JP6012629B2 - 細胞移植のための組成物および方法 - Google Patents

細胞移植のための組成物および方法 Download PDF

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JP6012629B2
JP6012629B2 JP2013549850A JP2013549850A JP6012629B2 JP 6012629 B2 JP6012629 B2 JP 6012629B2 JP 2013549850 A JP2013549850 A JP 2013549850A JP 2013549850 A JP2013549850 A JP 2013549850A JP 6012629 B2 JP6012629 B2 JP 6012629B2
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cells
cell
combination
liver
heparin
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JP2014508138A5 (cg-RX-API-DMAC7.html
JP2014508138A (ja
Inventor
ステファン,グザヴィエ
ソカル,エティエンヌ
ナジミ,ムスタファ
エークハウト,ステファン
ハーマンズ,セドリック
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Universite Catholique de Louvain UCL
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/407Liver; Hepatocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • A61K38/58Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2013549850A 2011-01-25 2012-01-25 細胞移植のための組成物および方法 Expired - Fee Related JP6012629B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11152119.1 2011-01-25
EP11152119 2011-01-25
PCT/EP2012/051157 WO2012101181A1 (en) 2011-01-25 2012-01-25 Compositions and methods for cell transplantation

Publications (3)

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JP2014508138A JP2014508138A (ja) 2014-04-03
JP2014508138A5 JP2014508138A5 (cg-RX-API-DMAC7.html) 2015-03-12
JP6012629B2 true JP6012629B2 (ja) 2016-10-25

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JP2013549850A Expired - Fee Related JP6012629B2 (ja) 2011-01-25 2012-01-25 細胞移植のための組成物および方法

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US (3) US20130302291A1 (cg-RX-API-DMAC7.html)
EP (1) EP2667878B1 (cg-RX-API-DMAC7.html)
JP (1) JP6012629B2 (cg-RX-API-DMAC7.html)
CN (1) CN103402527B (cg-RX-API-DMAC7.html)
CA (1) CA2825252C (cg-RX-API-DMAC7.html)
DK (1) DK2667878T3 (cg-RX-API-DMAC7.html)
ES (1) ES2573522T3 (cg-RX-API-DMAC7.html)
IL (1) IL227529A0 (cg-RX-API-DMAC7.html)
PL (1) PL2667878T3 (cg-RX-API-DMAC7.html)
PT (1) PT2667878E (cg-RX-API-DMAC7.html)
SG (1) SG192124A1 (cg-RX-API-DMAC7.html)
WO (1) WO2012101181A1 (cg-RX-API-DMAC7.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013110354A1 (en) 2012-01-25 2013-08-01 Université Catholique de Louvain Compositions and methods for cell transplantation
EP2667878B1 (en) 2011-01-25 2016-03-30 Université Catholique de Louvain Compositions and methods for cell transplantation
WO2014110180A1 (en) * 2013-01-12 2014-07-17 Cesca Therapeutics, Inc. Rapid infusion of autologous bone marrow derived stem cells
KR102278652B1 (ko) 2013-03-15 2021-07-19 미로매트릭스 메디칼 인크. 섬 세포 재세포화를 위한 관류 탈세포화된 간의 용도
US20160129047A1 (en) 2013-07-05 2016-05-12 Université Catholique de Louvain Conditioned medium from human adult liver stem cells and its use in the treatment of liver disorders
BR102013033827B1 (pt) * 2013-12-27 2021-09-08 Regenera - Medicina Veterinária Avançada Ltda. Concentrado multipotente e imunocompatível de células-tronco e biofármaco e forma de dosagem que o compreendem
WO2016198578A1 (en) * 2015-06-11 2016-12-15 Universiteit Maastricht Method for preventing transplant failure in a host.
CN106995796A (zh) * 2016-01-26 2017-08-01 李建业 基于细胞因子的细胞处理方法、试剂盒及冻干粉
CN116590227A (zh) * 2017-03-03 2023-08-15 日本乐敦制药株式会社 间充质干细胞和肝疾病治疗剂
MX2019014912A (es) * 2017-06-12 2020-08-06 Univ North Carolina Chapel Hill Composiciones de injerto tipo parche para injerto de células.
JP7264589B2 (ja) * 2017-12-25 2023-04-25 株式会社 資生堂 トロンビンの抑制作用を指標とした皮膚状態改善剤のスクリーニング方法、及びトロンビン作用阻害剤を含む皮膚状態改善剤
US12263275B2 (en) 2018-06-13 2025-04-01 Miromatrix Medical Inc. Fistula filler and deployment system
CN113677790B (zh) * 2019-03-26 2024-05-24 普罗米瑟拉疗法公司 用于治疗慢加急性肝衰竭的成体肝祖细胞
CN112608890B (zh) * 2020-12-17 2024-08-20 山东佰鸿干细胞生物技术有限公司 一种防止间充质干细胞粘连的培养方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9010552D0 (en) 1990-05-10 1990-07-04 Erba Carlo Spa Method for the recombinant production of hirudins and novel hirudins
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5837539A (en) 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
GB0014136D0 (en) 2000-06-10 2000-08-02 Astrazeneca Ab Combination therapy
DE10202982A1 (de) 2002-01-26 2003-07-31 Augustinus Bader Verfahren und Vorrichtung zum Einbringen von lebenden Zellen in eine biologische Körperflüssigkeit
US20060222640A1 (en) * 2005-03-29 2006-10-05 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for treatment of thrombosis
WO2006126219A1 (en) 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
AU2006292203A1 (en) * 2005-09-21 2007-03-29 Dask Technologies, Llc Methods and compositions for organ and tissue functionality
CA2634510C (en) * 2005-12-21 2018-01-09 Universite Catholique De Louvain Isolated liver stem cells
EP2667878B1 (en) 2011-01-25 2016-03-30 Université Catholique de Louvain Compositions and methods for cell transplantation
WO2013110354A1 (en) 2012-01-25 2013-08-01 Université Catholique de Louvain Compositions and methods for cell transplantation

Also Published As

Publication number Publication date
EP2667878B1 (en) 2016-03-30
EP2667878A1 (en) 2013-12-04
CN103402527B (zh) 2016-04-20
US10478459B2 (en) 2019-11-19
ES2573522T3 (es) 2016-06-08
SG192124A1 (en) 2013-08-30
IL227529A0 (en) 2013-09-30
US10039789B2 (en) 2018-08-07
US20170042940A1 (en) 2017-02-16
PL2667878T3 (pl) 2016-10-31
DK2667878T3 (en) 2016-06-27
WO2012101181A1 (en) 2012-08-02
CA2825252A1 (en) 2012-08-02
US20170354723A1 (en) 2017-12-14
CN103402527A (zh) 2013-11-20
CA2825252C (en) 2018-10-16
JP2014508138A (ja) 2014-04-03
US20130302291A1 (en) 2013-11-14
PT2667878E (pt) 2016-06-03

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