JP6005357B2 - てんかんの治療 - Google Patents
てんかんの治療 Download PDFInfo
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- JP6005357B2 JP6005357B2 JP2011509662A JP2011509662A JP6005357B2 JP 6005357 B2 JP6005357 B2 JP 6005357B2 JP 2011509662 A JP2011509662 A JP 2011509662A JP 2011509662 A JP2011509662 A JP 2011509662A JP 6005357 B2 JP6005357 B2 JP 6005357B2
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- Prior art keywords
- epilepsy
- seizures
- peptide
- tat
- episode
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US61/054,109 | 2008-05-16 | ||
| PCT/US2009/043831 WO2009140416A2 (en) | 2008-05-16 | 2009-05-13 | Treatment for epilepsy |
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| JP2016109744A Division JP2016199553A (ja) | 2008-05-16 | 2016-06-01 | てんかんの治療 |
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| JP2011520900A JP2011520900A (ja) | 2011-07-21 |
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| JP2016109744A Pending JP2016199553A (ja) | 2008-05-16 | 2016-06-01 | てんかんの治療 |
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| EP (1) | EP2307035B1 (https=) |
| JP (2) | JP6005357B2 (https=) |
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| DK (1) | DK2307035T3 (https=) |
| ES (1) | ES2446306T3 (https=) |
| WO (1) | WO2009140416A2 (https=) |
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| US7595297B2 (en) * | 1999-06-02 | 2009-09-29 | Michael Tymianski | Method of reducing injury to mammalian cells |
| WO2008112661A2 (en) | 2007-03-09 | 2008-09-18 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| CN102088990A (zh) * | 2008-05-16 | 2011-06-08 | 阿尔伯维塔公司 | 癫痫的治疗 |
| CN102202677A (zh) | 2008-09-03 | 2011-09-28 | 阿尔伯维塔公司 | 治疗疼痛的活性剂和方法 |
| US20140323924A1 (en) * | 2013-04-26 | 2014-10-30 | David J. Mishelevich | Targeted optogenetic neuromodulation for treatment of clinical conditions |
| EP2950715A4 (en) * | 2013-01-31 | 2016-11-30 | Univ California | SYSTEM AND METHOD FOR MODELING BRAIN DYNAMICS IN NORMAL AND ILLNESS STATES |
| HUE059559T2 (hu) | 2015-02-25 | 2022-12-28 | Univ California | 5HT agonisták az epilepsziás rendellenességek kezelésére |
| US10583171B2 (en) | 2015-11-30 | 2020-03-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | NMDAR antagonists for the treatment of diseases associated with angiogenesis |
| JP2019522675A (ja) * | 2016-04-27 | 2019-08-15 | ▲拝▼西欧斯（北京）生物技▲術▼有限公司 | 興奮製神経毒性に関連した損傷の治療方法 |
| KR102253900B1 (ko) * | 2016-04-27 | 2021-05-18 | 바이오셀즈(베이징) 바이오테크 코., 엘티디. | 흥분성 신경독성 관련 손상 치료용 펩타이드 |
| KR20250048151A (ko) * | 2016-12-09 | 2025-04-07 | 알렉스자 파마스티칼즈, 인크. | 간질 치료 방법 |
| BR112020000115A2 (pt) | 2017-07-05 | 2020-07-07 | Biocells (Beijing) Biotech Co., Ltd. | sais farmaceuticamente aceitáveis de polipeptídeos e uso dos mesmos |
| JP7073486B2 (ja) * | 2017-09-30 | 2022-05-23 | ▲拝▼西欧斯（北京）生物技▲術▼有限公司 | 興奮性神経毒性に関連した損傷の治療用ペプチド組成物 |
| CN111712252A (zh) | 2017-12-13 | 2020-09-25 | 纽约州立大学研究基金会 | 用于治疗疼痛和提高疼痛敏感性的肽和其它药剂 |
| US12214118B2 (en) | 2018-02-02 | 2025-02-04 | Alexza Pharmaceuticals, Inc. | Electrical condensation aerosol device |
| EP3856212A1 (en) * | 2018-09-27 | 2021-08-04 | Finch Therapeutics Holdings LLC | Compositions and methods for treating epilepsy and related disorders |
| US20210137853A1 (en) * | 2019-09-17 | 2021-05-13 | Zogenix International Limited | Methods of treating epileptic patients with fenfluramine |
| CN110627877A (zh) * | 2019-09-25 | 2019-12-31 | 成都奥达生物科技有限公司 | 一种psd-95抑制剂 |
| CN111285923B (zh) * | 2020-03-05 | 2023-02-03 | 成都奥达生物科技有限公司 | 一种psd-95抑制剂 |
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| US20060148711A1 (en) * | 1999-05-14 | 2006-07-06 | Arbor Vita Corporation | Molecular interactions in neurons |
| US20050019841A1 (en) | 1999-05-14 | 2005-01-27 | Arbor Vita Corporation | Modulation of signaling pathways |
| US7595297B2 (en) * | 1999-06-02 | 2009-09-29 | Michael Tymianski | Method of reducing injury to mammalian cells |
| US20050282743A1 (en) | 2001-08-03 | 2005-12-22 | Arbor Vita Corporation | Molecular interactions in cells |
| US20090075377A1 (en) | 2001-08-03 | 2009-03-19 | Arbor Vita Corporation | Molecular interactions in cells |
| EP1709084A4 (en) | 2003-12-23 | 2008-05-28 | Nono Inc | POLYPEPTIDES FOR MODULATING BINDING OF TRP-CHANNEL PROTEINS AND TRP-ASSOCIATED PROTEINS |
| WO2005097090A2 (en) * | 2004-04-05 | 2005-10-20 | Icos Corporation | AGENTS THAT DISRUPT PSD95 - nNOS INTERACTION, COMPOSITIONS CONTAINING THE SAME, AND THERAPEUTIC USES THEREOF |
| WO2007002395A1 (en) * | 2005-06-23 | 2007-01-04 | Arbor Vita Corporation | Methods and compositions for modulating cox |
| US20070021501A1 (en) * | 2005-07-12 | 2007-01-25 | Twyman Roy E | Methods of treating epileptogenesis |
| CA2641421C (en) * | 2005-12-30 | 2014-07-29 | Arbor Vita Corporation | Small molecule inhibitors of pdz interactions |
| US8633160B2 (en) | 2005-12-30 | 2014-01-21 | Nono Inc. | Small molecule inhibitors of PDZ interactions |
| EP1884521A1 (en) * | 2006-07-31 | 2008-02-06 | Xigen S.A. | Fusion peptide for inhibiting interaction of neuronal NMDA receptor (NMDAR) and NMDAR interacting proteins |
| DK2120987T3 (en) * | 2007-03-02 | 2014-02-24 | Nono Inc | Treatment of stroke and other diseases without inhibiting N-type calcium channels |
| US8008253B2 (en) | 2007-07-03 | 2011-08-30 | Andrew Tasker | Treatment for anxiety |
| US8080518B2 (en) | 2007-12-05 | 2011-12-20 | Arbor Vita Corporation | Co-administration of an agent linked to an internalization peptide with an anti-inflammatory |
| CN102088990A (zh) | 2008-05-16 | 2011-06-08 | 阿尔伯维塔公司 | 癫痫的治疗 |
| CN102202677A (zh) | 2008-09-03 | 2011-09-28 | 阿尔伯维塔公司 | 治疗疼痛的活性剂和方法 |
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2009
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- 2009-05-13 WO PCT/US2009/043831 patent/WO2009140416A2/en not_active Ceased
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- 2009-05-13 JP JP2011509662A patent/JP6005357B2/ja not_active Expired - Fee Related
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- 2009-05-14 US US12/466,208 patent/US9161965B2/en active Active
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2016
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Also Published As
| Publication number | Publication date |
|---|---|
| ES2446306T3 (es) | 2014-03-07 |
| US20100160240A1 (en) | 2010-06-24 |
| WO2009140416A2 (en) | 2009-11-19 |
| DK2307035T3 (da) | 2014-01-20 |
| AU2009246316A1 (en) | 2009-11-19 |
| CA2724483C (en) | 2018-01-02 |
| CN102088990A (zh) | 2011-06-08 |
| US9161965B2 (en) | 2015-10-20 |
| EP2307035A4 (en) | 2012-04-11 |
| EP2307035B1 (en) | 2013-12-04 |
| EP2307035A2 (en) | 2011-04-13 |
| AU2009246316B2 (en) | 2014-06-19 |
| WO2009140416A3 (en) | 2010-01-14 |
| JP2011520900A (ja) | 2011-07-21 |
| CA2724483A1 (en) | 2009-11-19 |
| JP2016199553A (ja) | 2016-12-01 |
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