JP6027125B2 - 容器アセンブリ用の混合要素 - Google Patents
容器アセンブリ用の混合要素 Download PDFInfo
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- JP6027125B2 JP6027125B2 JP2014537229A JP2014537229A JP6027125B2 JP 6027125 B2 JP6027125 B2 JP 6027125B2 JP 2014537229 A JP2014537229 A JP 2014537229A JP 2014537229 A JP2014537229 A JP 2014537229A JP 6027125 B2 JP6027125 B2 JP 6027125B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F29/00—Mixers with rotating receptacles
- B01F29/80—Mixers with rotating receptacles rotating about a substantially vertical axis
- B01F29/81—Mixers with rotating receptacles rotating about a substantially vertical axis with stationary mixing elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/15003—Source of blood for venous or arterial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150351—Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
- A61B5/154—Devices using pre-evacuated means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F29/00—Mixers with rotating receptacles
- B01F29/30—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles
- B01F29/31—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles the containers being supported by driving means, e.g. by rotating rollers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/50—Mixing receptacles
- B01F35/53—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
- B01F35/531—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/50—Mixing receptacles
- B01F35/53—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
- B01F35/531—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom
- B01F35/5312—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom with vertical baffles mounted on the walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/062—Carpules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/046—Function or devices integrated in the closure
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Analytical Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Description
以下の例は、本開示の実施形態を例示することが意図されており、本開示を限定することは意図されていない。
方法:全く同じカートリッジ/注射器の両端に、本開示の実施形態に基づく3つの異なる設計の混合要素(M Pro(図9および10に示されている)、SE(図11および12に示されている)およびCE(図13および14に示されている)と称される)を有する閉鎖体およびストッパを取り付けた。さらに、流体貯留室のどちらの端にも混合要素を持たないBD Preset注射器を対照として使用した。ヘッドスペースが存在せず、流体貯留室の底部に赤色染料が明瞭な層として含まれ、その上に透明な水の層が位置するような態様で、それぞれの注射器に水2mlおよび赤色染料200μlを(混合せずに)充填した。次いでそれらの注射器を、垂直位置に保持された試験装置(test rig)上に装填し、それぞれの注射器を、等しい力および速度で、往復運動するように回転させた。
Claims (15)
- 第1の端部、第2の端部、および前記第1の端部と前記第2の端部の間に延び、容器内部を画定する側壁を有する容器であり、容器縦軸を定める容器と、
前記容器の前記第1の端部を密封する第1の閉鎖体と、
前記容器の前記第2の端部を密封する第2の閉鎖体と、
前記容器内部に突き出た第1の混合要素であり、前記第1の閉鎖体の一部分に位置する第1の混合要素と、
前記容器内部に突き出た第2の混合要素であり、前記第2の閉鎖体の一部分に位置する第2の混合要素と
を備え、
それによって、前記容器を前記容器縦軸を軸に回転させると、前記第1の混合要素および前記第2の混合要素が、前記容器の内部に提供された第1の物質と前記容器の内部に提供された第2の物質の混合を達成する少なくとも1つの渦を形成する
ことを特徴とする容器アセンブリ。 - 前記第1の混合要素は、前記容器内部に提供された前記第1の物質と前記第2の物質のうちの少なくとも一方の物質の内部に非対称混合パターンを形成することを特徴とする請求項1に記載の容器アセンブリ。
- 前記第1の混合要素は少なくとも1つの混合ひれを含むことを特徴とする請求項1に記載の容器アセンブリ。
- 前記少なくとも1つの混合ひれは、
頂部と、
底部と、
前記底部から前記頂部まで第1の角度で延びる第1の混合面と、
前記底部から前記頂部まで第2の角度で延びる第2の混合面と
を備えることを特徴とする請求項3に記載の容器アセンブリ。 - 前記第1の角度は前記第2の角度と等しいことを特徴とする請求項4に記載の容器アセンブリ。
- 前記第1の角度は前記第2の角度よりも大きいことを特徴とする請求項5に記載の容器アセンブリ。
- 前記第1の角度は前記第2の角度よりも小さいことを特徴とする請求項5に記載の容器アセンブリ。
- 前記第1の混合面と前記第2の混合面は同じ形状を有することを特徴とする請求項5に記載の容器アセンブリ。
- 前記第1の混合面は第1の形状を有し、前記第2の混合面は第2の形状を有し、前記第2の形状は前記第1の形状とは異なることを特徴とする請求項5に記載の容器アセンブリ。
- 前記第1の混合要素は、前記第1の閉鎖体の一部分の周囲に沿って等間隔に配置された3つの混合ひれを含むことを特徴とする請求項1に記載の容器アセンブリ。
- 前記第1の混合要素は、前記第1の閉鎖体の一部分の少なくとも1つの傾斜した表面を含むことを特徴とする請求項1に記載の容器アセンブリ。
- 前記容器内部の第1の物質をさらに含むことを特徴とする請求項1に記載の容器アセンブリ。
- 前記容器内部の第2の物質をさらに含むことを特徴とする請求項12に記載の容器アセンブリ。
- 前記第1の閉鎖体は、前記容器の前記容器内部に摺動可能に配置されたストッパを含み、前記ストッパは、前記容器の前記側壁との密封係合を提供するように前記容器に対してサイズが決められていることを特徴とする請求項1に記載の容器アセンブリ。
- 容器アセンブリに収容された第1の物質と第2の物質を混合する方法であって、
第1の物質および第2の物質を収容する容器アセンブリを提供するステップであり、前記容器アセンブリが、
第1の端部、第2の端部、および前記第1の端部と前記第2の端部の間に延び、容器内部を画定する側壁を有する容器であり、容器縦軸を定める容器、
前記容器の前記第1の端部を密封する第1の閉鎖体、
前記容器の前記第2の端部を密封する第2の閉鎖体、
前記容器内部に突き出た第1の混合要素であり、前記第1の閉鎖体の一部分に位置する第1の混合要素、
前記容器内部に突き出た第2の混合要素であり、前記第2の閉鎖体の一部分に位置する第2の混合要素
を備えるステップと、
前記容器内部に、少なくとも第1の物質および第2の物質を提供するステップと、
前記容器を前記容器縦軸を軸に回転させるステップと、
回転中に、前記第1の混合要素および前記第2の混合要素によって少なくとも1つの渦を、前記少なくとも1つの渦が、前記容器アセンブリ内の前記第1の物質と前記第2の物質の混合を達成するような態様で形成するステップと
を含むことを特徴とする方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161549475P | 2011-10-20 | 2011-10-20 | |
US61/549,475 | 2011-10-20 | ||
PCT/US2012/060771 WO2013059425A1 (en) | 2011-10-20 | 2012-10-18 | Mixing element for container assemblies |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016158096A Division JP2016187733A (ja) | 2011-10-20 | 2016-08-10 | 容器アセンブリ用の混合要素 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2014534010A JP2014534010A (ja) | 2014-12-18 |
JP6027125B2 true JP6027125B2 (ja) | 2016-11-16 |
Family
ID=47216400
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
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JP2014537229A Active JP6027125B2 (ja) | 2011-10-20 | 2012-10-18 | 容器アセンブリ用の混合要素 |
JP2016158096A Pending JP2016187733A (ja) | 2011-10-20 | 2016-08-10 | 容器アセンブリ用の混合要素 |
JP2018193706A Pending JP2019034175A (ja) | 2011-10-20 | 2018-10-12 | 容器アセンブリ用の混合要素 |
Family Applications After (2)
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JP2016158096A Pending JP2016187733A (ja) | 2011-10-20 | 2016-08-10 | 容器アセンブリ用の混合要素 |
JP2018193706A Pending JP2019034175A (ja) | 2011-10-20 | 2018-10-12 | 容器アセンブリ用の混合要素 |
Country Status (10)
Country | Link |
---|---|
US (2) | US11203000B2 (ja) |
EP (2) | EP3632399B1 (ja) |
JP (3) | JP6027125B2 (ja) |
CN (1) | CN103957863B (ja) |
AU (1) | AU2012326097B2 (ja) |
BR (1) | BR112014009294B1 (ja) |
CA (1) | CA2852090C (ja) |
ES (1) | ES2773263T3 (ja) |
MX (2) | MX2014004368A (ja) |
WO (1) | WO2013059425A1 (ja) |
Families Citing this family (11)
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ES2773263T3 (es) | 2011-10-20 | 2020-07-10 | Becton Dickinson Co | Elemento de mezcla para conjuntos de envase |
WO2015103603A1 (en) | 2014-01-06 | 2015-07-09 | Omni International, Inc. | Homogenization tubes with flow disrupters for beadless interrupted flow |
EP4338668A1 (en) | 2014-10-14 | 2024-03-20 | Becton, Dickinson and Company | Blood sample management using open cell foam |
US9693723B2 (en) | 2014-10-14 | 2017-07-04 | Becton, Dickinson And Company | Blood sample management using open cell foam |
US9677988B1 (en) | 2015-07-10 | 2017-06-13 | David E. Doggett | Integrating radiation collection and detection apparatus |
US9366617B1 (en) * | 2015-07-10 | 2016-06-14 | David E. Doggett | Self-stirring container |
CN105167784B (zh) * | 2015-08-20 | 2018-03-27 | 武汉唐济科技有限公司 | 一种采血器混匀装置及自充盈式动脉采血器 |
CN111031915B (zh) * | 2017-07-13 | 2023-06-06 | 贝克顿·迪金森公司 | 生物流体收集设备 |
CA3116041A1 (en) * | 2018-12-03 | 2020-06-11 | Sirtex Medical Inc. | Apparatus for delivery of radioembolization microspheres |
JP7123343B2 (ja) * | 2020-01-17 | 2022-08-23 | 株式会社大協精工 | 製剤均一化練習用模型及び製剤均一化練習方法 |
CN117098979A (zh) * | 2021-04-06 | 2023-11-21 | 南京金斯瑞生物科技有限公司 | 混匀管 |
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2012
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- 2012-10-18 AU AU2012326097A patent/AU2012326097B2/en active Active
- 2012-10-18 MX MX2014004368A patent/MX2014004368A/es active IP Right Grant
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- 2012-10-18 WO PCT/US2012/060771 patent/WO2013059425A1/en active Application Filing
- 2012-10-18 BR BR112014009294-0A patent/BR112014009294B1/pt active IP Right Grant
- 2012-10-18 CA CA2852090A patent/CA2852090C/en active Active
- 2012-10-18 EP EP19208326.9A patent/EP3632399B1/en active Active
- 2012-10-18 US US14/350,969 patent/US11203000B2/en active Active
- 2012-10-18 EP EP12788672.9A patent/EP2768464B1/en active Active
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JP2019034175A (ja) | 2019-03-07 |
AU2012326097A1 (en) | 2014-05-01 |
US11203000B2 (en) | 2021-12-21 |
JP2014534010A (ja) | 2014-12-18 |
BR112014009294B1 (pt) | 2021-03-02 |
CN103957863B (zh) | 2018-11-02 |
MX2014004368A (es) | 2015-04-13 |
CA2852090C (en) | 2016-05-24 |
BR112014009294A2 (pt) | 2017-04-11 |
MX2020002636A (es) | 2020-09-18 |
JP2016187733A (ja) | 2016-11-04 |
CN103957863A (zh) | 2014-07-30 |
CA2852090A1 (en) | 2013-04-25 |
AU2012326097B2 (en) | 2015-08-13 |
EP3632399A1 (en) | 2020-04-08 |
EP2768464B1 (en) | 2019-11-27 |
WO2013059425A1 (en) | 2013-04-25 |
EP3632399C0 (en) | 2023-11-29 |
ES2773263T3 (es) | 2020-07-10 |
EP3632399B1 (en) | 2023-11-29 |
EP2768464A1 (en) | 2014-08-27 |
US20220072489A1 (en) | 2022-03-10 |
US20140269160A1 (en) | 2014-09-18 |
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