JP6054871B2 - クレブス回路前駆体塩、特にクエン酸塩を含んでなる医薬組成物、及び医薬としてのこれらの使用 - Google Patents
クレブス回路前駆体塩、特にクエン酸塩を含んでなる医薬組成物、及び医薬としてのこれらの使用 Download PDFInfo
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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- 150000008163 sugars Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 1
- 230000036325 urinary excretion Effects 0.000 description 1
- 208000014001 urinary system disease Diseases 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
前記組成物の全重量と比較して、10重量%〜40重量%、好ましくは25重量%〜35重量%の、微結晶セルロース、ポリビドン、ポリビニルピロリドン、コポビドン、シェラック、ゼラチン、ポリメタクリレート、合成樹脂、アクリレート、マルトデキストリン、及びでんぷんから選択される結合剤(好ましくは、前記結合剤は、少なくとも一つの微結晶セルロースを含んでなる);
前記組成物の全重量と比較して、0.01重量%〜5重量%、好ましくは、0.02重量%〜3重量%の、ステアリン酸、ポリエチレングリコール、ステアリン酸マグネシウム、ステアリン酸カルシウム、ステアリン酸亜鉛、タルク、シリカ、水素化キャスター油、ベヘン酸グリセリル、及びパルミトステアリン酸グリセリルから選択されるフロー剤(又は潤滑剤)(好ましくは、前記フロー剤は、ステアリン酸マグネシウム及びベヘン酸グリセリルから選択される);及び/又は
当該分野で従来用いられている量、例えば前記組成物の全重量の0.0001重量%〜20重量%の任意の好適な医薬賦形剤
を含んでなる。
2mmサイズ(平均直径)のマイクロ錠剤のバッチを、上述の方法、即ち粉末を混合する工程、続く圧搾工程、その後のコーティング工程により生産する。このバッチは、バッチAであり、200gのマイクロ錠剤からなる。これらのマイクロ錠剤は、以下の組成:
クエン酸カリウム(活性成分、Dr Paul Lohmannに由来):66.9%
微結晶セルロース(結合剤、Asahi社製Ceolus(登録商標)KG−802):19.7%
微結晶セルロース(結合剤、Asahi社製Ceolus(登録商標)UF−711):9.8%
ステアリン酸マグネシウム(フロー剤):2.0%
ベヘン酸グリセリル(潤滑剤、市販の対照、GATTEFOSSE社製Compritol(登録商標)ATO 888):0.01%;
エチルセルロースポリマー(コーティング剤、市販の対照、Dow社製Ethocel(登録商標)20スタンダードプレミアム):1.66%
を有する。
Claims (22)
- 少なくとも一つの錠剤形態における経口用の固体医薬組成物であって、前記錠剤は、活性成分として少なくとも一つのクレブス回路前駆体塩を含んでなるコア、及び少なくとも一つのコーティング剤を含んでなるコーティングからなり、前記組成物は、前記組成物の全重量に対して、40重量%〜80重量%のクレブス回路前駆体塩を含んでなり、前記組成物は、ヨーロッパ薬局方2.9.3「固体製剤のための溶出試験」による2型溶出装置を用いて、pH7の精製水の溶出媒体、及びpH1.3の緩衝液の溶出媒体の双方中で、15分に2〜15%、30分に15〜25%、及び1時間に30〜50%の速度で、試験管内でクレブス回路前駆体塩を放出することができ、ここで前記クレブス回路前駆体塩がクエン酸カリウムであり、そして、前記コーティング剤がエチルセルロースポリマーである、組成物。
- 前記組成物の全重量に対して、50重量%〜70重量%のクレブス回路前駆体塩を含んでなる、請求項1に記載の組成物。
- 前記組成物が、前記組成物の全重量と比較して、0.01重量%〜5重量%のコーティング剤を含んでなる、請求項1又は2に記載の組成物。
- 前記組成物が、前記組成物の全重量と比較して、0.01重量%〜2重量%のコーティング剤を含んでなる、請求項3に記載の組成物。
- 前記組成物が、前記組成物の全重量と比較して、1.4重量%〜2.5重量%のコーティング剤を含んでなる、請求項3に記載の組成物。
- 前記組成物が、前記組成物の全重量と比較して、10重量%〜40重量%の、微結晶セルロース、ポリビドン、ポリビニルピロリドン、コポビドン、シェラック、ゼラチン、ポリメタクリレート、合成樹脂、アクリレート、マルトデキストリン、及びでんぷんから選択される結合剤を含んでなる、請求項1〜5のいずれか一項に記載の組成物。
- 前記組成物の全重量と比較して、25重量%〜35重量%の結合剤を含んでなる、請求項6に記載の組成物。
- 前記結合剤が、少なくとも一つの微結晶セルロースを含んでなる、請求項6又は7に記載の組成物。
- 前記組成物が、前記組成物の全重量と比較して、0.01重量%〜5重量%の、ステアリン酸、ポリエチレングリコール、ステアリン酸マグネシウム、ステアリン酸カルシウム、ステアリン酸亜鉛、タルク、シリカ、水素化キャスター油、ベヘン酸グリセリル、及びパルミトステアリン酸グリセリルから選択されるフロー剤をさらに含んでなる、請求項1〜8のいずれか一項に記載の組成物。
- 前記組成物の全重量と比較して、0.02重量%〜3重量%のフロー剤を含んでなる、請求項9に記載の組成物。
- 前記フロー剤が、ステアリン酸マグネシウム及びベヘン酸グリセリルから選択される、請求項9又は10に記載の組成物。
- 前記錠剤コアが、前記組成物の全重量に対して、10重量%〜30重量%の範囲内に含まれる含量で、少なくとも一つの持続放出マトリックスを含んでなる、請求項1〜11のいずれか一項に記載の組成物。
- 前記錠剤コアが、前記組成物の全重量に対して、15重量%〜25重量%の範囲内に含まれる含量で、少なくとも一つの持続放出マトリックスを含んでなる、請求項12に記載の組成物。
- 前記組成物が、マイクロ錠剤の形態である、請求項1〜13のいずれか一項に記載の組成物。
- 前記マイクロ錠剤が2〜4mmの範囲のサイズを有する、請求項14に記載の組成物。
- 前記組成物が、前記組成物の全重量と比較して、55重量%〜70重量%のクエン酸カリウム、20重量%〜40重量%の微結晶セルロース、0.02重量%〜3重量%のステアリン酸マグネシウム、0.01重量%〜1重量%のベヘン酸グリセリル、及び1重量%〜3重量%のエチルセルロースポリマーを含んでなる、請求項1〜15のいずれか一項に記載の組成物。
- 医薬として用いるための、請求項1〜16のいずれか一項に記載の組成物。
- 生理的pH、及び/又は尿のアシドーシス、及び/又は低クエン酸尿症、及び/又は高カルシウム尿症、及び/又は高シュウ酸尿症において生じる尿路結石症の治療及び/又は予防において、医薬として使用のための、請求項1〜16のいずれか一項に記載の組成物。
- 請求項1〜16のいずれか一項に記載の組成物を含む、医薬。
- 生理的pH、及び/又は尿のアシドーシス、及び/又は低クエン酸尿症、及び/又は高カルシウム尿症、及び/又は高シュウ酸尿症において生じる尿路結石症の治療及び/又は予防のための、請求項19に記載の医薬。
- 医薬の製造における、請求項1〜16のいずれか一項に記載の組成物の使用。
- 前記医薬が、生理的pH、及び/又は尿のアシドーシス、及び/又は低クエン酸尿症、及び/又は高カルシウム尿症、及び/又は高シュウ酸尿症において生じる尿路結石症の治療及び/又は予防のために用いられる、請求項21に記載の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1059468A FR2967576B1 (fr) | 2010-11-18 | 2010-11-18 | Composition pharmaceutique comprenant du sel precurseur du cycle de krebs, en particulier du sel de citrate, et son utilisation comme medicament |
FR1059468 | 2010-11-18 | ||
PCT/FR2011/052691 WO2012066254A1 (fr) | 2010-11-18 | 2011-11-18 | Composition pharmaceutique comprenant du sel precurseur du cycle de krebs, en particulier du sel de citrate, et son utilisation comme medicament |
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JP2016234134A Division JP6386011B2 (ja) | 2010-11-18 | 2016-12-01 | クレブス回路前駆体塩、特にクエン酸塩を含んでなる医薬組成物、及び医薬としてのこれらの使用 |
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JP2014501722A JP2014501722A (ja) | 2014-01-23 |
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JP2016234134A Active JP6386011B2 (ja) | 2010-11-18 | 2016-12-01 | クレブス回路前駆体塩、特にクエン酸塩を含んでなる医薬組成物、及び医薬としてのこれらの使用 |
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US (1) | US9782352B2 (ja) |
EP (1) | EP2640365B1 (ja) |
JP (2) | JP6054871B2 (ja) |
DK (1) | DK2640365T3 (ja) |
ES (1) | ES2631577T3 (ja) |
FR (1) | FR2967576B1 (ja) |
HU (1) | HUE035229T2 (ja) |
PL (1) | PL2640365T3 (ja) |
WO (1) | WO2012066254A1 (ja) |
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US11273140B2 (en) | 2013-06-06 | 2022-03-15 | Stefanie A. Seixas-Mikelus | Juice beverage for prevention and treatment of renal stones |
ES2674550T3 (es) | 2013-08-06 | 2018-07-02 | Ppg Industries Ohio, Inc. | Ventana deformable para aeronave |
CN104739794A (zh) * | 2013-12-26 | 2015-07-01 | 广州医药研究总院有限公司 | 一种新的枸橼酸钾缓释片及其制备方法 |
CN104800180A (zh) * | 2015-04-02 | 2015-07-29 | 南京泽恒医药技术开发有限公司 | 枸橼酸钾双重缓释片的组合物及其制备方法 |
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HU165181B (ja) | 1971-11-08 | 1974-07-27 | ||
DE2931395A1 (de) | 1979-08-02 | 1981-02-26 | Henkel Kgaa | Verfahren zur herstellung von gewuerzextrakten |
JPH075457B2 (ja) | 1983-08-16 | 1995-01-25 | ザ ウエルカム フアウンデ−シヨン リミテツド | 調節された方法による有効成分の放出を可能にする医薬組成物 |
JPS6416A (en) * | 1986-12-23 | 1989-01-05 | Santen Pharmaceut Co Ltd | Remedy for arthritis |
CA1326040C (en) | 1989-11-16 | 1994-01-11 | Neill B. Walsdorf | Magnesium-potassium citrate |
IE80467B1 (en) * | 1995-07-03 | 1998-07-29 | Elan Corp Plc | Controlled release formulations for poorly soluble drugs |
US6887492B2 (en) * | 2000-12-14 | 2005-05-03 | Leiner Health Services Corp. | Magnesium plus interactive agent delivery |
US7645459B2 (en) | 2004-05-24 | 2010-01-12 | The Procter & Gamble Company | Dosage forms of bisphosphonates |
RU2408368C2 (ru) * | 2005-06-27 | 2011-01-10 | Биовэйл Лэборэториз Интернэшнл С.Р.Л. | Препараты соли бупропиона с модифицированным высвобождением |
US20090028935A1 (en) * | 2006-12-01 | 2009-01-29 | Kristin Arnold | Carvedilol forms, compositions, and methods of preparation thereof |
US20080131504A1 (en) * | 2006-12-01 | 2008-06-05 | Mission Pharmacal Co. | Short Term Slow Release Drug Delivery System |
EP1970066A1 (de) * | 2007-03-12 | 2008-09-17 | Medice Arzneimittel Pütter GmbH & Co. KG | Pharmazeutische Zusammensetzung zur Behandlung einer Übersäuerung des Blutes |
US20100221335A1 (en) | 2007-08-31 | 2010-09-02 | Daiichi Sankyo Company, Limited | Sustained-release preparation and method for producing the same |
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US20130224297A1 (en) | 2013-08-29 |
EP2640365B1 (fr) | 2017-05-10 |
HUE035229T2 (en) | 2018-05-02 |
DK2640365T3 (en) | 2017-07-24 |
US9782352B2 (en) | 2017-10-10 |
FR2967576B1 (fr) | 2013-07-12 |
JP2017061553A (ja) | 2017-03-30 |
EP2640365A1 (fr) | 2013-09-25 |
JP6386011B2 (ja) | 2018-09-05 |
WO2012066254A1 (fr) | 2012-05-24 |
PL2640365T3 (pl) | 2017-09-29 |
ES2631577T3 (es) | 2017-09-01 |
FR2967576A1 (fr) | 2012-05-25 |
JP2014501722A (ja) | 2014-01-23 |
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