JP6062432B2 - プロテインキナーゼ阻害薬用スピロ環状分子 - Google Patents

プロテインキナーゼ阻害薬用スピロ環状分子 Download PDF

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Publication number
JP6062432B2
JP6062432B2 JP2014521885A JP2014521885A JP6062432B2 JP 6062432 B2 JP6062432 B2 JP 6062432B2 JP 2014521885 A JP2014521885 A JP 2014521885A JP 2014521885 A JP2014521885 A JP 2014521885A JP 6062432 B2 JP6062432 B2 JP 6062432B2
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Japan
Prior art keywords
group
cancer
ring
membered
dichloro
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Expired - Fee Related
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JP2014521885A
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English (en)
Japanese (ja)
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JP2014521609A (ja
JP2014521609A5 (cg-RX-API-DMAC7.html
Inventor
ワン，ツァオイン
リー，リャンハイ
ワン，チーガン
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Nanjing Allgen Pharma Co Ltd
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Nanjing Allgen Pharma Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2014521885A 2011-07-27 2012-07-26 プロテインキナーゼ阻害薬用スピロ環状分子 Expired - Fee Related JP6062432B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161457980P 2011-07-27 2011-07-27
US61/457,980 2011-07-27
PCT/CA2012/000709 WO2013013308A1 (en) 2011-07-27 2012-07-26 Spirocyclic molecules as protein kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2014521609A JP2014521609A (ja) 2014-08-28
JP2014521609A5 JP2014521609A5 (cg-RX-API-DMAC7.html) 2015-09-10
JP6062432B2 true JP6062432B2 (ja) 2017-01-18

Family

ID=47600420

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014521885A Expired - Fee Related JP6062432B2 (ja) 2011-07-27 2012-07-26 プロテインキナーゼ阻害薬用スピロ環状分子

Country Status (6)

Country Link
US (1) US9226923B2 (cg-RX-API-DMAC7.html)
EP (1) EP2739617A4 (cg-RX-API-DMAC7.html)
JP (1) JP6062432B2 (cg-RX-API-DMAC7.html)
CN (1) CN103732588B (cg-RX-API-DMAC7.html)
CA (1) CA2842841C (cg-RX-API-DMAC7.html)
WO (1) WO2013013308A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6546596B2 (ja) * 2013-09-26 2019-07-17 カデント セラピューティクス，インコーポレーテッド Ｎｒ２ｂの選択的オクタヒドロ−シクロペンタ［ｃ］ピロール負調節因子
WO2018166855A1 (en) 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
CR20220141A (es) 2019-10-09 2022-05-03 Novartis Ag Derivados de 2-azaspiro[3,4]octano como agonistas de m4
KR102798432B1 (ko) 2019-10-09 2025-04-22 노파르티스 아게 M4 작용제로서의 5-옥사-2-아자스피로[3.4]옥탄 유도체
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021120890A1 (en) * 2019-12-20 2021-06-24 Novartis Ag Pyrazolyl derivatives useful as anti-cancer agents
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1104760B1 (en) * 1999-12-03 2003-03-12 Pfizer Products Inc. Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents
ES2401330T3 (es) * 2003-02-26 2013-04-18 Sugen, Inc. Compuesto de heteroarilamino inhibidores de proteín quinasas
CA2577937C (en) * 2004-08-26 2010-12-21 Pfizer Inc. Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors
EP1786777A1 (en) * 2004-08-26 2007-05-23 Pfizer, Inc. Aminoheteroaryl compounds as protein tyrosine kinase inhibitors
ES2336625T3 (es) * 2006-03-22 2010-04-14 Vertex Pharmaceuticals Incorporated Inhibidores de la proteina quinasa c-met para el tratamiento de trastornos proliferativos.
MX2010004491A (es) * 2007-10-25 2010-06-21 Astrazeneca Ab Derivados de piridina y pirazina utiles en el tratamiento de trastornos proliferativos celulares.
JP2011511005A (ja) * 2008-02-04 2011-04-07 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド ２−アミノピリジン系キナーゼ阻害薬
BRPI1010974A2 (pt) * 2009-05-22 2019-09-24 Exelixis Inc benzoxazepinas baseada em inibidores p13k/ m tor contra doenças proliferativas
CN101851237B (zh) * 2010-06-18 2012-10-17 南方医科大学 一种螺环化合物及其制备方法和应用
WO2013148537A1 (en) * 2012-03-29 2013-10-03 Ning Xi Substituted spirobicyclic compounds and methods of use

Also Published As

Publication number Publication date
EP2739617A1 (en) 2014-06-11
CA2842841C (en) 2016-04-19
US20140243303A1 (en) 2014-08-28
CN103732588B (zh) 2016-10-12
EP2739617A4 (en) 2015-01-28
WO2013013308A1 (en) 2013-01-31
JP2014521609A (ja) 2014-08-28
CA2842841A1 (en) 2013-01-31
CN103732588A (zh) 2014-04-16
US9226923B2 (en) 2016-01-05

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