JP6001168B2 - フェニルアルキルスルファメート化合物及びこれを含む筋弛緩剤組成物 - Google Patents
フェニルアルキルスルファメート化合物及びこれを含む筋弛緩剤組成物 Download PDFInfo
- Publication number
- JP6001168B2 JP6001168B2 JP2015517189A JP2015517189A JP6001168B2 JP 6001168 B2 JP6001168 B2 JP 6001168B2 JP 2015517189 A JP2015517189 A JP 2015517189A JP 2015517189 A JP2015517189 A JP 2015517189A JP 6001168 B2 JP6001168 B2 JP 6001168B2
- Authority
- JP
- Japan
- Prior art keywords
- production example
- dioxolan
- methylsulfamate
- methyl
- dioxaspiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261660064P | 2012-06-15 | 2012-06-15 | |
| US61/660,064 | 2012-06-15 | ||
| PCT/KR2013/005279 WO2013187727A1 (en) | 2012-06-15 | 2013-06-14 | Phenylalkyl sulfamate compound and muscle relaxant composition comprising the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015531746A JP2015531746A (ja) | 2015-11-05 |
| JP2015531746A5 JP2015531746A5 (enExample) | 2016-06-16 |
| JP6001168B2 true JP6001168B2 (ja) | 2016-10-05 |
Family
ID=49758484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015517189A Active JP6001168B2 (ja) | 2012-06-15 | 2013-06-14 | フェニルアルキルスルファメート化合物及びこれを含む筋弛緩剤組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9221783B2 (enExample) |
| EP (1) | EP2861571B1 (enExample) |
| JP (1) | JP6001168B2 (enExample) |
| KR (1) | KR101699145B1 (enExample) |
| CN (1) | CN104428292B (enExample) |
| BR (1) | BR112014031396B1 (enExample) |
| CA (1) | CA2874988C (enExample) |
| ES (1) | ES2635067T3 (enExample) |
| WO (1) | WO2013187727A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015088272A1 (en) | 2013-12-12 | 2015-06-18 | Bio-Pharm Solutions Co., Ltd. | Sulfamate derivative compounds for use in treating or alleviating pain |
| US9937145B2 (en) * | 2013-12-12 | 2018-04-10 | Bio-Pharm Solutions Co., Ltd. | Sulfamate derivative compound for use in preventing or treating epilepsy |
| ES2704928T3 (es) | 2013-12-12 | 2019-03-20 | Bio Pharm Solutions Co Ltd | Compuestos derivados de sulfamato para su uso en el tratamiento o alivio del dolor |
| US11896593B2 (en) * | 2020-09-10 | 2024-02-13 | Bio-Pharm Solutions Co., Ltd. | Sulfamate derivative compounds for use in treating or alleviating a psychiatric disorder |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US459160A (en) * | 1891-09-08 | Half to isaac l | ||
| US2884444A (en) | 1956-01-13 | 1959-04-28 | Carter Prod Inc | 2-phenyl-1,3 propane diol dicarbamate |
| US2937119A (en) | 1959-06-11 | 1960-05-17 | Carter Prod Inc | Nu-monosubstituted-2, 2-dialkyl-1, 3-propanediol dicarbamates |
| US3313692A (en) | 1958-04-21 | 1967-04-11 | Armour Pharma | Method of inducing calming and muscle relaxation with carbamates |
| US3265727A (en) | 1962-06-26 | 1966-08-09 | Armour Pharma | Phenyl alkyl-1, 2 dicarbamates |
| US4591601A (en) | 1985-04-12 | 1986-05-27 | Mcneilab, Inc. | Anticonvulsant dioxolane methane sulfamates |
| US4792569A (en) | 1987-08-27 | 1988-12-20 | Mcneilab, Inc. | Anticonvulsant phenethyl sulfamates |
| US5025031A (en) | 1989-11-30 | 1991-06-18 | A. H. Robins Co., Inc. | Aryl and aryloxyalkyl sulfamate esters useful as anticonvulsants |
| JPH05140144A (ja) * | 1991-11-14 | 1993-06-08 | Nitto Denko Corp | 新規なアルコール及びその製法、及び新規なエステル並びにこの新規なアルコールからニンジン類の発根誘起物質を製造する方法 |
| JPH07228549A (ja) * | 1994-02-17 | 1995-08-29 | Japan Tobacco Inc | 新規な４−アリール−２，３−ジヒドロキシ酪酸誘導体及びその製造方法 |
| JP4145492B2 (ja) * | 1998-09-23 | 2008-09-03 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | テトラヒドロピリドエーテル |
| IS7839A (is) * | 2002-11-22 | 2004-05-23 | Merck Frosst Canada Ltd. | 4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar |
| US20050192286A1 (en) | 2003-10-22 | 2005-09-01 | Neurocrine Biosciences, Inc. | Ligands of melanocortin receptors and compositions and methods related thereto |
| WO2007005935A2 (en) * | 2005-07-06 | 2007-01-11 | Molecular Neuroimaging, Llc | Norepinephrine transporter radiotracers and methods of syntheses thereof |
| EP1945651B1 (en) * | 2005-10-25 | 2014-06-25 | The Ludwig Institute for Cancer Research | Analogs of alpha galactosylceramide and uses thereof |
-
2013
- 2013-06-14 JP JP2015517189A patent/JP6001168B2/ja active Active
- 2013-06-14 EP EP13803704.9A patent/EP2861571B1/en active Active
- 2013-06-14 BR BR112014031396A patent/BR112014031396B1/pt active IP Right Grant
- 2013-06-14 KR KR1020147035195A patent/KR101699145B1/ko active Active
- 2013-06-14 ES ES13803704.9T patent/ES2635067T3/es active Active
- 2013-06-14 CA CA2874988A patent/CA2874988C/en active Active
- 2013-06-14 CN CN201380031295.2A patent/CN104428292B/zh active Active
- 2013-06-14 WO PCT/KR2013/005279 patent/WO2013187727A1/en not_active Ceased
- 2013-06-14 US US14/401,990 patent/US9221783B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2861571A1 (en) | 2015-04-22 |
| EP2861571A4 (en) | 2015-11-04 |
| BR112014031396B1 (pt) | 2019-11-26 |
| BR112014031396A2 (pt) | 2017-06-27 |
| EP2861571B1 (en) | 2017-05-03 |
| CN104428292B (zh) | 2017-02-08 |
| CA2874988C (en) | 2016-05-24 |
| JP2015531746A (ja) | 2015-11-05 |
| CN104428292A (zh) | 2015-03-18 |
| KR20150023393A (ko) | 2015-03-05 |
| US20150266848A1 (en) | 2015-09-24 |
| US9221783B2 (en) | 2015-12-29 |
| ES2635067T3 (es) | 2017-10-02 |
| KR101699145B1 (ko) | 2017-02-03 |
| WO2013187727A1 (en) | 2013-12-19 |
| CA2874988A1 (en) | 2013-12-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2710902T3 (es) | Compuesto derivado de carbamatos de fenilalquilo y composición farmacéutica que contiene el mismo | |
| JP5838226B2 (ja) | フェニルカルバメート誘導体の製造方法 | |
| KR20120022801A (ko) | 카르복실산 화합물 | |
| JP6001168B2 (ja) | フェニルアルキルスルファメート化合物及びこれを含む筋弛緩剤組成物 | |
| JP2007517781A (ja) | アルツハイマー病治療用のフェニルアミドおよびピリジルアミド系β−セクレターゼ阻害薬 | |
| JP6096329B2 (ja) | フェニルカルバメート化合物及び記憶損失−関連疾患の予防又は治療用組成物 | |
| JP2015524447A (ja) | Ｎ−置換ピラゾロ［３，４−ｄ］ピリミジノン類化合物、その製造方法及びその使用 | |
| JP2021063095A (ja) | アミノ酸誘導体のプロドラッグ | |
| KR20160045797A (ko) | 리소포스파티드산 수용체 길항제로서의 아미드 유도체 | |
| JP6335307B2 (ja) | てんかん予防または治療用スルファメート誘導体化合物 | |
| US20180155302A1 (en) | Muscarinic m1 receptor positive allosteric modulators | |
| JP6220975B2 (ja) | 痛症を治療又は緩和するためのスルファメート誘導体化合物。｛ｓｕｌｆａｍａｔｅ ｄｅｒｉｖａｔｉｖｅ ｃｏｍｐｏｕｎｄｓ ｆｏｒ ｕｓｅ ｉｎ ｔｒｅａｔｉｎｇ ｏｒ ａｌｌｅｖｉａｔｉｎｇ ｐａｉｎ｝ | |
| EP2666771A1 (en) | Synthesis of Aminocyclopentanetriol Derivatives | |
| JP7648746B2 (ja) | 精神疾患の治療又は軽減のためのスルファメート誘導体化合物 | |
| Miyagawa et al. | Synthesis of jaspine B regioisomers through palladium-catalyzed stereoselective tetrahydrofuran formation: Insight into the ligand recognition of sphingosine kinases | |
| RU2470018C2 (ru) | Новые производные пирокатехина | |
| JP7314494B2 (ja) | アミノ酸誘導体のプロドラッグを含有する医薬 | |
| TW202241845A (zh) | 經取代的環己烷甲醯胺、其製備方法及其治療用途 | |
| JP3778843B2 (ja) | 光学活性アミン誘導体および合成法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150109 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150109 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160126 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20160420 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160803 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160831 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6001168 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |