JP6067676B2 - 経口医薬分散組成物 - Google Patents
経口医薬分散組成物 Download PDFInfo
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- JP6067676B2 JP6067676B2 JP2014504385A JP2014504385A JP6067676B2 JP 6067676 B2 JP6067676 B2 JP 6067676B2 JP 2014504385 A JP2014504385 A JP 2014504385A JP 2014504385 A JP2014504385 A JP 2014504385A JP 6067676 B2 JP6067676 B2 JP 6067676B2
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- 229960003253 procainamide hydrochloride Drugs 0.000 description 1
- 229960002153 prochlorperazine maleate Drugs 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- JIVSXRLRGOICGA-UHFFFAOYSA-N promazine hydrochloride Chemical compound [H+].[Cl-].C1=CC=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 JIVSXRLRGOICGA-UHFFFAOYSA-N 0.000 description 1
- 229960001836 promazine hydrochloride Drugs 0.000 description 1
- XXPDBLUZJRXNNZ-UHFFFAOYSA-N promethazine hydrochloride Chemical compound Cl.C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 XXPDBLUZJRXNNZ-UHFFFAOYSA-N 0.000 description 1
- 229960002244 promethazine hydrochloride Drugs 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 229960004604 propranolol hydrochloride Drugs 0.000 description 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol hydrochloride Natural products C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 description 1
- 229960003908 pseudoephedrine Drugs 0.000 description 1
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 description 1
- 229960003447 pseudoephedrine hydrochloride Drugs 0.000 description 1
- 239000003368 psychostimulant agent Substances 0.000 description 1
- 229960002151 pyridostigmine bromide Drugs 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 229960001520 ranitidine hydrochloride Drugs 0.000 description 1
- GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- ZNCPFRVNHGOPAG-UHFFFAOYSA-L sodium oxalate Chemical compound [Na+].[Na+].[O-]C(=O)C([O-])=O ZNCPFRVNHGOPAG-UHFFFAOYSA-L 0.000 description 1
- 229940039790 sodium oxalate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 1
- JMHRGKDWGWORNU-UHFFFAOYSA-M sodium;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate Chemical compound [Na+].CC1=C(CC([O-])=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 JMHRGKDWGWORNU-UHFFFAOYSA-M 0.000 description 1
- KYITYFHKDODNCQ-UHFFFAOYSA-M sodium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical group [Na+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 KYITYFHKDODNCQ-UHFFFAOYSA-M 0.000 description 1
- FJPYVLNWWICYDW-UHFFFAOYSA-M sodium;5,5-diphenylimidazolidin-1-ide-2,4-dione Chemical compound [Na+].O=C1[N-]C(=O)NC1(C=1C=CC=CC=1)C1=CC=CC=C1 FJPYVLNWWICYDW-UHFFFAOYSA-M 0.000 description 1
- 229960003579 sotalol hydrochloride Drugs 0.000 description 1
- VIDRYROWYFWGSY-UHFFFAOYSA-N sotalol hydrochloride Chemical compound Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 VIDRYROWYFWGSY-UHFFFAOYSA-N 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229940006995 sulfamethoxazole and trimethoprim Drugs 0.000 description 1
- 229960003708 sumatriptan Drugs 0.000 description 1
- 229940070810 sumatriptan 25 mg Drugs 0.000 description 1
- 229960000658 sumatriptan succinate Drugs 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 229960003188 temazepam Drugs 0.000 description 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- 229960000699 terbinafine hydrochloride Drugs 0.000 description 1
- 229960005105 terbutaline sulfate Drugs 0.000 description 1
- KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 description 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
- RBTVSNLYYIMMKS-UHFFFAOYSA-N tert-butyl 3-aminoazetidine-1-carboxylate;hydrochloride Chemical compound Cl.CC(C)(C)OC(=O)N1CC(N)C1 RBTVSNLYYIMMKS-UHFFFAOYSA-N 0.000 description 1
- WUBVEMGCQRSBBT-UHFFFAOYSA-N tert-butyl 4-(trifluoromethylsulfonyloxy)-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(OS(=O)(=O)C(F)(F)F)=CC1 WUBVEMGCQRSBBT-UHFFFAOYSA-N 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229960004989 tetracycline hydrochloride Drugs 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229960004098 thioridazine hydrochloride Drugs 0.000 description 1
- NZFNXWQNBYZDAQ-UHFFFAOYSA-N thioridazine hydrochloride Chemical compound Cl.C12=CC(SC)=CC=C2SC2=CC=CC=C2N1CCC1CCCCN1C NZFNXWQNBYZDAQ-UHFFFAOYSA-N 0.000 description 1
- 229960000882 thiothixene hydrochloride Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 description 1
- 229960003386 triazolam Drugs 0.000 description 1
- 229960000315 trifluoperazine hydrochloride Drugs 0.000 description 1
- BXDAOUXDMHXPDI-UHFFFAOYSA-N trifluoperazine hydrochloride Chemical compound [H+].[H+].[Cl-].[Cl-].C1CN(C)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 BXDAOUXDMHXPDI-UHFFFAOYSA-N 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- 229960001593 triprolidine hydrochloride Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229960000881 verapamil hydrochloride Drugs 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 229960002647 warfarin sodium Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 229960001475 zolpidem Drugs 0.000 description 1
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
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Description
脂質相に分散している親水性薬剤と、水相に溶解している親水性薬剤、
脂質相に分散している親水性薬剤と、脂質相に溶解している親油性薬剤、
脂質相に分散している親水性薬剤と、脂質相に溶解している親油性薬剤と、水相に溶解している親水性薬剤、
油相に分散している親水性薬剤と、水相に分散している親油性薬剤、
水相に分散している親油性薬剤と、脂質相に溶解している親油性薬剤、
水相に分散している親油性薬剤と、水相に溶解している親水性薬剤、
水相に分散している親油性薬剤と、水相に溶解している親水性薬剤と、脂質相に溶解している親油性薬剤。
以下の原料から水相が形成される。
ゼラチン 7.5重量%
キシリトール 36重量%
ソルビトール 14重量%
50%クエン酸 1重量%
レモン香味料 0.15重量%
水 全体が100重量%になるまで添加
上記表1中の薬剤を、表1に記載されている用量単位あたりの濃度で、実施例1で用いられている水相中に溶解させ油相中に分散させてから、実施例1に記載されているように乳剤を生成、注入し、凝固させる。凝固ゲル用量単位を、実施例1にあるように包装する。
ゼラチン 84mg
アラビアゴム(gum arabicum) 55.5mg
ソルビトール 155mg
キシリトール 360mg
クエン酸 9mg
香味料 18mg
着色剤 10.5mg
油 0〜600mg
スルファメトキサゾール 200mg
トリメトプリム 40mg
水 1500mgになるまで
ゼラチン 84mg
アラビアゴム 55.5mg
ソルビトール 155mg
キシリトール 360mg
クエン酸 9mg
香味料 18mg
着色剤 10.5mg
油 0〜600mg
ナルトレキソン 50mg
水 1500mgになるまで
ゼラチン 84mg
アラビアゴム 55.5mg
ソルビトール 155mg
キシリトール 360mg
クエン酸 9mg
香味料 18mg
着色剤 10.5mg
油 0〜600mg
プロメタジン 12.5mg
水 1500mgになるまで
ゼラチン 84mg
アラビアゴム 55.5mg
ソルビトール 155mg
キシリトール 360mg
クエン酸 9mg
香味料 18mg
着色剤 10.5mg
油 0〜600mg
ロイコボリン 10mg
水 1500mgになるまで
ゼラチン 84mg
アラビアゴム 55.5mg
ソルビトール 155mg
キシリトール 360mg
クエン酸 9mg
香味料 18mg
着色剤 10.5mg
油 0〜600mg
アテノロール 50mg
水 1500mgになるまで
ゼラチン 84mg
アラビアゴム 55.5mg
ソルビトール 155mg
キシリトール 360mg
クエン酸 9mg
香味料 18mg
着色剤 10.5mg
油 0〜600mg
スマトリプタン 25mg
水 1500mgになるまで
結晶イブプロフェンを10重量%の濃度で、以下に挙げた原料を含む水溶液に分散させ、その分散液を先の実施例で記載された細長の金型に注入し凝固させて封止する。
結晶イブプロフェンを6.7重量%の濃度で、以下に挙げた原料を含む水溶液に分散させ、その分散液を先の実施例で記載された円形の金型に注入し凝固させて封止する。
実施例9に係るゲル化分散液(ただし、細長ではなく円形の金型で凝固させたもの)について、それらのイブプロフェン放出特性を、ニュロフェン(商標)の錠剤(レキットベンキーザー)、即ち、薬剤および担体を覆う従来の糖衣を有する、イブプロフェン含有の試験ユニット(test unit)と比較した。分散液と錠剤の双方は、イブプロフェンを200mg含有していた。
パラセタモールを7.5重量%の濃度で、以下に挙げた原料を含む水溶液に分散させ、その分散液を先の実施例で記載された円形の金型に注入し凝固させて封止する。
実施例12に係るゲル状分散液のパラセタモール放出特性を調べるために実験を行った。
ケトプロフェンを2.5重量%の濃度で、以下に挙げた原料を含む水溶液に分散させ、その分散液を先の実施例で記載された細長の金型に注入し凝固させて封止する。
パラセタモールおよびジフェニルヒドラミンHCIをそれぞれ7.5重量%および0.38重量%の濃度で、以下に挙げた原料を含む水溶液に分散させ、その分散液を先の実施例で記載された細長の金型に注入し凝固させて封止する。
パラセタモール、デキストロメトルファンHBr、およびフェニレフリンHCIをそれぞれ7.5重量%、0.23重量%、および0.12重量%の濃度で、以下に挙げた原料を含む水溶液に分散させ、その分散液を先の実施例で記載された細長の金型に注入し凝固させて封止する。
パラセタモール、マレイン酸クロルフェニラミン、およびフェニレフリンHCIをそれぞれ7.5重量%、0.046重量%、および0.12重量%の濃度で、以下に挙げた原料を含む水溶液に分散させ、その分散液を先の実施例で記載された細長の金型に注入し凝固させて封止する。
Claims (4)
- ゲル化剤としてゼラチンを含む生理学的に許容可能な連続水性ゲルに分散している親油性薬物物質を含む、用量単位形態の経口医薬組成物であって、前記薬物物質はイブプロフェンまたはケトプロフェンであり、前記連続水性ゲルは、pHが4〜4.5の範囲内である、経口医薬組成物。
- 前記生理学的に許容可能な連続水性ゲルはB型ゼラチンを含む、請求項1に記載の組成物。
- 前記生理学的に許容可能な連続水性ゲルはA型ゼラチンを含む、請求項1または2に記載の組成物。
- イブプロフェンまたはケトプロフェンである親油性薬物物質の使用法であって、人間または人間以外の動物を対象とした治療法で、前記親油性薬物物質に反応を示す症状を抑制する目的で経口投与により用いられる請求項1に記載の経口医薬組成物を製造するための使用法。
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GBPCT/GB2011/000563 | 2011-04-11 | ||
PCT/GB2011/000563 WO2011128633A2 (en) | 2010-04-14 | 2011-04-11 | Oral pharmaceutical dispersion compositions |
PCT/GB2011/052027 WO2012140392A1 (en) | 2011-04-11 | 2011-10-19 | Oral pharmaceutical dispersion compositions |
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JP2016177656A Division JP6609532B2 (ja) | 2010-04-14 | 2016-09-12 | 経口医薬分散組成物 |
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EP (2) | EP3178470A1 (ja) |
JP (1) | JP6067676B2 (ja) |
CN (2) | CN103635178A (ja) |
CA (2) | CA3023121A1 (ja) |
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Cited By (1)
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KR101288488B1 (ko) * | 2011-05-25 | 2013-07-26 | 정국배 | 달력홀더 자동결합장치 |
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WO2018175261A1 (en) | 2017-03-20 | 2018-09-27 | Bayer Healthcare Llc | Chewable gel products for active pharmaceutical ingredients |
GB201916960D0 (en) * | 2019-11-21 | 2020-01-08 | Vitus Group As | Compositions |
GB202202754D0 (en) | 2022-02-28 | 2022-04-13 | Vitux Group As | Compositions |
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US3137630A (en) * | 1961-06-09 | 1964-06-16 | Eastman Kodak Co | Process for preparing a dry, finely divided, gelatin particle product |
US4788220A (en) * | 1987-07-08 | 1988-11-29 | American Home Products Corporation (Del.) | Pediatric ibuprofen compositions |
DE4140179C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Akutform für ein Ibuprofen enthaltendes Arzneimittel |
GB9700624D0 (en) * | 1997-01-14 | 1997-03-05 | Danbiosyst Uk | Drug delivery composition |
US6482465B1 (en) * | 1997-06-24 | 2002-11-19 | Biovail Technologies Ltd. | Positive hydration method of preparing confectionery and product therefrom |
NZ333474A (en) * | 1998-01-02 | 1999-06-29 | Mcneil Ppc Inc | A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat |
US6432442B1 (en) * | 1998-02-23 | 2002-08-13 | Mcneil-Ppc, Inc. | Chewable product |
AU2002244865A1 (en) * | 2001-03-02 | 2002-09-19 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical composition of ibuprofen |
ATE487470T1 (de) * | 2002-09-11 | 2010-11-15 | Elan Pharma Int Ltd | Gel-stabilisierte wirkstoff-zusammensetzungen in nanoteilchengrösse |
GB0229258D0 (en) * | 2002-12-16 | 2003-01-22 | Boots Healthcare Int Ltd | Medicinal compositions |
FR2850275B1 (fr) * | 2003-01-24 | 2005-04-08 | Scherer Technologies Inc R P | Capsules molles a macher contenant une substance active a gout masque |
GB0317869D0 (en) * | 2003-07-30 | 2003-09-03 | Disperse Ltd | Improved drug delivery system |
JP2005187416A (ja) * | 2003-12-26 | 2005-07-14 | Lion Corp | マイクロカプセル及びその製造方法 |
WO2006108637A2 (de) * | 2005-04-13 | 2006-10-19 | Abbott Gmbh & Co.Kg | Verfahren zur schonenden herstellung hochfeiner partikelsuspensionen und hochfeiner partikel sowie deren verwendung |
JP2009514857A (ja) * | 2005-11-02 | 2009-04-09 | テイコク ファーマ ユーエスエー インコーポレーテッド | 感覚器官的に許容されるイブプロフェン経口投与用製剤、該製剤の製法並びに使用法 |
GB0601498D0 (en) | 2006-01-25 | 2006-03-08 | Probio Nutraceuticals As | Product |
CN101045041A (zh) * | 2007-04-29 | 2007-10-03 | 武汉兵兵药业有限公司 | 含布洛芬的巴布剂及其制备方法和应用 |
GB0818473D0 (en) * | 2008-10-08 | 2008-11-12 | Probio Nutraceuticals As | Composition |
EP2380657B1 (en) * | 2008-11-21 | 2015-10-07 | FUJIFILM Corporation | Ceramide dispersion, and process for producing same |
GB0907019D0 (en) * | 2009-04-24 | 2009-06-03 | Oxford Nutrascience Ltd | Pharmaceutical,therapeutic or nutritional delivery systems for functional ingredients |
GB201006214D0 (en) * | 2010-04-14 | 2010-06-02 | Ayanda As | Composition |
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- 2011-10-19 CA CA3023121A patent/CA3023121A1/en not_active Abandoned
- 2011-10-19 PL PL11781582T patent/PL2696846T3/pl unknown
- 2011-10-19 JP JP2014504385A patent/JP6067676B2/ja active Active
- 2011-10-19 EP EP16205962.0A patent/EP3178470A1/en not_active Withdrawn
- 2011-10-19 WO PCT/GB2011/052027 patent/WO2012140392A1/en active Application Filing
- 2011-10-19 CN CN201180070775.0A patent/CN103635178A/zh active Pending
- 2011-10-19 CN CN201711183170.8A patent/CN107875117A/zh active Pending
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KR101288488B1 (ko) * | 2011-05-25 | 2013-07-26 | 정국배 | 달력홀더 자동결합장치 |
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EP2696846A1 (en) | 2014-02-19 |
CA3023121A1 (en) | 2012-10-18 |
PL2696846T3 (pl) | 2018-06-29 |
CN107875117A (zh) | 2018-04-06 |
JP2014510778A (ja) | 2014-05-01 |
EP3178470A1 (en) | 2017-06-14 |
EP2696846B1 (en) | 2018-01-17 |
CA2833105A1 (en) | 2012-10-18 |
CN103635178A (zh) | 2014-03-12 |
CA2833105C (en) | 2019-04-23 |
WO2012140392A1 (en) | 2012-10-18 |
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