JP6049812B2 - 培養培地中の抗生物質の中和方法 - Google Patents
培養培地中の抗生物質の中和方法 Download PDFInfo
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- JP6049812B2 JP6049812B2 JP2015132841A JP2015132841A JP6049812B2 JP 6049812 B2 JP6049812 B2 JP 6049812B2 JP 2015132841 A JP2015132841 A JP 2015132841A JP 2015132841 A JP2015132841 A JP 2015132841A JP 6049812 B2 JP6049812 B2 JP 6049812B2
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- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 229960001019 oxacillin Drugs 0.000 description 1
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- 239000001301 oxygen Substances 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- RZXMPPFPUUCRFN-UHFFFAOYSA-N p-toluidine Chemical compound CC1=CC=C(N)C=C1 RZXMPPFPUUCRFN-UHFFFAOYSA-N 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 229950011346 panipenem Drugs 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- WSHJJCPTKWSMRR-RXMQYKEDSA-N penam Chemical compound S1CCN2C(=O)C[C@H]21 WSHJJCPTKWSMRR-RXMQYKEDSA-N 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 229960002292 piperacillin Drugs 0.000 description 1
- WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
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- 159000000001 potassium salts Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- XFGOMLIRJYURLQ-GOKYHWASSA-N razupenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)SC(SC=1)=NC=1C1=C[C@H](C)NC1 XFGOMLIRJYURLQ-GOKYHWASSA-N 0.000 description 1
- 229910052703 rhodium Inorganic materials 0.000 description 1
- 239000010948 rhodium Substances 0.000 description 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 238000003998 size exclusion chromatography high performance liquid chromatography Methods 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 229940073490 sodium glutamate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000002594 sorbent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- FKENQMMABCRJMK-RITPCOANSA-N sulbactam Chemical compound O=S1(=O)C(C)(C)[C@H](C(O)=O)N2C(=O)C[C@H]21 FKENQMMABCRJMK-RITPCOANSA-N 0.000 description 1
- 229960005256 sulbactam Drugs 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- LPQZKKCYTLCDGQ-WEDXCCLWSA-N tazobactam Chemical compound C([C@]1(C)S([C@H]2N(C(C2)=O)[C@H]1C(O)=O)(=O)=O)N1C=CN=N1 LPQZKKCYTLCDGQ-WEDXCCLWSA-N 0.000 description 1
- 229960003865 tazobactam Drugs 0.000 description 1
- BVCKFLJARNKCSS-DWPRYXJFSA-N temocillin Chemical compound N([C@]1(OC)C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C(C(O)=O)C=1C=CSC=1 BVCKFLJARNKCSS-DWPRYXJFSA-N 0.000 description 1
- 229960001114 temocillin Drugs 0.000 description 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical group 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000001974 tryptic soy broth Substances 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- DQWFTGPZPKZMAB-UHFFFAOYSA-N undecane-1,6,11-triamine Chemical compound NCCCCCC(N)CCCCCN DQWFTGPZPKZMAB-UHFFFAOYSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
Classifications
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
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Description
本願は、2009年7月1日に出願した米国仮特許出願第61/269,953号「培養培地中の抗生物質の中和方法(Method for Neutralization of Antibiotics in a Culture Medium)」の恩典を主張する。この米国仮特許出願の開示内容を本明細書に援用する。
スクリューキャップチューブ中で、1.8gのUSP等級イミペネムを14mMのK2HPO4(pH7.0)10mLに対して溶解して、USP等級イミペネムのストック溶液を調製した。2mLのポリプロピレン遠心分離機管中で、システィン31.3mgを14mMのK2HPO41.08mLに対して溶解して、システィンのストック溶液を調製した。
イミペネム4.0mgを、pH7.0のリン酸緩衝生理食塩水(PBS)100mLに溶解して、0.2μ無菌フィルターでろ過して、イミペネム溶液を調製した。システィン300mgをPBS10mLに対して溶解し、0.2μ無菌フィルターでろ過し、500μLの追加を含んだBacT/Alert(登録商標)瓶(米国ミズーリ州、bioMerieux社)中の最終濃度が4mMとした。S.aureusの培養物を一晩培養して生成し、最終濃度を30〜300CFU(コロニー形成単位)/500μLとした。
Claims (3)
- 試験試料中の微生物を検出するためのキットであって、
前記キットが、
(1)試験試料を培養できる培養培地を含む内側容器を備える、封止可能な標本容器と、
(2)システィンを含む補給剤と、
を含み、
前記補給剤が、前記標本容器および前記培養培地に対して加えられ、
前記システィンが、前記培養培地中に存在しうるカルバペネムを中和、結合、又は阻害するための有効量で前記培養培地中に含まれるようにし、
前記有効量が、約0.5g/L〜約20g/Lの最終濃度を含む、キット。 - 前記試験試料が、前記標本容器および前記培養培地に対して加えられ、
前記システィンが、前記試験試料中に存在しうるあらゆる抗菌剤を中和、結合、又は阻害するための有効量で前記培養培地中に含まれるようにする、請求項1に記載のキット。 - 前記封止可能な標本容器および前記培養培地が、オートクレーブで殺菌される、請求項1に記載のキット。
Applications Claiming Priority (2)
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US26995309P | 2009-07-01 | 2009-07-01 | |
US61/269,953 | 2009-07-01 |
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JP2012517880A Division JP5774586B2 (ja) | 2009-07-01 | 2010-06-30 | 培養培地中の抗生物質の中和方法 |
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US (3) | US8420346B2 (ja) |
EP (2) | EP2449130B8 (ja) |
JP (2) | JP5774586B2 (ja) |
CN (2) | CN102656275A (ja) |
AU (1) | AU2010266341B2 (ja) |
BR (1) | BRPI1015021B1 (ja) |
CA (1) | CA2766600C (ja) |
ES (1) | ES2818374T3 (ja) |
WO (1) | WO2011002856A2 (ja) |
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FR2993900B1 (fr) * | 2012-07-27 | 2016-03-25 | Biomerieux Sa | Procede de detection de bacteries productrices de carbapenemases de type oxa-48 |
EP3119420B1 (en) | 2014-03-20 | 2021-09-22 | Technion Research & Development Foundation Ltd. | Delivery system comprising a proteolytic enzyme or effector thereof for use in a method for oral treatment and uses thereof |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3497504A (en) * | 1968-07-10 | 1970-02-24 | Lilly Co Eli | Removal of penicillins from cephalosporins |
US4221871A (en) * | 1970-12-16 | 1980-09-09 | Rohm And Haas Company | Reticular crosslinked monovinylidene N-heterocyclic copolymer |
BE885951Q (fr) * | 1977-12-02 | 1981-02-16 | Baylor College Medicine | Resine et procede pour separer des agents antimicrobiens contenus dans les fluides corporels |
US4174277A (en) * | 1977-12-02 | 1979-11-13 | Melnick Joseph L | Resin and method for removing antimicrobials from body fluids |
US4212948A (en) * | 1978-10-18 | 1980-07-15 | J. K. And Susie L. Wadley Research Institute And Blood Bank | Apparatus for detecting microbial pathogens employing a cushioning agent |
US4632902A (en) * | 1981-08-20 | 1986-12-30 | Becton, Dickinson And Company | Method for detecting biological activity in a body fluid |
US5624814A (en) * | 1981-08-20 | 1997-04-29 | Becton Dickinson And Company | Culture medium and method for culturing body fluids containing antibiotics |
JPS59106289A (ja) * | 1982-12-11 | 1984-06-19 | Terumo Corp | 多層微生物培養検査具および多層微生物培養検査器 |
CA1264275A (en) * | 1985-09-04 | 1990-01-09 | Wadley Technologies, Inc. | Stabilization of specimens for microbial analysis |
US5162229A (en) * | 1988-03-15 | 1992-11-10 | Akzo N.V. | Device and method for enhanced recovery and detection of microbial growth in the presence of antimicrobial substances |
US5217876A (en) * | 1988-03-15 | 1993-06-08 | Akzo N.V. | Method for detecting microorganisms |
US4945060A (en) * | 1988-03-15 | 1990-07-31 | Akzo N. V. | Device for detecting microorganisms |
US5164796A (en) | 1988-03-15 | 1992-11-17 | Akzo N.V. | Apparatus and method for detection of microorganisms |
US5518895A (en) * | 1990-02-15 | 1996-05-21 | Akzo N.V. | Device for detecting microorganisms using piezoelectric means |
US5094955A (en) | 1988-03-15 | 1992-03-10 | Akzo N.V. | Device and method for detecting microorganisms |
US5858769A (en) * | 1989-05-15 | 1999-01-12 | Akzo Nobel N.V. | Device for detecting microorganisms |
US5074505A (en) | 1990-06-01 | 1991-12-24 | Akzo N.V. | Support attachment for holding bottles within a bottle block |
US5070017A (en) * | 1990-12-11 | 1991-12-03 | General Electric Company | Method for biodegrading bisphenol alkanes |
JPH05139242A (ja) | 1991-11-19 | 1993-06-08 | Toyota Motor Corp | 車体の前部構造 |
PT611001E (pt) * | 1993-02-11 | 2002-10-31 | Dsm Nv | Unidade para a detencao de residuos de compostos antibacterianos em liquidos |
ATE197477T1 (de) * | 1995-02-01 | 2000-11-11 | Dsm Nv | Ein schneller mikrobiologischer test zum nachweis antibakterieller verbindungen |
ES2294787T3 (es) * | 1995-06-05 | 2008-04-01 | Biomerieux, Inc. | Dispositivo y metodo para detectar microorganismos. |
US6596532B1 (en) * | 1997-12-12 | 2003-07-22 | BIOMéRIEUX, INC. | Device for isolation and surface culture of microorganisms from bulk fluids |
GB0024203D0 (en) * | 2000-10-03 | 2000-11-15 | Peptide Therapeutics Ltd | Stabilisation of plasmid inheritance in bacteria |
US7291480B2 (en) * | 2002-03-13 | 2007-11-06 | Black Jennifer A | Device and method for detecting antibiotic-inactivating enzymes |
US20060035310A1 (en) * | 2004-08-13 | 2006-02-16 | Millipore Corporation | Media for recovery of microorganism in the presence of antibiotics |
WO2006047517A2 (en) * | 2004-10-26 | 2006-05-04 | University Of Maryland Baltimore | Live attenuated bacterial vaccine to reduce or inhibit carriage and shedding of enterohemorrhagic escherichia coli in cattle |
US8414903B2 (en) | 2006-11-29 | 2013-04-09 | Tufts University | Escherichia coli mutants and methods of use thereof |
US20090123960A1 (en) * | 2007-11-09 | 2009-05-14 | Becton, Dickinson And Company | Method for Removing Antibiotics From Blood Culture Samples |
CN101565728A (zh) * | 2008-04-21 | 2009-10-28 | 曲奕 | 衣原体中和营养消化液 |
CN101353622A (zh) * | 2008-05-28 | 2009-01-28 | 天津市康赛生物技术有限公司 | 用于全自动血液培养系统的血液增菌培养瓶及其制备方法 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101936047B1 (ko) * | 2018-03-14 | 2019-01-08 | 주식회사 이디에스 | 문틀의 문선 조립구조 |
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AU2010266341B2 (en) | 2015-12-03 |
CA2766600A1 (en) | 2011-01-06 |
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US20130164822A1 (en) | 2013-06-27 |
US8911962B2 (en) | 2014-12-16 |
EP2449130A2 (en) | 2012-05-09 |
EP2449130B1 (en) | 2020-09-09 |
JP2015211686A (ja) | 2015-11-26 |
JP2012531899A (ja) | 2012-12-13 |
US8420346B2 (en) | 2013-04-16 |
US20140234889A1 (en) | 2014-08-21 |
US8603770B2 (en) | 2013-12-10 |
ES2818374T3 (es) | 2021-04-12 |
JP5774586B2 (ja) | 2015-09-09 |
BRPI1015021A2 (pt) | 2019-02-26 |
CA2766600C (en) | 2022-11-08 |
AU2010266341A1 (en) | 2012-02-02 |
WO2011002856A2 (en) | 2011-01-06 |
EP3763809A1 (en) | 2021-01-13 |
BRPI1015021B1 (pt) | 2019-12-10 |
CN107312714A (zh) | 2017-11-03 |
EP2449130B8 (en) | 2020-11-04 |
WO2011002856A3 (en) | 2012-05-31 |
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