JP6006875B2 - 小型流体分析デバイスおよび製造方法 - Google Patents

小型流体分析デバイスおよび製造方法 Download PDF

Info

Publication number
JP6006875B2
JP6006875B2 JP2015527009A JP2015527009A JP6006875B2 JP 6006875 B2 JP6006875 B2 JP 6006875B2 JP 2015527009 A JP2015527009 A JP 2015527009A JP 2015527009 A JP2015527009 A JP 2015527009A JP 6006875 B2 JP6006875 B2 JP 6006875B2
Authority
JP
Japan
Prior art keywords
fluid
substrate
lid
present
fluid sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015527009A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015530900A (ja
Inventor
リースベト・ラハー
ペーテル・プーマンス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Interuniversitair Microelektronica Centrum vzw IMEC
Original Assignee
Interuniversitair Microelektronica Centrum vzw IMEC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Interuniversitair Microelektronica Centrum vzw IMEC filed Critical Interuniversitair Microelektronica Centrum vzw IMEC
Publication of JP2015530900A publication Critical patent/JP2015530900A/ja
Application granted granted Critical
Publication of JP6006875B2 publication Critical patent/JP6006875B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00436—Shaping materials, i.e. techniques for structuring the substrate or the layers on the substrate
    • B81C1/00523—Etching material
    • B81C1/00539—Wet etching
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
    • A61B5/1405—Devices for taking blood samples
    • A61B5/1411—Devices for taking blood samples by percutaneous method, e.g. by lancet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150221—Valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150847—Communication to or from blood sampling device
    • A61B5/15087—Communication to or from blood sampling device short range, e.g. between console and disposable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C5/00—Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C7/00—Hybrid elements, i.e. circuit elements having features according to groups F15C1/00 and F15C3/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/22—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
    • G01N27/227—Sensors changing capacitance upon adsorption or absorption of fluid components, e.g. electrolyte-insulator-semiconductor sensors, MOS capacitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4148—Integrated circuits therefor, e.g. fabricated by CMOS processing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1833—Means for temperature control using electrical currents in the sample itself
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00222—Integrating an electronic processing unit with a micromechanical structure
    • B81C1/00238—Joining a substrate with an electronic processing unit and a substrate with a micromechanical structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/494—Fluidic or fluid actuated device making
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Mechanical Engineering (AREA)
  • Electrochemistry (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Hardware Design (AREA)
  • Power Engineering (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
JP2015527009A 2013-05-22 2014-05-22 小型流体分析デバイスおよび製造方法 Active JP6006875B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13168743.6 2013-05-22
EP13168743 2013-05-22
PCT/EP2014/060591 WO2014187926A1 (en) 2013-05-22 2014-05-22 Compact fluid analysis device and method to fabricate

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016115240A Division JP2016179198A (ja) 2013-05-22 2016-06-09 小型流体分析デバイスおよび製造方法

Publications (2)

Publication Number Publication Date
JP2015530900A JP2015530900A (ja) 2015-10-29
JP6006875B2 true JP6006875B2 (ja) 2016-10-12

Family

ID=48537773

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2015527009A Active JP6006875B2 (ja) 2013-05-22 2014-05-22 小型流体分析デバイスおよび製造方法
JP2016115240A Pending JP2016179198A (ja) 2013-05-22 2016-06-09 小型流体分析デバイスおよび製造方法
JP2019166416A Pending JP2020016659A (ja) 2013-05-22 2019-09-12 小型流体分析デバイスおよび製造方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2016115240A Pending JP2016179198A (ja) 2013-05-22 2016-06-09 小型流体分析デバイスおよび製造方法
JP2019166416A Pending JP2020016659A (ja) 2013-05-22 2019-09-12 小型流体分析デバイスおよび製造方法

Country Status (11)

Country Link
US (2) US9617149B2 (enExample)
EP (1) EP2827988B1 (enExample)
JP (3) JP6006875B2 (enExample)
AU (3) AU2014270412B2 (enExample)
BR (1) BR112015029245A2 (enExample)
CA (1) CA2912947C (enExample)
ES (1) ES2583413T3 (enExample)
MX (1) MX2015016017A (enExample)
RU (1) RU2015150548A (enExample)
WO (1) WO2014187926A1 (enExample)
ZA (1) ZA201509084B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8837159B1 (en) * 2009-10-28 2014-09-16 Amazon Technologies, Inc. Low-profile circuit board assembly
TWI532530B (zh) * 2010-10-29 2016-05-11 萬國商業機器公司 具有浸入通道之多層微流體探針頭及其製造方法
ES2583413T3 (es) 2013-05-22 2016-09-20 Imec Vzw Dispositivo compacto de análisis de fluido y método de fabricación
EP3223944B1 (en) 2014-11-26 2020-05-06 IMEC vzw A fluid analysis device
US20170326552A1 (en) * 2014-11-26 2017-11-16 Imec Vzw Compact Fluid Analysis Device and Method to Fabricate
DE102015111712B4 (de) * 2015-07-20 2017-06-01 Infineon Technologies Ag Teststreifen und System zum Bestimmen von Messdaten einer Testflüssigkeit
US9795964B2 (en) 2015-11-20 2017-10-24 International Business Machines Corporation Direct bond transfer layers for manufacturable sealing of microfluidic chips
GB2545009A (en) * 2015-12-03 2017-06-07 Univ Ulster Liquid sample collection apparatus
US11268927B2 (en) 2016-08-30 2022-03-08 Analog Devices International Unlimited Company Electrochemical sensor, and a method of forming an electrochemical sensor
US12188893B2 (en) 2016-08-30 2025-01-07 Analog Devices International Unlimited Company Electrochemical sensor, and a method of forming an electrochemical sensor
US10620151B2 (en) 2016-08-30 2020-04-14 Analog Devices Global Electrochemical sensor, and a method of forming an electrochemical sensor
KR102596975B1 (ko) * 2017-12-11 2023-11-01 덴카 주식회사 액체 시료 검사 키트용 막 담체, 액체 시료 검사 키트 및 막 담체
US11022579B2 (en) 2018-02-05 2021-06-01 Analog Devices International Unlimited Company Retaining cap
CN111836582A (zh) * 2018-03-16 2020-10-27 国立大学法人东京大学 检测芯片以及检测装置
KR102877061B1 (ko) 2018-05-22 2025-10-27 플럭서스, 인크. 도파로 구조체의 제조
EP3840635A4 (en) * 2018-08-23 2022-05-18 Sanwa Biotech Ltd. PORTABLE DIAGNOSTIC APPARATUS AND RELATED METHOD
US11173486B2 (en) 2019-02-13 2021-11-16 International Business Machines Corporation Fluidic cavities for on-chip layering and sealing of separation arrays
WO2020214224A1 (en) * 2019-04-18 2020-10-22 Siemens Healthcare Diagnostics Inc. Integrated microfluidic device with pipette adaptation
JP7329180B2 (ja) 2020-02-03 2023-08-18 三菱マテリアル株式会社 表面被覆切削工具
KR102575966B1 (ko) * 2021-02-08 2023-09-07 성균관대학교산학협력단 식품 신선도 감지 센서 및 이의 제조 방법
US12242107B2 (en) 2022-10-07 2025-03-04 Fluxus, Inc. Optofluidic devices
EP4596106A1 (en) * 2024-01-31 2025-08-06 Imec VZW Integrated fluidic-electrical bonding
WO2025166149A1 (en) * 2024-02-02 2025-08-07 Life Technologies Corporation Microfluidic devices

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006202A (en) * 1990-06-04 1991-04-09 Xerox Corporation Fabricating method for silicon devices using a two step silicon etching process
ATE209782T1 (de) * 1993-05-18 2001-12-15 Univ Utah Res Found Vorrichtung und verfahren fuer homogene multianalyt-immuno-assays
US5919712A (en) * 1993-05-18 1999-07-06 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5385635A (en) * 1993-11-01 1995-01-31 Xerox Corporation Process for fabricating silicon channel structures with variable cross-sectional areas
US5563067A (en) * 1994-06-13 1996-10-08 Matsushita Electric Industrial Co., Ltd. Cell potential measurement apparatus having a plurality of microelectrodes
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US6054277A (en) 1996-05-08 2000-04-25 Regents Of The University Of Minnesota Integrated microchip genetic testing system
US6123820A (en) * 1998-06-05 2000-09-26 Grupo Ch-Werfen, S.A. Sensor cartridges
US6416642B1 (en) * 1999-01-21 2002-07-09 Caliper Technologies Corp. Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection
US6322683B1 (en) * 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US8071051B2 (en) * 2004-05-14 2011-12-06 Honeywell International Inc. Portable sample analyzer cartridge
US20020160520A1 (en) * 2001-03-16 2002-10-31 Phoenix Bioscience Silicon nano-collection analytic device
US6602791B2 (en) * 2001-04-27 2003-08-05 Dalsa Semiconductor Inc. Manufacture of integrated fluidic devices
US20040094733A1 (en) * 2001-08-31 2004-05-20 Hower Robert W. Micro-fluidic system
KR100472092B1 (ko) * 2002-05-14 2005-03-08 주식회사 헬스피아 이동통신단말기를 이용한 혈당측정장치 및 그 측정치를인터넷상의 서버에 전송하는 방법.
SE0201738D0 (sv) * 2002-06-07 2002-06-07 Aamic Ab Micro-fluid structures
US8153081B2 (en) * 2003-05-29 2012-04-10 Bayer Healthcare Llc Test sensor and method for manufacturing the same
JPWO2005024437A1 (ja) * 2003-09-05 2007-11-08 日本電気株式会社 測定システム
EP2489437A1 (en) * 2003-09-09 2012-08-22 BioGenex Laboratories Sample processing system
JP4179169B2 (ja) * 2004-01-08 2008-11-12 カシオ計算機株式会社 分析装置
WO2005071056A1 (ja) * 2004-01-23 2005-08-04 Kitakyushu Foundation For The Advancement Of Industry, Science And Technology バイオチップ及びそれを用いた試料溶液の機能性検査方法
JP2006058280A (ja) * 2004-03-16 2006-03-02 Fuji Photo Film Co Ltd 分析チップ
US8323564B2 (en) * 2004-05-14 2012-12-04 Honeywell International Inc. Portable sample analyzer system
US20060078475A1 (en) * 2004-07-29 2006-04-13 Yu-Chong Tai Modular microfluidic packaging system
CN101300352B (zh) * 2005-09-01 2013-03-20 佳能美国生命科学公司 检测、分析和鉴定基因组dna的方法和分子诊断装置
JP5377972B2 (ja) * 2005-11-22 2013-12-25 マイクロラボ ピーティーワイ エルティーディー 流体構造、装置、方法、及び機器構成方法
US8323570B2 (en) * 2006-03-21 2012-12-04 Koninklijke Philips Electronics N.V. Microelectronic sensor device with sensor array
FR2903679B1 (fr) * 2006-07-17 2014-07-04 Centre Nat Rech Scient Fabrication de dispositifs microfluidiques polymeriques par impression photo-assistee.
FR2906237B1 (fr) * 2006-09-22 2008-12-19 Commissariat Energie Atomique Composants fluidiques double-face
JP4458133B2 (ja) * 2007-02-27 2010-04-28 ソニー株式会社 核酸増幅装置
EP2011574A1 (en) 2007-07-02 2009-01-07 STMicroelectronics (Research & Development) Limited Assaying device and method of transporting a fluid in an assaying device
US9101931B2 (en) * 2007-12-28 2015-08-11 Intel Corporation Controlled fluid delivery in a microelectronic package
US20090317302A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Microfluidic System Comprising MEMS Integrated Circuit
JP5383138B2 (ja) * 2008-10-01 2014-01-08 シャープ株式会社 エレクトロウエッティングバルブ付き送液構造体、これを用いたマイクロ分析チップ及び分析装置
EP3514519B1 (en) * 2009-12-07 2022-02-09 Meso Scale Technologies, LLC. Assay cartridges
JP2011169695A (ja) * 2010-02-17 2011-09-01 Sharp Corp 送液装置
US10024819B2 (en) * 2010-10-21 2018-07-17 The Regents Of The University Of California Microfluidics with wirelessly powered electronic circuits
US20120225491A1 (en) * 2010-12-30 2012-09-06 Ayal Ram Portable detection devices and methods for detection of biomarkers and other analytes
US9050593B2 (en) * 2011-11-23 2015-06-09 Wisconsin Alumni Research Foundation Self-loading microfluidic device and methods of use
CN103212455B (zh) * 2012-01-20 2016-12-28 奥索临床诊断有限公司 在角附近具有均匀流的测定装置
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
ES2583413T3 (es) 2013-05-22 2016-09-20 Imec Vzw Dispositivo compacto de análisis de fluido y método de fabricación

Also Published As

Publication number Publication date
AU2014270412A1 (en) 2015-12-03
AU2014270412B2 (en) 2017-06-08
BR112015029245A2 (pt) 2017-07-25
RU2015150548A (ru) 2017-06-23
JP2015530900A (ja) 2015-10-29
EP2827988A1 (en) 2015-01-28
EP2827988B1 (en) 2016-04-27
WO2014187926A1 (en) 2014-11-27
MX2015016017A (es) 2016-06-21
US20150353351A1 (en) 2015-12-10
CA2912947A1 (en) 2014-11-27
CA2912947C (en) 2017-06-20
AU2018204016A1 (en) 2018-06-21
HK1210736A1 (zh) 2016-05-06
JP2020016659A (ja) 2020-01-30
ES2583413T3 (es) 2016-09-20
US20150093816A1 (en) 2015-04-02
ZA201509084B (en) 2017-07-26
US10843922B2 (en) 2020-11-24
JP2016179198A (ja) 2016-10-13
US9617149B2 (en) 2017-04-11
AU2017203450A1 (en) 2017-06-08

Similar Documents

Publication Publication Date Title
JP6006875B2 (ja) 小型流体分析デバイスおよび製造方法
Baillargeon et al. Microsampling tools for collecting, processing, and storing blood at the point‐of‐care
EP3223945B1 (en) Compact glass-based fluid analysis device and method to fabricate
CA2846675C (en) Rotatable fluid sample collection device
JP2016179198A5 (enExample)
EP2778679A1 (en) Rotable disk-shaped fluid sample collection device
CN104668002B (zh) 紧凑流体分析器件及其制造方法
EP3223944B1 (en) A fluid analysis device
CN109937092B (zh) 具有微珠集成系统的微流体芯片和芯片中集成受体的方法
US11684915B2 (en) Compact fluid analysis device and method to fabricate
HK1210736B (en) Compact fluid analysis device and method to fabricate
Sen et al. Microfluidics-Based Point-of-Care Diagnostic Devices
Hayes et al. Programmable Bio-Nano-Chip System

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150212

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20150212

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20150707

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150714

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20151007

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20151111

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20151209

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160113

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20160209

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160609

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20160616

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160719

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160720

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160816

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160909

R150 Certificate of patent or registration of utility model

Ref document number: 6006875

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250