JP6059734B2 - ２−アルキル−又は２−アリール−置換タンシノン誘導体、その調製方法及び適用 - Google Patents

２−アルキル−又は２−アリール−置換タンシノン誘導体、その調製方法及び適用 Download PDF

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Publication number
JP6059734B2
JP6059734B2 JP2014543760A JP2014543760A JP6059734B2 JP 6059734 B2 JP6059734 B2 JP 6059734B2 JP 2014543760 A JP2014543760 A JP 2014543760A JP 2014543760 A JP2014543760 A JP 2014543760A JP 6059734 B2 JP6059734 B2 JP 6059734B2
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JP
Japan
Prior art keywords
tanshinone
cancer
pharmaceutically acceptable
derivative
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2014543760A
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English (en)
Japanese (ja)
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JP2014534267A5 (enExample
JP2014534267A (ja
Inventor
フランク ロン
フランク ロン
ロンツェン シュー
ロンツェン シュー
フーウェン シェ
フーウェン シェ
ホンシ ライ
ホンシ ライ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hangzhou Bensheng Pharmaceutical Co Ltd
Original Assignee
Hangzhou Bensheng Pharmaceutical Co Ltd
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Publication of JP2014534267A publication Critical patent/JP2014534267A/ja
Publication of JP2014534267A5 publication Critical patent/JP2014534267A5/ja
Application granted granted Critical
Publication of JP6059734B2 publication Critical patent/JP6059734B2/ja
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2014543760A 2011-11-30 2012-11-30 ２−アルキル−又は２−アリール−置換タンシノン誘導体、その調製方法及び適用 Expired - Fee Related JP6059734B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2011/083256 2011-11-30
CN2011083256 2011-11-30
PCT/CN2012/085649 WO2013079017A1 (zh) 2011-11-30 2012-11-30 2-位烷基或芳香基取代的丹参酮衍生物、及其制备方法和应用

Publications (3)

Publication Number Publication Date
JP2014534267A JP2014534267A (ja) 2014-12-18
JP2014534267A5 JP2014534267A5 (enExample) 2016-01-14
JP6059734B2 true JP6059734B2 (ja) 2017-01-11

Family

ID=48534678

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014543760A Expired - Fee Related JP6059734B2 (ja) 2011-11-30 2012-11-30 ２−アルキル−又は２−アリール−置換タンシノン誘導体、その調製方法及び適用

Country Status (5)

Country Link
US (1) US9771343B2 (enExample)
EP (1) EP2786989B1 (enExample)
JP (1) JP6059734B2 (enExample)
CN (1) CN103958490B (enExample)
WO (1) WO2013079017A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105884723B (zh) * 2014-12-25 2019-08-02 上海三帆生物医药科技有限公司 丹参酮衍生物、其制备方法及其应用
CN105037427B (zh) * 2015-06-22 2017-05-31 石家庄学院 丹参酮iia亚乙基亚胺磷酸酯衍生物及其制备方法与应用
CN109369771B (zh) * 2018-10-09 2020-06-02 深圳市第二人民医院 一种丹参酮iia衍生物的合成及应用
FR3110307B1 (fr) 2020-05-12 2023-08-11 Commissariat Energie Atomique Circuit générateur de nombres aléatoires

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
CN100387585C (zh) * 2006-04-26 2008-05-14 秦引林 丹参酮ⅰ衍生物及其在制药中的应用
CN1837200A (zh) * 2006-04-26 2006-09-27 秦引林 丹参酮ⅰ衍生物及其在制药中的应用
KR20080047957A (ko) * 2006-11-27 2008-05-30 주식회사 엠디바이오알파 고혈압의 치료 및 예방을 위한 약제 조성물
CN101012270A (zh) * 2007-01-26 2007-08-08 广东工业大学 丹参酮衍生物及在制备醛糖还原酶抑制剂药物中的应用
CN101274925A (zh) * 2007-03-29 2008-10-01 中国科学院上海药物研究所 一类萘并呋喃邻醌化合物及其制备方法和用途
US20100209513A1 (en) * 2007-10-11 2010-08-19 In Geun Jo Pharmaceutical composition containing micronized particles of naphthoquinone-based compound
KR20090073381A (ko) * 2007-12-31 2009-07-03 주식회사 머젠스 심장질환의 치료 및 예방을 위한 약제 조성물
CN102304166A (zh) * 2011-07-02 2012-01-04 中国科学院昆明植物研究所 丹参酮衍生物，其药物组合物及其在制药中的应用
EP2786990B1 (en) 2011-11-30 2018-08-08 Hangzhou Bensheng Pharmaceutical Co., Ltd. 2-aminated methylene or 2-esterified methylene tanshinone derivatives, and preparation method and application thereof

Also Published As

Publication number Publication date
EP2786989A4 (en) 2015-07-22
US9771343B2 (en) 2017-09-26
JP2014534267A (ja) 2014-12-18
EP2786989A1 (en) 2014-10-08
US20140336249A1 (en) 2014-11-13
EP2786989B1 (en) 2018-12-26
CN103958490B (zh) 2016-10-19
CN103958490A (zh) 2014-07-30
WO2013079017A1 (zh) 2013-06-06

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