JP5996647B2 - ４−置換イミダゾールの新規な調製プロセス - Google Patents
４−置換イミダゾールの新規な調製プロセス Download PDFInfo
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- JP5996647B2 JP5996647B2 JP2014522149A JP2014522149A JP5996647B2 JP 5996647 B2 JP5996647 B2 JP 5996647B2 JP 2014522149 A JP2014522149 A JP 2014522149A JP 2014522149 A JP2014522149 A JP 2014522149A JP 5996647 B2 JP5996647 B2 JP 5996647B2
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- CKNOCKWLNHPVRL-UHFFFAOYSA-N CC(C(C=O)Br)c1c(C)c(C)ccc1 Chemical compound CC(C(C=O)Br)c1c(C)c(C)ccc1 CKNOCKWLNHPVRL-UHFFFAOYSA-N 0.000 description 2
- CUHVIMMYOGQXCV-UHFFFAOYSA-N CC(c1c[nH]cn1)c1c(C)c(C)ccc1 Chemical compound CC(c1c[nH]cn1)c1c(C)c(C)ccc1 CUHVIMMYOGQXCV-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
- C07C47/105—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing rings
- C07C47/11—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing rings monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/228—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings, e.g. phenylacetaldehyde
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161510538P | 2011-07-22 | 2011-07-22 | |
| US61/510,538 | 2011-07-22 | ||
| PCT/GB2012/051746 WO2013014428A1 (en) | 2011-07-22 | 2012-07-20 | New processes for preparing 4-substituted imidazoles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014520901A JP2014520901A (ja) | 2014-08-25 |
| JP2014520901A5 JP2014520901A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2014-10-16 |
| JP5996647B2 true JP5996647B2 (ja) | 2016-09-21 |
Family
ID=46939718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014522149A Active JP5996647B2 (ja) | 2011-07-22 | 2012-07-20 | ４−置換イミダゾールの新規な調製プロセス |
Country Status (13)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103588711B (zh) | 2013-11-27 | 2015-04-08 | 天津炜捷制药有限公司 | 一种美托咪定中间体的制备方法 |
| GB201501593D0 (en) * | 2015-01-30 | 2015-03-18 | Cambrex Karlskoga Ab | New compounds and processes |
| KR101940663B1 (ko) | 2017-08-11 | 2019-01-22 | 충남대학교산학협력단 | 촉매 반응부를 가지는 산화제 과잉 시험장치 |
| KR101940662B1 (ko) | 2017-08-11 | 2019-01-22 | 충남대학교산학협력단 | 직류전원 공급부를 가지는 산화제 과잉환경 시험장치 |
| US12050293B2 (en) | 2018-12-19 | 2024-07-30 | Pgs Geophysical As | Medetomidine compositions having improved anti-fouling characteristics |
| ES2991795T3 (es) | 2020-10-21 | 2024-12-04 | I Tech Ab | Compuestos antiincrustantes |
| WO2023182903A1 (ru) | 2022-03-22 | 2023-09-28 | Общество с ограниченной ответственностью "ВИК-здоровье животных" | Способ получения медетомидина и его производных |
| EP4580398A1 (en) | 2022-09-01 | 2025-07-09 | I-Tech AB | Composition protecting wood against marine woodborers |
| CN115745893A (zh) * | 2022-11-16 | 2023-03-07 | 西安近代化学研究所 | 一种合成2-氰基-5-芳基-1h-咪唑类化合物的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL34269A (en) * | 1969-04-10 | 1974-11-29 | Prb Sa | Process for the arylation of olefins |
| GB2101114B (en) | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
| PL361054A1 (en) * | 2000-08-17 | 2004-09-20 | Pfizer Inc. | Substituted imidazoles as tafia inhibitors |
| EP1918282A1 (en) | 2006-11-06 | 2008-05-07 | "Joint Stock Company Grindeks" | Method for preparing medetomidine and its salts |
| WO2008142576A2 (en) * | 2007-05-24 | 2008-11-27 | Eldrug S.A. | 1,(3,)5-substituted imidazoles, their use in the treatment of hypertension and methods for their preparation |
| GB2453982B (en) * | 2007-10-24 | 2009-09-16 | Norbrook Lab Ltd | Chemical process for the preparation of Medetomidine |
| CN101921234B (zh) | 2009-06-12 | 2012-05-30 | 中国中化股份有限公司 | 一种制备美托咪啶的方法 |
| CN102753532B (zh) | 2009-12-09 | 2015-05-13 | I-技术有限公司 | 美托咪定的制备方法 |
-
2012
- 2012-07-20 KR KR1020147004568A patent/KR101932206B1/ko active Active
- 2012-07-20 JP JP2014522149A patent/JP5996647B2/ja active Active
- 2012-07-20 PL PL12766318T patent/PL2734508T3/pl unknown
- 2012-07-20 DK DK12766318.5T patent/DK2734508T3/en active
- 2012-07-20 WO PCT/GB2012/051746 patent/WO2013014428A1/en active Application Filing
- 2012-07-20 ES ES12766318.5T patent/ES2665093T3/es active Active
- 2012-07-20 IN IN144DEN2014 patent/IN2014DN00144A/en unknown
- 2012-07-20 CN CN201280035891.3A patent/CN103748077B/zh active Active
- 2012-07-20 EP EP12766318.5A patent/EP2734508B1/en active Active
- 2012-07-20 HU HUE12766318A patent/HUE037591T2/hu unknown
- 2012-07-20 US US14/234,263 patent/US8962862B2/en active Active
- 2012-07-20 HR HRP20180397TT patent/HRP20180397T1/hr unknown
-
2013
- 2013-01-26 NO NO13000388A patent/NO2650436T3/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014520901A (ja) | 2014-08-25 |
| HUE037591T2 (hu) | 2018-09-28 |
| ES2665093T3 (es) | 2018-04-24 |
| KR20140068888A (ko) | 2014-06-09 |
| EP2734508B1 (en) | 2018-02-28 |
| EP2734508A1 (en) | 2014-05-28 |
| DK2734508T3 (en) | 2018-05-22 |
| CN103748077B (zh) | 2016-08-17 |
| HRP20180397T1 (hr) | 2018-05-18 |
| IN2014DN00144A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-05-22 |
| KR101932206B1 (ko) | 2018-12-24 |
| PL2734508T3 (pl) | 2018-08-31 |
| US8962862B2 (en) | 2015-02-24 |
| NO2650436T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2018-03-10 |
| CN103748077A (zh) | 2014-04-23 |
| WO2013014428A1 (en) | 2013-01-31 |
| US20140187789A1 (en) | 2014-07-03 |
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