110112048A1 (en) | 2011-05-12 |
ES2580159T3 (es) | 2016-08-19 |
EP3072518B1 (en) | 2018-05-09 |
KR20160067982A (ko) | 2016-06-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6078105B2 (ja) | 上気道感染症の症状および心理的安寧のβ−グルカン治療 | |
JP5498698B2 (ja) | シロキクラゲ雑多糖またはその抽出物の新用途 | |
CN108430479A (zh) | β-1,3-葡聚糖用于调节免疫功能和治疗肠道炎症的用途 | |
US8946193B2 (en) | Medical uses of glucans | |
EP3739068A1 (en) | Nanovesicles derived from faecalibacterium prausnitzii, and uses thereof | |
CN1964722A (zh) | 与抗生素、疫苗和病毒单克隆抗体组合的全葡聚糖颗粒 | |
Kawano et al. | High-parameter immune profiling and subjective health assessment of the immunomodulatory effects of paramylon-rich Euglena gracilis EOD-1: A randomized, double-blind, placebo-controlled, parallel-group study | |
CN110156910A (zh) | 酵母葡聚糖提取物、组合物及在制备预防便秘制剂中的应用 | |
EP2486931B1 (en) | Therapeutic agent for influenza virus infectious diseases | |
CN102917716B (zh) | 免疫印记的营养组合物 | |
CN115381863B (zh) | 一种海蓬子提取物及其制备方法和应用 | |
JP7372112B2 (ja) | 抗i型アレルギー剤 | |
WO2019108319A1 (en) | Compositions containing euglena gracilis for viral protection and related methods | |
CN104056252B (zh) | 一种辅助抗辐射的组合物 | |
EP3760743A1 (en) | Nanovesicles derived from rhizobium sp. bacteria, and use thereof | |
CN116942685A (zh) | 酸性羊乳寡糖组合物在制备抗过敏药物或食物中的应用 | |
CN117257828A (zh) | 竹节参多糖在防治非酒精性脂肪肝与肠道菌群紊乱中的应用 | |
US20140212494A1 (en) | Methods of Improving Digestive Health | |
CN102441002A (zh) | 细菌内毒素的另一种新用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150702 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150702 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160530 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20160829 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20161031 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20161214 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170113 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6078105 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |