JP6059734B2 - ２−アルキル−又は２−アリール−置換タンシノン誘導体、その調製方法及び適用 - Google Patents
２−アルキル−又は２−アリール−置換タンシノン誘導体、その調製方法及び適用 Download PDFInfo
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- JP6059734B2 JP6059734B2 JP2014543760A JP2014543760A JP6059734B2 JP 6059734 B2 JP6059734 B2 JP 6059734B2 JP 2014543760 A JP2014543760 A JP 2014543760A JP 2014543760 A JP2014543760 A JP 2014543760A JP 6059734 B2 JP6059734 B2 JP 6059734B2
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- tanshinone
- cancer
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- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003641 trioses Chemical class 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 206010047470 viral myocarditis Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011083256 | 2011-11-30 | ||
| CNPCT/CN2011/083256 | 2011-11-30 | ||
| PCT/CN2012/085649 WO2013079017A1 (zh) | 2011-11-30 | 2012-11-30 | 2-位烷基或芳香基取代的丹参酮衍生物、及其制备方法和应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014534267A JP2014534267A (ja) | 2014-12-18 |
| JP2014534267A5 JP2014534267A5 (enExample) | 2016-01-14 |
| JP6059734B2 true JP6059734B2 (ja) | 2017-01-11 |
Family
ID=48534678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014543760A Expired - Fee Related JP6059734B2 (ja) | 2011-11-30 | 2012-11-30 | ２−アルキル−又は２−アリール−置換タンシノン誘導体、その調製方法及び適用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9771343B2 (enExample) |
| EP (1) | EP2786989B1 (enExample) |
| JP (1) | JP6059734B2 (enExample) |
| WO (1) | WO2013079017A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105884723B (zh) * | 2014-12-25 | 2019-08-02 | 上海三帆生物医药科技有限公司 | 丹参酮衍生物、其制备方法及其应用 |
| CN105037427B (zh) * | 2015-06-22 | 2017-05-31 | 石家庄学院 | 丹参酮iia亚乙基亚胺磷酸酯衍生物及其制备方法与应用 |
| FR3110307B1 (fr) | 2020-05-12 | 2023-08-11 | Commissariat Energie Atomique | Circuit générateur de nombres aléatoires |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070207989A1 (en) | 2006-03-03 | 2007-09-06 | Savipu Pharmaceuticals | Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases |
| CN100387585C (zh) * | 2006-04-26 | 2008-05-14 | 秦引林 | 丹参酮ⅰ衍生物及其在制药中的应用 |
| CN1837200A (zh) | 2006-04-26 | 2006-09-27 | 秦引林 | 丹参酮ⅰ衍生物及其在制药中的应用 |
| KR20080047956A (ko) * | 2006-11-27 | 2008-05-30 | 주식회사 엠디바이오알파 | 발기부전의 치료 및 예방을 위한 약제 조성물 |
| CN101012270A (zh) | 2007-01-26 | 2007-08-08 | 广东工业大学 | 丹参酮衍生物及在制备醛糖还原酶抑制剂药物中的应用 |
| CN101274925A (zh) * | 2007-03-29 | 2008-10-01 | 中国科学院上海药物研究所 | 一类萘并呋喃邻醌化合物及其制备方法和用途 |
| JP2011500557A (ja) * | 2007-10-11 | 2011-01-06 | マゼンス インコーポレイテッド | ナフトキノン系化合物の微粒化粒子を含有する医薬組成物 |
| KR20090073381A (ko) * | 2007-12-31 | 2009-07-03 | 주식회사 머젠스 | 심장질환의 치료 및 예방을 위한 약제 조성물 |
| CN102304166A (zh) * | 2011-07-02 | 2012-01-04 | 中国科学院昆明植物研究所 | 丹参酮衍生物，其药物组合物及其在制药中的应用 |
| DK2786990T3 (en) | 2011-11-30 | 2018-11-19 | Hangzhou Bensheng Pharmaceutical Co Ltd | 2-AMINED METHYLE OR 2-ESTERIFIED METHYLENE-TANSHINON DERIVATIVES, AND METHOD OF PREPARING AND USING THEREOF |
-
2012
- 2012-11-30 WO PCT/CN2012/085649 patent/WO2013079017A1/zh not_active Ceased
- 2012-11-30 JP JP2014543760A patent/JP6059734B2/ja not_active Expired - Fee Related
- 2012-11-30 EP EP12853162.1A patent/EP2786989B1/en not_active Not-in-force
- 2012-11-30 US US14/361,533 patent/US9771343B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20140336249A1 (en) | 2014-11-13 |
| EP2786989B1 (en) | 2018-12-26 |
| WO2013079017A1 (zh) | 2013-06-06 |
| JP2014534267A (ja) | 2014-12-18 |
| US9771343B2 (en) | 2017-09-26 |
| EP2786989A1 (en) | 2014-10-08 |
| EP2786989A4 (en) | 2015-07-22 |
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