JP6038452B2 - 生物学的に活性なペプチド - Google Patents

生物学的に活性なペプチド Download PDF

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Publication number
JP6038452B2
JP6038452B2 JP2011505212A JP2011505212A JP6038452B2 JP 6038452 B2 JP6038452 B2 JP 6038452B2 JP 2011505212 A JP2011505212 A JP 2011505212A JP 2011505212 A JP2011505212 A JP 2011505212A JP 6038452 B2 JP6038452 B2 JP 6038452B2
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JP
Japan
Prior art keywords
peptide
fviii
peptides
thrombin generation
item
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Expired - Fee Related
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JP2011505212A
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English (en)
Japanese (ja)
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JP2011518179A5 (OSRAM
JP2011518179A (ja
Inventor
フリードリッヒ シェイフリンガー，
フリードリッヒ シェイフリンガー，
ミハエル ドッカル，
ミハエル ドッカル，
Original Assignee
バクスアルタ ゲーエムベーハー
バクスアルタ ゲーエムベーハー
バクスアルタ インコーポレイテッド
バクスアルタ インコーポレイテッド
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Publication of JP2011518179A publication Critical patent/JP2011518179A/ja
Publication of JP2011518179A5 publication Critical patent/JP2011518179A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2011505212A 2008-04-17 2009-04-16 生物学的に活性なペプチド Expired - Fee Related JP6038452B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US932608P 2008-04-17 2008-04-17
US61/009,326 2008-04-17
US11305508P 2008-11-10 2008-11-10
US61/113,055 2008-11-10
PCT/US2009/040857 WO2009137256A1 (en) 2008-04-17 2009-04-16 Biologically active peptides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013263345A Division JP5977223B2 (ja) 2008-04-17 2013-12-20 生物学的に活性なペプチド

Publications (3)

Publication Number Publication Date
JP2011518179A JP2011518179A (ja) 2011-06-23
JP2011518179A5 JP2011518179A5 (OSRAM) 2011-12-22
JP6038452B2 true JP6038452B2 (ja) 2016-12-07

Family

ID=40887122

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2011505212A Expired - Fee Related JP6038452B2 (ja) 2008-04-17 2009-04-16 生物学的に活性なペプチド
JP2013263345A Expired - Fee Related JP5977223B2 (ja) 2008-04-17 2013-12-20 生物学的に活性なペプチド
JP2016143368A Pending JP2017019797A (ja) 2008-04-17 2016-07-21 生物学的に活性なペプチド

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013263345A Expired - Fee Related JP5977223B2 (ja) 2008-04-17 2013-12-20 生物学的に活性なペプチド
JP2016143368A Pending JP2017019797A (ja) 2008-04-17 2016-07-21 生物学的に活性なペプチド

Country Status (19)

Country Link
US (6) US8563688B2 (OSRAM)
EP (2) EP3115370B1 (OSRAM)
JP (3) JP6038452B2 (OSRAM)
KR (2) KR101606248B1 (OSRAM)
CN (2) CN105524163A (OSRAM)
AR (1) AR071478A1 (OSRAM)
AU (1) AU2009244635B2 (OSRAM)
BR (1) BRPI0911203A2 (OSRAM)
CA (1) CA2721694C (OSRAM)
DK (2) DK2279200T3 (OSRAM)
ES (2) ES2594706T3 (OSRAM)
HK (1) HK1223946A1 (OSRAM)
MX (1) MX2010011397A (OSRAM)
NZ (1) NZ588200A (OSRAM)
PL (1) PL2279200T3 (OSRAM)
PT (1) PT2279200T (OSRAM)
SG (2) SG10201809286XA (OSRAM)
TW (2) TWI573806B (OSRAM)
WO (1) WO2009137256A1 (OSRAM)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI573806B (zh) * 2008-04-17 2017-03-11 巴克斯歐塔公司 生物活性胜肽
US8716448B2 (en) 2009-02-03 2014-05-06 Amunix Operating Inc. Coagulation factor VII compositions and methods of making and using same
CN103262532B (zh) 2010-07-19 2018-03-09 杜比实验室特许公司 用于经采样复用的图像和视频数据的增强方法
ES2724778T3 (es) 2011-06-10 2019-09-16 Bioverativ Therapeutics Inc Compuestos procoagulantes y procedimientos de uso de los mismos
EA201491388A1 (ru) 2012-02-15 2015-01-30 Байоджен Айдек Ма Инк. Рекомбинантные белки фактора viii
DK3564260T5 (da) 2012-02-15 2024-09-02 Bioverativ Therapeutics Inc Faktor viii-sammensætninger og fremgangsmåder til fremstilling og anvendelse deraf
BR112015028502B1 (pt) * 2013-06-11 2022-03-22 Cj Cheiljedang Corporation Microrganismo produtor de l-isoleucina e método para a produção de l-isoleucina utilizando o mesmo
WO2015023891A2 (en) 2013-08-14 2015-02-19 Biogen Idec Ma Inc. Factor viii-xten fusions and uses thereof
WO2015023894A1 (en) 2013-08-14 2015-02-19 Biogen Idec Ma Inc. Recombinant factor viii proteins
US10584147B2 (en) 2013-11-08 2020-03-10 Biovertiv Therapeutics Inc. Procoagulant fusion compound
US9321812B2 (en) 2014-03-28 2016-04-26 Perle Bioscience Insulin independence among patients with diabetes utilizing an optimized hamster REG3 gamma peptide
JP6484468B2 (ja) * 2014-06-03 2019-03-13 ＡｖａｎＳｔｒａｔｅ株式会社 ガラス板製造方法およびガラス板製造装置
GB201410507D0 (en) * 2014-06-12 2014-07-30 Univ Bath Drug delivery enhancement agents
MX2018001497A (es) 2015-08-03 2018-05-15 Bioverativ Therapeutics Inc Proteinas de fusion de factor ix y metodos para producirlas y usarlas.
EP3519431A1 (en) 2016-09-28 2019-08-07 Cohbar Inc. Therapeutic mots-c related peptides
IL308416B2 (en) 2016-12-02 2025-08-01 Bioverativ Therapeutics Inc Methods of treating hemophilic arthropathy using chimeric clotting factors
CN110831613A (zh) 2017-01-31 2020-02-21 比奥维拉迪维治疗股份有限公司 因子ix融合蛋白及其制备和使用方法
MA52630B1 (fr) 2018-05-18 2025-07-31 Bioverativ Therapeutics Inc. Procédés de traitement de l'hémophilie a

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US4447356A (en) * 1981-04-17 1984-05-08 Olivera Baldomero M Conotoxins
IT1190891B (it) 1982-06-24 1988-02-24 Anic Spa Metodo per la sintesi in fase solida di polipeptidi retroinvertiti
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5093317A (en) * 1989-06-05 1992-03-03 Cephalon, Inc. Treating disorders by application of insulin-like growth factor
JPH0725794B2 (ja) * 1990-03-23 1995-03-22 呉羽化学工業株式会社 新規なペプチド
US5595732A (en) 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US6037452A (en) 1992-04-10 2000-03-14 Alpha Therapeutic Corporation Poly(alkylene oxide)-Factor VIII or Factor IX conjugate
US5439686A (en) 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
CN1245156C (zh) 1993-02-22 2006-03-15 美国生物科学有限公司 用于体内传送生物制品的方法及用于该方法的组合物
EP0805864A1 (en) * 1994-12-30 1997-11-12 Seminis Vegetable Seeds, Inc. Papaya ringspot virus replicase gene
US5532153A (en) * 1995-03-23 1996-07-02 New England Biolabs, Inc. Method for cloning and producing the SacI restriction endonuclease
US7279548B2 (en) * 1996-04-03 2007-10-09 Cytogen Corporation Identification and isolation of novel polypeptides having WW domains and methods of using same
US6197526B1 (en) 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US6624289B1 (en) 1999-06-16 2003-09-23 Saint Louis University Region of factor IXa protease domain that interacts with factor VIIIa and methods therefor
US7109170B2 (en) 1999-06-16 2006-09-19 Saint Louis University Region of factor IXa protease domain that interacts with factor VIIIa and methods therefor
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AT411997B (de) 1999-09-14 2004-08-26 Baxter Ag Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate
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TWI573806B (zh) * 2008-04-17 2017-03-11 巴克斯歐塔公司 生物活性胜肽

Also Published As

Publication number Publication date
NZ588200A (en) 2012-11-30
US20190225648A1 (en) 2019-07-25
AU2009244635B2 (en) 2012-04-19
US9598464B2 (en) 2017-03-21
ES2594706T3 (es) 2016-12-22
US20100022445A1 (en) 2010-01-28
CA2721694A1 (en) 2009-11-12
JP2014074052A (ja) 2014-04-24
US20120077749A1 (en) 2012-03-29
US8563688B2 (en) 2013-10-22
EP3115370A1 (en) 2017-01-11
EP2279200B1 (en) 2016-07-13
HK1154255A1 (zh) 2012-04-13
PT2279200T (pt) 2016-10-12
CN105524163A (zh) 2016-04-27
CN102007140A (zh) 2011-04-06
AU2009244635A1 (en) 2009-11-12
KR20110005873A (ko) 2011-01-19
CN102007140B (zh) 2016-02-24
TW201443085A (zh) 2014-11-16
HK1223946A1 (zh) 2017-08-11
EP2279200A1 (en) 2011-02-02
KR20130112959A (ko) 2013-10-14
PL2279200T3 (pl) 2017-08-31
US8822638B2 (en) 2014-09-02
JP5977223B2 (ja) 2016-08-24
ES2739676T3 (es) 2020-02-03
AR071478A1 (es) 2010-06-23
TWI573806B (zh) 2017-03-11
JP2017019797A (ja) 2017-01-26
TW200944226A (en) 2009-11-01
US10822376B2 (en) 2020-11-03
WO2009137256A1 (en) 2009-11-12
SG10201608071YA (en) 2016-11-29
US9206234B2 (en) 2015-12-08
US20160060295A1 (en) 2016-03-03
CA2721694C (en) 2018-11-06
EP3115370B1 (en) 2019-06-26
MX2010011397A (es) 2010-11-12
US20170174724A1 (en) 2017-06-22
DK2279200T3 (en) 2016-08-22
KR101606248B1 (ko) 2016-03-24
US20150038676A1 (en) 2015-02-05
JP2011518179A (ja) 2011-06-23
US10287319B2 (en) 2019-05-14
SG10201809286XA (en) 2018-11-29
KR101434712B1 (ko) 2014-10-01
TWI541020B (zh) 2016-07-11
BRPI0911203A2 (pt) 2016-07-05
DK3115370T3 (da) 2019-07-29

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