JP6072516B2 - アレルギー改善剤 - Google Patents
アレルギー改善剤 Download PDFInfo
- Publication number
- JP6072516B2 JP6072516B2 JP2012253718A JP2012253718A JP6072516B2 JP 6072516 B2 JP6072516 B2 JP 6072516B2 JP 2012253718 A JP2012253718 A JP 2012253718A JP 2012253718 A JP2012253718 A JP 2012253718A JP 6072516 B2 JP6072516 B2 JP 6072516B2
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- JP
- Japan
- Prior art keywords
- allergy
- galactopyranosyl
- galactooligosaccharide
- improving
- glucose
- Prior art date
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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Description
すなわち本発明は、以下の様態を含むものである。
(1)O -β- D - galactopyranosyl - (1 → 6) - O - β - D - galactopyranosyl - (1 → 4) - D - glucose、または、O -β- D - galactopyranosyl - (1 → 4) - [O - β - D - galactopyranosyl - (1 → 6)] - D - glucoseで表される構造式を有する ガラクトオリゴ糖を有効成分とするアレルギー改善剤。
(2)前記ガラクトオリゴ糖が哺乳類の乳に由来することを特徴とする(1)記載のアレルギー改善剤。
(3)前記ガラクトオリゴ糖が牛乳由来であることを特徴とする(1)乃至(2)記載のアレルギー改善剤。
(4)(1)乃至(3)のいずれかに記載のアレルギー改善剤を含むことを特徴とするアレルギー改善用飲食品、アレルギー改善用栄養組成物、アレルギー改善用飼料又はアレルギー改善用医薬品。
(5)(1)乃至(3)のいずれかに記載のアレルギー改善剤を経口摂取することによるアレルギーの改善方法。
また、上記のように調製したガラクトオリゴ糖は、逆浸透膜(RO)膜等で濃縮することや、凍結乾燥等により乾燥することも可能である。
さらに、これらを製剤化した後に、これを栄養剤やヨーグルト、飲料、ウエハース等の飲食品、栄養組成物、飼料及び医薬品に配合することも可能である。
また、そのようなアレルギー改善用飲食品、アレルギー改善用栄養組成物、アレルギー改善用飼料又はアレルギー改善用医薬品を原材料として、他の飲食品等に通常含まれる原材料等を配合して調製することも可能である。
このようにして得られたガラクトオリゴ糖は、そのまま本発明のアレルギー改善剤として使用可能である。
このようにして得られたガラクトオリゴ糖は、そのまま本発明のアレルギー改善剤として使用可能である。
(動物実験)
実施例品1、2のガラクトオリゴ糖を使用して、アレルギー改善作用について評価した。実験には4週齢のBALB/cマウスを使用した。マウスの右耳介内側に0.3%TNCB溶液を10μl塗布して感作させた。1週間後、2から3日おきに0.3%TNCB溶液10μlをマウスの右耳介内側に塗布した。その間、マウスを、生理食塩水を投与する群(A群)、実施例品1のガラクトオリゴ糖をマウス体重1kgあたり50mg投与する群(B群)、実施例品2のガラクトオリゴ糖をマウス体重1kgあたり50mg投与する群(C群)の3試験群(各群8匹ずつ)にわけ、実施例品1、2を、それぞれ生理食塩水に懸濁して、B、C群に2週間経口投与した。試験終了時に、マウスの右耳を摘出して重量を測定するとともに、炎症性マーカー(F4/80、P40phox)のmRNAの発現量をリアルタイムPCR法で測定した。その結果を表1に示す。
表2に示す配合で原材料を混合後、常法により1gに成型、打錠して本発明のアレルギー改善用錠剤を製造した。
実施例品2のガラクトオリゴ糖50gを4,950gの脱イオン水に溶解し、50℃まで加熱後、TKホモミクサー(TK ROBO MICS;特殊機化工業社製)にて、6,000rpmで30分間撹拌混合して実施例品2のガラクトオリゴ糖含量50g/5kgのガラクトオリゴ糖溶液を得た。このガラクトオリゴ糖溶液5.0kgに、カゼイン5.0kg、大豆タンパク質5.0kg、魚油1.0kg、シソ油3.0kg、デキストリン17.0kg、ミネラル混合物6.0kg、ビタミン混合物1.95kg、乳化剤2.0kg、安定剤4.0kg、香料0.05kgを配合し、200mlのレトルトパウチに充填し、レトルト殺菌機 (第1種圧力容器、TYPE: RCS−4CRTGN、日阪製作所製)で121℃、20分間殺菌して、本発明のアレルギー改善用液状栄養組成物50kgを製造した。
脱脂粉乳300gを409gの脱イオン水に溶解した後、実施例品1のガラクトオリゴ糖1gを溶解し、50℃まで加熱後、ウルトラディスパーサー(ULTRA−TURRAX T−25;IKAジャパン社製)にて、9,500rpmで30分間撹拌混合した。マルチトール100g、酸味料2g、還元水飴20g、香料2g、脱イオン水166gを添加した後、100mlのガラス瓶に充填し、95℃、15秒間殺菌後、密栓し、本発明のアレルギー改善用飲料10本(100ml入り)を調製した。
実施例品2のガラクトオリゴ糖2kgを98kgの脱イオン水に溶解し、50℃まで加熱後、TKホモミクサー(MARK II 160型;特殊機化工業社製)にて、3,600rpmで40分間撹拌混合して実施例品2のガラクトオリゴ糖含量2g/100gのガラクトオリゴ糖溶液を得た。このガラクトオリゴ糖溶液10kgに大豆粕12kg、脱脂粉乳14kg、大豆油4kg、コーン油2kg、パーム油23.2kg、トウモロコシ澱粉14kg、小麦粉9kg、ふすま2kg、ビタミン混合物5kg、セルロース2.8kg、ミネラル混合物2kgを配合し、120℃、4分間殺菌して、本発明のイヌ用アレルギー改善飼料100kgを製造した。
Claims (4)
- O−β−D−ガラクトピラノシル−(1→6)−O−β−D−ガラクトピラノシル−(1→4)−D−グルコースと、O−β−D−ガラクトピラノシル−(1→4)−O−β−D−ガラクトピラノシル−(1→6)−D−グルコースと、を有効成分とし、前記O−β−D−ガラクトピラノシル−(1→6)−O−β−D−ガラクトピラノシル−(1→4)−D−グルコースと、前記O−β−D−ガラクトピラノシル−(1→4)−O−β−D−ガラクトピラノシル−(1→6)−D−グルコースと、の比が85:12〜90:9程度であることを特徴とするアレルギー改善剤。
- 前記ガラクトオリゴ糖が哺乳類の乳に由来することを特徴とする請求項1記載のアレルギー改善剤。
- 前記ガラクトオリゴ糖が牛乳由来であることを特徴とする請求項1乃至2記載のアレルギー改善剤。
- 請求項1乃至3に記載のいずれかに記載のアレルギー改善剤を含むことを特徴とするアレルギー改善用飲食品、アレルギー改善用栄養組成物、アレルギー改善用飼料又はアレルギー改善用医薬品。
Priority Applications (6)
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JP2012253718A JP6072516B2 (ja) | 2012-11-19 | 2012-11-19 | アレルギー改善剤 |
CN201380060243.8A CN104797260A (zh) | 2012-11-19 | 2013-11-18 | 变态反应改善剂 |
PCT/JP2013/081016 WO2014077383A1 (ja) | 2012-11-19 | 2013-11-18 | アレルギー改善剤 |
MYPI2015701404A MY177993A (en) | 2012-11-19 | 2013-11-18 | Agent for ameliorating allergy |
TW102142097A TW201427603A (zh) | 2012-11-19 | 2013-11-19 | 過敏症改善劑 |
HK15108025.5A HK1207311A1 (en) | 2012-11-19 | 2015-08-19 | Agent for ameliorating allergy |
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JP2012253718A JP6072516B2 (ja) | 2012-11-19 | 2012-11-19 | アレルギー改善剤 |
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CN (1) | CN104797260A (ja) |
HK (1) | HK1207311A1 (ja) |
MY (1) | MY177993A (ja) |
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EP3636077B1 (en) * | 2015-01-26 | 2022-11-16 | Cadena Bio, Inc. | Oligosaccharide compositions for use animal feed and methods of producing thereof |
JP6579603B2 (ja) * | 2015-05-20 | 2019-09-25 | 再生ファーマ株式会社 | アレルギー疾患の予防改善剤 |
WO2020050318A1 (ja) * | 2018-09-05 | 2020-03-12 | 再生ファーマ株式会社 | 炎症性サイトカイン産生抑制剤 |
DE102020133860A1 (de) | 2020-12-16 | 2022-06-23 | MNT Systeme GmbH | VERWENDUNG VON β-GALAKTOOLIGOSACCHRIDEN FÜR DIE HERSTELLUNG EINER KOSMETISCHEN UND/ODER PHARMAKOLOGISCH WIRKSAMEN ZUSAMMENSETZUNG |
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JP2904687B2 (ja) * | 1993-09-17 | 1999-06-14 | 雪印乳業株式会社 | 新規オリゴ糖 |
JP2000060541A (ja) * | 1998-08-27 | 2000-02-29 | Fuyuki Mitsuyama | ビフィズス菌増殖促進物質と整腸物質とビフィズス菌製剤 |
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JP4844922B2 (ja) * | 2006-01-24 | 2011-12-28 | 日新製糖株式会社 | アレルギー体質改善組成物 |
JP2009114080A (ja) * | 2007-11-02 | 2009-05-28 | Icreo Co Ltd | アトピー性皮膚炎治療組成物 |
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WO2014077383A1 (ja) | 2014-05-22 |
MY177993A (en) | 2020-09-28 |
JP2014101305A (ja) | 2014-06-05 |
HK1207311A1 (en) | 2016-01-29 |
CN104797260A (zh) | 2015-07-22 |
TW201427603A (zh) | 2014-07-16 |
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