JP6077162B1 - White turmeric dry powder containing a high content of labdan-type diterpene compounds - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a powder containing a high content of a labdan type diterpene compound. The present invention is a dry powder of white turmeric rhizome characterized by containing a high content of labdane-type diterpene compounds, the dry powder containing a high content of labdane-type diterpenes compound, The labdane-type diterpene compounds, which are known in the past, have a high content of labdane-type diterpene compounds to the extent that they can be used as powders in pharmaceuticals, functional foods, and health foods. [Selection figure] None

Description

  The present invention relates to a dry powder of white turmeric used for various uses such as pharmaceuticals, functional foods and health foods.

  Labdan-type diterpene compounds are known to exhibit various pharmacological actions, and are used as active ingredients in compositions for beautifying skin (Patent Document 1) and synovial growth inhibitors (Patent Document 2).

JP 2013-60403 A JP 2014-152165 A

  Although it is known that labdan-type diterpene compounds are contained in plants belonging to the genus Ginger, Turmeric, Hanamyouga and Shukusha, such as Myouga, Purple Turmeric, Hanamyouga, Ghetto, Sanna, Hanashukusha and Kibanaranga In addition, the labdan type diterpene compounds are different in content in natural products and have a small absolute amount in the first place.

  Moreover, even if it is the same kind of plant, its content varies greatly depending on the time of growth, the time of collection, etc., and even in the same plant, it is contained in leaves, stems, rhizomes, flowers, etc. The amount of labdan-type diterpene compounds varies greatly.

  Therefore, in order to obtain a labdane-type diterpene compound as an active ingredient, it must be extracted, concentrated and purified from a plant containing a small amount of the labdane-type diterpene compound. Complicated operations were required.

  In addition, the labdan-type diterpene compounds are not stable compounds, and when left standing, there is a problem that the activity is lost due to a reaction such as polymerization, so that handling is difficult.

  The present inventors have surprisingly found that labdan-type diterpene compounds are much higher in the dry powder obtained by drying white turmeric (scientific name: Curcuma caesia) than other turmeric powders. It was found that it can be used in various applications as it is in dry powder without being contained in the content and without being extracted, thereby completing the present invention.

  An object of the present invention is to provide a labdane-type diterpene compound as a powder containing a high content without extracting and purifying the labdane-type diterpene compound. It is not known at all until now.

The present invention relates to (E) -8β (17) -labd-12-ene-15,16,17-trial, (E) -8β (17) -epoxylabd-12-ene-15,16-dial, 16 500 μg / g of one or more labdan- type diterpenes selected from oxo-8 (17), 12 (E) -labdadien-15-oic acid and labd-8 (17), 12-diene-15,16-dial g or more ,
The particle size is 0.1 to 1.0 mm,
A dry powder of white turmeric rhizome having excellent storage stability , characterized by having a water content of 10% or less .

  According to the present invention, white turmeric dry powder contains a high content of labdane-type diterpene compounds, and the powders of labdane-type diterpene compounds known so far are used for pharmaceuticals, functional foods, and health foods. Contains a high content of labdane-type diterpene compounds to the extent that they can be used as they are.

  In addition, according to the present invention, since the labdan type diterpene compound is contained in an amount of 500 μg or more in 1 g of white turmeric dry powder, it can be used as a raw material for health foods and pharmaceuticals, and can be molded or formulated for use. Just by doing, you can make health foods and medicines.

  In the present invention, the labdane-type diterpene compound comprises (E) -8β (17) -labd-12-ene-15,16,17-trial, (E) -8β (17) -epoxylabd-12. One selected from ene-15,16-dial, 16-oxo-8 (17), 12 (E) -labdadiene-15-oicic acid and labda-8 (17), 12-diene-15,16-dial Since it is above, the outstanding pharmacological effect can be show | played.

  Moreover, since this invention is 0.1-1.0 mm in particle size, it is excellent in preservability and storage property, formulation is easy, and handling is easy.

  The dry powder of white turmeric rhizome of the present invention (hereinafter sometimes referred to as white turmeric dry powder) is a powder having a white to slightly yellow appearance, a water content of 3 to 10%, and a particle size of 0.1 to 0.1%. 1.0 mm powder.

  The appearance of the dry powder is whiter when the particle size of the powder is smaller. The water content is 3 to 10%, preferably 5 to 8%, particularly preferably 6 to 7%.

  If the water content is 10% or more, the labdan-type diterpene compound contained in the powder is not preferable because it decomposes or polymerizes during storage and the content decreases.

  This powder contains 500 μg or more of labdan-type diterpene compound per 1 g of powder, preferably 1000 μg per 1 g of powder, and particularly preferably 1200 μg or more per 1 g of powder.

  This powder includes various types of labdan-type diterpene compounds, and as typical labdan-type diterpene compounds, (E) -8β (17) -labd-12-ene-15,16, 17-trial, (E) -8β (17) -epoxylabd-12-ene-15,16-dial, 16-oxo-8 (17), 12 (E) -labdadien-15-oiic acid and labda-8 (17), 12-diene-15,16-dial and the like.

  The content varies depending on cultivation conditions, harvest time, production place, drying conditions, etc., but (E) -8β (17) -Rabdo-12-ene-15,16,17-trial is 25.0 to 56. 0.0%, (E) -8β (17) -Epoxylabd-12-ene-15,16-diar is 3.5-8%, 16-oxo-8 (17), 12 (E) -labdadiene-15 -Oic acid is 10.0 to 15.5% and Rabda-8 (17), 12-diene-15,16-dial is 4.5 to 10.5%.

  In the present invention, these labdan type diterpene compounds may be free compounds or various salts. Moreover, it is not necessary to contain all four types, and it is sufficient that any one type is contained, but four equivalent mixtures may be used, and two to three types are equivalent mixtures, and remain. The content of 2 to 1 type may be different, and further, the content ratio of all 4 types may be different.

  In addition to the diterpene compounds, the white turmeric dry powder of the present invention contains diterpene compounds such as cruzolenone and kurdione, sesquiterpene compounds, and the like.

  These labdan-type diterpene compounds have been found by the present inventors to be contained in a very high content only in dry powder of white turmeric, and are known to contain labdane-type diterpene compounds. Other white plants, such as ginger, purple turmeric, hanamyoga, ghetto, sannah, hanashukusha and kibanaranga, plants belonging to the genus turmeric, genus genus, and genus Shuksha, even when made into a dry powder, Compared with dry powder of turmeric, the content of labdane type diterpene compounds is very small.

  Compared with other turmeric powders, the white turmeric dry powder of the present invention contains a high amount of labdane-type diterpene compounds because most of the terpene compounds contained are labdane-type, and other terpene-type compounds contain It has the characteristic that it does not contain substantially.

  Furthermore, the white turmeric dry powder of the present invention contains 0.5 to 5.0% of pinene, which is a monoterpene compound, containing 0.1 to 0.3% of α-tocopherol, containing no curcumin, and sesquiterpene Dehydrocrudione, a similar compound, is contained in an amount of 3.0 to 8.0%, culudione in an amount of 1.0 to 6.5%, curcumenone in an amount of 2.5 to 7.0%, and curzelenone in an amount of 5.0 to 10%. It has the characteristics of.

In addition, the particle size of the dry white turmeric dry powder of the present invention is not particularly limited as long as it is a powder suitable for formulation and use in functional foods or health foods. Examples include 0 mm powder.
Furthermore, the white turmeric dry powder of the present invention can be used as an excipient for stabilizing labdane-type diterpene compounds.

  In addition, the particle size distribution is not particularly limited. For example, those that do not pass through a 24 mesh standard sieve (particles exceeding a particle size of 1.08 mm) are less than 1%, and pass through a 24 mesh standard sieve to 90 mesh. 80% to 85% (particle size: 1.08 to 0.29 mm) passes through the 90 mesh standard sieve and does not pass through the 180 mesh standard sieve (particle size: 0.29 to 0.2 mm). 141 mm) passes through a standard sieve of 8 to 12%, 180 mesh but does not pass through a standard sieve of 250 mesh (particle size 0.141 to 0.105 mm) passes through a standard sieve of 5 to 10%, 250 mesh. Examples thereof include dry powders containing 1 to 2% of particles (particle size less than 0.105 mm).

  The white turmeric dry powder of the present invention can be produced by drying and pulverizing white turmeric. Either drying or pulverization may be performed first, or a combination of drying and pulverization is performed a plurality of times. May be implemented.

The white turmeric used as the raw material of the dried white turmeric powder of the present invention is clearly different from the known turmeric. For example, white turmeric, spring turmeric, autumn turmeric, and purple turmeric are not much different in form and color except that they are slightly smaller in appearance. There is a clear difference when compared.
The rhizomes of spring turmeric and autumn turmeric are yellow in spring turmeric and orange-yellow in autumn turmeric due to the difference in curcumin content contained in the rhizome. Purple turmeric accumulates a specific purple pigment in the tissue. However, since white turmeric does not contain the above-mentioned pigment at all, its cut surface has a white color. Therefore, identification of white turmeric is extremely easy.

  White turmeric is cultivated in Kyushu, Okinawa and the like in Japan, and the inventors also cultivate outside of Japan such as the Asian countries such as the Philippines, Taiwan and China.

  White turmeric may be produced in Japan, but can be used even if it is cultivated overseas, for example, in the Philippines, Taiwan, China and the like. Further, it may be naturally grown or artificially cultivated.

  Also, white turmeric leaves, flowers, branches, stems, etc. have a low content of labdane-type diterpene compounds and a high content of labdane-type diterpene compounds contained in the rhizome. As a material, it is preferable to use a rhizome.

  Drying can be carried out using a known method. When the form of white turmeric to be dried is used as it is, or the rhizome is processed into small pieces or fine pieces, natural drying such as sun drying or indoor drying, and air drying can be given. For example, the white turmeric rhizome is once ground. In the case of drying in the form of a paste or solution by a method such as crushing or crushing, methods such as freeze drying and spray drying can be employed.

  Although drying depends on the form of white turmeric, when pulverization after drying is planned, the moisture content is 8% or less, preferably 6% or less.

  Further, when the white turmeric rhizome is in the form of a paste or solution and is powdered as it is, it is dried so that the water content is 15% or less, preferably 10% or less.

  When white turmeric rhizomes are dried as they are, or as rhizomes are cut into small pieces or fine pieces, crushing is performed by crushing crushers such as jaw crushers, gyratory crushers, corn crushers, shearing crushers such as cutter mills and shredders. , Impact crushers such as hammer crushers, roll mills such as roll crushers, rotary crushers such as disintegrators and cage mills, screw mills such as coffee mills, roll shaking mills such as edge runners, striking mills such as stamp mills, centrifugal Roller mills, ball bearing mills, ball mills, roller mills such as Zegomiru, Ong mills, swing hammer mills, cage mills, turbo type mills, centrifugal classification mills and other high-speed rotating mills, rolling ball mills, vibration ball mills, planetary ball mills, Container vibration mill such as F mill, airflow collision mill, impact plate collision, a jet mill, such as a fluidized bed mill, using an ultrasonic pulverizer, may be performed.

  In the white turmeric dry powder of the present invention, the content of the labdan-type diterpene compound contained in the white turmeric rhizome is lowered by heat. Therefore, the drying and pulverization are preferably performed at a temperature of 80 ° C. or lower. In particular, it is particularly preferable to maintain 60 to 70 ° C.

  The white turmeric dry powder of the present invention thus obtained contains a high content of labdane-type diterpene compounds and can be used as it is as a beautifying skin composition or as a synovial growth inhibitor.

  The white turmeric dry powder thus obtained can be formulated as it is, or if necessary, by mixing with excipients, lubricants, binders, colorants and the like, and granulated and tableted.

  Furthermore, if necessary, it can be made into oral preparations such as capsules, tablets, granules, fine granules, and powders by coating with capsules or filling capsules.

  In the above preparation, excipients include water-soluble saccharides such as glucose, lactose, sucrose, maltose and trehalose, polysaccharides such as corn starch, starch and crystalline cellulose, amino acids such as glycine, sorbitol, mannitol, xylitol, erythritol, Examples thereof include sugar alcohols such as maltitol, phosphates or silicates such as calcium citrate, potassium phosphate, calcium phosphate, calcium hydrogen phosphate, and magnesium aluminate metasilicate.

  Lubricants include alkaline earth metal salts such as magnesium stearate and calcium stearate, talc, silica, light anhydrous silicic acid, hydrous silicon dioxide and other silicon compounds, sucrose stearate, sucrose behen. Examples include higher sucrose fatty acid esters such as acid esters, and higher glycerin fatty acid esters such as glycerol behenate.

  Examples of the binder include syrup, gum arabic, gelatin, sorbit, tragacanth, polyvinylpyrrolidone, starch, hydroxypropylcellulose, hydroxypropylmethylcellulose, dextrin, and ethylcellulose.

  As a coloring agent, β-carotene, tar pigment, lake pigment, caramel, iron oxide, copper chlorophyll, edible red No. 2, No. 3, edible yellow No. 4, No. 5, edible green No. 3, edible blue No. 1, 2 No., these aluminum lakes, ferric oxide, yellow ferric oxide, etc.

  Examples of natural animal and vegetable oils and fats that are base materials for external preparations include olive oil, mink oil, castor oil, palm oil, beef tallow, evening primrose oil, coconut oil, castor oil, cacao oil, and macadamia nut oil. Examples of the wax include jojoba oil, beeswax, lanolin, carnauba wax, and candelilla wax. Examples of the higher alcohol include lauryl alcohol, stearyl alcohol, cetyl alcohol, and oleyl alcohol.

  Examples of higher fatty acids include lauric acid, palmitic acid, stearic acid, oleic acid, behenic acid, lanolin fatty acid, and the like. Examples of higher aliphatic hydrocarbons include liquid paraffin, solid paraffin, squalane, petrolatum, ceresin, and microcrystalline wax. Synthetic ester oils include, for example, butyl stearate, hexyl laurate, diisopropyl adipate, diisopropyl sebacate, octyldodecyl myristate, isopropyl myristate, isopropyl palmitate isopropyl myristate, cetyl isooctanoate, neopentyl glycol dicaprate Etc.

  Examples of silicone derivatives include silicone oils such as methyl silicone and methyl phenyl silicone. Examples of the surfactant include anionic surfactants such as alkyl sulfates, fatty acid salts, alkyl phosphates, phosphates and sulfates of polyoxyethylene alkyl ethers. Examples of the nonionic surfactant include glycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether, sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester and the like.

  Examples of the double-sided activator include alkylbetaines, phosphobetaines, phosphatidylcholines, phosphatidylethanolamines, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol and lysates thereof, and phosphophatidic acid and salts thereof.

  Furthermore, examples of the polyhydric alcohol include polyethylene glycols such as ethylene glycol, diethylene glycol, and triethylene glycol, polypropylene glycols such as propylene glycol and dipropylene glycol, 1,3-butylene glycol, and 1,4-butylene glycol. Butylene glycols such as glycerol, polyglycerols such as glycerin and diglycerol, sugar alcohols such as sorbitol, mannitol, xylitol, maltitol, ethylene oxide of glycerol (hereinafter abbreviated as EO), propylene oxide (hereinafter abbreviated as PO) ) Adduct, EO of sugar alcohols, PO adduct, saccharides such as galactose, glucose, fructose and polysaccharides such as EO, PO adduct, maltose, lactose Of EO, polyhydric alcohols such as PO adducts thereof.

  Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited only to these examples.

Example 1
In Yamakawa, Miyama, Fukuoka Prefecture, 1.0 kg of white turmeric rhizomes harvested from November to December are washed with water, sliced into thicknesses of 5 and 5 cm, dried at 60 to 70 ° C. for 2 days, and residual moisture Was set to 10%.

  Subsequently, the dried slice of white turmeric was pulverized using a screw-type crusher to obtain a white turmeric dry powder having a particle size of 0.1 to 1.0 mm.

  The obtained white turmeric dry powder was further pulverized and 4 g of white turmeric dry powder having a particle size of less than 0.1 mm was suspended in 20 ml of hexane and extracted at room temperature for 3 days. Subsequently, the solid substance was removed by filtration to obtain a hexane extract. This hexane extract is analyzed using GC-MS (E1, 70e, manufactured by JEOL Ltd., JMN-ECA-600 type), and compared with a calibration curve in which the peak area is measured in advance, the labdan type contained When the total amount of diterpene compounds was determined, 1000 μg of labdane-type diterpene compounds per 1 g of white turmeric dry powder was contained.

The hexane extract obtained above was fractionated by silica gel column chromatography using hexane, ethyl acetate, and methanol, and the labdane-type diterpene compounds in the obtained fraction were classified into MS (mass spectrum) and ¹³ When the C-NMR spectrum was measured and confirmed, the spectrum data shown in Tables 1 to 4 were obtained.

  The spectral data in Table 1 is consistent with the spectral data described in the literature (Biosci. Biotechnol. Biochem., 70 (10), 2494-2500, 2006). Therefore, the first component having the spectral data is represented by (E ) -8β (17) -labd-12-ene-15,16,17-trial.

  The spectral data in Table 2 is consistent with the spectral data described in the literature (Biosci. Biotechnol. Biochem., 66 (12), 2698-2700, 2002), so the second component having the spectral data is represented by (E ) -8β (17) -epoxylabdo-12-ene-15,16-dial.

  Since the spectrum data in Table 3 is consistent with the spectrum data described in the literature (J. Nat. Prod., 60, 1287- 1293, 1997), the third component having the spectrum data is designated as 16-oxo-8. (17), 12 (E) -Labdadien-15-oiic acid was identified.

Since the spectrum data in Table 4 coincide with the spectrum data described in the literature (Phytochemistry, 36 (3), 699-701, 1994), the fourth component having the spectrum data is referred to as Rabda-8 (17), It was identified as 12-diene-15,16-dial.

  From the above results, it was found that the white turmeric dry powder of Example 1 contained four types of labdan-type diterpenes having the spectrum data shown in Tables 1 to 4 above.

Experimental example 1
(Content of labdan-type diterpene compounds in white turmeric dry powder)
<Experiment method>
4 g each of dry powder of white turmeric rhizome, dry powder of white turmeric leaf, dried powder of spring turmeric rhizome and dry powder of myoga leaves are suspended in 20 ml of n-hexane, respectively, except for occasional shaking at room temperature for 3 days. Left and extracted. After extraction, the solid was removed by filtration to obtain a hexane extract.

  The amount of labdane type diterpene compound contained in this hexane extract was measured using GC-MS (JEOL Ltd., JMN-ECA-600 type).

<Result>
The results are as shown in Table 5. The dry powder of white turmeric rhizome contained a labdan-type diterpene compound that was much higher than other dry powders.

注：ミョウガ茎葉の乾燥粉末の抽出物中には、ラブダン型ジテルペン類化合物以外のテルペンを含む。

Note: The dry powder extract of myoga stems and leaves contains terpenes other than labdan-type diterpenes.

Experimental example 2
(Heating stability of white turmeric dry powder)
<Experiment method>
Among the white turmeric dry powder, 5 g of each white turmeric dry powder having a particle size of 0.29 to 1.08 mm was placed in a weighing bottle and heated at 70 ° C., 80 ° C. and 90 ° C. for 60 minutes.

  After heating, each powder was extracted with n-hexane. The obtained extract was concentrated under reduced pressure to obtain an oily substance containing a labdane type diterpene compound. As a control, an untreated powder having the same particle size was extracted with n-hexane and concentrated under reduced pressure to obtain an oily substance containing a labdane-type diterpene compound.

The obtained oil was evaluated for hyaluronidase activity.
<Method for evaluating hyaluronidase inhibitory activity>

  40 μl of a sample solution (treatment concentration: 5 mg / ml) in which oil is dissolved in DMSO and 160 μl of 0.1 M acetate buffer (pH 3.8 to 4.0) are placed in a tube and mixed well, and hyaluronidase is mixed there. 100 μl of solution (4000 units / ml) was added and incubated at 37 ° C. for 20 minutes. Next, 200 μl of Compound 48/80 solution (0.5 mg / ml) was added as a hyaluronidase activator, and further incubated at 37 ° C. for 20 minutes.

  Subsequently, 500 μl of sodium hyaluronate solution (0.8 mg / ml) was added and incubated at 37 ° C. for 40 minutes. Thereafter, 200 μl of 0.4N sodium hydroxide aqueous solution was added as a reaction terminator, and the reaction was terminated by cooling on ice.

After stopping the reaction, 200 μl of 0.1 M borate buffer (pH 9.1) was added and mixed well, heated at 100 ° C. for 5 minutes, and then cooled on ice. Subsequently, the mixture was centrifuged at 20000 G for 10 minutes. Next, 140 μl of the supernatant after centrifugation and 600 μl of the coloring reagent were mixed well and incubated at 37 ° C. for 20 minutes. This is referred to as sample _{S 1.}

  In addition, as the coloring reagent, a stock solution in which 25 g of p-dimethylaminobenzaldehyde was dissolved in a mixed solution of 12.5 ml of 10N hydrochloric acid and 37.5 ml of acetic acid and stored at 10 ° C. or less for a period of one month was used immediately before use. And 10-fold diluted with acetic acid.

Similarly, a sample using DMSO instead of the sample solution (hereinafter referred to as “control C ₁ ”), a sample using 0.1 M acetate buffer (pH 3.8 to 4.0) instead of hyaluronidase ( Hereinafter, “sample blank SB ₁ ” and DMSO instead of the sample solution and 0.1 M acetate buffer (pH 3.8 to 4.0) instead of hyaluronidase (hereinafter “control”) was prepared) that blank CB ₁ ". Hyaluronidase, Compound 48/80, and sodium hyaluronate were all dissolved in 0.1 M acetate buffer (pH 3.8 to 4.0) and used for the test.

The absorbance at a wavelength of 585 nm was measured for sample S ₁ , control C ₁ and sample blank SB _{1 using} control blank CB ₁ as a measurement blank. From the measurement results, the hyaluronidase activity inhibition rate was calculated according to the following formula (A). The test was performed 3 times, and the average was expressed as 1 data. The higher the value of the hyaluronidase activity inhibition rate, the higher the hyaluronidase inhibitory activity.

Hyaluronidase activity inhibition rate (%) =
{C _1- (S ₁ -SB ₁ )} / C ₁ × 100 (A)
[In the formula, symbol C ₁ indicates the absorbance of control C ₁ , S ₁ indicates the absorbance of sample S ₁ , and SB ₁ indicates the absorbance of sample blank SB ₁ . ]

<Result>
The experimental results are as shown in Table 6.

表６の記載から明らかなように、油状物の収率は９０℃の加熱で若干の低下が認められるものの、その他の温度では明確な差異が認められなかった。
しかし、ヒアルロニダーゼ活性阻害作用は、加熱温度が高いほど、低下し、明らかに有効成分であるラブダン型ジテルペン類化合物の熱変性が観察された。

As is clear from the description in Table 6, although the oil yield was slightly reduced by heating at 90 ° C., no clear difference was observed at other temperatures.
However, the hyaluronidase activity inhibitory action decreased as the heating temperature increased, and it was apparent that thermal denaturation of the labdane-type diterpene compound, which is an active ingredient, was observed.

Claims (4)

(E) -8β (17) -Rubbed-12-ene-15,16,17-trial, (E) -8β (17) -epoxylabd-12-ene-15,16-dial, 16-oxo-8 500 μg / g or more of at least one labdane- type diterpene compound selected from (17), 12 (E) -labdadien-15-oiic acid and labdah-8 (17), 12-diene-15,16-dial ,
The particle size is 0.1 to 1.0 mm,
A dry powder of white turmeric rhizome having excellent storage stability , characterized by having a water content of 10% or less . The powder having a particle size of 1.08 mm is less than 1%, the powder having a particle size of 1.08 to 0.29 mm is 80 to 85%, the powder having a particle size of 0.29 to 0.141 mm is 8 to 12%, and the particle size is 0.1. 2. The dry powder of white turmeric rhizome according to claim 1, comprising 5 to 10% of a powder having a particle size of 141 to 0.105 mm and 1 to 2% of a powder having a particle size of less than 0.105 mm. Does not contain curcumin, α-tocopherol 0.1-0.3%, monoterpene compound pinene 0.5-5.0%, sesquiterpene compound dehydrocrudione 3.0- 3. The composition according to claim 1, comprising 8.0%, 1.0 to 6.5% of kurdione, 2.5 to 7.0% of curcumenone, and 5.0 to 10% of cruzelenone. White turmeric rhizome dry powder. A dry powder formulation of white turmeric rhizome excellent in storage stability, comprising the dry powder of white turmeric rhizome according to any one of claims 1 to 3.