CN103958490B - 2-位烷基或芳香基取代的丹参酮衍生物、及其制备方法和应用 - Google Patents

2-位烷基或芳香基取代的丹参酮衍生物、及其制备方法和应用 Download PDF

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Publication number
CN103958490B
CN103958490B CN201280056730.2A CN201280056730A CN103958490B CN 103958490 B CN103958490 B CN 103958490B CN 201280056730 A CN201280056730 A CN 201280056730A CN 103958490 B CN103958490 B CN 103958490B
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China
Prior art keywords
tanshinone
pharmaceutically acceptable
substituted
group
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201280056730.2A
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English (en)
Chinese (zh)
Other versions
CN103958490A (zh
Inventor
荣风光
徐荣臻
谢福文
赖洪喜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Benson Pharmaceutical Shanghai Co ltd
Original Assignee
Hangzhou Bensheng Pharmaceutical Co Ltd
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Publication date
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Priority to CN201280056730.2A priority Critical patent/CN103958490B/zh
Publication of CN103958490A publication Critical patent/CN103958490A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201280056730.2A 2011-11-30 2012-11-30 2-位烷基或芳香基取代的丹参酮衍生物、及其制备方法和应用 Expired - Fee Related CN103958490B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201280056730.2A CN103958490B (zh) 2011-11-30 2012-11-30 2-位烷基或芳香基取代的丹参酮衍生物、及其制备方法和应用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CNPCT/CN2011/083256 2011-11-30
CN2011083256 2011-11-30
CN201280056730.2A CN103958490B (zh) 2011-11-30 2012-11-30 2-位烷基或芳香基取代的丹参酮衍生物、及其制备方法和应用
PCT/CN2012/085649 WO2013079017A1 (zh) 2011-11-30 2012-11-30 2-位烷基或芳香基取代的丹参酮衍生物、及其制备方法和应用

Publications (2)

Publication Number Publication Date
CN103958490A CN103958490A (zh) 2014-07-30
CN103958490B true CN103958490B (zh) 2016-10-19

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CN201280056730.2A Expired - Fee Related CN103958490B (zh) 2011-11-30 2012-11-30 2-位烷基或芳香基取代的丹参酮衍生物、及其制备方法和应用

Country Status (5)

Country Link
US (1) US9771343B2 (enExample)
EP (1) EP2786989B1 (enExample)
JP (1) JP6059734B2 (enExample)
CN (1) CN103958490B (enExample)
WO (1) WO2013079017A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109369771A (zh) * 2018-10-09 2019-02-22 深圳市第二人民医院 一种丹参酮iia衍生物的合成及应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105884723B (zh) * 2014-12-25 2019-08-02 上海三帆生物医药科技有限公司 丹参酮衍生物、其制备方法及其应用
CN105037427B (zh) * 2015-06-22 2017-05-31 石家庄学院 丹参酮iia亚乙基亚胺磷酸酯衍生物及其制备方法与应用
FR3110307B1 (fr) 2020-05-12 2023-08-11 Commissariat Energie Atomique Circuit générateur de nombres aléatoires

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1837200A (zh) * 2006-04-26 2006-09-27 秦引林 丹参酮ⅰ衍生物及其在制药中的应用
CN1837199A (zh) * 2006-04-26 2006-09-27 秦引林 丹参酮ⅰ衍生物及其在制药中的应用
CN101012270A (zh) * 2007-01-26 2007-08-08 广东工业大学 丹参酮衍生物及在制备醛糖还原酶抑制剂药物中的应用
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080047957A (ko) * 2006-11-27 2008-05-30 주식회사 엠디바이오알파 고혈압의 치료 및 예방을 위한 약제 조성물
CN101274925A (zh) * 2007-03-29 2008-10-01 中国科学院上海药物研究所 一类萘并呋喃邻醌化合物及其制备方法和用途
US20100209513A1 (en) * 2007-10-11 2010-08-19 In Geun Jo Pharmaceutical composition containing micronized particles of naphthoquinone-based compound
KR20090073381A (ko) * 2007-12-31 2009-07-03 주식회사 머젠스 심장질환의 치료 및 예방을 위한 약제 조성물
CN102304166A (zh) * 2011-07-02 2012-01-04 中国科学院昆明植物研究所 丹参酮衍生物，其药物组合物及其在制药中的应用
EP2786990B1 (en) 2011-11-30 2018-08-08 Hangzhou Bensheng Pharmaceutical Co., Ltd. 2-aminated methylene or 2-esterified methylene tanshinone derivatives, and preparation method and application thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
CN1837200A (zh) * 2006-04-26 2006-09-27 秦引林 丹参酮ⅰ衍生物及其在制药中的应用
CN1837199A (zh) * 2006-04-26 2006-09-27 秦引林 丹参酮ⅰ衍生物及其在制药中的应用
CN101012270A (zh) * 2007-01-26 2007-08-08 广东工业大学 丹参酮衍生物及在制备醛糖还原酶抑制剂药物中的应用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
丹参二萜醌的结构修饰;杨东 等;《中国药科大学学报》;19980830;第29卷(第4期);第255-258页，参见第256-257页 *
丹参酮化合物对 HeLa细胞抑制作用与构效关系探讨;叶因涛 等;《医药导报》;20091031;第28卷(第10期);第1261-1264页 *
丹参酮类化合物对SPC-A-1细胞的生长抑制及其构效关系探讨;石华月 等;《中国肺癌杂志》;20110131;第14卷(第1期);第7-12页 *
丹参酮类及有关化合物抑菌作用的构效关系;罗厚蔚 等;《中国药科大学学报》;19880609;第19卷(第4期);第258-262页，参见第261页化合物19 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109369771A (zh) * 2018-10-09 2019-02-22 深圳市第二人民医院 一种丹参酮iia衍生物的合成及应用

Also Published As

Publication number Publication date
EP2786989A4 (en) 2015-07-22
US9771343B2 (en) 2017-09-26
JP2014534267A (ja) 2014-12-18
EP2786989A1 (en) 2014-10-08
US20140336249A1 (en) 2014-11-13
JP6059734B2 (ja) 2017-01-11
EP2786989B1 (en) 2018-12-26
CN103958490A (zh) 2014-07-30
WO2013079017A1 (zh) 2013-06-06

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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
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Effective date of registration: 20180510

Address after: Room 102, No. 131, Kai Qing Road, Pudong New Area, Shanghai

Patentee after: Benson Pharmaceutical (Shanghai) Co.,Ltd.

Address before: 310051 4 4, 6 Jiangling Road, Binjiang District, Hangzhou, Zhejiang.

Patentee before: HANGZHOU BENSHENG PHARMACEUTICAL Co.,Ltd.

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20161019

CF01 Termination of patent right due to non-payment of annual fee